WO2015023077A1 - Apparatus and method for manufacturing biodegradable stent - Google Patents

Apparatus and method for manufacturing biodegradable stent Download PDF

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Publication number
WO2015023077A1
WO2015023077A1 PCT/KR2014/007259 KR2014007259W WO2015023077A1 WO 2015023077 A1 WO2015023077 A1 WO 2015023077A1 KR 2014007259 W KR2014007259 W KR 2014007259W WO 2015023077 A1 WO2015023077 A1 WO 2015023077A1
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WO
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Prior art keywords
biodegradable
hoejeonbong
biodegradable material
method
characterized
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PCT/KR2014/007259
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French (fr)
Korean (ko)
Inventor
조동우
심진형
하동헌
윤원수
이한철
Original Assignee
주식회사 티앤알바이오팹
포항공과대학교 산학협력단
부산대학교 산학협력단
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10Processes of additive manufacturing
    • B29C64/106Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00Processes of additive manufacturing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00Products made by additive manufacturing

Abstract

An apparatus for manufacturing a biodegradable stent, according to the present invention, comprises: a 3D printer provided with a precision multi-axis discharging device, which moves in x, y, and z axes so as to spray a biodegradable material, and an integrated control device, which controls the operation of the precision multi-axis discharging device; and a rotating shaft on which the material, which has been molten and discharged by means of the 3D printer, is discharged. Therefore, a biodegradable stent can be manufactured by means of a 3D printer and a rotating shaft, using 3D printing technology.

Description

The biodegradable stent manufacturing device and the manufacturing method

The present invention relates to a biodegradable stent manufacturing device, and relates to a method of manufacturing the same, and more particularly, to a biodegradable stent manufacturing device and a manufacturing method for manufacturing a biodegradable stent having a mechanical strength.

For vascular stent (stent) is used to maintain the space, so that when the stenosis of the blood vessel occurs, and extended by adding a physical force the occlusion region from the outside, not the expanded vascular stenosis again as a scaffold.

Application we are currently stents are expanded to various fields such as cardiovascular, femoral vascular, biliary, The use of these stents can be replaced open surgery, burdening the patient is emerging as a big advantage.

The stent is implanted into a temporary stent to provide a treatment for, or the narrowing of the blood vessel occurs, or partially closed, weakened, or abnormally enhance the extended portion within the hyeopgwan permanent stent, or a damaged blood vessel. Stents and urinary tract, but also be applied to the bile duct, is typically used in the subsequent balloon angioplasty (angioplasty) of a blood vessel to prevent restenosis of a blood vessel is damaged.

The stent of one of the metal material biocompatible materials are mainly used.

However, in the case of a conventional metallic stent, because of a too tight mechanical strength than the surrounding vascular tissue at the same time the advantages having sufficient mechanical strength to prevent the blood vessel stricture there is a problem such as this do not occur fused together properly.

In addition, due to the characteristics of the non-absorbent patients have to live without the burden of having a foreign substance in the body lifelong.

Moreover, the damage to the vascular endothelium when porting a conventional metal stent is let this neointimal hyperplasia (neointimal hyperplasia). This vessel has been reported that the problem of restenosis (restenosis) continue to occur within a few months.

In order to solve these problems are biodegradable stent disclosed in Korea Patent No. 2009-0092775 disclosure have been developed.

However, although FIG conventional biodegradable stent attempts to manufacture via laser cutting methods, such as for producing a metallic stent, a manufacturing method of the thermoplastic nature of the polymer is not suitable.

In addition, although the nation's leading companies are applying the weaving method using a polymer fiber, for textile weaving methods had disadvantages that do not provide sufficient mechanical strength.

Moreover, the weaving method using a laser cutting method and the fiber has a problem in a long time is required to manufacture an increased production cost.

Further, the laser cutting system becomes much material is lost in production.

Therefore, a situation that is required for the development of mechanical strength and at the same time has a simple manufacturing method as biodegradable stents biodegradability of the improved form of sex capable of producing a stent manufacturing device and a manufacturing method thereof.

The present invention has been conceived to solve the various problems of the above prior art, an object of the present invention is a biodegradable stent for producing a biodegradable stent having a simple, yet sufficient mechanical strength than the conventional production method using three-dimensional printing technique to provide a manufacturing apparatus and a manufacturing method thereof.

The biodegradable stent manufacturing device of the present invention for achieving the same purpose as above, integrated control for controlling the operation of a precision multi-axis the discharge device and the precision multi-screw discharge device moving in the x, y, z-axis so as to inject the biodegradable material 3D printer is configured as a device; It characterized in that it comprises; hoejeonbong and that discharge the 3D printer to the discharged melted material at.

Further, the three-dimensional printer is characterized in that for moving the divided sections at equal intervals along the longitudinal direction of the hoejeonbong respectively, and sequentially discharging the molten biodegradable material.

Further, the three-dimensional printer is characterized in that the hoejeonbong repeated round trip and discharging the molten biodegradable material in a section of the hoejeonbong one period of the divided period of the hoejeonbong during rotation than one rotation in the longitudinal direction .

Further, the three-dimensional printer is characterized in that the discharge of the discharge, even when the moving range of the divided plurality biodegradable material continuously or biodegradable material of the hoejeonbong stopped.

In addition, the hoejeonbong is characterized in that the rotation at a constant speed or rotation speed of the hoejeonbong is varying.

In addition, the hoejeonbong consists times in total, and a support for rotatably supporting the rotating, the rotor is characterized in that the separation from the support.

In addition, the multi-axis fine ejection apparatus, the laminated head for ejecting the biodegradable material in the hoejeonbong; The laminated head is coupled, z-axis displacement of the moving part supporting and elevating a predetermined height of the stacked head; Operation includes, that the stacking head and wherein the z-axis displacement the moving part and the plane displacement moving part; (108) connected to the supporting parts of the z-axis displacement movement of the z-axis displacement movement section plane displacement the moving part of the axial motion on the xy plane according to it characterized in that the interlocking.

Further, the laminated head has a syringe that is the biodegradable material contained; Heater to transfer heat to the syringe in a solid state transformation to the biodegradable material in a liquid state; Coupled with the syringe nozzle is ejected to the thickness that the biodegradable material in the liquid state is set; It characterized in that it comprises a; and wherein the biodegradable material is Reply to pressure before applying pressure in the syringe to be ejected by the nozzles in the nozzle.

Preparation biodegradable stent of the present invention,

Ⅰ) comprising: melting a biodegradable material;

Ⅱ) the step of moving the biodegradable material in the liquid state in hoejeonbong rotating at a constant speed, each of the divided sections of hoejeonbong and ejected;

Ⅲ) comprising: a biodegradable material discharged to the hoejeonbong is solidified producing a biodegradable stent; And

It characterized in that it comprises a; Ⅳ) separating the biodegradable stent in the hoejeonbong.

In addition, the Ⅱ) comprises:

Biodegradable material molten during the hoejeonbong rotates more than one rotation is characterized in that the repeated round-trip, and the ejection period of one of the divided sections of the hoejeonbong in the longitudinal direction.

In addition, the biodegradable material is characterized in that the polycaprolactone, poly glycolic acid, poly lactic acid, poly lactic-co-glycolic acid 1 alone or in mixture of two or more of the plurality of applications.

In addition, the biodegradable material, characterized in that further comprising a heat-resistant anti-cancer agents.

According to the biodegradable stent manufacturing device and the manufacturing method according to the invention, this has the effect of making the biodegradable stent by the 3D printer and hoejeonbong to 3D printing technology.

Accordingly, there is no material loss in the production process, as in the conventional method of laser cutting, also eliminating the need for treatment step after post-production.

In addition, the possible thickness of the line forming the stent, the width and so on easily controlled in the manufacturing process, and controlled by the mechanical strength it also becomes easy.

Further, in the conventional stents, but can be mounted over the drug coating, it is possible to continue the drug during the process of a biodegradable stent with a drug decomposition by integral to the stent itself when using a heat-resistant hamamje be released.

1 is a schematic diagram illustrating the components of the biodegradable stent manufacturing device according to the invention.

Figure 2 is a perspective view of the hoejeonbong of Figure 1;

Figure 3 is a perspective view of the 3D printer shown in Fig.

4 are each a schematic view showing the step of injecting the biodegradable material using the laminate head shown in Figure 3 at each stage.

Figure 5 is an exemplary view showing the biodegradable stent made of a biodegradable stent manufacturing device according to the invention.

Figure 6 is a flow chart illustrating a biodegradable stent manufacturing method according to the present invention.

With reference to the accompanying drawings, preferred embodiments of the present invention will be described in detail.

1 is a schematic diagram illustrating the components of the biodegradable stent manufacturing device according to the invention, Figure 2 is a perspective view showing the hoejeonbong of Figure 1, Figure 3 is a perspective view of the 3D printer shown in Figure 1 , Figure 4 illustrates the biodegradable stent made of a deulyigo schematic view showing each of the step of injecting the biodegradable material using a laminated head for each step, Figure 5 is a biodegradable stent manufacturing device according to the invention shown in Figure 3 one is also illustrated.

FIG biodegradable stent manufacturing device according to the invention as shown in Figs. 1 to 5 (A) is provided with a precision multi-screw discharge device 100 moving in the x, y, z-axis so as to inject the biodegradable material, the precise It consists of a 3D printer (P) and hoejeonbong 200 at which the material is ejected molten and discharged from the 3D printer (P) consisting of an integrated control device 30 for controlling the operation of the multi-screw discharge device 100.

In addition, the 3D printer (P) is moving the hoejeonbong 200 is divided at equal intervals along the longitudinal direction the first to the fifth interval of (d1, d2, d3, d4, d5), with each sequence and the molten the biodegradable material is discharged in sequence.

Specifically, the 3D printer (P) is the hoejeonbong 200 is one repeated reciprocating the first section (d1) of the hoejeonbong during rotation or rotation at least twice in the longitudinal direction, and the molten biodegradable material hoejeonbong It is discharged to the first section (d1) of 200.

Then, the second to the hoejeonbong 200, a fifth interval is producing a (d2, d3, d4, d5) the biodegradable material to the discharge 'Z' shaped stent of Figure 5 in the melt.

In addition, the 3D printer (P) is the first to fifth sections (d1, d2, d3, d4, d5) the longitudinal direction by continuously discharging a biodegradable material they move the split plurality of said hoejeonbong 200 to thereby continuously producing a stent to be connected.

On the other hand, the hoejeonbong 200 is to produce a stent having a uniform thickness by rotating at a constant speed. In this case, the hoejeonbong 200 is rotated by receiving the rotational force of the motor.

In addition, the hoejeonbong 200 rotatably supports the rotating body 210 and the rotor 210, and is composed of a support 220 which is installed on the work table 110, the rotor 210 includes a support body thereby separating the composed so as to be separated from the 220 complete once the entire stent (210).

Then, precision multi-screw discharge device 100 is provided with a stacking head (180 190) for ejecting a thickness predetermined biodegradable material, as well as plane coordinates consisting of the laminated head 180 in the x-axis and y-axis in the vertical direction thereby also the behavior in the z-axis.

Precision multi-axis the discharge device 100 for this purpose is a y-axis displacement movement unit (120, 130), x-axis displacement the moving part of the behavior of the laminated head 180 in the x-axis direction of motion of the laminated head 180 in the y-axis direction 140, and the laminated head 180 having a vertical z-axis displacement behavior mobile unit 160 to the z-axis direction, respectively.

That is, such a precision multi-screw discharge device 100 is to produce a three-dimensional shape of the stent by discharging the biodegradable material in hoejeonbong 200 provided on the work table (110).

Further, the data model 20 of the three-dimensional shape of the stent is inputted to the integrated controller 30. The data model 20 of the three-dimensional shape of the stent is preferably by being input to the 3D CAD data, and each coordinate of the three-dimensional shape stent configuration.

In addition, the integrated controller 30 will control the operation of the multi-axis fine ejection apparatus 100 according to the three-dimensional shape data model of the biodegradable stent. Then, precision multi-screw discharge device 100, while the behavior of the coordinates to set the lamination head 180 according to the three-dimensional shape data of the stent to be delivered from the integrated controller 30 value is discharging the biodegradable material.

On the other hand, the temperature controller 40 is connected to the stacking head (180) of precise multi-screw discharge device 100, thereby varying the degree of heat delivered to the stacking head (180). That is, the temperature controller 40 is to heat the biodegradable material in the laminating head (180) group in the set melt temperature. This causes the biodegradable material in the solid state is converted to the biodegradable material in the liquid state, the biodegradable material may be ejected to a predetermined thickness in the lamination head 180. Temperature controller 40 is preferably linked to the behavior of by being discharged as well as a precision multi-axis unit 100, connected together in the integrated controller 30, the laminated head 180.

Further, the pressure controller 50 is connected to the stacking head (180) of precise multi-screw discharge device 100, unlike the degree of pressure delivered to the stacking head (180). That is, as the pressure controller 50 is means for controlling the pressure delivered groups pressure transfer of the laminated head 180 described below, to vary the ejection speed of the biodegradable material to be sprayed through the nozzle of the laminated head 180 It can be so.

Pressure controller 50 according to an embodiment of the present invention, but the delivery pressure of the pressure transmission groups lamination head 180 by a pneumatic system. To this end, it includes a pneumatic machine (60) for applying direct pressure groups pressure transmission of 3D stacking head 180, this pneumatic group 60 is operated by a pressure controller (50).

Further, the laminated head 180 has a heater to convert the biodegradable material (11) is contained which the syringe 181 and, by transferring heat to the syringe 181, in solid form wherein the biodegradable material in a liquid state ( 183) and the syringe (181) as connected to the so that the biodegradable material ejected by the nozzle 184 and the nozzle 184 in which the biodegradable material 12 of the liquid ejection to set the thickness syringe (181 ) it consists of the pressure transmitters 182 to pressure within.

At this time, the pressure around the Reply 182 by being connected to a pressure controller 50 and the pneumatic group 60 shown in Figure 1, the pressure level is passed into the syringe (181) is controlled. The heater 183 are connected to the temperature controller 40 shown in Figure 1, the temperature at the internal syringe 181 is controlled in real time.

Of a biodegradable material described above is applied to the biodegradable are possible ingredients of the polyester-based and Examples polycaprolactone, poly glycolic acid, one or more of the plurality of the mixture consisting of poly lactic acid, poly lactic-co-glycolic acid, and the above-described materials It is possible.

In addition, it is possible with the heat-resistant cancer drugs with biodegradable materials.

That is, in the case of a mounted cancer after implantation of the stent, to inhibit the generation of new tissue around the stent is possible and can act as a functional stent by significantly reducing the restenosis rate of the vessel. In particular, the present invention is applied to the hot melt method a refractory cancer is used.

In this case, the material is biodegradable as soon produced at the same time for effective drug delivery-type biodegradable stent with the release of the anticancer agent may be made at the same time also possible.

And 5-FU (Fluorouracil) having a heat resistance to the anticancer agent it that allows the representative, the 5-FU is widely used as an anticancer agent as a drug to interfere with DNA synthesis of cellular metabolism agent, wherein the colon cancer, pancreatic cancer, breast cancer, colorectal cancer and it used much like liver cancer, endometrial cancer, esophageal cancer, bladder cancer.

According to the invention, by a three-dimensional printer (P) and hoejeonbong 200 is making a biodegradable stent in 3D printing technology.

Accordingly, there is no material loss in the production process, as in the conventional method of laser cutting, also eliminating the need for treatment step after post-production.

In addition, the possible thickness of the line forming the stent, the width and so on easily controlled in the manufacturing process, and controlled by the mechanical strength it also becomes easy.

Further, in the conventional stents, but can be mounted over the drug coating, it is possible to continue the drug during the process of a biodegradable stent with a drug decomposition by integral to the stent itself when using a heat-resistant hamamje be released.

Hereinafter, reference to Figure 6 will be described in the biodegradable stent manufacturing method of the present invention;

First, the molten biodegradable material (S110).

Next, move the biodegradable material in the liquid state in hoejeonbong rotating at a constant speed, each of the divided sections of hoejeonbong and discharging (S120).

At this time, while the hoejeonbong rotates over one turn, the molten biodegradable material is repeated reciprocally and discharging the one period of the divided period of the hoejeonbong in the longitudinal direction.

Then, the biodegradable material discharged to the hoejeonbong is solidified producing a biodegradable stent (S130).

Next, remove the biodegradable stent in the hoejeonbong (S140).

Or higher, but will be described in detail preferred embodiments of the present invention, the technical scope of the present invention is to be construed by the claims is not limited to the embodiments described above. At this time, if a gain is to be understood chair in the art, it should be considered to many modifications and variations are possible without departing from the scope of the invention.

Claims (12)

  1. To inject biodegradable material x, y, 3-D printer configured as a precision multi-screw discharge device and an integrated control device for controlling the operation of the multi-axis fine discharge device that moves in the z-axis; And
    The biodegradable stent manufacturing device comprising the; hoejeonbong that is ejected to the ejected melt in the three-dimensional printer material.
  2. According to claim 1,
    The three-dimensional printer is biodegradable stent manufacturing device, characterized in that for moving the divided sections at equal intervals along the longitudinal direction of the hoejeonbong respectively, and sequentially discharging the molten biodegradable material.
  3. 3. The method of claim 2,
    The three-dimensional printer is biodegradable, characterized in that the hoejeonbong repeated round trip and discharging the molten biodegradable material in a section of the hoejeonbong one period of the divided period of the hoejeonbong during rotation than one rotation in the longitudinal direction Castle stent manufacturing device.
  4. 3. The method of claim 2,
    The three-dimensional printer is biodegradable stent manufacturing device, characterized in that the discharge of the discharge, even when the moving range of the divided plurality biodegradable material continuously or biodegradable material of the hoejeonbong stopped.
  5. According to claim 1,
    The hoejeonbong is biodegradable stent manufacturing device, characterized in that rotates at a constant speed or rotation speed of the hoejeonbong is varying.
  6. According to claim 1,
    The hoejeonbong consists times in total, and a support for rotatably supporting the rotating,
    The rotating body is biodegradable stent manufacturing device, characterized in that the separation from the support.
  7. The method according to any one of the preceding claims,
    The multi-axis fine ejection apparatus,
    A biodegradable material stacking head for discharging to the hoejeonbong;
    The laminated head is coupled, z-axis displacement of the moving part supporting and elevating a predetermined height of the stacked head; And
    Coupled to support parts of the z-axis displacement movement plane displacement of the moving part axially behavior on the xy-plane z-axis displacement moving portion; includes,
    The biodegradable stent manufacturing device, characterized in that the interlocking head stack in accordance with the z-axis displacement and the moving part operating the displacement plane moving part.
  8. The method of claim 7,
    The laminated head is a syringe which is the biodegradable material contained;
    Heater to transfer heat to the syringe in a solid state transformation to the biodegradable material in a liquid state;
    Coupled with the syringe nozzle is ejected to the thickness that the biodegradable material in the liquid state is set; And
    The biodegradable stent manufacturing device comprising the; Thread pressure before applying the pressure in the syringe is the biodegradable material to be ejected by the nozzles in the nozzle.
  9. Ⅰ) comprising: melting a biodegradable material;
    Ⅱ) the step of moving the biodegradable material in the liquid state in hoejeonbong rotating at a constant speed, each of the divided sections of hoejeonbong and ejected;
    Ⅲ) comprising: a biodegradable material discharged to the hoejeonbong is solidified producing a biodegradable stent; And
    The biodegradable stent manufacturing method comprising the; Ⅳ) separating the biodegradable stent in the hoejeonbong.
  10. 10. The method of claim 9,
    The Ⅱ) comprises:
    The hoejeonbong one of biodegradable material melt while rotating at least the biodegradable stent manufacturing method, characterized in that the repeated round-trip, and the ejection period of one of the divided sections of the hoejeonbong in the longitudinal direction.
  11. 10. The method of claim 9,
    The biodegradable material is polycaprolactone, poly glycolic acid, a biodegradable stent manufacturing method, characterized in that poly lactic acid, poly lactic-co-glycolic acid in that one or a plurality of the mixture or more species applied.
  12. 10. The method of claim 9,
    The biodegradable material, method of manufacturing a biodegradable stent, characterized in that further comprises heat-resistant cancer.
PCT/KR2014/007259 2013-08-13 2014-08-06 Apparatus and method for manufacturing biodegradable stent WO2015023077A1 (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016133430A1 (en) * 2015-02-20 2016-08-25 Игорь Валерьевич МИХАЙЛОВ Product for forming a stent and method for forming same
CN106176000A (en) * 2016-08-31 2016-12-07 杭州捷诺飞生物科技有限公司 3D printing device and facility for preparing cardiovascular stent
WO2017113156A1 (en) * 2015-12-30 2017-07-06 四川蓝光英诺生物科技股份有限公司 Printing module for biological printer, and biological printer
WO2018086792A1 (en) * 2016-11-14 2018-05-17 Robert Bosch Gmbh Print head for a 3d printer, with improved control

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Publication number Priority date Publication date Assignee Title
JP2008194968A (en) * 2007-02-14 2008-08-28 Imoto Seisakusho:Kk Direct molding method and direct molding device of polymer material
KR20120090944A (en) * 2009-09-30 2012-08-17 테루모 가부시키가이샤 Stent
US20130084322A1 (en) * 2010-07-29 2013-04-04 Tim Wu Drug-impregnated biodegradable stent and methods of making the same
US20130150943A1 (en) * 2007-01-19 2013-06-13 Elixir Medical Corporation Biodegradable endoprostheses and methods for their fabrication

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130150943A1 (en) * 2007-01-19 2013-06-13 Elixir Medical Corporation Biodegradable endoprostheses and methods for their fabrication
JP2008194968A (en) * 2007-02-14 2008-08-28 Imoto Seisakusho:Kk Direct molding method and direct molding device of polymer material
KR20120090944A (en) * 2009-09-30 2012-08-17 테루모 가부시키가이샤 Stent
US20130084322A1 (en) * 2010-07-29 2013-04-04 Tim Wu Drug-impregnated biodegradable stent and methods of making the same

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016133430A1 (en) * 2015-02-20 2016-08-25 Игорь Валерьевич МИХАЙЛОВ Product for forming a stent and method for forming same
WO2017113156A1 (en) * 2015-12-30 2017-07-06 四川蓝光英诺生物科技股份有限公司 Printing module for biological printer, and biological printer
CN106176000A (en) * 2016-08-31 2016-12-07 杭州捷诺飞生物科技有限公司 3D printing device and facility for preparing cardiovascular stent
WO2018086792A1 (en) * 2016-11-14 2018-05-17 Robert Bosch Gmbh Print head for a 3d printer, with improved control

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