WO2015084357A1 - Oral care whitening compositions containing fatty amphiphiles - Google Patents
Oral care whitening compositions containing fatty amphiphiles Download PDFInfo
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- WO2015084357A1 WO2015084357A1 PCT/US2013/073234 US2013073234W WO2015084357A1 WO 2015084357 A1 WO2015084357 A1 WO 2015084357A1 US 2013073234 W US2013073234 W US 2013073234W WO 2015084357 A1 WO2015084357 A1 WO 2015084357A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/594—Mixtures of polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging
Definitions
- Dentifrice formulations comprising peroxide are known and useful for cleaning and whitenmg teeth.
- the peroxide can bleach the teeth, remove stains, and kil l cariogenic bacteria.
- peroxide compounds are highly reactive, and consequently difficult to formulate.
- hydrogen peroxide can spontaneously decompose to form oxygen gas (0 2 ) and water, so that on storage, the dentifrice containers may bloat, burst or leak, and the remaining formulation will not have enough peroxide remaining to clean and whiten teeth effectively.
- Some dentifrices initially comprise very high levels of peroxide, which decomposes over time, so that the exact amount of peroxide delivered on application is variable and largely depends on how long and under what conditions the dentifrice has been stored,
- H 2 0 2 complexed with polyvinylpyrrol done. PVP
- PVP-H 2 0 2 dissociates into individual species (PVP polymer and H 2 0 2 ).
- the PVP-H 2 Q 2 complex is generally comprised of about 80% by weight polyvinyl pyrrolidone and 20% by weight H 2 O 2 .
- PVP-H 2 0 2 complexes and/or single phase whitening dentifrice compositions comprising same are described, e.g., in
- Phase separation is a significant challenge for gel dentifrices containing peroxides.
- Bloating can also be a problem in gel dentifrices containing peroxides.
- the present invention provides oral care compositions that are single phase dentifrices that can be facilely dispensed by the consumer from a single chamber tube.
- the oral care compositions are stable during long term storage and remain effective to clean and whiten teeth.
- the invention provides an oral care composition comprising: (i) a crosslinked polyvinylpyrrolidone complexed with hydrogen
- the fatty amphiphile is stearyl alcohol, cetyl alcohol or a combination of both
- the present invention provides oral care compositions and methods for administration, or application to, a human or other animal subject.
- an "oral care composition” is any composition that is suitable for administration or application to the oral cavity of a human or animal subject for enhancing the health, hygiene or appearance of the subject.
- an oral care composition is retained in the oral cavity for a time sufficient to affect the intended utility.
- the oral care composition is a dentifrice.
- dentifrice denotes a paste, gel, toothpowder, dental tablet or liquid formulation.
- the dentifrice deep striped, surface striped, or multilayered, having a gel surrounding the paste.
- the composition is used with a tape, tray, mouthpiece or similar appliance.
- the oral composition is a single phase toothpaste or gel.
- phase separation As used herein, the phrase "unacceptabl e level of phase separation” means phase separation that can be observed by the unaided eye after storage for 24 hours
- the present invention provides oral care compositions comprising (i) a crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide, (ii) a fatty
- the present invention provides oral care compositions comprising (i) a cross! Inked polyvinylpyrrolidone compiexed with hydrogen peroxide, (ii) a fatty
- amphiphile and (iii) a carrier comprising (a) an ethylene oxide, propylene oxide block copolymer of formula (ethylene oxide) x -(propylene oxide) y wherein x is an integer of 80-150 and y is an integer 30-80, having an average molecular weight of greater than 5000 Da, and (b) an abrasive.
- the abrasive is a calcium abrasive.
- the composition further comprises a surfactant.
- the composition further comprises a humectant.
- the composition further comprises a solvent.
- the invention provides an abrasive-free gel.
- composition 1 a toothpaste comprising (i) a whitening complex comprising crosslinked polyvinylpyrrolidone compiexed with hydrogen peroxide, (ii) a fatty amphiphile, e.g.,
- Composition I wherein the whitening complex contains about 10-30%, e.g., 15-25%, for example about 17-22% of hydrogen peroxide by weight, and about 5-15%, for example about 7- 12% total nitrogen by weight; for example, having substantially the same specifications as Polyplasdone® XL- 10, e.g., Polyplasdone® XL-IOF, e.g., available from International Specialty Products (Wayne, NJ);
- composition I or 1.1 wherein the fatty amphiphile is selected from fatty C n to Cas alcohols or mixtures thereof
- compositions wherein the amount of fatty amphiphile is from about 0.05% to about 30% or from about 0.1% to about 20% or from about 0.5% to about 10%, by weight of the composition;
- compositions further comprising a calcium abrasive such as calcium carbonate or calcium pyrophosphate;
- weight of the composition is 0.5-5%, e.g., 0.75 -3%, e.g. about 1%;
- compositions which contains less than 10 water e.g., less than 2%
- compositions mrther comprising polymer thickeners selected from (i) polyethylene glycol, (ii) polyethylene glycol - polypropylene glycol co-polymers having a molecular weight of at least 1000, and (iii) combinations thereof;
- composition comprising an ethylene oxide, propylene oxide co-polymer having an average molecular weight of greater than 1000, e.g. 5000 - 13000 Da, e.g. about 9800;
- composition additionally comprising polyethylene glycol of average molecular weight 400 to 800, e.g., about 600 Da;
- compositions additionally comprising humectants, e.g. selected from glycerin, propylene glycol or a combination thereof;
- compositions additionally comprising a tartar control agent, e.g., selected from tetrasodium pyrophosphate (TSPP) and sodium tripolyphosphate (STPP);.
- a surfactant e.g., sodium lauryl sulfate (8LS);
- compositions additionally comprising an antibacterial agent, e.g., triclosan;
- compositions additionally comprising an antioxidant, e.g., butvlated hydoxytoluene (BHT);
- BHT butvlated hydoxytoluene
- compositions additionally comprising a fluoride ion source such as sodium fluoride or sodium monofluorophosphate ;
- compositions comprising any or all of the following ingredient classes and/or particular ingredients by weight:
- Ethylene oxide, propylene oxide co-polymer avg. MW >lkDa 5-15%, e.g., about 7-10% or
- Polyethylene glycol 600 0-15%, e.g., about 10% Thickeners, e.g.
- peroxide 3-22% e.g., about 5- 12% or about 9-12%
- Sodium monofiuorophosphate 0.5 - 1 %, e.g., about 0.76%
- Surfactant e.g., SLS 0-5 e.g., 0-3%, e.g.,.1 -3%, e.g., about 2%
- Antioxidant 0.01-5%), e.g.
- Tartar control agent e.g. TSPP 0.1-5%, or 0.3-5%, e.g., about 0.3-0.5%o
- composition resulting from the combination of the preceding ingredients 1.19.
- the composition resulting from the combination of the preceding ingredients 1.19.
- the present invention provides oral care compositions comprising: a crosslmked poiyvinyipynOlidone complexed with hydrogen peroxide, a fatty amphiphile, a solvent, a polymer thickener an abrasive and a humectant.
- Some embodiments provide oral care compositions comprising: from about 0.5 to about 22%, by weight, crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide. Other embodiments provide oral care compositions comprising from about 1 to about 15%, by weight, crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide. Still other embodiments provide oral care compositions comprising from about 3 to about 15%, by weight, crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide. Yet other embodiments provide oral care compositions comprising from about 4 to about 12%, by weight, crosslinked
- polyvinylpyrrolidone complexed with hydrogen peroxide While other embodiments provide oral care compositions comprising from about 5 to about 11%, by weight, crosslinked polyvi.nylpyrroli.done complexed with, hydrogen peroxide. In some embodiments, the oral care compositions comprise about 5%, 6%, 7%, 8%), 8%, 9%), 10%, 1 1% or 12%. » by weight, crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide. In some embodiments, the oral care compositions comprise 5.5% by weight, crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide.
- compositions of the present invention comprise at least one fatty amphiphile.
- fatty amphiphile refers to a compound having a hydrophobic tail group of R) as defined below and a hydrophilic head group which does not make the compound water soluble (immiscible), wherein the compound also has a net neutral charge at the pH of the oral composition.
- the term ''water soluble means that the material is soluble in water in the present composition. In general the materia! should be soluble at 25° C, at a concentration of 0.1% by weight of the water solvent, preferably at 1%, more preferably at 5%, more preferably at 15%.
- the fatty amphiphile of the present invention may be characterized as a compound having a Hydrophihc-Lipophi!ic Balance ("HLB") of 6 or less.
- HLB Hydrophihc-Lipophi!ic Balance
- the HLB is the standard HLB according to Griffin, J. Soc. Cosm. Chem., vol, 5, 249 (1954), If using a mixture of fatty amp hip biles, it is desired that the mixture have a HLB of from about 1 to about 6 and preferably from about 1 to about 3. Therefore, fatty amphiphile having an HLB above 6 can be used if it is mixed with another fatty amphiphile having a lower HLB.
- the oral compositions of the present invention comprise fatty amphiphile in an amount from about 0.05% to about 30%, preferably from about 0.1% to about 20%, and more preferably from about 0.5 % to about 10%, by weight of the final oral composition .
- the amount of fatty amphiphile in the final oral composition is from about 2% to about 8% and more preferably from about 4% to about 6%.
- suitable fatty aniphiphiies, or suitable mixtures of two or more feity aniphiphiies preferably have a melting point of at least about 40° C. l some embodiments, it is preferred thai the melting point be at least about 50° C. or greater than about 55° C.
- the melting point may be measured by a standard melting point method as described in U.S. Pharmacopeia, USP- F General Chapter 741 "Melting range or temperature ' '.
- the melting point of a mixture of two or more materials is determined by mixing the two or more materials at a temperature above the respecti e melt points and then allowing the mixture to cool. If the resulting composite is a homogeneous solid below about 45° C, then the mixture has a suitable melting point for use in the present invention.
- suitable fatty amphiphiles have a hydrophobic tail group of R j .
- R.-. is an alkyl, alkenyi (containing up to 3 double bonds), alkyl aromatic, or branched alkyl group of C 12 ⁇ C7o length.
- Non-limiting examples of alkyl, alkenyi, or branched alkyl groups suitable for the fatty aniphiphiies of the present invention include lauryl, tridecyl, myristyl, pentadecyL cetyl, heptadecyi, stearyl, araehidyl, behenyi, undecyienyl, palmiioieyk oieyi, palmoleyi, linoleyi, linolenyl, arahchidonyl, elaidyl, elaeosiearyl, erucyi, isolauryl, isotridecyi, isornyrisiai, isopentadecyl, petroseiinyi, isocetyi, isoheptadecyi, isostearyl, isoarachidyL isobehnyl, gadoieyl, brassidyl, and technical-
- Rj may be alkyl, alkenyi or branched carbon chams of vegetable origin, such as wheat genu, sunflower, grape seed, sesame, maize, apricot, castor, avocado, olive, soybean, sweet almond, palm, rapeseed, cotton seed, hazelnut, macadamia, kariie, jojoba, alfalfa, poppy, pumpkinseed, sesame, cucumber, blackcurrant, evening primrose, millet, barley, quinoa, rye, safflower, candienut, passion flower or musk rose oi l, and karite butter,
- Suitable fatt aniphiphiies of the present invention also have a hydrophiiic head group which does not make the compound water soluble, such as in compounds having an HkB of 6 or less.
- Non-dimiting examples of classes of compounds having such a hydrophiiic head group include fatty alcohols, alkoxylated tatty alcohols, atty phenols, alkoxylated fatt phenols, tatty amides, alkyoxylated fatty amides, fatty amines, fatty aikyiamidoalkylamines, fatly a!kyoxy ailed amines, fatly carbamates, fatty amine oxides, fatty acids, alkoxylated fatty acids, fatty diesters, tatty sorbitan esters, fatty sugar esters, methyl glucoside esters, fatty glycol esters, mono, di & tri glycerides, polyglycerine fatty eslers, alkyl glyceryl
- Fatty amphiphiles of the present invention also may be selected from fatty alcohol compounds or alkoxylated fatty alcohol ether compounds according to the following formula:
- R is as described above; k is a C 1-C5 carbon cham winch may be branched or hydroxy substituted; and k is a number ranging from about 0 to about 5.
- the fatty alcohols useful herein are those havmg from about 12 to about 60 carbon atoms, preferably from about 16 lo about 60 carbon atoms.
- T hese fatly alcohols may be straight or branched chain alcohols and may be saturated or unsaturated.
- suitable fa ly alcohols include cetyl alcohol, steary!
- Suitable alkoxylated tatty alcohol elhers include addition products of 1 to 5 mol of ethylene oxide with a linear fatty alcohol having about 12 to about 60 carbon atoms, which are all addxicts obtainable by the known industrial oxyetbylation processes.
- polyethylene oxide condensates of alkyl phenols tor example, the condensation products of alkyl phenols having an alkyl group containing from about 12 to about 60 carbon atoms in either a straight chain or branched chain configuration, with ethylene oxide, wherein the ethylene oxide is present m amounts equal to from about I to about 5 moles of ethylene oxide per mole of alkyl phenol.
- alkoxylated ta ty alcohol ethers include those derived from the condensation of ethylene oxide wr h the product resulting from the reaction of propylene oxide and ethylene diamine products.
- Non-limiting examples of suitable alkoxylated fatty alcohol ethers include steareth-2, beheneth-2, beheneth-5, beheneth-IG, C20-4G Pareth-3, C20-40 Pareth-10, C30-50 Pareth-3, and C30-50-Pareth-lG.
- a combination of tatty alcohols such as cetyl and stearyi alcohol is preferred.
- the ratio of cetyl to stearyi alcohol can be from about 4: 1 to about 1 :4, preferably from about 2: 1 ro about 1 :2, ao i in some embodiments 1 : 1 .
- Fatty amphiphi!es of the present invention also may be selected from di -fatty ethers, fatty amides including fatty alkanoiarnides and fatty alkoxylated amides, fatty carbamates, fatty alkylamido a!ky!amines, fatty amirses including fatty
- compositions of the present invention may comprise a surface active agent
- surfactant Suitable surfactants include anionic, zwitterionic, amphoteric, cationic, and nonionic surfactants.
- the surfactants may be a combination of more than one type of surfactants, such as an anionic and nonionic surfactant.
- the surfactant is typically water soluble or miscible in the solvent or oral carrier.
- anionic surfactants such as sodium lauryi sulfate, are preferred.
- Suitable surfactants include without limitation water-soluble salts of Cg-20 alkyl sulfates, sulfonated monoglycerides of Cg-20 fatty acids, sarcosinates, taurates, sodium lauryi sulfate (SLS), sodium cocoyl monoglyceride sulfonate, sodium lauryi sarcosinate, sodium lauryi isoefhionate, sodium laureth carboxylate and sodium dodecyl benzenesuifonate, and
- cocoamidopropyl betaine The surfactant is typically present in an amount from about 0.01% to about 15%, in another embodiment from about 0.1% to about 10%, and in another embodiment from about 0.3% to about 5%, by weight of the oral composition. In some embodiments, a diluted solution of surfactant in water is utilized. In one embodiment, the amount of surfactant is chosen based on the level of foaming desired in the oral composition and on the irritation caused by the surfactant,
- compositions of the invention also comprise solvents, such as water or other suitable solvents, such as humectants.
- suitable solvents for the present invention include water, edible polyhydric alcohols such as glycerin, diglycerin, triglycerin, sorbitol, xylitol, butyiene glycol, erythritol, polyethylene glycol, propylene glycol, and combinations thereof. Sorbitol, glycerin, and combinations thereof are preferred solvents
- the oral compositions may comprise at least abou t 0.05% of a solvent, by weight of the oral composition.
- the solvent may be present in the oral composition in amount of from about 0.1% to about 99%, from about 0.5% to about 95%, and from about 1% to about 90%.
- compositions of the invention typically have a pH of about 5 to about 9, more particularly about 6 to about 8, and more particularly about 7.
- compositions of the invention also typically comprise an orally acceptable carrier or vehicle.
- the carrier may comprise abrasives, thickening agents, humectants, other polymers, colorants, viscosity modifiers, foam modulators, emulsifiers, pH modifying agents, diluents, mouth feel agents, sweetening agents, flavor agents, preservatives, suitable cosmetic and/or therapeutic actives, and combinations thereof, it is understood that while general attributes of each of the above categories of materials may differ, there may be some common attributes and any given material may serve multiple purposes within two or more of such categories of materials.
- ingredients in the compositions may have functions in addition to their primary function, and may contribute to the overall properties of the composition, including its stability, efficacy, consistency, mouthfeei, taste, odor and so forth.
- the carrier is selected for compatibility with other ingredients of the composition.
- Actives include any material that is generally considered safe for use in the oral cavity which is operable for the prevention or treatment of a condition or disorder of hard or soft tissue of the oral cavity, the prevention or treatment of a physiological disorder or condition, or to provide a cosmetic benefit.changes to the overall appearance and/or health of the oral cavity.
- actives include, but are not limited to, anti-calculus agents, fluoride ion sources, stannous ion sources, other whitening agents, anti-microbial agents, anti-malodor agents, anti- sensitivity agents, anti-erosion agents, anti-caries agents, anti-plaque agents, anti-inflammatory agents, saliva-stimulating agents, nutrients, antioxidants, anti-viral agents, analgesic and anesthetic agents, H-2 antagonists, and mixtures thereof.
- the level of cosmetic and/or therapeutic active in the oral care composition is, in one embodiment is from about 0.001% to about 90%, in another embodiment from about 0.01% to about 50%, and in another embodiment from about 0.1% to about 30%, by weight of the oral care composition.
- polyvinylpyrrolidone i.e., in addition to the PVP that is part of the PVP-H 2 0 2 complex, is not necessary to provi de stable or single phase compositions.
- additional linear and/or crosslinked polyvinylpyrrolidone can be added from about I to about 15%, by weight.
- Some embodiments of the present invention provide gel-based peroxide oral compositions further comprising a calcium abrasive.
- the compositions comprise from about 9 to about 25%, by weight, propylene glycol.
- the compositions comprise from about 14 to about 32%, by weight, glycerin.
- compositions comprise less than 20%, by weight, of a calcium abrasive.
- Some embodiments provide compositions comprising from about 9 to about 25%, by weight, propylene glycol; from about 14 to about 32%, by weight, glycerin; and less than 20%, by weight, of a calcium abrasive.
- Still other embodiments provide oral care compositions comprising from about 20 to about 60%, by weight, humectant.
- compositions comprising from about 5 to about 15%), by weight, abrasive,
- compositions of the invention are "low water” content, meaning that a total concentration of water, including any free water and all water contained in any ingredients, is less than about 20% total water, or less than about 10% total water, in another embodiment, less than about 5%), in another embodiment less than 3%, in another embodiment less than 2% water, in another embodiment less that 1 % water, i.e., is anhydrous.
- the average particle size is generally about 0.1 to about 30 microns, for example about 1 to about 20 or about 5 to about 15 microns.
- the oral composition comprises an anticalculus (tartar control) agent.
- tartar control agents are categorized as being incompatible with some whitening agents, but embodiments of the present invention incorporate tartar control agents and whitening agents in a single phase whitening composition.
- Suitable anticalculus agents include without limitation phosphates and polyphosphates (for example pyrophosphates), polyaminopropanesuifonic acid (AMPS), hexametaphosphate salts, zinc citrate trihydrate, polypeptides, polyolefin sulfonates, polyolefm phosphates, diphosphonat.es.
- the anticalculus agent is present at about 0.1% to about 30%.
- the oral composition may include a mixture of different anticalculus agents. In one preferred embodiment, tetrasodium
- the anticalculus agent comprises TSPP at about 1-2% and STPP at about 7% to about 10%.
- the oral care composition can optionally include at least one orally acceptable source of fluoride ions. Any known or to be developed in the art may be used, e.g., soluble fluoride salts. A wide variety of fluoride ion-yielding materials can be employed as sources of soluble fluoride in the present compositions. Examples of suitable fluoride ion-yielding materials are found in U.S. Pat, No. 3,535,421 , to Briner et al.; U.S. Pat. No. 4,885,155, to Parran, Jr. et al. and U.S. Pat. No. 3,678,154, to Widder et al, incorporated herein by reference.
- Representative fluoride ion sources include, but are not limited to, stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combmations thereof.
- the fluoride ion source includes stannous fluoride, sodium fluoride, sodium monofluorophosphate as well as mixtures thereof.
- the oral care composition of the invention may also contain a source of fluoride ions or fluorine-providing ingredient in amounts sufficient to supply about 25 ppm to about 25,000 ppm of fluoride ions, generally at least about 500 ppm, e.g., about 500 to about 2000 ppm, e.g., about 1000 to about 1600 ppm, e.g., about 1450 ppm.
- the appropriate level of fluoride will depend on the particular application, A toothpaste for general consumer use would typically have about 1000 to about 1 00 ppm, with pediatric toothpaste having somewhat less, in other embodiments the level of fluoride is about 100 to about 20,000 ppm, about 200 to about 5,000 ppm, or about 500 to about 2,500 ppm, fluoride ions. A dentifrice or coating for professional application could have as much as about 5,000 or even about 25,000 ppm fluoride.
- Fluoride ion sources may be added to the compositions of the invention at a level of about 0.01 wt. % to about 10 wt. % in one embodiment or about 0.03 wt. % to about 5 wt.
- Weights of fluoride salts to provide the appropriate level of fluoride ion will obviously vary based on the weight of the counter ion in the salt.
- compositions of the invention may also comprise various dentifrice ingredients to adjust the rheology and feel of the composition such as humectants, surface active agents, thickening or gelling agents, etc.
- compositions of the present invention optionally comprise a thickener.
- a thickening agent can be used, including without limitation carbomers, also known as carboxyvinyl polymers, carrageenans, also known as Irish moss and more particularly - carrageenan (iota-carrageenan), high molecular weight polyethylene glycols (such as
- CARBOWAX® available from The Dow Chemical Company
- cellulosic polymers such as hydroxyethylcelluiose, carboxymethylcellulose (CMC) and salts thereof, e.g., CMC sodium, natural gums such as karaya, xanthan, gum arable and tragacanth, colloidal magnesium aluminum silicate, and colloidal and/or fumed silica and mixtures of the same.
- CMC carboxymethylcellulose
- One or more thickening agents are optionally present in a total amount of about 0.1% to about 90%, for example about 1% to about 50% or about 5% to about 35%.
- the carrier may comprise polymers and/or copolymers of polyethylene glycol, of ethylene oxide / propylene oxide, and of silicone. If such
- copolyrners/polyrners are used, they may be selected from commercially available materials.
- Block copolymers of ethylene oxide / propylene oxide are useful, but higher molecular weight, e.g., > lOOODa are preferred, e.g. including PLU A CARE ⁇ LI.220 (available from BASF, Wyandotte, Mich., United States of America).
- Low or medium molecular weight polyethylene glycol, e.g., PEG 400, PEG 600, PEG 800, PEG 1000 and mixtures thereof are also useful.
- the compositions may include a stannous ion or a stannous ion source.
- Suitable stannous ion sources include without limitation stannous fluoride, other stannous halides such as stannous chloride dihydrate, stannous pyrophosphate, organic stannous carboxylate salts such as stannous formate, acetate, gluconate, lactate, tartrate, oxalate, malonate and citrate, stannous ethylene glyoxi.de and the like.
- One or more stannous ion sources are optionally and illustratively present in a total amount of about 0.01% to about 10%, for example about 0.1% to about 7% or about 1% to about 5%.
- compositions of the present invention optionally comprise an antimicrobial (e.g., antibacterial) agent.
- an antimicrobial agent e.g., antibacterial
- a further illustrative list of useful antibacterial agents is provided in such as those listed in U.S. Pat. No. 5,776,435 to Gaffar et al., the contents of which are incorporated herein by reference.
- One or more antimicrobial agents are optionally present in an antimicrobial effective total amount, typically about 0.05% to about 10%, for example about 0.1 % to about 3%.
- compositions of the present invention optionally comprise an antioxidant.
- Any orally acceptable antioxidant can be used, including butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), vitamin A, carotenoids, vitamin E, flavonoids, polyphenols, ascorbic acid, herbal antioxidants, chlorophyll, melatonin, and mixtures thereof,
- Methods are provided to whiten an oral surface in a human or animal subject comprising storing in stable form a composition of the invention, e.g., Composition 1, et seq., as described above, and contacting said composition with the oral surface.
- a composition of the invention e.g., Composition 1, et seq., as described above
- animal subject includes higher order non-human mammals such as canines, felines, and horses.
- the oral care composition is contacted with an oral surface of the mammalian subject to thereby whiten teeth in a highly efficacious manner, without any negative interaction between the whitening agent, the peroxide incompatible abrasive, and other ingredients.
- the oral care composition is applied and contacted with the oral surface.
- the dentifrice, prepared in accordance with the present invention is preferably applied regularly to an oral surface, preferably on a daily basis, at least one time daily for multiple days, but alternately every second or third day.
- the oral composition is applied to the oral surfaces from 1 to 3 times daily, for at least 2 weeks up to 8 weeks, from four months to three years, or more up to lifetime.
- compositions of the present invention do not exhibit an unacceptable level of phase separation after storage at room temperature for 24 hours. In other embodiments, the compositions of the present invention do not exhibit an unacceptable level of phase separation after storage at room temperature for 48 hours, 72 hours, 200 hours, 1 week, 1 month, 3 months, or six months.
- the diam eter of the top of th e tube in which a composition of the present invention is packaged expands less than 0.01% of the top diameter of the tube, after 1 week of aging at 60°C. In some embodiments, the diameter of the top of the tube in which a composition of the present invention is packaged, expands less than 0.05% of the top diameter of the tube, after 1 week of aging at 60°C. In some embodiments, the diameter of the top of the tube in which a composition of the present invention is packaged, expands less than 0.1% of the top diameter of the tube, after 1 week of aging at 60°C.
- the diameter of the top of the tube in which a composition of the present invention is packaged expands less than 0.5% of the top diameter of the tube, after 1 week of aging at 60°C. in some embodiments, the diameter of the top of the tube in which a composition of the present invention is packaged, expands less than 1% of the top diameter of the tube, after 1 week of aging at 60°C. In some embodiments, the diameter of the top of the tube in which a composition of the present invention is packaged, expands less than 3% of the top diameter of the tube, after 1 week of aging at 60°C.
- the diameter of the top of the tube in which a composition of the present invention is packaged expands less than 5% of the top diameter of the tube, after 1 week of aging at 60°C. In some embodiments, the diameter of the top of the tube in which a composition of the present invention is packaged, expands less than 10% of the top diameter of the tube, after 1 week of aging at 60°C. In some embodiments, the diameter of the top of the tube in which a composition of the present invention is packaged, expands less than 15% of the top diameter of the tube, after 1 week of aging at 60°C. In some embodiments, the diameter of the top of the tube in which a composition of the present invention is packaged, expands less than 20% of the top diameter of the tube, after 1 week of aging at 60°C.
- the diam eter of the top of th e tube in which a composition of the present invention is packaged expands less than 25% of the top diameter of the tube, after 1 week of aging at 60°C. In other embodiments, the diameter of the top of the tube in which a composition of the present invention is packaged, expands less than 30% of the top diameter of the tube, after 1 week of aging at 60°C. In some embodiments, the diameter of the top of the tube in which a composition of the present invention is packaged, expands less than 35% of the top diameter of the tube, after 1 week of aging at 60°C.
- the diameter of the top of the tube in which a composition of the present invention is packaged expands less than 40% of the top diameter of the tube, after 1 week of aging at 60°C. In some embodiments, the diameter of the top of the tube in which a composition of the present invention is packaged, expands less than 45% of the top diameter of the tube, after 1 week of aging at 60°C. In some embodiments, the diameter of the top of the tube in which a composition of the present invention is packaged, expands l ess than 50% of the top diameter of the tube, after 1 week of aging at 60°C.
- a gel dentifrice having a peroxide composition of abou t 2% is prepared having the ingredients in Table 1.
- a gel dentifrice having a peroxide composition of abou t 2% is prepared having the ingredients in Table 2.
- Table 2 A gel dentifrice having a peroxide composition of abou t 2% is prepared having the ingredients in Table 2.
- a toothpaste having a peroxide content of about 2% is prepared with the ingredients in Table 3.
- Example 2-4 The toothpastes of Example 2-4 are tested for stability to remain in a single phase. Samples are stored at room temperature for 24 and examined for visible phase separation. Examples 2 and 3, containing stearyl alcohol and cetyl alcohol respectively, are stable in that no phase separation is observed. Example 4 is not stable in that a separation into two distinct phases is observed.
Abstract
Description
Claims
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
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CA2926396A CA2926396C (en) | 2013-12-05 | 2013-12-05 | Oral care whitening compositions containing fatty amphiphiles |
CN201380081340.5A CN105792805A (en) | 2013-12-05 | 2013-12-05 | Oral care whitening compositions containing fatty amphiphiles |
RU2016121898A RU2646484C2 (en) | 2013-12-05 | 2013-12-05 | Whitening compositions for oral care containing fatty amphiphiles |
PCT/US2013/073234 WO2015084357A1 (en) | 2013-12-05 | 2013-12-05 | Oral care whitening compositions containing fatty amphiphiles |
EP13824693.9A EP3076926B1 (en) | 2013-12-05 | 2013-12-05 | Oral care whitening compositions containing fatty amphiphiles |
US15/101,153 US20160303011A1 (en) | 2013-12-05 | 2013-12-05 | Oral Care Whitening Compositions Containing Fatty Amphiphiles |
BR112016011932A BR112016011932A2 (en) | 2013-12-05 | 2013-12-05 | CLEANSING COMPOSITIONS FOR ORAL CARE CONTAINING FATTY AMPHIPHILIC COMPOUNDS |
AU2013406744A AU2013406744B2 (en) | 2013-12-05 | 2013-12-05 | Oral care whitening compositions containing fatty amphiphiles |
MX2016006948A MX353023B (en) | 2013-12-05 | 2013-12-05 | Oral care whitening compositions containing fatty amphiphiles. |
TW103141895A TW201534338A (en) | 2013-12-05 | 2014-12-03 | Oral care whitening compositions containing fatty amphiphiles |
ARP140104554A AR098652A1 (en) | 2013-12-05 | 2014-12-05 | WHITENING COMPOSITIONS FOR ORAL CARE CONTAINING EXPENSIVE FATS |
PH12016500890A PH12016500890A1 (en) | 2013-12-05 | 2016-05-12 | Oral care whitening compositions containing fatty amphiphiles |
IL245701A IL245701A0 (en) | 2013-12-05 | 2016-05-18 | Oral care whitening compositions containing fatty amphiphiles |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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PCT/US2013/073234 WO2015084357A1 (en) | 2013-12-05 | 2013-12-05 | Oral care whitening compositions containing fatty amphiphiles |
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WO2015084357A1 true WO2015084357A1 (en) | 2015-06-11 |
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PCT/US2013/073234 WO2015084357A1 (en) | 2013-12-05 | 2013-12-05 | Oral care whitening compositions containing fatty amphiphiles |
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Country | Link |
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US (1) | US20160303011A1 (en) |
EP (1) | EP3076926B1 (en) |
CN (1) | CN105792805A (en) |
AR (1) | AR098652A1 (en) |
AU (1) | AU2013406744B2 (en) |
BR (1) | BR112016011932A2 (en) |
CA (1) | CA2926396C (en) |
IL (1) | IL245701A0 (en) |
MX (1) | MX353023B (en) |
PH (1) | PH12016500890A1 (en) |
RU (1) | RU2646484C2 (en) |
TW (1) | TW201534338A (en) |
WO (1) | WO2015084357A1 (en) |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022216666A1 (en) * | 2021-04-08 | 2022-10-13 | Colgate-Palmolive Company | Oral care compositions |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11141364B2 (en) * | 2017-11-30 | 2021-10-12 | Colgate-Palmolive Company | Oral care compositions |
WO2024015246A1 (en) * | 2022-07-11 | 2024-01-18 | Basf Se | Oral care composition comprising a peroxide and an ethylene oxide/propylene oxide block copolymer |
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2013
- 2013-12-05 US US15/101,153 patent/US20160303011A1/en not_active Abandoned
- 2013-12-05 BR BR112016011932A patent/BR112016011932A2/en not_active IP Right Cessation
- 2013-12-05 MX MX2016006948A patent/MX353023B/en active IP Right Grant
- 2013-12-05 WO PCT/US2013/073234 patent/WO2015084357A1/en active Application Filing
- 2013-12-05 CN CN201380081340.5A patent/CN105792805A/en active Pending
- 2013-12-05 RU RU2016121898A patent/RU2646484C2/en active
- 2013-12-05 CA CA2926396A patent/CA2926396C/en active Active
- 2013-12-05 EP EP13824693.9A patent/EP3076926B1/en active Active
- 2013-12-05 AU AU2013406744A patent/AU2013406744B2/en active Active
-
2014
- 2014-12-03 TW TW103141895A patent/TW201534338A/en unknown
- 2014-12-05 AR ARP140104554A patent/AR098652A1/en unknown
-
2016
- 2016-05-12 PH PH12016500890A patent/PH12016500890A1/en unknown
- 2016-05-18 IL IL245701A patent/IL245701A0/en unknown
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Also Published As
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MX2016006948A (en) | 2016-08-19 |
IL245701A0 (en) | 2016-07-31 |
AR098652A1 (en) | 2016-06-01 |
CN105792805A (en) | 2016-07-20 |
CA2926396A1 (en) | 2015-06-11 |
CA2926396C (en) | 2021-06-15 |
EP3076926B1 (en) | 2018-02-14 |
EP3076926A1 (en) | 2016-10-12 |
AU2013406744B2 (en) | 2017-06-22 |
AU2013406744A1 (en) | 2016-06-02 |
PH12016500890A1 (en) | 2016-06-20 |
RU2646484C2 (en) | 2018-03-05 |
TW201534338A (en) | 2015-09-16 |
BR112016011932A2 (en) | 2017-08-08 |
US20160303011A1 (en) | 2016-10-20 |
MX353023B (en) | 2017-12-18 |
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