WO2015086789A1 - Use of a modified sweet whey and a modified sweet whey containing infant formula for promoting the postnatal development of the infant central nervous system and related cognitive functions - Google Patents
Use of a modified sweet whey and a modified sweet whey containing infant formula for promoting the postnatal development of the infant central nervous system and related cognitive functions Download PDFInfo
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- WO2015086789A1 WO2015086789A1 PCT/EP2014/077484 EP2014077484W WO2015086789A1 WO 2015086789 A1 WO2015086789 A1 WO 2015086789A1 EP 2014077484 W EP2014077484 W EP 2014077484W WO 2015086789 A1 WO2015086789 A1 WO 2015086789A1
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- mswp
- sweet whey
- protein
- infant
- young
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Definitions
- the central nervous system drives the cognitive functions.
- the cerebral cortex which is a sheet of neural tissue that is outermost to the cerebrum of the mammalian brain, plays a key role in attention, perceptual awareness, thought, language, higher order cognition (executive function) and information integration of sensory input.
- Cognitive Function refers to an intellectual process by which one becomes aware of, perceives, or comprehends ideas. It involves all aspects of perception, attention, thinking, reasoning, understanding and remembering. "Higher reasoning” refers to the process of thinking about something in a logical way in order to form a conclusion or judgment. It can also be referred to as executive functions.
- infant formulae according to the Commission Directives 2006/141/EC of 22 December 2006 and/or 91/321/EEC of 14 May 1991 on infant formulae and follow-on formulae, article 1.2 (c), the term “infant formulae” means foodstuffs intended for particular nutritional use by infants during the first four to six months of life and satisfying by themselves the nutritional requirements of this category of persons. It has to be understood that infants can be fed solely with infant formulas, or that the infant formula can be used by the carer as a complement of human milk. It is synonymous to the widely used expression "starter formula”.
- the dose of MSWP administered is such that the protein intake of the subject is within the appropriate guidelines (for example, WHO or ESPGHAN committee recommendations).
- a composition comprises about 9.0 to about 10.0 w/w% of protein, more preferably about 9.5% w/w%. This corresponds to about 1.8g protein /lOOkcal.
- An advantage provided by this concentration of protein is that it is equivalent to the amount of protein generally present in human milk and it corresponds to the lower limit described in the Codex Alimentarius.
- MSWP and/or MSWP-containing compositions of the present invention promotes the expression of two proteins involved in neuronal and glial cell growth, survival, plasticity and differentiation (notably, Brain Derived Neurotrophic Factor (BDNF)) and in neuronal myelination (notably, MBP).
- BDNF Brain Derived Neurotrophic Factor
- MSWP prevents or treats disorders such as impaired learning ability, loss of, or impaired higher reasoning and executive functions, memory impairment, concentration difficulties, delay in language development, abnormally low intelligence, abnormally low mental performance, mood deregulation/disturbance, or autism in children from birth to early adulthood (20 years old).
- Neuronal maturation has been positively impacted, in particular, in the structures of the brain associated with cognitive function. Neuronal growth, survival, plasticity and differentiation has been positively impacted by increased expression of BDNF. Signal transmission in the brain has been positively impacted by the increased expression of MBP which supports myelination.
- MSWP may be administered, when there has been already observed a retardation in the development of the CNS and, in particular, in the brain.
- This may follow, for example, any stress situations, such as those affecting the foetus (in utero) such as IUGR, that may have occurred following any adverse event during the gestation (for example, active or passive smoking of the mother, medication of the mother, low placenta quality, abnormal placenta positioning, malnutrition of the mother and/or the foetus, etc).
- a retardation in the development of the CNS and, in particular, in the brain may also occur in newborns (hypoxia-ischemia at birth, oxygen therapy and hyperoxia, inflammation, need for parenteral support, etc.), or any cause leading to oxidative stress.
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2014363470A AU2014363470B2 (en) | 2013-12-13 | 2014-12-12 | Use of a modified sweet whey and a modified sweet whey containing infant formula for promoting the postnatal development of the infant central nervous system and related cognitive functions |
US15/103,521 US10517918B2 (en) | 2013-12-13 | 2014-12-12 | Use of a modified sweet whey and a modified sweet whey containing infant formula for promoting the postnatal development of the infant central nervous system and related cognitive functions |
EP14811887.0A EP3079485B2 (en) | 2013-12-13 | 2014-12-12 | Use of a modified sweet whey and a modified sweet whey containing infant formula for promoting the postnatal development of the infant central nervous system and related cognitive functions |
MX2016007630A MX2016007630A (en) | 2013-12-13 | 2014-12-12 | Use of a modified sweet whey and a modified sweet whey containing infant formula for promoting the postnatal development of the infant central nervous system and related cognitive functions. |
CN201480067123.5A CN105979796A (en) | 2013-12-13 | 2014-12-12 | Use of a modified sweet whey and a modified sweet whey containing infant formula for promoting the postnatal development of the infant central nervous system and related cognitive functions |
RU2016128274A RU2692488C1 (en) | 2013-12-13 | 2014-12-12 | Using modified sweet milk whey and baby mixture containing modified sweet milk whey to stimulate postnatal development of central nervous system and corresponding cognitive functions of infant |
PH12016500732A PH12016500732A1 (en) | 2013-12-13 | 2016-04-19 | Use of a modified sweet whey and a modified sweet whey containing infant formula for promoting the postnatal development of the infant central nervous system and related cognitive functions |
AU2018211313A AU2018211313A1 (en) | 2013-12-13 | 2018-08-03 | Use of a modified sweet whey and a modified sweet whey containing infant formula for promoting the postnatal development of the infant central nervous system and related cognitive functions |
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AU (2) | AU2014363470B2 (en) |
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WO2017194068A1 (en) | 2016-05-12 | 2017-11-16 | Arla Foods Amba | Whey preparation for improving brain development |
WO2018002240A1 (en) * | 2016-07-01 | 2018-01-04 | Nestec S.A. | Nutritional composition comprising a probiotic for the prevention and/or treatment of anxiety disorders and related conditions in a mammal |
WO2019027974A1 (en) * | 2017-07-31 | 2019-02-07 | Immunotec Inc. | Compositions and methods for treatment of autism spectrum disorder |
CN110312516A (en) * | 2017-04-26 | 2019-10-08 | 株式会社明治 | Brainwork ability raising composition and cognitive ability raising composition |
WO2020001863A1 (en) * | 2018-06-25 | 2020-01-02 | Societe Des Produits Nestle S.A. | Composition comprising human milk oligosaccharides for use in improving, enhancing, promoting or modulating a gabaergic function in the central nervous system |
WO2020001862A1 (en) * | 2018-06-25 | 2020-01-02 | Societe Des Produits Nestle S.A. | Composition comprising human milk oligosaccharides for use in improving, enhancing, promoting or modulating a serotonergic function in the central nervous system |
US20210106017A1 (en) * | 2018-03-23 | 2021-04-15 | Morinaga Milk Industry Co., Ltd. | Composition for enhancing breast milk component |
RU2810236C2 (en) * | 2018-06-25 | 2023-12-25 | Сосьете Де Продюи Нестле С.А. | Composition containing breast milk oligosaccharides for use in improving, strengthening, stimulating or modulating gambergic function in central nervous system |
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Also Published As
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CN105979796A (en) | 2016-09-28 |
EP3079485B1 (en) | 2019-05-01 |
AU2014363470A1 (en) | 2016-04-14 |
PH12016500732A1 (en) | 2016-05-30 |
AU2018211313A1 (en) | 2018-08-23 |
MX2016007630A (en) | 2016-09-09 |
EP3079485A1 (en) | 2016-10-19 |
RU2692488C1 (en) | 2019-06-25 |
CL2016001486A1 (en) | 2017-01-20 |
US20160310557A1 (en) | 2016-10-27 |
US10517918B2 (en) | 2019-12-31 |
AU2014363470B2 (en) | 2018-09-06 |
EP3079485B2 (en) | 2022-03-30 |
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