WO2015053871A3 - NUCLEIC ACIDS ENCODING HUMAN ANTIBODIES TO SIALYL-LEWISa - Google Patents

NUCLEIC ACIDS ENCODING HUMAN ANTIBODIES TO SIALYL-LEWISa Download PDF

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Publication number
WO2015053871A3
WO2015053871A3 PCT/US2014/052631 US2014052631W WO2015053871A3 WO 2015053871 A3 WO2015053871 A3 WO 2015053871A3 US 2014052631 W US2014052631 W US 2014052631W WO 2015053871 A3 WO2015053871 A3 WO 2015053871A3
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WO
WIPO (PCT)
Prior art keywords
functional fragment
antibody
sialyl
lewisa
nucleic acids
Prior art date
Application number
PCT/US2014/052631
Other languages
French (fr)
Other versions
WO2015053871A2 (en
WO2015053871A4 (en
WO2015053871A8 (en
Inventor
Ritsuko Sawada
Shu-Man Sun
Wolfgang Scholz
Original Assignee
MabVax Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DK14852746.8T priority Critical patent/DK3041507T3/en
Priority to JP2016539019A priority patent/JP6626445B2/en
Application filed by MabVax Therapeutics, Inc. filed Critical MabVax Therapeutics, Inc.
Priority to AU2014332442A priority patent/AU2014332442B2/en
Priority to KR1020207019821A priority patent/KR102313341B1/en
Priority to KR1020217019368A priority patent/KR102362630B1/en
Priority to EP14852746.8A priority patent/EP3041507B1/en
Priority to KR1020227004406A priority patent/KR102553717B1/en
Priority to PL14852746T priority patent/PL3041507T3/en
Priority to CN201480057851.8A priority patent/CN105764526B/en
Priority to KR1020167007644A priority patent/KR20160054501A/en
Priority to LTEPPCT/US2014/052631T priority patent/LT3041507T/en
Priority to EP21181759.8A priority patent/EP3906945A3/en
Priority to RS20210929A priority patent/RS62189B1/en
Priority to BR112016004133-0A priority patent/BR112016004133B1/en
Priority to RU2016111015A priority patent/RU2699289C2/en
Priority to NZ717428A priority patent/NZ717428B2/en
Priority to ES14852746T priority patent/ES2880709T3/en
Priority to CA2922478A priority patent/CA2922478C/en
Priority to SI201431854T priority patent/SI3041507T1/en
Publication of WO2015053871A2 publication Critical patent/WO2015053871A2/en
Publication of WO2015053871A3 publication Critical patent/WO2015053871A3/en
Publication of WO2015053871A4 publication Critical patent/WO2015053871A4/en
Priority to IL244297A priority patent/IL244297B/en
Priority to ZA2016/01354A priority patent/ZA201601354B/en
Publication of WO2015053871A8 publication Critical patent/WO2015053871A8/en
Priority to AU2020201225A priority patent/AU2020201225B2/en
Priority to IL276819A priority patent/IL276819A/en
Priority to HRP20211129TT priority patent/HRP20211129T1/en
Priority to CY20211100653T priority patent/CY1124435T1/en
Priority to AU2022209226A priority patent/AU2022209226A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
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    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
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    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Proteomics, Peptides & Aminoacids (AREA)
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Abstract

The present invention provides compositions for the production of an antibody or functional fragment thereof directed against Sialyl-Lewisa (sLea). The compositions of the invention include polynucleotides encoding a heavy chain and/or a light chain variable domain that binds to sLea. The invention also provides an isolated antibody or functional fragment thereof and methods of treating or preventing a disease, such as cancer or tumor formation, wherein the antibody or functional fragment includes a variable heavy chain domain and a variable light chain domain that has an amino acid sequence provided herein. The invention further provides a conjugate of an antibody or functional fragment thereof conjugated or recombinantly fused to a diagnostic agent, detectable agent or therapeutic agent, and methods of treating, preventing or diagnosing a disease in a subject in need thereof.
PCT/US2014/052631 2013-08-26 2014-08-26 NUCLEIC ACIDS ENCODING HUMAN ANTIBODIES TO SIALYL-LEWISa WO2015053871A2 (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
NZ717428A NZ717428B2 (en) 2013-08-26 2014-08-26 NUCLEIC ACIDS ENCODING HUMAN ANTIBODIES TO SIALYL-LEWISa
BR112016004133-0A BR112016004133B1 (en) 2013-08-26 2014-08-26 ISOLATED POLYNUCLEOTIDES, ISOLATED ANTIBODY OR FUNCTIONAL FRAGMENT THEREOF THAT BINDS TO SIALILLEWISA, USES THEREOF, CONJUGATE AND PHARMACEUTICAL COMPOSITION
AU2014332442A AU2014332442B2 (en) 2013-08-26 2014-08-26 Nucleic acids encoding human antibodies to Sialyl-Lewis
KR1020207019821A KR102313341B1 (en) 2013-08-26 2014-08-26 Nucleic acids encoding human antibodies to sialyl-lewis a
KR1020217019368A KR102362630B1 (en) 2013-08-26 2014-08-26 Nucleic acids encoding human antibodies to sialyl-lewis a
EP14852746.8A EP3041507B1 (en) 2013-08-26 2014-08-26 Nucleic acids encoding human antibodies to sialyl-lewis a
KR1020227004406A KR102553717B1 (en) 2013-08-26 2014-08-26 Nucleic acids encoding human antibodies to sialyl-lewis a
PL14852746T PL3041507T3 (en) 2013-08-26 2014-08-26 Nucleic acids encoding human antibodies to sialyl-lewis a
CN201480057851.8A CN105764526B (en) 2013-08-26 2014-08-26 Nucleic acids encoding human antibodies against sialyl-lewis a antigens
KR1020167007644A KR20160054501A (en) 2013-08-26 2014-08-26 Nucleic acids encoding human antibodies to sialyl-lewis a
LTEPPCT/US2014/052631T LT3041507T (en) 2013-08-26 2014-08-26 Nucleic acids encoding human antibodies to sialyl-lewis a
EP21181759.8A EP3906945A3 (en) 2013-08-26 2014-08-26 Nucleic acids encoding human antibodies to sialyl-lewis a
JP2016539019A JP6626445B2 (en) 2013-08-26 2014-08-26 Nucleic acids encoding human antibodies to sialyl-Lewis a
DK14852746.8T DK3041507T3 (en) 2013-08-26 2014-08-26 NUCLEIC ACIDS ENCOODING HUMAN ANTIBODIES TO SIALYL-LEWIS A
RS20210929A RS62189B1 (en) 2013-08-26 2014-08-26 Nucleic acids encoding human antibodies to sialyl-lewis a
RU2016111015A RU2699289C2 (en) 2013-08-26 2014-08-26 Nucleic acids encoding human antibodies to sialyl-lewisa
ES14852746T ES2880709T3 (en) 2013-08-26 2014-08-26 Nucleic acids encoding human antibodies against Sialyl-Lewis A
CA2922478A CA2922478C (en) 2013-08-26 2014-08-26 Nucleic acids encoding human antibodies to sialyl-lewisa
SI201431854T SI3041507T1 (en) 2013-08-26 2014-08-26 Nucleic acids encoding human antibodies to sialyl-lewis a
IL244297A IL244297B (en) 2013-08-26 2016-02-25 Nucleic acids encoding human antibodies to sialyl-lewisa
ZA2016/01354A ZA201601354B (en) 2013-08-26 2016-02-26 Nucleic acids encoding human antibodies to sialyl-lewisa
AU2020201225A AU2020201225B2 (en) 2013-08-26 2020-02-20 Nucleic acids encoding human antibodies to Sialyl-Lewisa
IL276819A IL276819A (en) 2013-08-26 2020-08-19 Nucleic acids encoding human antibodies to sialyl-lewisa
HRP20211129TT HRP20211129T1 (en) 2013-08-26 2021-07-14 Nucleic acids encoding human antibodies to sialyl-lewis a
CY20211100653T CY1124435T1 (en) 2013-08-26 2021-07-21 NUCLEIC ACIDS ENCODING HUMAN ANTIBODIES TO SIALYL-LEWIS A
AU2022209226A AU2022209226A1 (en) 2013-08-26 2022-07-26 Nucleic acids encoding human antibodies to Sialyl-Lewisa

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361870137P 2013-08-26 2013-08-26
US61/870,137 2013-08-26

Publications (4)

Publication Number Publication Date
WO2015053871A2 WO2015053871A2 (en) 2015-04-16
WO2015053871A3 true WO2015053871A3 (en) 2015-06-11
WO2015053871A4 WO2015053871A4 (en) 2015-07-30
WO2015053871A8 WO2015053871A8 (en) 2016-03-31

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PCT/US2014/052631 WO2015053871A2 (en) 2013-08-26 2014-08-26 NUCLEIC ACIDS ENCODING HUMAN ANTIBODIES TO SIALYL-LEWISa

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