WO2015033191A1 - A process for preparation of (2s, 5r)- sulfuric acid mono-{[(4-aminopiperidin-4-yl) carbonyl]-7-oxo-1,6-diaza-bicyclo[3.2.1]-oct-6-yl} ester - Google Patents
A process for preparation of (2s, 5r)- sulfuric acid mono-{[(4-aminopiperidin-4-yl) carbonyl]-7-oxo-1,6-diaza-bicyclo[3.2.1]-oct-6-yl} ester Download PDFInfo
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- the invention relates to a process for preparation of (2S, 5R)- Sulfuric acid mono- ⁇ [(4-aminopiperidin-4-yl) carbonyl]-7-oxo-l,6-diaza-bicyclo[3.2.1]-oct-6-yl ⁇ ester.
- a compound of Formula (I), chemically known as (2S, 5R)- Sulfuric acid mono- ⁇ [(4- aminopiperidin-4-yl) carbonyl]-7-oxo-l,6-diaza-bicyclo[3.2.1]-oct-6-yl ⁇ ester has antibacterial properties.
- the compound of Formula (I) is also known as MK-7655 and is disclosed in PCT International Patent Application No PCT/US2009/031047.
- HOBt refers to 1 -hydro xybenzotriazole.
- EDC l-ethyl-3-(3-dimethylaminopropyl) carbodiimide
- the compound of Formula (IV) is obtained by reacting a compound of Formula (II) with a compound of Formula (III). In some embodiments, the compound of Formula (IV) is obtained by reacting a compound of Formula (II) with a compound of Formula (III) in presence of a suitable coupling reagent. In some other embodiments, the compound of Formula (IV) is obtained by reacting a compound of Formula (II) with a compound of Formula (III) in presence of 1 -hydro xybenzotriazole and l-ethyl-3-(3- dimethylaminopropyl)carbodhmide hydrochloride. This reaction may be carried out in presence of a suitable solvent. In some embodiments, this reaction is carried out in water as a reaction solvent.
- the compound of Formula (V) is obtained by hydrogenolysis of a compound of Formula (IV).
- the hydrogenolysis reaction can be carried out using a suitable hydrogenolysis agent.
- hydrogenolysis of a compound of Formula (IV) to obtain a compound of Formula (V) is carried out in presence of a transition metal catalyst and hydrogen source.
- the transition metal catalyst is palladium on carbon and hydrogen source is hydrogen gas.
- the hydrogenolysis reaction is carried out in presence of a suitable solvent such as, for example, methanol.
- the hydrogenolysis of a compound of Formula (IV) to obtain a compound of Formula (V) is carried out using 10% palladium on carbon catalyst, in presence of hydrogen gas in methanol as a solvent.
- the compound of Formula (VI) is obtained by sulfonating a compound of Formula (V).
- the sulfo nation reaction can be carried out in presence of a suitable solvent.
- the sulfonation of a compound of Formula (V) to obtain a compound of Formula (VI) is carried out by reacting a compound of Formula (V) with sulfur trioxide - pyridine complex, followed by treatment with tetrabutyl ammonium hydrogen sulphate.
- the compound of Formula (VI) is converted to a compound of Formula (I) in presence of a suitable reagent.
- the compound of Formula (VI) is converted to a compound of Formula (I) by reacting a compound of Formula (VI) with trifluoro acetic acid.
- the compound of Formula (I) is prepared using a process described in Scheme 1.
- Step-1 Preparation of (2S, 5R)-tert-butyl ⁇ (6-benzyloxy-7-oxo-l,6-diaza-bicyclo[3.2.1]oct- 2-yl-carbonyl) amino ⁇ piperidine-l-carboxylate (IV):
- reaction mixture was stirred for 24 hours at 30°C to provide a suspension.
- the suspension was filtered under suction and washed with 45°C warm water (40 ml) to provide (2S, 5R)-tert-butyl ⁇ (6-benzyloxy-7-oxo- l,6-diaza-bicyclo[3.2.1]oct-2-yl-carbonyl) amino ⁇ piperidine-l-carboxylate in 12.7 gm quantity in 74% yield after drying under vacuum.
- Step-2 Preparation of (2S, 5R)-tert-butyl ⁇ (6-hydroxy-7-oxo-l,6-diaza-bicyclo[3.2.1]oct-2- yl-carbonyl) amino ⁇ piperidine-l-carboxylate (V):
- Step-4 Synthesis of (2S, 5R)- Sulfuric acid mono- ⁇ [(4-aminopiperidin-4-yl) carbonyl]-7- oxo-l,6-diaza-bicyclo[3.2.1]-oct-6-yl ⁇ ester (I):
- the thick residue was stirred twice with diethyl ether (60 ml each time) to provide a precipitation.
- the solid obtained was filtered at suction and suspended in acetone (90 ml).
- To the suspension was added 10% solution of sodium-2-ethyl-hexanoate in acetone to adjust pH between 4.5 to 5.5.
- the suspension was stirred for 10 minutes and filtered under suction.
- the wet cake was washed with acetone and dried under vacuum below 40°C to provide 3 gm crude compound.
- the crude compound was stirred with aqueous isopropanol (3ml water: 21 ml iospropanol) for overnight to purify further.
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Abstract
A process for preparation of (2S, 5R)- Sulfuric acid mono-{[(4- aminopiperidin-4-yl) carbonyl]-7-oxo-1,6-diaza-bicyclo[3.2.1]-oct-6-yl} ester is disclosed which comprises reacting a compound of Formula (II) with a compound of Formula (III) to obtain a compound of Formula (IV).
Description
A PROCESS FOR PREPARATION OF (2S, 5R)- SULFURIC ACID MONO-{r(4-AMINOPIPERIDIN-4-YL) CARBONYLl-7-OXO-l,6- DIAZA-BICYCLOr3.2.11-OCT-6-YL} ESTER
RELATED PATENT APPLICATIONS
This application claims benefit of Indian Patent Application No. 716/MUM/2013 filed on March 08, 2013, the disclosures of which are incorporated herein by reference in its entirety as if fully rewritten herein. All references including patents, patent applications, and literature cited in the specification are expressly incorporated herein by reference in their entirety.
FIELD OF THE INVENTION
The invention relates to a process for preparation of (2S, 5R)- Sulfuric acid mono- { [(4-aminopiperidin-4-yl) carbonyl]-7-oxo-l,6-diaza-bicyclo[3.2.1]-oct-6-yl} ester.
BACKGROUND OF THE INVENTION
A compound of Formula (I), chemically known as (2S, 5R)- Sulfuric acid mono- { [(4- aminopiperidin-4-yl) carbonyl]-7-oxo-l,6-diaza-bicyclo[3.2.1]-oct-6-yl} ester has antibacterial properties. The compound of Formula (I) is also known as MK-7655 and is disclosed in PCT International Patent Application No PCT/US2009/031047.
Formula (I)
SUMMARY OF THE INVENTION
In one general aspect, there is provided a process for preparation of a compound of Formula (I), comprising:
Formula (I)
(a) reacting a compound of Formula (II) with a compound of Formula (III) to obtain a compound of Formula (IV);
Formula (II) Formula (III) Formula (IV)
(b) hydrogenolysis of a compound of Formula (IV) to obtain a compound of Formula
Formula (V)
(c) sulfonating a compound of Formula (V) to obtain a compound of Formula (VI); and
Formula (VI)
(d) converting a compound of Formula (VI) into a compound of Formula (I).
The details of one or more embodiments of the invention are set forth in the description below. Other features, objects and advantages of the invention will be apparent from the following description including claims.
DETAILED DESCRIPTION OF THE INVENTION
Reference will now be made to the exemplary embodiments, and specific language will be used herein to describe the same. It should nevertheless be understood that no limitation of the scope of the invention is thereby intended. Alterations and further modifications of the inventive features illustrated herein, and additional applications of the principles of the invention as illustrated herein, which would occur to one skilled in the relevant art and having possession of this disclosure, are to be considered within the scope of the invention. It must be noted that, as used in this specification and the appended claims, the singular forms "a," "an," and "the" include plural referents unless the content clearly dictates otherwise. All references including patents, patent applications, and literature cited in the specification are expressly incorporated herein by reference in their entirety as if fully rewritten herein.
The term "HOBt" as used herein refers to 1 -hydro xybenzotriazole.
The term "EDC" as used herein refers to l-ethyl-3-(3-dimethylaminopropyl) carbodiimide.
In one general aspect, there is provided a process for preparation of a compound of Formula (I), comprising:
Formula (I)
(a) reacting a compound of Formula (II) with a compound of Formula (III) to obtain a compound of Formula (IV);
Formula (II) Formula (III) Formula (IV)
(b) hydrogenolysis of a compound of Formula (IV) to obtain a compound of Formula
Formula (V)
(c) sulfonating a compound of Formula (V) to obtain a compound of Formula (VI); and
Formula (VI)
(d) converting a compound of Formula (VI) into a compound of Formula (I).
The compound of Formula (IV) is obtained by reacting a compound of Formula (II) with a compound of Formula (III). In some embodiments, the compound of Formula (IV) is obtained by reacting a compound of Formula (II) with a compound of Formula (III) in presence of a suitable coupling reagent. In some other embodiments, the compound of Formula (IV) is obtained by reacting a compound of Formula (II) with a compound of Formula (III) in presence of 1 -hydro xybenzotriazole and l-ethyl-3-(3- dimethylaminopropyl)carbodhmide hydrochloride. This reaction may be carried out in presence of a suitable solvent. In some embodiments, this reaction is carried out in water as a reaction solvent.
The compound of Formula (V) is obtained by hydrogenolysis of a compound of Formula (IV). The hydrogenolysis reaction can be carried out using a suitable hydrogenolysis agent. In some embodiments, hydrogenolysis of a compound of Formula (IV) to obtain a compound of Formula (V) is carried out in presence of a transition metal catalyst and hydrogen source. In some other embodiments, the transition metal catalyst is palladium on carbon and hydrogen source is hydrogen gas. In some other embodiments, the hydrogenolysis reaction is carried out in presence of a suitable solvent such as, for example, methanol. In some embodiments, the hydrogenolysis of a compound of Formula (IV) to obtain a compound of Formula (V) is carried out using 10% palladium on carbon catalyst, in presence of hydrogen gas in methanol as a solvent.
The compound of Formula (VI) is obtained by sulfonating a compound of Formula (V). The sulfo nation reaction can be carried out in presence of a suitable solvent. In some embodiments, the sulfonation of a compound of Formula (V) to obtain a compound of Formula (VI) is carried out by reacting a compound of Formula (V) with sulfur trioxide - pyridine complex, followed by treatment with tetrabutyl ammonium hydrogen sulphate.
The compound of Formula (VI) is converted to a compound of Formula (I) in presence of a suitable reagent. In some embodiments, the compound of Formula (VI) is converted to a compound of Formula (I) by reacting a compound of Formula (VI) with trifluoro acetic acid.
In some embodiments, the compound of Formula (I) is prepared using a process described in Scheme 1.
Formula (V)
Formula (VI)
Formula (I)
Scheme - 1
It will be readily apparent to one skilled in the art that varying substitutions and modifications may be made to the invention disclosed herein without departing from the scope and spirit of the invention. For example, those skilled in the art will recognize that the invention may be practiced using a variety of different compounds within the described generic descriptions.
EXAMPLES
The following examples illustrate the embodiments of the invention that are presently best known. However, it is to be understood that the following are only exemplary or illustrative of the application of the principles of the present invention. Numerous modifications and alternative compositions, methods, and systems may be devised by those skilled in the art without departing from the spirit and scope of the present invention. The appended claims are intended to cover such modifications and arrangements. Thus, while the present invention has been described above with particularity, the following examples provide further detail in connection with what are presently deemed to be the most practical and preferred embodiments of the invention.
Example -1
Preparation of (2S, 5R)-Sulfuric acid mono-{2-[N'-(4-aminopiperidinyl)-carbonyl]-7-oxo- l,6-diaza-bicyclo[3.2.1]oct-6-yl} ester (I).
Step-1: Preparation of (2S, 5R)-tert-butyl { (6-benzyloxy-7-oxo-l,6-diaza-bicyclo[3.2.1]oct- 2-yl-carbonyl) amino} piperidine-l-carboxylate (IV):
To a 250 ml round bottom flask equipped with magnetic stirrer was charged a solution of (2S, 5R)-sodium 6-benzyloxy-7-oxo-l,6-diaza-bicyclo [3.2.1] octane-2-carboxylate (11.1 gm, 0.037 mol, prepared using a method disclosed in Indian Patent Application No 699/MUM/2013) in water (180 ml) followed by l-tert-butoxycarbonyl-4-amino-piperidine (7.8 gm, 0.039 mol), EDC hydrochloride (11 gm, 0.055 mol) and 1 -hydro ybenzotriazole (4.8 gm, 0.037 mol) at 30°C successively under stirring. The reaction mixture was stirred for
24 hours at 30°C to provide a suspension. The suspension was filtered under suction and washed with 45°C warm water (40 ml) to provide (2S, 5R)-tert-butyl { (6-benzyloxy-7-oxo- l,6-diaza-bicyclo[3.2.1]oct-2-yl-carbonyl) amino} piperidine-l-carboxylate in 12.7 gm quantity in 74% yield after drying under vacuum.
Analysis
NMR: (CDC13,) = 7.36-7.44 (m, 5H), 6.56 (d,lH), 5.06 (d,lH), 4.91 (d, 1H), 4.03 (br s, 1H), 3.88-3.97 (m, 2H), 3.29 (s, 1H), 3.00 (d, 1H), 2.86 (t, 2H), 2.64 (d, 1H), 2.37 (dd, 1H), 1.85-2.01 (m, 4H), 1.54-1.62 (m, 2H), 1.45 (s, 9H), 1.25-1.36 (m, 2H).
MS (ES+) C24H34N405 = 459.5 (M+l).
Step-2: Preparation of (2S, 5R)-tert-butyl { (6-hydroxy-7-oxo-l,6-diaza-bicyclo[3.2.1]oct-2- yl-carbonyl) amino} piperidine-l-carboxylate (V):
To a 100 ml single neck round bottom flask equipped with magnetic stirrer was charged a solution of (2S, 5R)-tert-butyl { (6-benzyloxy-7-oxo-l,6-diaza-bicyclo[3.2.1]oct-2- yl-carbonyl) amino} piperidine-l-carboxylate (9 g, 19.5 mmol) in methanol (90 ml) followed by 10% palladium on carbon (2.7 g) at 35°C. The reaction mixture was stirred under 1 atm hydrogen pressure at 35°C for 2 hours. The catalyst was removed by filtering the reaction mixture under suction over a celite bed. The celite bed was washed with dichloromethane (50 ml). The combined filtrate was evaporated under vacuum below 35°C to provide (2S, 5R)- tert-butyl {(6-hydroxy-7-oxo-l,6-diaza-bicyclo[3.2.1]oct-2-yl-carbonyl) amino} piperidine- l-carboxylate in 8.45 g quantity; it was used as such for the next reaction.
Analysis
NMR: (CDC13,) = 6.60 (d, 1H), 3.88-4.10 (m, 4H), 3.78 (s, 1H), 3.20 (d, 1H), 3.90 (t, 2H), 2.80 (d, 1H), 2.46 (dd, 1H), 2.1-2.2 (m, 1H), 2.85-2.20 (m, 4H), 1.70-1.80 (m, 1H), 2.47 (s, 9H), 1.30-1.41 (m, 3H).
MS (ES+) C17H28N405 = 369.4 (M+l).
Step-3: Preparation of Tetrabutyl ammonium salt of (2S, 5R)-tert-butyl {(6-sulfooxy-7-oxo- l,6-diaza-bicyclo[3.2.1]oct-2-yl-carbonyl) amino} piperidine-l-carboxylate (VI):
To a 100 ml single neck round bottom flask equipped with magnetic stirrer was charged a solution of (2S, 5R)-tert-butyl {(6-hydroxy-7-oxo-l,6-diaza-bicyclo [3.2.1 ]oct-2-yl- carbonyl) amino} piperidine-l-carboxylate (6.40 g, 7.6 mmol) in dichloromethane (90 ml), triethyl amine (9.3 ml), followed by pyridine - sulfur trioxide complex (5.4 g, 34.2 mmol) at 35°C under stirring. The reaction mixture was stirred for additional 4 hours at 35°C. The solvent was evaporated under vacuum below 40°C to provide a residue. The residue was stirred with 0.5N aqueous potassium dihydrogen phosphate solution (90 ml) for 1 hour. The resulting solution was extracted with dichloromethane (2 x 100 ml) to remove impurities. To the aqueous layer was added tetrabutyl ammonium hydrogen sulfate (6.9 g, 20.52 mmol) and the reaction mixture was stirred for 14 hours at 35°C. It was extracted with dichloromethane (3 x 30 ml). Combined organic layer was dried over sodium sulfate and evaporated under vacuum to provide tetrabutyl ammonium salt of (2S, 5R)-tert-butyl {(6-sulfooxy-7-oxo-l,6- diaza-bicyclo[3.2.1]oct-2-yl-carbonyl) amino} piperidine-l-carboxylate in 8.0 g quantity in 62% yield.
Analysis
NMR: (CDC13,) - 6.64 (d, 1H), 4.36 (br s, 1H), 4.05(br s, 2H), 3.90-4.00 (m, 1H), 3.87 (d, 1H), 2.28-3.34 (m, 10H), 3.80-3.95 (m, 2H), 3.74 (d, 1H), 2.42 (dd, 1H), 2.15-2.24 (m, 1H), 1.82-1.97 (m, 4H), 1.61-1.74 (m, 14 H), 1.41-1.52 (m, 10 H), 1.02 (t, 12H).
MS (ES-) C17H27N408S. N(C4H9)4 = 447.4 (M-l) as a free sulfonic acid.
Step-4: Synthesis of (2S, 5R)- Sulfuric acid mono-{ [(4-aminopiperidin-4-yl) carbonyl]-7- oxo-l,6-diaza-bicyclo[3.2.1]-oct-6-yl} ester (I):
To a 100 ml round bottom flask equipped with magnetic stirrer was charged a solution of tetrabutyl ammonium salt of (2S, 5R)-tert-butyl {(6-sulfooxy-7-oxo-l,6-diaza- bicyclo[3.2.1]oct-2-yl-carbonyl) amino} piperidine-l-carboxylate (6.0 g) in dichloromethane (15 ml). The solution was cooled to -10°C under stirring and to it was added trifluoro acetic acid (15 ml) drop wise. The reaction mixture was stirred at -10°C for 1 hour. Solvents were evaporated under vacuum below 30°C to its 1/3 volume to provide a thick residue. The thick
residue was stirred twice with diethyl ether (60 ml each time) to provide a precipitation. The solid obtained was filtered at suction and suspended in acetone (90 ml). To the suspension was added 10% solution of sodium-2-ethyl-hexanoate in acetone to adjust pH between 4.5 to 5.5. The suspension was stirred for 10 minutes and filtered under suction. The wet cake was washed with acetone and dried under vacuum below 40°C to provide 3 gm crude compound. The crude compound was stirred with aqueous isopropanol (3ml water: 21 ml iospropanol) for overnight to purify further. The resulting suspension was filtered under suction and washed with aqueous isopropanol (1 ml water: 7 ml IPA mixture). Finally the cake was dried under vacuum below 40°C to provide the title compound as a off-white solid in 1.8 g quantity in 65% yield.
Analysis
H1NMR (DMSO-d6, D20 exchange) = 8.19 (d, exchanges with D20), 3.99 (s, 1H), 3.82-3.92 (m, 1H), 3.72 (d, 1H), 2.24 (br d, 3H), 2.90-3.04 (m, 5H), 1.96-2.06 (m, 1H), 1.80- 1.94 (m, 3H), 1.58-1.72 (m, 4H).
MS (ES+) C12H20N4O6S = 349.2 (M+l) as a free sulfonic acid;
Purity by HPLC: 99.2%
Specific rotation: [a] D -45.25 °, (c 0.3%, water)
Claims
1. A process for preparation of a compound of Formula (I), comprising:
Formula (I)
(a) reacting a compound of Formula (II) with a compound of Formula (III) to obtain a compound of Formula (IV);
Formula (II) Formula (III) Formula (IV)
(b) hydrogenolysis of a compound of Formula (IV) to obtain a compound of Formula
(V);
Formula (V)
(c) sulfonating a compound of Formula (V) to obtain a compound of Formula (VI); and
Formula (VI)
(d) converting a compound of Formula (VI) into a compound of Formula (I).
2. A process according to Claim 1, wherein a compound of Formula (IV) is obtained by reaction a compound of Formula (II) with a compound of Formula (III) in presence of l-ethyl-3-(3-dimethylaminopropyl)carbodiimide and 1 -hydro xybenzotriazole.
3. A process according to Claim 2, wherein the reaction is carried out in presence of water as a solvent.
4. A process according to Claim 1, wherein the hydrogeno lysis of a compound of Formula (IV) to obtain a compound of Formula (V) is carried out in presence of a transition metal catalyst and hydrogen source.
5. A process according to Claim 4, wherein the transition metal catalyst is palladium on carbon and hydrogen source is hydrogen gas.
6. A process according to Claim 1, wherein the sulfonation of a compound of Formula (V) to obtain a compound of Formula (VI) is carried out by reacting a compound of Formula (V) with sulfur trioxide - pyridine complex, followed by treatment with aqueous tetrabutyl ammonium hydrogen sulphate.
7. A process according to Claim 1, wherein a compound of Formula (VI) is converted to a compound of Formula (I) by reacting a compound of Formula (VI) with trifluoro acetic acid.
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020157027186A KR101780577B1 (en) | 2013-03-08 | 2013-10-12 | A process for preparation of (2s, 5r)-sulfuric acid mono-{[(4-aminopiperidin-4-yl)carbonyl]-7-oxo-1,6-diaza-bicyclo[3.2.1]-oct-6-yl}ester |
| CA2904084A CA2904084C (en) | 2013-03-08 | 2013-10-12 | A process for preparation of (2s, 5r)- sulfuric acid mono-{[(4-aminopiperidin-4-yl) carbonyl]-7-oxo-1,6-diaza-bicyclo[3.2.1]-oct-6-yl} ester |
| BR112015021151A BR112015021151A2 (en) | 2013-03-08 | 2013-10-12 | Process for the preparation of (2s, 5r) -sulfuric acid mono - {[(4-aminopiperidin-4-yl) carbonyl] -7-oxo-1,6-diazabicyclo [3.2.1] -oct-6-yl} ester |
| RU2015142581A RU2621051C2 (en) | 2013-03-08 | 2013-10-12 | Method for production of (2s,5r)-mono-{[(4-aminopiperidine-4-yl) carbonyl]-7-oxo-1,6-diazabicyclo[3,2,1]oct-6-yl}ic ester of sulfuric acid |
| US14/769,805 US9556174B2 (en) | 2013-03-08 | 2013-10-12 | (2S, 5R)-sulfuric acid mono-{[(4-aminopiperidin-4-yl) carbonyl]-7-oxo-1,6-diaza-bicyclo[3.2.1]-oct-6-yl} ester |
| MX2015011720A MX2015011720A (en) | 2013-03-08 | 2013-10-12 | A process for preparation of (2s, 5r)- sulfuric acid mono-{[(4-aminopiperidin-4-yl) carbonyl]-7-oxo-1,6-diaza-bicyclo [3.2.1]-oct-6-yl} ester. |
| NZ711329A NZ711329A (en) | 2013-03-08 | 2013-10-12 | A process for preparation of (2s, 5r)- sulfuric acid mono-{ [(4-aminopiperidin-4-yl) carbonyl]-7-oxo-1,6-diaza-bicyclo[3.2.1]-oct-6-yl} ester |
| JP2015560793A JP6182621B2 (en) | 2013-03-08 | 2013-10-12 | (2S, 5R) -Sulfuric acid mono-{[(4-aminopiperidin-4-yl) carbonyl] -7-oxo-1,6-diaza-bicyclo [3.2.1] oct-6-yl} ester Method for preparation |
| AU2013399862A AU2013399862B2 (en) | 2013-03-08 | 2013-10-12 | A process for preparation of (2S, 5R)- sulfuric acid mono-{[(4-aminopiperidin-4-yl) carbonyl]-7-oxo-1,6-diaza-bicyclo[3.2.1]-oct-6-yl} ester |
| CN201380074161.9A CN105143224A (en) | 2013-03-08 | 2013-10-12 | A process for preparation of (2s, 5r)- sulfuric acid mono-{[(4-aminopiperidin-4-yl) carbonyl]-7-oxo-1,6-diaza-bicyclo[3.2.1]-oct-6-yl} ester |
Applications Claiming Priority (2)
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| IN716MU2013 | 2013-03-08 | ||
| IN716/MUM/2013 | 2013-03-08 |
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| WO2015033191A1 true WO2015033191A1 (en) | 2015-03-12 |
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Country Status (11)
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| US (1) | US9556174B2 (en) |
| JP (1) | JP6182621B2 (en) |
| KR (1) | KR101780577B1 (en) |
| CN (1) | CN105143224A (en) |
| AU (1) | AU2013399862B2 (en) |
| BR (1) | BR112015021151A2 (en) |
| CA (1) | CA2904084C (en) |
| MX (1) | MX2015011720A (en) |
| NZ (1) | NZ711329A (en) |
| RU (1) | RU2621051C2 (en) |
| WO (1) | WO2015033191A1 (en) |
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| CA2904089C (en) * | 2013-03-08 | 2017-05-02 | Wockhardt Limited | A process for sodium salt of (2s, 5r)-2-carboxamido-7-oxo-6-sulfooxy -1,6-diaza-bicyclo[3.2.1]octane |
| CN111072660B (en) * | 2018-10-22 | 2021-05-18 | 新发药业有限公司 | Simple preparation method of rilibatan |
| CN111943950B (en) * | 2020-09-10 | 2022-03-29 | 山东安信制药有限公司 | Preparation method of rilibatan |
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| WO2009091856A2 (en) * | 2008-01-18 | 2009-07-23 | Merck & Co., Inc. | Beta-lactamase inhibitors |
| WO2012086241A1 (en) * | 2010-12-22 | 2012-06-28 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | Optically-active diazabicyclooctane derivative and method for manufacturing same |
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| HUT74682A (en) * | 1993-12-29 | 1997-01-28 | Pfizer | Diazabicyclic neurokinin antagonists and pharmaceutical compositions containing them |
| CA2691052A1 (en) * | 2007-06-27 | 2008-12-31 | Sekisui Chemical Co., Ltd. | Apparatus and method for manufacturing multiplex interlayer for safety glass |
| US20120053350A1 (en) * | 2009-04-30 | 2012-03-01 | Ian Mangion | Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids |
| EP3052497B1 (en) * | 2011-09-13 | 2017-06-28 | Wockhardt Limited | Nitrogen containing compounds and their use |
| CA2904089C (en) * | 2013-03-08 | 2017-05-02 | Wockhardt Limited | A process for sodium salt of (2s, 5r)-2-carboxamido-7-oxo-6-sulfooxy -1,6-diaza-bicyclo[3.2.1]octane |
| BR112015021332B1 (en) * | 2013-03-08 | 2020-06-30 | Wockhardt Limited | sodium salt of (2s, 5r) -6-benzyloxy-7-oxo-1,6-diaza-bicyclo [3.2.1] octane-2-carboxylic and its preparation |
| BR112015021186A2 (en) * | 2013-03-08 | 2017-07-18 | Wockhardt Ltd | process for the preparation of (2s, 5r) -7-oxo-6-sulfoxy-2 - [((3r) -pyrrolidine-3-carbonyl) hydrazino carbonyl] -1,6-diaza-bicyclo [3.2.1] octane |
| CN108191864A (en) * | 2013-03-08 | 2018-06-22 | 沃克哈特有限公司 | The method for preparing oxo sulfonyloxy [(piperidinyl carbonyl)-Hydrazinocarbonyl] diaza-double-octane |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2009091856A2 (en) * | 2008-01-18 | 2009-07-23 | Merck & Co., Inc. | Beta-lactamase inhibitors |
| WO2012086241A1 (en) * | 2010-12-22 | 2012-06-28 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | Optically-active diazabicyclooctane derivative and method for manufacturing same |
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| JP6182621B2 (en) | 2017-08-16 |
| CN105143224A (en) | 2015-12-09 |
| US20160002233A1 (en) | 2016-01-07 |
| KR20150125998A (en) | 2015-11-10 |
| RU2621051C2 (en) | 2017-05-31 |
| AU2013399862B2 (en) | 2016-07-14 |
| NZ711329A (en) | 2016-06-24 |
| JP2016510063A (en) | 2016-04-04 |
| CA2904084A1 (en) | 2015-03-12 |
| RU2015142581A (en) | 2017-04-20 |
| US9556174B2 (en) | 2017-01-31 |
| BR112015021151A2 (en) | 2017-07-18 |
| MX2015011720A (en) | 2015-12-01 |
| AU2013399862A1 (en) | 2015-09-10 |
| CA2904084C (en) | 2017-03-28 |
| KR101780577B1 (en) | 2017-09-21 |
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