WO2015080433A1 - Pharmaceutical combination formulation comprising amlodipine, losartan and rosuvastatin - Google Patents
Pharmaceutical combination formulation comprising amlodipine, losartan and rosuvastatin Download PDFInfo
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- WO2015080433A1 WO2015080433A1 PCT/KR2014/011205 KR2014011205W WO2015080433A1 WO 2015080433 A1 WO2015080433 A1 WO 2015080433A1 KR 2014011205 W KR2014011205 W KR 2014011205W WO 2015080433 A1 WO2015080433 A1 WO 2015080433A1
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- pharmaceutically acceptable
- losartan
- rosuvastatin
- amlodipine
- acceptable salt
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- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
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Definitions
- the present invention relates to a pharmaceutical combination formulation comprising amlodipine, losartan and rosuvastatin. More specifically, it relates to a pharmaceutical combination formulation comprising a first discrete part containing amlodipine and rosuvastatin and a second discrete part containing losartan, which exhibits improved dissolution rate and stability.
- hypertension cases are categorized as primary hypertension which means high blood pressure with no obvious underlying medical cause.
- the exact cause of primary hypertension is unknown, but a number of factors including increase in cardiac output (the volume of blood being pumped out by the heart) or peripheral resistance are believed to contribute to the onset of the disease.
- Risk factors that are related to hypertension include psychological and environmental factors such as drinking, smoking, aging, lack of exercise, obesity, too much salt in the diet, stress and the like. Genetically, when both parents have hypertension, the offspring has an 80% chance of having hypertension; if one of the parents has hypertension, the offspring has a 25 to 50% chance of having hypertension.
- the ultimate goal in the treatment of hypertension is to maintain an optimal blood pressure to minimize tissue damage caused by hypertension.
- adopting a preventative lifestyle is as important as taking a medication. It is a goal to keep blood pressure less than 140/90 mmHg for patients with hypertension, and less than 130/80 mml lg for hypertensive patients with diabetic or nephritis complications.
- hypertension may reduce mortality caused by stroke and cardiovascular disorders.
- patients with hypertension When patients with hypertension are properly treated, it is estimated that risks of experiencing stroke, myocardial infarction and heart failure are lowered by about 35-40%, 20-25% and more than 50%, respectively.
- Lowering systolic blood pressure by 5 mmHg reduces all-cause mortality by 7% on a population basis, while mortality for coronary heart disease and stroke can be reduced by 9% and 14%, respectively.
- blood pressure is closely related to Alzheimer's disease and, thus, blood pressure management may reduce the risk of Alzheimer's disease.
- a combination of drugs of different mechanisms has an advantage over individual drugs in terms of preventive and therapeutic effect. Also, a combination therapy reduces doses of individual drugs, thereby reducing side effects which may occur due to long-term administration of individual drugs.
- vasodilators are further categorized in accordance with their mechanism of action, as follows: angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers and calcium channel blockers.
- ACE angiotensin-converting enzyme
- hyperlipidemia is a disorder in which an excessively high level of lipids in the blood cause a buildup of plaque on the walls of the arteries, followed by inflammation and, ultimately, cardiovascular disorders.
- an abnormal amount of lipids in the blood is defined as dyslipidemia.
- non-drug therapies such as lifestyle changes
- Statin-based drugs are often used, and these drugs act as an HMG-CoA reductase inhibitor which has an ability to inhibit cholesterol synthesis and thereby to cause significant reduction in plasma LDL-cholesterol levels, and also result in partial reduction in triglycerides levels.
- Amlodipine is a generic name for
- amlodipine besylate is commercially available under the trade name Novasc ® .
- Amlodipine camsylate as disclosed in Korean Patent No. 452491, shows superior solubility and stability to amlodipine besylate, and is currently available under the trade name Amodipin ® .
- Amlodipine blocks calcium channel, and is useful in the treatment of cardiovascular disorders such as angina, hypertension and congestive heart failure.
- Losartan is a generic name for
- losartan potassium is commercially available under the trade name Cozaar ® , By blocking the interaction of angiotensin II and its receptor, losartan is mainly used for treating hypertension, heart failure, ischemic peripheral circulatory disorder, myocardial ischemia (angina pectoris), diabetic neuropathy and glaucoma, and also for preventing the progression of post-myocardial infarction heart failure.
- a combination formulation of amlodipine and losartan that have different mechanism of action from each other has an advantage over the individual drugs in terms of preventive and therapeutic effect.
- such formulation reduces doses of the individual drugs, thereby decreasing side effects which may occur due to a long-term administration of the individual drugs.
- the combination formulation is disclosed in Korean Patent Nos. 1 160151, 1232296, etc., and currently sold under the trade name Amosartan .
- the co-occurrence rate of hypertension and hyperlipidemia is approximately 49%, and co-administration of Amosartan ® and statin-based drugs takes up about 30% in the drug treatment of cardiovascular disorders.
- the present inventors have conducted intensive research to redress the problems of the conventional formulations, and found that dissolution rate and stability of the active ingredients varied depending on the structure of a bilayer tablet and the manufacturing method thereof, and thus accomplished a pharmaceutical combination formulation comprising amlodipine, losartan and rosuvastatin having improved dissolution rate and stability.
- a pharmaceutical combination formulation for the treatment of a cardiovascular disorder comprising amlodipine, losartan and rosuvastatin, having different action mechanisms from one another, which exhibits excellent dissolution and stability properties.
- a pharmaceutical combination formulation for the prevention or treatment of a cardiovascular disorder comprising: (1) a first discrete part comprising amlodipine or a pharmaceutically acceptable salt thereof, rosuvastatin or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive; and (2) a second discrete part comprising losartan or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive, wherein said discrete parts are physically separated from each other.
- the pharmaceutical combination formulation comprising amlodipine, losartan and rosuvastatin can be effectively used to prevent or treat a cardiovascular disorder. Designed to minimize an interaction among active ingredients, the pharmaceutical combination formulation exhibits excellent storage stability and dissolution rates of amlodipine, losartan and rosuvastatin, and thus can be useful in pharmaceutical industries.
- Fig. 1 is a schematic view showing a bilayer tablet according to one embodiment of the present invention.
- Fig. 2 is a graph showing dissolution rate of amlodipine in the formulations of Example 1 and Comparative Example 1.
- Fig. 3 is a graph showing dissolution rate of rosuvastatin in the formulations of Example 1 and Comparative Example 1.
- Fig. 4 is a graph showing dissolution rate of losartan in the formulations of Example 1 and Comparative Example 1.
- Fig. 5 is a graph showing dissolution rate of amlodipine in the formulations of Example 1 and Comparative Example 2.
- Fig. 6 is a graph showing dissolution rate of rosuvastatin in the formulations of Example 1 and Comparative Example 2.
- Fig. 7 is a graph showing dissolution rate of losartan in the formulations of Example 1 and Comparative Example 2.
- Fig. 8 is a graph showing dissolution rate of amlodipine in the formulations of Examples 1 to 3 and Comparative Examples 3 to 5.
- Fig. 9 is a graph showing dissolution rate of rosuvastatin in the formulations of Examples 1 to 3 and Comparative Examples 3 to 5. ?
- Fig. 10 is a graph showing dissolution rate of losartan in the formulations of Examples 1 to 3 and Comparative Examples 3 to 5.
- Fig. 1 1 is a graph showing dissolution rate of amlodipine in the formulations of Example 1 and Comparative Examples 6 and 7.
- Fig. 12 is a graph showing dissolution rate of rosuvastatin in the formulations of Example 1 and Comparative Examples 6 and 7.
- Fig. 13 is a graph showing dissolution rate of losartan in the formulations of Example 1 and Comparative Examples 6 and 7.
- Fig. 14 is a graph showing dissolution rate of amlodipine in. the formulations of Examples 4 to 6 and Comparative Examples 8 to 10.
- Fig. 15 is a graph showing dissolution rate of rosuvastatin in the formulations of Examples 4 to 6 and Comparative Examples 8 to 10.
- Fig. 16 is a graph showing dissolution rate of losartan in the formulations of Examples 4 to 6 and Comparative Examples 8 to 10.
- the present invention provides a pharmaceutical combination formulation for the prevention or treatment of a cardiovascular disorder, comprising: (1) a first discrete part comprising amlodipine or a pharmaceutically acceptable salt thereof, rosuvastatin or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive; and (2) a second discrete part comprising losartan or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive, wherein said discrete parts are physically separated from each other.
- the combination formulation according to the present invention comprises the first and the second discrete parts in which said discrete parts are physically separated, i.e., amlodipine and losartan are separately contained.
- amlodipine and losartan are separately contained.
- the first discrete part and the second discrete part in the combination formulation may be a first layer and a second layer, respectively.
- the combination formulation may be in the form of a bilayer tablet comprising: (1) a first layer comprising amlodipine or a pharmaceutically acceptable salt thereof, rosuvastatin or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive; and (2) a second layer comprising losartan or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive (see Fig. 1).
- the combination formulation may be prepared in various forms where a first discrete part and a second discrete part are physically separated from each other (for example, core-shell structure).
- the combination formulation of the present invention comprises amlodipine or a pharmaceutically acceptable salt thereof in the first discrete part (or the first layer).
- the pharmaceutically acceptable salt of amlodipine employed in the present invention may be prepared by using an acid containing a pharmaceutically acceptable anion which can form a non-toxic acid addition salt, e.g., hydrogen chloride, hydrogen bromide, sulfate, phosphate, acetate, malate, furmarate, lactate, tartrate, citrate, gluconate, besylate and camsylate, but are not limited thereto.
- the pharmaceutically acceptable salt of amlodipine is amlodipine besylate and camsylate, more preferably camsylate.
- amlodipine of . the present invention includes a racemic mixture and (S)-amlodipine. Amlodipine or a pharmaceutically acceptable salt thereof may be administered at a daily dose of from 5 to 10 mg.
- the combination formulation of the present invention comprises rosuvastatin or a pharmaceutically acceptable salt thereof in the first discrete part (or the first layer).
- the pharmaceutically acceptable salt of rosuvastatin include inorganic salts having polycation, preferably rosuvastatin calcium, but are not limited thereto. Rosuvastatin or a pharmaceutically acceptable salt thereof may be administered at a daily dose of from 10 to 20 mg.
- the combination formulation of the present invention comprises losartan or a pharmaceutically acceptable salt thereof in the second discrete part (or the second layer).
- examples of the pharmaceutically acceptable salt of losartan include losartan potassium, but are not limited thereto.
- Losartan or a pharmaceutically acceptable salt thereof may be administered at a daily dose of from 45 to 100 mg.
- amlodipine or a pharmaceutically acceptable salt thereof, rosuvastatin or a pharmaceutically acceptable salt thereof and losartan or a pharmaceutically acceptable salt thereof may be admixed in a weight ratio of 1 : 1-4 : 10-20, but not limited thereto.
- the first discrete part (or the first layer) arid the second discrete part (or the second layer) of the combination formulation may further comprise a pharmaceutically acceptable additive, e.g., a pharmaceutically acceptable ; . carrier or excipient.
- a pharmaceutically acceptable carrier or excipient include lactose (lactose hydrate), micro-crystalline cellulose, mannitol, sodium citrate, ⁇ 3 ⁇ citrate, calcium phosphate, glycine and starch, a disintegrant (e.g., crospovidone, copovidone, sodium starch glycolate, croscarmellose sodium, and combination silicates) and a binder (e.g. , polyvinylpyrrolidone, hydroxypropyl methyl cellulose (HPMC), hydroxypropyl cellulose (HPC), sucrose, gelatin and acacia gum.
- lactose lactose hydrate
- micro-crystalline cellulose mannitol
- mannitol sodium cit
- the combination formulation of the present invention comprises lactose hydrate and micro-crystalline cellulose in the first discrete part (or the first layer) as additives.
- the lactose hydrate may be comprised in an amount of from 20 to 40 wt% based on the total weight of the first discrete part (or the first layer).
- the micro-crystalline cellulose may be comprised in an amount of from 50 to 70 wt% based on the total weight of the first discrete part (or the first layer).
- the lactose hydrate and micro-crystalline cellulose may be employed in a ratio of 1 : 1.5 to 1 :3.
- the lactose hydrate When the lactose hydrate is employed in said range, the lactose hydrate may form hydrophilic channels which promote dissolution of active ingredients, thereby allowing a fast dissolution.
- a fast dissolution profile cannot be obtained if the amount falls below said range, and if the amount exceeds said range, time required for complete dissolution of the lactose hydrate is extended and thereby slowing down the dissolution of active ingredients.
- the tableting process becomes easy if the micro-crystalline cellulose is employed in said range.
- an amount smaller than said range may cause some difficulties during the tableting process, whereas an excessive amount may lead to an excessively large size of formulation.
- dissolution rates of amlodipine, rosuvastatin and losartan may be improved significantly by employing the lactose hydrate and micro-crystalline cellulose in said range.
- the second discrete part (or the second layer) of the inventive combination formulation may be prepared in a conventional manner, e.g., compaction granulation followed by tableting.
- the second discrete part is in the form of granules prepared by a dry roller compaction process.
- a problem of gelation of losartan occurs when a combination formulation is prepared by simply mixing amlodipine, rosuvastatin and losartan.
- Losartan readily dissolves in purified water and is easily released at a relatively high pH (e.g., pH 4.0, pH 6.8), but is released very slowly at a low pH (e.g., pH 1.2, pH 2.0) because of the gelation.
- This problem significantly imparts undesired effects on the dissolution rate and bioavailability of formulation because the formulation is first exposed to the acidic gastric juice having a low pH value when orally administered.
- the combination formulation of the present invention separates the first discrete part comprising amlodipine and rosuvastatin from the second discrete part comprising losartan, thereby reducing the contact area of losartan.
- the gelation of losartan can be prevented under a low pH condition and thus exhibit improved stability and dissolution rate of amlodipine, rosuvastatin and losartan.
- the present invention also provides a fixed-dose combination formulation for the prevention or treatment of a cardiovascular disorder, comprising: (1) a first discrete part comprising amlodipine or a pharmaceutically acceptable salt thereof, rosuvastatin or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive; and (2) a second discrete part comprising losartan or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive, wherein said discrete parts are physically separated from each other.
- the amount of amlodipine or a pharmaceutically acceptable salt thereof, as converted to amlodipine free base form is 5 to 10 mg. In one embodiment of the fixed-dose combination formulation, the amount of rosuvastatin or a pharmaceutically acceptable salt thereof, as converted to rosuvastatin free acid form, is 10 to 20 mg. Also, in one embodiment of the fixed-dose combination formulation, the amount of losartan or a pharmaceutically acceptable salt thereof, as converted to losartan free base form, is 45 to 100 mg.
- the present; invention provides a method for preparing a pharmaceutical combination formulation for the prevention or treatment of a cardiovascular disorder, comprising: a) admixing amlodipine or a pharmaceutically acceptable salt thereof, rosuvastatin or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive; b) admixing losartan or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable salt thereof; and c) loading a discrete part prepared in Step a) and a discrete part prepared in Step b) into a formulation, wherein said discrete parts are physically separated from each other.
- Step b) further comprises a granulizing step, and in Step c) the discrete part obtained in Step a) and the granules obtained in Step b) are tableted to obtain a bilayer tablet.
- the cardiovascular disorder is selected from the group consisting of angina pectoris, hypertension, arteriospasm, cardiac arrhythmia, cardiomegaly, cerebral infarction, congestive heart failure and myocardial infarction, but not limited thereto.
- amlodipine camsylate, rosuvastatin calcium, lactose hydrate, micro-crystalline cellulose and crospovidone were admixed, sieved through a 30 mesh screen, added with magnesium stearate and finally admixed in a mixer to obtain a discrete part comprising amlodipine and rosuvastatin - , ⁇
- losartan potassium, micro-crystalline cellulose, hydroxypropyl cellulose and crospovidone were admixed, and sieved through a 30 mesh screen.
- the sieved powder was pressed using a roller compactor ( WP200, Alexanderwerk) at a minimum compaction force of 20 kN with a roll speed of from 2 to 10 rpm to form granules in the form of flakes.
- Granules thus obtained were pulverized by using a Fitz Mill (BAS 06, Fitzpatrick, USA), sieved through a 20 mesh screen, added with magnesium stearate and finally admixed in a mixer to obtain a discrete part comprising losartan.
- the discrete parts were formulated into a combination bilayer tablet comprising the discrete part comprising amlodipine and rosuvastatin (first layer, upper layer) and the discrete part comprising losartan (second layer, lower layer) by using a tablet press (Kilian Synthesis 700, Germany).
- Comparative Example 1 Preparation of single-layer tablet by using dry direct tableting
- amlodipine camsylate, rosuvastatin calcium, losartan potassium, lactose hydrate, micro-crystallirie cellulose and crospovidone and hydroxypropyl cellulose were admixed, sieved through a 30 mesh screen, added with magnesium stearate and finally admixed in a mixer.
- the mixed powder was formulated to obtain a single-layer tablet.
- amlodipine camsylate, rosuvastatin calcium, lactose hydrate, micro-crystalline cellulose, and crospovidone were admixed, sieved through a 30 mesh screen, added with magnesium stearate and finally admixed in a mixer to obtain a discrete part comprising amlodipine and rosuvastatin:
- losartan potassium, micro-crystalline cellulose, hydroxypropyl cellulose and crospovidone were admixed, sieved through a 30 mesh screen, added with magnesium stearate and finally admixed in a mixer to obtain a discrete part comprising losartan.
- the discrete parts were formulated into a combination bilayer tablet comprising the discrete part comprising amlodipine and rosuvastatin (first -layer, upper layer) and the discrete part comprising losartan (second layer, lower layer) by using a tablet press.
- Example 1 The procedure of Example 1 was repeated except for changing the ratio of lactose and cellulose in accordance with the ingredients as described in Table 4 below to obtain a combination bilayer tablet.
- Ratio of lactose hydrate in the first layer 0% 36% 53%
- Discrete part Losartan potassium 100.0 , . l o.o 100.0 comprising (Losartan, 91.6 mg)
- Comparative Example 6 Preparation of combination bilayer tablet having different combination of active ingredients in the discrete part The procedure of Example 1 was repeated except for employing the ingredients as described in Table 5 below to obtain a combination bilayer tablet which comprises amlodipine and losartan in the first discrete part and rosuvastatin in the second discrete part.
- Comparative Example 7 Preparation of combination bilayer tablet having different combination of active ingredients in the discrete part The procedure of Example 1 was repeated except for employing the ingredients as described in Table 6 below to obtain a combination bilayer tablet which comprises amlodipine in the first discrete part and losartan and rosuvastatin in the second discrete part.
- Ratio of lactose hydrate in the first layer 28% 22% 36%
- Discrete part Losartan potassium 50.0 50.0 50.0 comprising (Losartan, 45.8 mg)
- Ratio of lactose hydrate in the first layer 0% 39% 56%
- Discrete part Losartan potassium 50.0 50.0 ' 50.0 comprising (Losartan, 45.8 mg)
- Example 1 Tablets prepared in Example 1 and Comparative Example 1 were each subjected to a drug dissolution test under the following conditions.
- Dissolution media artificial gastric juice 900 mL (pH 1.2)
- Dissolution media were taken 5, 10, 15, 30, 45, 60, 90 and 120 minutes after the test was commenced.
- the paddle speed was raised from 50 rpm to 150 rpm, and after 30 minutes, i.e., 150 minutes after the test was commenced, dissolution media was taken for final analysis.
- Dissolution rate of 80% or greater after 30 minutes (amlodipine, rosuvastatin)
- the results of the dissolution test are shown in Figs. 2 to 4.
- the bilayer tablet of Example 1 in which the discrete part comprising amlodipine and rosuvastatin and the discrete part comprising losartan are physically separated from each other exhibited a high dissolution rate as compared with the single layer tablet of Comparative Example 1 prepared by dry direct tableting.
- the bilayer tablet of Example 1 showed a good dissolution profile of amlodipine and rosuvastatin, while satisfying the test criterion.
- the bilayer tablet of Example 1 showed a significantly high dissolution rate of losartan compared with the single layer tablet of Comparative Example 1 which had dissolution rate of 40% or lower after 60 minutes.
- the above results show that the gelation of losartan slows down the dissolution of amlodipine or rosuvastatin when losartan is present with amlodipine or rosuvastatin in the same layer.
- the bilayer tablet of Example 1 prepared by compaction granulation and the bilayer tablet of Comparative Example 2 prepared by simple mixing followed by dry direct tableting were each subjected to a dissolution test by using the same conditions as described in Experimental Example 1 to evaluate dissolution rate of amlodipine, rosuvastatin and losartan.
- the results are shown in Figs. 5 to 7.
- the bilayer tablet of Example 1 which was prepared by using a roller compactor and the bilayer tablet of Comparative Example 2 which was prepared without using a roller compactor did not show much difference in dissolution rate of losartan.
- the bilayer tablet of Comparative Example 2 which was prepared by simple mixing and dry direct tableting without using roller compactor exhibited a large deviation in dissolution, and a relatively low dissolution rate. Also, the bilayer tablet of Comparative Example 2 did not satisfy the test criterion (dissolution rate of 80% or greater after 30 minutes) in terms of amlodipine and rosuvastatin. Moreover, the losartan layer of Comparative Example 2 which was prepared without going through compaction granulation process, suffered from low productivity due to a problem associated with capping of the tablet. On the other hand, the bilayer tablet of Example 1 prepared by using a roller compactor showed an excellent dissolution rate of amlodipine and rosuvastatin, and also satisfied the test criterion.
- the bilayer tablet of Example 1 which comprises the amlodipine-rosuvastatin layer and the losartan layer exhibited a fast and high dissolution rate, and showed a good dissolution profile of amlodipine and rosuvastatin by meeting the test criterion.
- the bilayer tablet of Comparative Example 6 having the amlodipine-Iosartan layer and the rosuvastatin layer and the bilayer tablet of Comparative Example 7 having the amlodipine layer and the losartan-rosuvastatin layer failed to pass the test criterion in terms of dissolution rate of all three ingredients.
- Test time initial, 1, 2, 4 and 6 months
- Analysis target amlodipine, rosuvastatin and losartan
- the tablets of Examples 1 to 3 exhibited high stability under accelerated light and heat conditions, while producing a very small amount of amlodipine-, rosuvastatin- and losartan-related substances.
- the tablet obtained in Comparative Example 1 which was prepared by simple mixing of three ingredient followed by direct-compaction, produced related substances at least 5 to 10 times greater than the tablets obtained in Examples 1 to 3. This result indicates that tablets prepared by simple mixing have poor stability under accelerated light and heat conditions.
- Comparative Example 6 shows that the bilayer tablet having the amlodipine-losartan layer and the rosuvastatin layer exhibits poor stability under accelerated light and heat conditions.
- Comparative Example 7 shows that the bilayer tablet having the amlodipine layer and the losartan-rosuvastatin layer also exhibits poor stability under accelerated light and heat conditions.
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Abstract
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Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
UAA201606918A UA120043C2 (en) | 2013-11-29 | 2014-11-20 | Pharmaceutical combination formulation comprising amlodipine, losartan and rosuvastatin |
US15/039,238 US9833413B2 (en) | 2013-11-29 | 2014-11-20 | Pharmaceutical combination formulation comprising amlodipine, losartan and rosuvastatin |
EP14866739.7A EP3073998A4 (en) | 2013-11-29 | 2014-11-20 | Pharmaceutical combination formulation comprising amlodipine, losartan and rosuvastatin |
AU2014354475A AU2014354475B2 (en) | 2013-11-29 | 2014-11-20 | Pharmaceutical combination formulation comprising amlodipine, losartan and rosuvastatin |
CN201480064825.8A CN105792813B (en) | 2013-11-29 | 2014-11-20 | A kind of medicine composition containing Amlodipine, Losartan and rosuvastatin |
MX2016006415A MX370041B (en) | 2013-11-29 | 2014-11-20 | Pharmaceutical combination formulation comprising amlodipine, losartan and rosuvastatin. |
BR112016011603A BR112016011603A2 (en) | 2013-11-29 | 2014-11-20 | PHARMACEUTICAL COMBINATION FORMULATION COMPRISING AMLODIPINE, LOSARTAN AND ROSUVASTATIN |
CA2929862A CA2929862A1 (en) | 2013-11-29 | 2014-11-20 | Pharmaceutical combination formulation comprising amlodipine, losartan and rosuvastatin |
RU2016125749A RU2660586C1 (en) | 2013-11-29 | 2014-11-20 | Pharmaceutical combination formulation containing amlodipine, losartan and rosuvastatin |
JP2016531655A JP6427572B2 (en) | 2013-11-29 | 2014-11-20 | Pharmaceutical combination containing amlodipine, losartan and rosuvastatin |
PH12016500833A PH12016500833A1 (en) | 2013-11-29 | 2016-05-05 | Pharmaceutical combination formulation comprising amlodipine, losartan and rosuvastatin |
ZA2016/03272A ZA201603272B (en) | 2013-11-29 | 2016-05-13 | Pharmaceutical combination formulation comprising amlodipine, losartan and rosuvastatin |
SA516371218A SA516371218B1 (en) | 2013-11-29 | 2016-05-26 | Pharmaceutical combination formulation comprising amlodipine, losartan and rosuvastatin |
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KR10-2013-0147883 | 2013-11-29 | ||
KR1020130147883A KR101910901B1 (en) | 2013-11-29 | 2013-11-29 | Pharmaceutical complex formulation comprising amlodipine, losartan and rosuvastatin |
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WO2015080433A1 true WO2015080433A1 (en) | 2015-06-04 |
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PCT/KR2014/011205 WO2015080433A1 (en) | 2013-11-29 | 2014-11-20 | Pharmaceutical combination formulation comprising amlodipine, losartan and rosuvastatin |
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Country | Link |
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US (1) | US9833413B2 (en) |
EP (1) | EP3073998A4 (en) |
JP (1) | JP6427572B2 (en) |
KR (1) | KR101910901B1 (en) |
CN (1) | CN105792813B (en) |
AR (1) | AR098417A1 (en) |
AU (1) | AU2014354475B2 (en) |
BR (1) | BR112016011603A2 (en) |
CA (1) | CA2929862A1 (en) |
CL (1) | CL2016001298A1 (en) |
JO (1) | JO3557B1 (en) |
MX (1) | MX370041B (en) |
PH (1) | PH12016500833A1 (en) |
RU (1) | RU2660586C1 (en) |
SA (1) | SA516371218B1 (en) |
TW (1) | TWI649099B (en) |
UA (1) | UA120043C2 (en) |
UY (1) | UY35859A (en) |
WO (1) | WO2015080433A1 (en) |
ZA (1) | ZA201603272B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017003186A1 (en) * | 2015-06-30 | 2017-01-05 | Hanmi Pharm. Co., Ltd. | Pharmaceutical complex formulation comprising amlodipine, losartan and rosuvastatin |
Families Citing this family (12)
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WO2017007287A1 (en) * | 2015-07-08 | 2017-01-12 | 씨제이헬스케어 주식회사 | Pharmaceutical composition containing amlodipine, valsartan, and rosuvastatin |
SG11201903132YA (en) * | 2016-11-15 | 2019-05-30 | Hanmi Pharmaceutical Co Ltd | Pharmaceutical complex preparation comprising amlodipine, losartan and rosuvastatin |
KR101920996B1 (en) * | 2017-04-26 | 2018-11-22 | 알보젠코리아 주식회사 | A Complex Formulation Comprising HMG-CoA Reductase Inhibitor and Calcium Channel Blocker |
KR20190043076A (en) * | 2017-10-17 | 2019-04-25 | 한미약품 주식회사 | Pharmaceutical composition comprising amlodipine, losartan and rosuvastatin for prevention and treatment of cardiovascular diseases accompanied by diabetes and formulated combination including the same |
KR101997652B1 (en) * | 2018-01-22 | 2019-07-08 | 보령제약 주식회사 | Pharmaceutical formulation |
KR102569271B1 (en) * | 2018-03-19 | 2023-08-23 | 한미약품 주식회사 | Pharmaceutical combination preparation comprising ezetimibe and rosuvastatin |
KR102108396B1 (en) * | 2018-04-25 | 2020-05-07 | 제일약품주식회사 | Pharmaceutical formulation |
KR101992400B1 (en) * | 2018-04-30 | 2019-06-24 | 보령제약 주식회사 | Pharmaceutical formulation |
KR102500643B1 (en) * | 2019-04-18 | 2023-02-16 | 한미약품 주식회사 | Pharmaceutical combination preparation comprising ezetimibe and losartan |
KR102608889B1 (en) * | 2020-07-14 | 2023-12-04 | 한미약품 주식회사 | Pharmaceutical combination preparation comprising proton pump inhibitor and antacid and preparation method thereof |
KR20220026641A (en) * | 2020-08-25 | 2022-03-07 | 주식회사 대웅제약 | A single dosage form of a pharmaceutical composition for the treatment or prevention of hypertension and hyperlipidemia |
CN116761589A (en) * | 2020-12-18 | 2023-09-15 | 株式会社大熊制药 | New formulations for oral administration containing 1- (5- (2, 4-difluorophenyl) -1- ((3-fluorophenyl) sulfonyl) -4-methoxy-1H-pyrrol-3-yl) -N-methyl methylamine |
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- 2014-11-20 AU AU2014354475A patent/AU2014354475B2/en not_active Ceased
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- 2014-11-20 JP JP2016531655A patent/JP6427572B2/en not_active Expired - Fee Related
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Cited By (4)
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---|---|---|---|---|
WO2017003186A1 (en) * | 2015-06-30 | 2017-01-05 | Hanmi Pharm. Co., Ltd. | Pharmaceutical complex formulation comprising amlodipine, losartan and rosuvastatin |
CN108156807A (en) * | 2015-06-30 | 2018-06-12 | 韩美药品株式会社 | Medicine compound preparation containing Amlodipine, Losartan and Rosuvastatin |
RU2724338C2 (en) * | 2015-06-30 | 2020-06-23 | Ханми Фарм. Ко., Лтд. | Pharmaceutical complex composition containing amlodipine, losartan and rosuvastatin |
CN112933093A (en) * | 2015-06-30 | 2021-06-11 | 韩美药品株式会社 | Pharmaceutical composite preparation containing amlodipine, losartan and rosuvastatin |
Also Published As
Publication number | Publication date |
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CL2016001298A1 (en) | 2017-01-06 |
UA120043C2 (en) | 2019-09-25 |
US20170027871A1 (en) | 2017-02-02 |
CN105792813B (en) | 2019-11-19 |
CN105792813A (en) | 2016-07-20 |
TWI649099B (en) | 2019-02-01 |
ZA201603272B (en) | 2018-08-29 |
KR20150067777A (en) | 2015-06-19 |
EP3073998A1 (en) | 2016-10-05 |
RU2660586C1 (en) | 2018-07-06 |
SA516371218B1 (en) | 2017-12-21 |
KR101910901B1 (en) | 2018-10-24 |
CA2929862A1 (en) | 2015-06-04 |
MX2016006415A (en) | 2016-07-19 |
AU2014354475A1 (en) | 2016-05-26 |
TW201609198A (en) | 2016-03-16 |
UY35859A (en) | 2015-06-30 |
MX370041B (en) | 2019-11-29 |
JO3557B1 (en) | 2020-07-05 |
AR098417A1 (en) | 2016-05-26 |
PH12016500833A1 (en) | 2016-06-13 |
JP6427572B2 (en) | 2018-11-21 |
BR112016011603A2 (en) | 2022-07-12 |
US9833413B2 (en) | 2017-12-05 |
EP3073998A4 (en) | 2017-05-31 |
AU2014354475B2 (en) | 2019-12-19 |
JP2017501126A (en) | 2017-01-12 |
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