WO2015077442A3 - Grass pollen immunogens and methods and uses thereof for immune response modulation - Google Patents

Grass pollen immunogens and methods and uses thereof for immune response modulation Download PDF

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Publication number
WO2015077442A3
WO2015077442A3 PCT/US2014/066591 US2014066591W WO2015077442A3 WO 2015077442 A3 WO2015077442 A3 WO 2015077442A3 US 2014066591 W US2014066591 W US 2014066591W WO 2015077442 A3 WO2015077442 A3 WO 2015077442A3
Authority
WO
WIPO (PCT)
Prior art keywords
grass pollen
immune response
immunogens
methods
response modulation
Prior art date
Application number
PCT/US2014/066591
Other languages
French (fr)
Other versions
WO2015077442A2 (en
WO2015077442A9 (en
Inventor
Bjoern Peters
Alessandro Sette
Jason GREENBAUM
Ilka HOOF
Lars Harder CHRISTENSEN
Original Assignee
La Jolla Institute For Allergy And Immunology
Alk-Abelló A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by La Jolla Institute For Allergy And Immunology, Alk-Abelló A/S filed Critical La Jolla Institute For Allergy And Immunology
Publication of WO2015077442A2 publication Critical patent/WO2015077442A2/en
Publication of WO2015077442A9 publication Critical patent/WO2015077442A9/en
Publication of WO2015077442A3 publication Critical patent/WO2015077442A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A61K39/36—Allergens from pollen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to pan grass pollen immunogens such as polypeptides, proteins and peptides, and methods and uses of such immunogens for modulating or relieving an immune response in a subject. For example, the pan grass pollen immunogens can be used for treating a subject for an allergic immune response or inducing or promoting immunological tolerance to the immunogen or a non-grass pollen allergen in a subject.
PCT/US2014/066591 2013-11-20 2014-11-20 Grass pollen immunogens and methods and uses for immune response modulation WO2015077442A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361906798P 2013-11-20 2013-11-20
US61/906,798 2013-11-20
US201461946370P 2014-02-28 2014-02-28
US61/946,370 2014-02-28

Publications (3)

Publication Number Publication Date
WO2015077442A2 WO2015077442A2 (en) 2015-05-28
WO2015077442A9 WO2015077442A9 (en) 2015-07-02
WO2015077442A3 true WO2015077442A3 (en) 2015-11-12

Family

ID=52101593

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/066591 WO2015077442A2 (en) 2013-11-20 2014-11-20 Grass pollen immunogens and methods and uses for immune response modulation

Country Status (1)

Country Link
WO (1) WO2015077442A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110563800B (en) * 2019-08-26 2022-07-05 天津科技大学 Anti-tumor active peptide and preparation method and application thereof
WO2023242436A1 (en) * 2022-06-17 2023-12-21 Danmarks Tekniske Universitet Allergy vaccines based on consensus allergens

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1403280A1 (en) * 2002-09-27 2004-03-31 BIOMAY Produktions- und Handels- Aktiengesellschaft Hypoallergenic allergy vaccines based on the timothy grass pollen allergen Phl p 7
US20110167514A1 (en) * 2007-07-05 2011-07-07 Ceres, Inc. Nucleotide sequences and corresponding polypeptides conferring modulated plant characteristics
WO2012049310A1 (en) * 2010-10-15 2012-04-19 Alk-Abelló A/S Suppression of a hypersensitivity immune response with unrelated antigen derived from allergen source material
WO2013119863A1 (en) * 2012-02-07 2013-08-15 La Jolla Institute For Allergy And Immunology Timothy grass allergens and methods and uses for immune response modulation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
FR2649013B1 (en) 1989-07-03 1991-10-25 Seppic Sa VACCINES AND VECTORS OF FLUID ACTIVE INGREDIENTS CONTAINING METABOLIZABLE OIL
US5962406A (en) 1991-10-25 1999-10-05 Immunex Corporation Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
ES2320315T5 (en) 1994-07-15 2012-12-05 University Of Iowa Research Foundation Immunostimulatory oligonucleotides
UA56132C2 (en) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Vaccine composition (variants), method for stabilizing qs21 providing resistance against hydrolysis (variants), method for manufacturing vaccine
ATE292980T1 (en) 1996-10-11 2005-04-15 Univ California IMMUNO-STIMULATING OLIGONUCLEOTIDE CONJUGATES
GB9711990D0 (en) 1997-06-11 1997-08-06 Smithkline Beecham Biolog Vaccine
EP1279401B1 (en) 1997-09-05 2008-01-09 GlaxoSmithKline Biologicals S.A. Oil in water emulsions containing saponins
GB9718901D0 (en) 1997-09-05 1997-11-12 Smithkline Beecham Biolog Vaccine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1403280A1 (en) * 2002-09-27 2004-03-31 BIOMAY Produktions- und Handels- Aktiengesellschaft Hypoallergenic allergy vaccines based on the timothy grass pollen allergen Phl p 7
US20110167514A1 (en) * 2007-07-05 2011-07-07 Ceres, Inc. Nucleotide sequences and corresponding polypeptides conferring modulated plant characteristics
WO2012049310A1 (en) * 2010-10-15 2012-04-19 Alk-Abelló A/S Suppression of a hypersensitivity immune response with unrelated antigen derived from allergen source material
WO2013119863A1 (en) * 2012-02-07 2013-08-15 La Jolla Institute For Allergy And Immunology Timothy grass allergens and methods and uses for immune response modulation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DR BJOERN PETERS ET AL: "800 A Systematic Analysis Of Pollen Transcriptomes From Plant Allergens Reveals Conserved Targets Of Immune Responses", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 133, no. 2, February 2014 (2014-02-01), pages AB231, XP055188731 *

Also Published As

Publication number Publication date
WO2015077442A2 (en) 2015-05-28
WO2015077442A9 (en) 2015-07-02

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