WO2015116524A1 - Offline glucose control based on preceding periods - Google Patents
Offline glucose control based on preceding periods Download PDFInfo
- Publication number
- WO2015116524A1 WO2015116524A1 PCT/US2015/012861 US2015012861W WO2015116524A1 WO 2015116524 A1 WO2015116524 A1 WO 2015116524A1 US 2015012861 W US2015012861 W US 2015012861W WO 2015116524 A1 WO2015116524 A1 WO 2015116524A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- insulin
- glucose
- correction
- dose
- control
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
- A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
- A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16804—Flow controllers
- A61M5/16827—Flow controllers controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H15/00—ICT specially adapted for medical reports, e.g. generation or transmission thereof
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M2005/14208—Pressure infusion, e.g. using pumps with a programmable infusion control system, characterised by the infusion program
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M2005/14288—Infusion or injection simulation
- A61M2005/14296—Pharmacokinetic models
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0468—Liquids non-physiological
- A61M2202/0486—Glucose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/07—Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/35—Communication
- A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
- A61M2205/3584—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver using modem, internet or bluetooth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/502—User interfaces, e.g. screens or keyboards
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/005—Parameter used as control input for the apparatus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
- A61M2230/201—Glucose concentration
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Primary Health Care (AREA)
- Pathology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Emergency Medicine (AREA)
- Optics & Photonics (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medical Treatment And Welfare Office Work (AREA)
Abstract
Description
Claims
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2015211258A AU2015211258A1 (en) | 2014-01-31 | 2015-01-26 | Offline glucose control based on preceding periods |
CN201580017176.0A CN106456064B (en) | 2014-01-31 | 2015-01-26 | Offline glucose control based on previous epochs |
EP15744078.5A EP3089667B1 (en) | 2014-01-31 | 2015-01-26 | Offline glucose control based on preceding periods |
CN202011391971.5A CN112515665B (en) | 2014-01-31 | 2015-01-26 | Blood glucose level control system |
CA2938078A CA2938078C (en) | 2014-01-31 | 2015-01-26 | Offline glucose control based on preceding periods |
EP22167586.1A EP4091541A1 (en) | 2014-01-31 | 2015-01-26 | Offline glucose control based on preceding periods |
JP2016548643A JP6243546B2 (en) | 2014-01-31 | 2015-01-26 | Offline glucose level control based on preceding period |
DK15744078.5T DK3089667T3 (en) | 2014-01-31 | 2015-01-26 | Offline glucose management based on prior time periods |
MX2016009787A MX2016009787A (en) | 2014-01-31 | 2015-01-26 | Offline glucose control based on preceding periods. |
IL246934A IL246934B (en) | 2014-01-31 | 2016-07-25 | Offline glucose level control based on preceding periods of online glucose level control |
US15/221,871 US10543313B2 (en) | 2014-01-31 | 2016-07-28 | Glucose level control system with offline control based on preceding periods of online control |
AU2017251868A AU2017251868B2 (en) | 2014-01-31 | 2017-10-30 | Offline glucose level control based on preceding periods of online glucose level control |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461933996P | 2014-01-31 | 2014-01-31 | |
US61/933,996 | 2014-01-31 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/221,871 Continuation US10543313B2 (en) | 2014-01-31 | 2016-07-28 | Glucose level control system with offline control based on preceding periods of online control |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2015116524A1 true WO2015116524A1 (en) | 2015-08-06 |
Family
ID=53757655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2015/012861 WO2015116524A1 (en) | 2014-01-31 | 2015-01-26 | Offline glucose control based on preceding periods |
Country Status (10)
Country | Link |
---|---|
US (1) | US10543313B2 (en) |
EP (2) | EP4091541A1 (en) |
JP (1) | JP6243546B2 (en) |
CN (2) | CN112515665B (en) |
AU (2) | AU2015211258A1 (en) |
CA (1) | CA2938078C (en) |
DK (1) | DK3089667T3 (en) |
IL (1) | IL246934B (en) |
MX (2) | MX2016009787A (en) |
WO (1) | WO2015116524A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107209800A (en) * | 2014-12-04 | 2017-09-26 | 美敦力迷你迈德公司 | The method and related infusion apparatus and system changed for operational mode |
JP2020500348A (en) * | 2016-09-30 | 2020-01-09 | ノボ・ノルデイスク・エー/エス | System and method for communicating dose history representing mean and variability of drug injection distribution |
US11154656B2 (en) | 2019-07-16 | 2021-10-26 | Beta Bionics, Inc. | Blood glucose control system with medicament bolus recommendation |
DE112020003392T5 (en) | 2019-07-16 | 2022-05-19 | Beta Bionics, Inc. | BLOOD SUGAR CONTROL SYSTEM |
DE112020004780T5 (en) | 2019-10-04 | 2022-09-01 | Beta Bionics, Inc. | BLOOD SUGAR CONTROL SYSTEM |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
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US9629901B2 (en) * | 2014-07-01 | 2017-04-25 | Bigfoot Biomedical, Inc. | Glucagon administration system and methods |
JP2018525093A (en) | 2015-08-07 | 2018-09-06 | トラスティーズ オブ ボストン ユニバーシティ | Glucose control system with automatic adaptation of glucose targets |
US11147920B2 (en) * | 2017-04-18 | 2021-10-19 | Lifescan Ip Holdings, Llc | Diabetes management system with automatic basal and manual bolus insulin control |
JP6874155B2 (en) | 2017-05-05 | 2021-05-19 | イーライ リリー アンド カンパニー | Closed loop control of physiological glucose |
GB201710822D0 (en) * | 2017-07-05 | 2017-08-16 | Zealand Pharma As | Methods and medical uses relating to the treatment of hypoglycaemia |
WO2019125932A1 (en) | 2017-12-21 | 2019-06-27 | Eli Lilly And Company | Closed loop control of physiological glucose |
CA3099113A1 (en) * | 2018-05-04 | 2019-11-07 | Insulet Corporation | Safety constraints for a control algorithm-based drug delivery system |
US11071821B2 (en) * | 2018-09-28 | 2021-07-27 | Medtronic Minimed, Inc. | Insulin infusion device with efficient confirmation routine for blood glucose measurements |
US11957876B2 (en) | 2019-07-16 | 2024-04-16 | Beta Bionics, Inc. | Glucose control system with automated backup therapy protocol generation |
US11278661B2 (en) | 2020-03-10 | 2022-03-22 | Beta Bionics, Inc. | Infusion system and components thereof |
US11688501B2 (en) | 2020-12-07 | 2023-06-27 | Beta Bionics, Inc. | Ambulatory medicament pump with safe access control |
US20220199218A1 (en) | 2020-12-07 | 2022-06-23 | Beta Bionics, Inc. | Ambulatory medicament pump with integrated medicament ordering interface |
US20220265143A1 (en) | 2020-12-07 | 2022-08-25 | Beta Bionics, Inc. | Ambulatory medicament pumps with selective alarm muting |
US11497852B2 (en) | 2020-12-21 | 2022-11-15 | Beta Bionics, Inc. | Ambulatory medicament device with power saving mode |
WO2023070253A1 (en) * | 2021-10-25 | 2023-05-04 | Medtrum Technologies Inc. | Closed-loop artificial pancreas insulin infusion control system |
Citations (11)
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DK85633C (en) | 1953-09-04 | 1958-06-02 | Gestetner Ltd | Duplicating machine. |
US20040253736A1 (en) * | 2003-06-06 | 2004-12-16 | Phil Stout | Analytical device with prediction module and related methods |
US20050272640A1 (en) * | 2004-05-13 | 2005-12-08 | Doyle Francis J Iii | Method and apparatus for glucose control and insulin dosing for diabetics |
US20080183060A1 (en) * | 2007-01-31 | 2008-07-31 | Steil Garry M | Model predictive method and system for controlling and supervising insulin infusion |
US20080208113A1 (en) | 2005-05-13 | 2008-08-28 | Trustees Of Boston University | Fully Automated Control System for Type I Diabetes |
US20100125241A1 (en) * | 2008-11-17 | 2010-05-20 | Disetronic Licensing, Ag | Prandial Blood Glucose Excursion Optimization Method Via Computation of Time-Varying Optimal Insulin Profiles and System Thereof |
US20110054391A1 (en) * | 2006-07-28 | 2011-03-03 | Ward W Kenneth | Analyte sensing and response system |
US20110208156A1 (en) * | 2010-02-11 | 2011-08-25 | The Regents Of The University Of California | Systems, devices and methods to deliver biological factors or drugs to a subject |
US20110208155A1 (en) * | 2010-02-19 | 2011-08-25 | Medtronic Minimed, Inc. | Closed-loop glucose control startup |
WO2012058694A2 (en) | 2010-10-31 | 2012-05-03 | Trustees Of Boston University | Blood glucose control system |
US20140031786A1 (en) | 2006-06-19 | 2014-01-30 | Dose Safety | System, method and article for controlling the dispensing of insulin |
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CN100446724C (en) * | 2005-11-28 | 2008-12-31 | 中国科学院电子学研究所 | Non-invasive blood sugar instrument for closed-loop insulin injection |
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-
2015
- 2015-01-26 EP EP22167586.1A patent/EP4091541A1/en active Pending
- 2015-01-26 WO PCT/US2015/012861 patent/WO2015116524A1/en active Application Filing
- 2015-01-26 CN CN202011391971.5A patent/CN112515665B/en active Active
- 2015-01-26 MX MX2016009787A patent/MX2016009787A/en active IP Right Grant
- 2015-01-26 CN CN201580017176.0A patent/CN106456064B/en active Active
- 2015-01-26 EP EP15744078.5A patent/EP3089667B1/en active Active
- 2015-01-26 DK DK15744078.5T patent/DK3089667T3/en active
- 2015-01-26 JP JP2016548643A patent/JP6243546B2/en active Active
- 2015-01-26 AU AU2015211258A patent/AU2015211258A1/en not_active Abandoned
- 2015-01-26 CA CA2938078A patent/CA2938078C/en active Active
-
2016
- 2016-07-25 IL IL246934A patent/IL246934B/en active IP Right Grant
- 2016-07-27 MX MX2020004660A patent/MX2020004660A/en unknown
- 2016-07-28 US US15/221,871 patent/US10543313B2/en active Active
-
2017
- 2017-10-30 AU AU2017251868A patent/AU2017251868B2/en active Active
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
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DK85633C (en) | 1953-09-04 | 1958-06-02 | Gestetner Ltd | Duplicating machine. |
US20040253736A1 (en) * | 2003-06-06 | 2004-12-16 | Phil Stout | Analytical device with prediction module and related methods |
US20050272640A1 (en) * | 2004-05-13 | 2005-12-08 | Doyle Francis J Iii | Method and apparatus for glucose control and insulin dosing for diabetics |
US20110106049A1 (en) * | 2005-05-13 | 2011-05-05 | Trustees Of Boston University | Fully automated control system for type 1 diabetes |
US20080208113A1 (en) | 2005-05-13 | 2008-08-28 | Trustees Of Boston University | Fully Automated Control System for Type I Diabetes |
US20140031786A1 (en) | 2006-06-19 | 2014-01-30 | Dose Safety | System, method and article for controlling the dispensing of insulin |
US20110054391A1 (en) * | 2006-07-28 | 2011-03-03 | Ward W Kenneth | Analyte sensing and response system |
US20080183060A1 (en) * | 2007-01-31 | 2008-07-31 | Steil Garry M | Model predictive method and system for controlling and supervising insulin infusion |
US20100125241A1 (en) * | 2008-11-17 | 2010-05-20 | Disetronic Licensing, Ag | Prandial Blood Glucose Excursion Optimization Method Via Computation of Time-Varying Optimal Insulin Profiles and System Thereof |
US20110208156A1 (en) * | 2010-02-11 | 2011-08-25 | The Regents Of The University Of California | Systems, devices and methods to deliver biological factors or drugs to a subject |
US20110208155A1 (en) * | 2010-02-19 | 2011-08-25 | Medtronic Minimed, Inc. | Closed-loop glucose control startup |
WO2012058694A2 (en) | 2010-10-31 | 2012-05-03 | Trustees Of Boston University | Blood glucose control system |
US20130245547A1 (en) | 2010-10-31 | 2013-09-19 | Trustees Of Boston University | Blood glucose control system |
Non-Patent Citations (1)
Title |
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See also references of EP3089667A4 |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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CN107209800B (en) * | 2014-12-04 | 2021-01-01 | 美敦力迷你迈德公司 | Method for operating mode switching and associated infusion device and system |
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DE112020004780T5 (en) | 2019-10-04 | 2022-09-01 | Beta Bionics, Inc. | BLOOD SUGAR CONTROL SYSTEM |
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MX2016009787A (en) | 2017-02-22 |
JP6243546B2 (en) | 2017-12-06 |
US20160331898A1 (en) | 2016-11-17 |
CN112515665A (en) | 2021-03-19 |
CA2938078C (en) | 2019-06-11 |
CN106456064B (en) | 2020-11-27 |
US10543313B2 (en) | 2020-01-28 |
IL246934B (en) | 2021-05-31 |
AU2017251868B2 (en) | 2019-07-11 |
JP2017511911A (en) | 2017-04-27 |
CN112515665B (en) | 2024-03-29 |
EP3089667A4 (en) | 2017-09-13 |
EP4091541A1 (en) | 2022-11-23 |
CN106456064A (en) | 2017-02-22 |
CA2938078A1 (en) | 2015-08-06 |
AU2017251868A1 (en) | 2017-11-16 |
EP3089667B1 (en) | 2022-04-13 |
IL246934A0 (en) | 2016-09-29 |
MX2020004660A (en) | 2020-07-24 |
DK3089667T3 (en) | 2022-05-09 |
EP3089667A1 (en) | 2016-11-09 |
AU2015211258A1 (en) | 2016-08-11 |
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