WO2014198753A1 - A computer implemented method for measuring specific heart chambers from heart radiographic images and computer program products thereof. - Google Patents
A computer implemented method for measuring specific heart chambers from heart radiographic images and computer program products thereof. Download PDFInfo
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- WO2014198753A1 WO2014198753A1 PCT/EP2014/062097 EP2014062097W WO2014198753A1 WO 2014198753 A1 WO2014198753 A1 WO 2014198753A1 EP 2014062097 W EP2014062097 W EP 2014062097W WO 2014198753 A1 WO2014198753 A1 WO 2014198753A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
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- A61B6/503—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of the heart
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
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- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
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- A61B6/5217—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data extracting a diagnostic or physiological parameter from medical diagnostic data
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- the present invention generally refers to imaging methods. Particularly, present invention refers to a computer implemented method for measuring specific heart chambers based on specific measurements imposed on thoracic radiographs images and computer program products thereof.
- the imaging measurements achieved by this invention provide data that are suitable for establishing a diagnosis of left atrial enlargement (LAE).
- LAE left atrial enlargement
- VHS vertebral heart scale
- Radiographic left atrial bisecting line is defined as a line arising at a 45- degree angle from the intersection of VHS long (L) and short (S) axis of the heart and extending to the border of the left atrium (LA) (Sanchez et al, 2010) [5].
- LABL left atrial bisecting line
- LA Ao left atrial to aortic root ratio
- the aim of this invention is to evaluate the usefulness of new radiographic measurements mainly to detect left atrial enlargement (LAE) overcoming the above difficulties.
- LAE left atrial enlargement
- New measurements were obtained as the distance from the intersection of the long (L) and short (S) axis of the heart to caudal heart limit (R-half-VHS), the distance from the intersection of the L and S axis of the heart to ventral border of carina (top-half- VHS), the sum of these measurements (Sum R-Top) and the distance from midpoint of R-half-VHS to LA roof (LA roof measurement).
- LABL was defined as a line arising at a 45-degree angle from the intersection of L and S axis of the heart and extending to the border of the left atrium and VHS was measured as described previously (Buchanan, 2000) [7].
- LA Ao ratio was obtained by two-dimensional ultrasonographic mode from right parasternal short axis view at the level of the aortic valves in early diastole.
- the provided computer implemented method for measuring specific heart chambers from heart radiographic measurements images comprises the known steps of:
- R-half-VHS equal to the distance from the intersection of the L and S axis of the heart to caudal heart border
- Top-half-VHS equal to the distance from the intersection of the L and S axis of the heart to ventral border of carina
- LA roof equal to the distance from midpoint of R-half-VHS to LA roof.
- Sum R-Top equal to the sum of R-half-VHS and top-half-VHS.
- the subject matter described herein can be implemented in software in combination with hardware and/or firmware, or a suitable combination of them.
- the subject matter described herein can be implemented in software executed by a processor.
- Fig. 1 the new four proposed measurements are depictured on a radiographic image, taken by a radiography imaging system or X-ray apparatus (not shown), of a heart of a dog.
- FIG.1 The heart is schematically depicted by a contour line and the following references have been indicated in the Fig.1 :
- the "Type III Tests of Fixed Effects" table contains hypothesis tests for the significance of each of the fixed effects
- ACVIM class clinical stage of DMVD
- Stage B left atrial enlargement without congestive heart failure dogs
- Stage C left atrial enlargement with congestive heart failure dogs
- Stage D left atrial enlargement with congestive heart failure refractory to treatment dogs
- Results show that using the predictive formula by using Top Half VHS and LA roof measurements allows predicting the clinical stage of DMVD in dogs.
- Each of these sub-tables shows the net contribution of each variable (first line) and (second line) the extra contribution of the predictive formula.
- Source DF Type I SS Mean Square F Value Pr > F VHS 1 13.64638711 13.64638711 39.10 ⁇ .0001 Pred 1 13.40522734 13.40522734 38.41 ⁇ .0001
- Type I SS type I sum of squares
- the "Pred" line p-value is ⁇ 0.05: this shows that the predictive formula improves separately each predictive tool.
- combination of new measurements Top-half and LA roof is a better tool to detect LAE.
- method for determining enlargement of specific heart chambers from heart radiographic measurements comprising:
- R-half-VHS equal to the distance from the intersection of the L and S axis of the heart to caudal heart limit
- top-half-VHS equal to the distance from the intersection of the L and S axis of the heart to ventral border of carina
- LA roof equal to the distance from midpoint of R-half-VHS to LA roof.
- method for determining enlargement of specific heart chambers from heart radiographic measurements comprising:
- R-half-VHS equal to the distance from the intersection of the L and S axis of the heart to caudal heart limit
- top-half-VHS equal to the distance from the intersection of the L and S axis of the heart to ventral border of carina
- LA roof equal to the distance from midpoint of R-half-VHS to LA roof, wherein a fourth measure Sum R-Top equal to the sum of R-half-VHS and top-half- VHS, is further used.
- R-half-VHS equal to the distance from the intersection of the L and S axis of the heart to caudal heart limit
- top-half-VHS equal to the distance from the intersection of the L and S axis of the heart to ventral border of carina
- LA roof equal to the distance from midpoint of R-half-VHS to LA roof, wherein said individual heart chambers pertain to a dog and the method allowing to detect left atrial enlargement.
- method for determining enlargement of specific heart chambers from heart radiographic measurements comprising:
- R-half-VHS equal to the distance from the intersection of the L and S axis of the heart to caudal heart limit
- top-half-VHS equal to the distance from the intersection of the L and S axis of the heart to ventral border of carina
- LA roof equal to the distance from midpoint of R-half-VHS to LA roof, wherein said individual heart chambers pertain to a human being and the method allowing to detect cardiomegaly.
- method for determining enlargement of specific heart chambers from heart radiographic measurements comprising:
- R-half-VHS equal to the distance from the intersection of the L and S axis of the heart to caudal heart limit
- top-half-VHS equal to the distance from the intersection of the L and S axis of the heart to ventral border of carina
- LA roof equal to the distance from midpoint of R-half-VHS to LA roof.
- method for determining enlargement of specific heart chambers from heart radiographic measurements comprising:
- said size measurement on said thoracic radiographs comprise at least following three measures: R-half-VHS equal to the distance from the intersection of the L and S axis of the heart to caudal heart limit;
- top-half-VHS equal to the distance from the intersection of the L and S axis of the heart to ventral border of carina
- LA roof equal to the distance from midpoint of R-half-VHS to LA roof., wherein said measures where compared to radiographic left atrial bisecting line (LABL) of healthy dogs and dogs with degenerative mitral valve disease (DMDV).
- LAL radiographic left atrial bisecting line
- method for determining enlargement of specific heart chambers from heart radiographic measurements comprising:
- R-half-VHS equal to the distance from the intersection of the L and S axis of the heart to caudal heart limit
- top-half-VHS equal to the distance from the intersection of the L and S axis of the heart to ventral border of carina
- LA roof equal to the distance from midpoint of R-half-VHS to LA roof., wherein said measures where compared to left atrium to aortic root ratio (LA Ao) of healthy dogs and of dogs with degenerative mitral valve disease (DMDV).
- LA Ao left atrium to aortic root ratio
- method for determining enlargement of specific heart chambers from heart radiographic measurements comprising:
- said size measurement on said thoracic radiographs comprise at least following three measures:
- R-half-VHS equal to the distance from the intersection of the L and S axis of the heart to caudal heart limit
- top-half-VHS equal to the distance from the intersection of the L and S axis of the heart to ventral border of carina
- LA roof equal to the distance from midpoint of R-half-VHS to LA roof.
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Abstract
A computer implemented method for determining enlargement of specific heart chambers from heart radiographic measurements and computer program products thereof The computer implemented method is based on radiographic measurements of heart size performed on thoracic radiographs images using as a reference the long L and short S cardiac axes of the heart and on a comparison between some of the measurements obtained on thoracic radiographs of healthy subjects or subjects with degenerative mitral valve disease (DMDV). The method proposes the following three radiographic measurements: R-half-VHS equal to the distance from the intersection of the L and S axis of the heart to caudal heart limit; top-half-VHS equal to the distance from the intersection of the L and S axis of the heart to ventral border of carina; and LA roof equal to the distance from midpoint of R-half-VHS to LA roof.15.
Description
A computer implemented method for measuring specific heart chambers from heart radiographic images and computer program products thereof
Field of the invention
The present invention generally refers to imaging methods. Particularly, present invention refers to a computer implemented method for measuring specific heart chambers based on specific measurements imposed on thoracic radiographs images and computer program products thereof.
Although tests using heart radiographic images measurements according to the invention have been conducted with dogs it is considered the application of the measures are extensible to other mammals including humans as evidenced with some publications that will be following referred.
The imaging measurements achieved by this invention provide data that are suitable for establishing a diagnosis of left atrial enlargement (LAE).
Background of the invention
The vertebral heart scale (VHS) method is an established indicator of global heart enlargement in dogs but is relatively nonspecific for enlargement of individual heart chambers.
In (Flavio R. Alves et al, 2012) [1] related to anatomical and radiographic appearance of the capuchin monkey thoracic cavity, it was declared that "the radiographic evaluation allowed the description of biometric values associated with the cardiac silhouette and thoracic structures. Application of the VHS (vertebral heart size) method showed positive correlation (p<0.05) with depth of the thoracic cavity, as well as between the body length of vertebrae T3, T4, T5 and T6 and the cardiac length and width." From this paragraph it can be inferred the possible usefulness of the VHS in capuchin monkey that can sustain as hypothesis its utility also in humans.
Radiographic left atrial bisecting line (LABL) is defined as a line arising at a 45- degree angle from the intersection of VHS long (L) and short (S) axis of the heart and extending to the border of the left atrium (LA) (Sanchez et al, 2010) [5].
A recent study comparing VHS and radiographic left atrial bisecting line (LABL) measurements to each other and to left atrial to aortic root ratio (LA Ao) found that LABL was not significantly different in dogs with and without congestive heart failure (CHF) as opposed to VHS measured on the left lateral view (Hernandez-Lopez et al, 2012) [6]. Researchers of the original study (Sanchez et al, 2010) [5] argued that the lack of correlation between LABL and LA Ao measurements was due to difficulty in accurately
estimating the limit of the left atrium (LA) as it is obscured by normal anatomical structures and by perihilar pulmonary edema in the setting of CHF.
The aim of this invention is to evaluate the usefulness of new radiographic measurements mainly to detect left atrial enlargement (LAE) overcoming the above difficulties.
With the help of a few simple measurements imposed on thoracic radiographs images, information can be collected determining size of individual heart chambers.. These new radiographic image measurements which differ from previous image measurements used as indicator of global heart enlargements are data useful for establishing a diagnosis of left atrial enlargement (LAE).
Summary of the invention
New measurements were obtained as the distance from the intersection of the long (L) and short (S) axis of the heart to caudal heart limit (R-half-VHS), the distance from the intersection of the L and S axis of the heart to ventral border of carina (top-half- VHS), the sum of these measurements (Sum R-Top) and the distance from midpoint of R-half-VHS to LA roof (LA roof measurement).
LABL was defined as a line arising at a 45-degree angle from the intersection of L and S axis of the heart and extending to the border of the left atrium and VHS was measured as described previously (Buchanan, 2000) [7]. LA Ao ratio was obtained by two-dimensional ultrasonographic mode from right parasternal short axis view at the level of the aortic valves in early diastole.
The provided computer implemented method for measuring specific heart chambers from heart radiographic measurements images, according to the invention comprises the known steps of:
a) obtaining, through a detector, thoracic radiographs images of a subject;
b) performing, a processor running in a computing device, on said thoracic radiographs images, measurements using as a reference the long L and short S cardiac axes;
c) comparing, said processor, some of these radiographic images measurements with equivalent radiographic images measurements of healthy subjects and of subjects with degenerative mitral valve disease (DMVD);
d) analysing, the processor, similarities and differences between the compared measurements, and
e) storing the results in an storage medium such as a database or a memory.
According to this invention at least three of the cited new measurements are performed on the thoracic radiographs images:
R-half-VHS equal to the distance from the intersection of the L and S axis of the heart to caudal heart border;
Top-half-VHS equal to the distance from the intersection of the L and S axis of the heart to ventral border of carina; and
LA roof equal to the distance from midpoint of R-half-VHS to LA roof.
Besides a further fourth measurement is used, termed Sum R-Top equal to the sum of R-half-VHS and top-half-VHS.
Sum R-Top, LA Roof measurement and LABL showed high sensitivity (all of them 84.6%) and specificity (90.5%, 95.2 % and 95.2 % respectively). For instance, these obtained results could be used to detect Left Atrial Enlargement (LAE). Maximal reference values were 3.1 v, 1.2v and 1.8v respectively. Good significant correlation between these measurements and LA Ao was found. LA Roof measurements and Sum R-Top appear to be interesting alternatives to LABL in detecting LAE in dogs with degenerative mitral valve disease (DMVD).
These new measurements were compared to VHS, LABL and left atrium to aortic root ratio (LA Ao) in healthy dogs and dogs with (DMVD). Healthy patients (n=10) and dogs with DMVD (n=24) were prospectively selected to be included in a study.
The subject matter described herein can be implemented in software in combination with hardware and/or firmware, or a suitable combination of them. For example, the subject matter described herein can be implemented in software executed by a processor.
Brief description of the drawings
In the attached Fig. 1 the new four proposed measurements are depictured on a radiographic image, taken by a radiography imaging system or X-ray apparatus (not shown), of a heart of a dog.
The heart is schematically depicted by a contour line and the following references have been indicated in the Fig.1 :
1 : R-Half VHS
2: Top Half VHS
3: LA Roof
Description of the invention
Statistical AnalysisA multivariate regression model considering ACVIM (American College of Veterinary Internal Medicine) class (clinical stage of DMVD) as quantitative
response variable was analysed using all potential diagnostic markers as explanatory variables.
Interactions between markers and quadratic terms were also evaluated. Non-significant terms were removed from the model.
All statistical decisions were based on a 5% significance level. Statistical Analysis was performed using SAS System v9.2 (SAS Institute Inc., Cary, USA).
Statistical combination of these new measurements:
By statistical combination of measurements R-half-VHS, VHS, top-half-VHS, LA roof measurement, LABL and Sum R-Top, a new tool was obtained as follows:
After making a selection of variables and compare interactions and quadratic terms, a predictive model based on joint optimization of the tools above is as follows:
PRED = -3.8164 + Top_Half_VHS * 2.7707 + LA_Roof * 2.3931 +
Top_Half_VHS*LA_Roof * -1.0379
The "Type III Tests of Fixed Effects" table contains hypothesis tests for the significance of each of the fixed effects
Type 3 Tests of Fixed Effects
Numb Den
Effect DF DF F Value Pr > F
Top Half VHS 1 33 8.82 0.0055
LA Roof 1 33 13.27 0.0009
Top Half VHS*LA Roof 1 33 5.50 0.0252 where:
DF: degree of freedom
F value: significance
Pr: probability
Statistical summary of the combination of these new measurements for each ACVIM class are detailed in the following Table.
Predicted
ACVIM Class
0 B C D
Mean 0.30 1.31 1.91 2.25
Std 0.39 0.35 0.59 0.32
Min -0.38 0.73 0.54 1.79
Max 0.85 1.75 2.55 2.66
N 10 7 15 5
ACVIM class: clinical stage of DMVD
Stage 0: healthy dogs
Stage B: left atrial enlargement without congestive heart failure dogs
Stage C: left atrial enlargement with congestive heart failure dogs
Stage D: left atrial enlargement with congestive heart failure refractory to treatment dogs
Results show that using the predictive formula by using Top Half VHS and LA roof measurements allows predicting the clinical stage of DMVD in dogs.
Comparisons between individual tests and composite were performed using a linear model and evaluating type I sum of squares.
Each of these sub-tables shows the net contribution of each variable (first line) and (second line) the extra contribution of the predictive formula.
Source DF Type I SS Mean Square F Value Pr >F
R_half_VHS 1 16.00512582 16.00512582 45.76 <.0001
Pred 1 1 1.02083132 11 .02083132 31 .51 <.0001
Source DF Type I SS Mean Square F Value Pr > F VHS 1 13.64638711 13.64638711 39.10 <.0001 Pred 1 13.40522734 13.40522734 38.41 <.0001
Source DF Type I SS Mean Square F Value Pr > F
Top_Half_VHS 1 21 .34354351 21 .34354351 61.00 <.0001 Pred 1 5.67836087 5.67836087 16.23 0.0003
Source DF Type I SS Mean Square F Value Pr > F
LA_Roof 1 23.46758402 23.46758402 67.07 <.0001
Pred 1 3.55432036 3.55432036 10.16 0.0031
Source DF Type I SS Mean Square F Value Pr > F
LAB 1 22.37104606 22.37104606 64.08 <.0001
Pred 1 4.67739714 4.67739714 13.40 0.0008
DF: degree of freedom
Type I SS: type I sum of squares
In all variables, the "Pred" line p-value is <0.05: this shows that the predictive formula improves separately each predictive tool. Thus, combination of new measurements Top-half and LA roof is a better tool to detect LAE.
In other embodiment, method for determining enlargement of specific heart chambers from heart radiographic measurements, comprising:
- obtaining thoracic radiographs;
- performing on said thoracic radiographs, measurements using as a reference the long L and short S cardiac axes;
- comparing some of these radiographic measurements in healthy subjects and subjects with degenerative mitral valve disease (DMVD);
- analysing similarities and differences between the compared measures, and
- storing the results.
characterized in that said size measurement on said thoracic radiographs comprise at least following three measures:
R-half-VHS equal to the distance from the intersection of the L and S axis of the heart to caudal heart limit;
top-half-VHS equal to the distance from the intersection of the L and S axis of the heart to ventral border of carina; and
LA roof equal to the distance from midpoint of R-half-VHS to LA roof.
In other embodiment, method for determining enlargement of specific heart chambers from heart radiographic measurements, comprising:
- obtaining thoracic radiographs;
- performing on said thoracic radiographs, measurements using as a reference the long L and short S cardiac axes;
- comparing some of these radiographic measurements in healthy subjects and subjects with degenerative mitral valve disease (DMVD);
- analysing similarities and differences between the compared measures, and
- storing the results.
characterized in that said size measurement on said thoracic radiographs comprise at least following three measures:
R-half-VHS equal to the distance from the intersection of the L and S axis of the heart to caudal heart limit;
top-half-VHS equal to the distance from the intersection of the L and S axis of the heart to ventral border of carina; and
LA roof equal to the distance from midpoint of R-half-VHS to LA roof, wherein a fourth measure Sum R-Top equal to the sum of R-half-VHS and top-half- VHS, is further used.
In other embodiment for determining enlargement of specific heart chambers from heart radiographic measurements, comprising:
- obtaining thoracic radiographs;
- performing on said thoracic radiographs, measurements using as a reference the long L and short S cardiac axes;
- comparing some of these radiographic measurements in healthy subjects and subjects with degenerative mitral valve disease (DMVD);
- analysing similarities and differences between the compared measures, and
- storing the results.
characterized in that said size measurement on said thoracic radiographs comprise at least following three measures:
R-half-VHS equal to the distance from the intersection of the L and S axis of the heart to caudal heart limit;
top-half-VHS equal to the distance from the intersection of the L and S axis of the heart to ventral border of carina; and
LA roof equal to the distance from midpoint of R-half-VHS to LA roof, wherein said individual heart chambers pertain to a dog and the method allowing to detect left atrial enlargement.
In other embodiment, method for determining enlargement of specific heart chambers from heart radiographic measurements, comprising:
- obtaining thoracic radiographs;
- performing on said thoracic radiographs, measurements using as a reference the long L and short S cardiac axes;
- comparing some of these radiographic measurements in healthy subjects and subjects with degenerative mitral valve disease (DMVD);
- analysing similarities and differences between the compared measures, and
- storing the results.
characterized in that said size measurement on said thoracic radiographs comprise at least following three measures:
R-half-VHS equal to the distance from the intersection of the L and S axis of the heart to caudal heart limit;
top-half-VHS equal to the distance from the intersection of the L and S axis of the heart to ventral border of carina; and
LA roof equal to the distance from midpoint of R-half-VHS to LA roof, wherein said individual heart chambers pertain to a human being and the method allowing to detect cardiomegaly.
In other embodiment, method for determining enlargement of specific heart chambers from heart radiographic measurements, comprising:
- obtaining thoracic radiographs;
- performing on said thoracic radiographs, measurements using as a reference the long L and short S cardiac axes;
- comparing some of these radiographic measurements in healthy subjects and subjects with degenerative mitral valve disease (DMVD);
- analysing similarities and differences between the compared measures, and
- storing the results.
characterized in that said size measurement on said thoracic radiographs comprise at least following three measures:
R-half-VHS equal to the distance from the intersection of the L and S axis of the heart to caudal heart limit;
top-half-VHS equal to the distance from the intersection of the L and S axis of the heart to ventral border of carina; and
LA roof equal to the distance from midpoint of R-half-VHS to LA roof., wherein said measures where compared to radiographic vertebral heart scale (VHS) measurements of healthy dogs and dogs with degenerative mitral valve disease (DMDV)
In other embodiment, method for determining enlargement of specific heart chambers from heart radiographic measurements, comprising:
- obtaining thoracic radiographs;
- performing on said thoracic radiographs, measurements using as a reference the long L and short S cardiac axes;
- comparing some of these radiographic measurements in healthy subjects and subjects with degenerative mitral valve disease (DMVD);
- analysing similarities and differences between the compared measures, and
- storing the results.
characterized in that said size measurement on said thoracic radiographs comprise at least following three measures:
R-half-VHS equal to the distance from the intersection of the L and S axis of the heart to caudal heart limit;
top-half-VHS equal to the distance from the intersection of the L and S axis of the heart to ventral border of carina; and
LA roof equal to the distance from midpoint of R-half-VHS to LA roof., wherein said measures where compared to radiographic left atrial bisecting line (LABL) of healthy dogs and dogs with degenerative mitral valve disease (DMDV).
In other embodiment, method for determining enlargement of specific heart chambers from heart radiographic measurements, comprising:
- obtaining thoracic radiographs;
- performing on said thoracic radiographs, measurements using as a reference the long L and short S cardiac axes;
- comparing some of these radiographic measurements in healthy subjects and subjects with degenerative mitral valve disease (DMVD);
- analysing similarities and differences between the compared measures, and
- storing the results.
characterized in that said size measurement on said thoracic radiographs comprise at least following three measures:
R-half-VHS equal to the distance from the intersection of the L and S axis of the heart to caudal heart limit;
top-half-VHS equal to the distance from the intersection of the L and S axis of the heart to ventral border of carina; and
LA roof equal to the distance from midpoint of R-half-VHS to LA roof., wherein said measures where compared to left atrium to aortic root ratio (LA Ao) of healthy dogs and of dogs with degenerative mitral valve disease (DMDV).
In other embodiment, method for determining enlargement of specific heart chambers from heart radiographic measurements, comprising:
- obtaining thoracic radiographs;
- performing on said thoracic radiographs, measurements using as a reference the long L and short S cardiac axes;
- comparing some of these radiographic measurements in healthy subjects and subjects with degenerative mitral valve disease (DMVD);
- analysing similarities and differences between the compared measures, and
- storing the results.
characterized in that said size measurement on said thoracic radiographs comprise at least following three measures:
R-half-VHS equal to the distance from the intersection of the L and S axis of the heart to caudal heart limit;
top-half-VHS equal to the distance from the intersection of the L and S axis of the heart to ventral border of carina; and
LA roof equal to the distance from midpoint of R-half-VHS to LA roof.
, wherein a statistical combination of measurements R-half-VHS, VHS , top-half-VHS, LA roof measurement, LABL and Sum R-Top t is performed and after making a selection of variables and compare interactions and quadratic terms, a predictive model based on joint optimization of the above measures is obtained as follows:
PRED = -3.8164 + Top_Half_VHS*2.7707 + LA_Roof * 2.3931 + Top_Half_VHS*LA_Roof * (-1 .0379)
References
[1] Flavio R. Alves, Francisco B. Costa et al: Anatomical and radiographic appearance of the capuchin monkey thoracic cavity. Pesq.Vet Bras 32 (12):1345, December 2012
[2] Mai HARADA, Hiroshi KOIE et al.: Establishment of Vertebral Heart Scale in the Growth Period of the Japanese Macaque (Macaca fuscata). J. Vet. Med. Sci. 72(4): 503-505, 2010
[3] Anaemilia das N. Diniz, Jose R. da Silva et al: Thoracic and heart biometrics of non- anesthetized agouti (Dasyprocta primnolopha Wagler, 1831 ) measured on radiographic images Pesq. Vet. Bras, vol.33 no.3 Rio de Janeiro Mar. 2013
[4] X.Sanchez, D.Prandi et al: A new method of computing the vertebral heart scale by means of direct standardisation. Journal of Small Animal Practice (2012).
[5] Sanchez X., Prandi D., Domenech O. A new radiologic measurement to study left atrial enlargement in dogs with mitral insufficiency: preliminary study. ACVIM Annual Meeting, Anaheim, CA, 2010.
[6] Hernandez-Lopez J., Machen M.C., Oyama M.A. Radiographic Vertebral Heart Size and Left Atrial Bisecting Line: I nterobserver variability and comparison to
echocardiographic left atrial size in dogs with degenerative mitral valve disease. ACVIM Annual Meeting, Louisiana, NO, 2012.
[7] Buchanan J. Vertebral scale system to measure heart size in radiographs. Veterinary Clinics of North America Small Animal Practice, 2000; 30: 379-93.
Claims
1 . A computer implemented method for measuring specific heart chambers from heart radiographic images, comprising:
a) obtaining, through a detector, thoracic radiograph images of a subject;
b) performing through a processor, on said obtained subject thoracic radiograph images, measurements using as a reference the long L and short S cardiac axes; c) comparing through said processor, some of these thoracic radiographic images measurements with thoracic radiographic images of healthy subjects and with thoracic radiographic images of subjects with degenerative mitral valve disease (DMVD);
d) analysing, through the processor, similarities and differences between the compared measures, and
e) storing the results at least in an storage medium,
characterized in that said measurements on said thoracic radiographs images comprises at least the following three measurements:
- R-half-VHS equal to the distance from the intersection of the L and S axis of the heart to caudal heart limit;
- top-half-VHS equal to the distance from the intersection of the L and S axis of the heart to ventral border of carina; and
- LA roof equal to the distance from midpoint of R-half-VHS to LA roof.
2. Method according to claim 1 , wherein a fourth measurement Sum R-Top equal to the sum of R-half-VHS and top-half-VHS, is further used.
3. Method according to claims 1 or 2, wherein said measurements where compared to radiographic vertebral heart scale (VHS) measurements of healthy dogs and dogs with degenerative mitral valve disease (DMDV).
4. Method according to claims 1 or 2, wherein said measurements where compared to radiographic left atrial bisecting line (LABL) images of healthy dogs and dogs with degenerative mitral valve disease (DMDV).
5. Method according to claims 1 or 2, wherein said measurements where compared to left atrium to aortic root ratio (LA Ao) of healthy dogs and of dogs with degenerative mitral valve disease (DMDV).
6. Method according to claims 1 or 2, wherein a statistical combination of measurements R-half-VHS, VHS, top-half-VHS, LA roof measurement, LABL and Sum R-Top t is performed and after making a selection of variables and compare interactions and quadratic terms, a predictive model based on joint optimization of the above
measurements is obtained as follows:
PRED = -3.8164 + Top_Half_VHS*2.7707 + LA_Roof * 2.3931 + Top_Half_VHS*LA_Roof * (-1 .0379)
7. A computer program product comprising computer program code means adapted to perform steps b) to e) of the method of claim 1 when said program is run on a computer, a digital signal processor, a field-programmable gate array, an application-specific integrated circuit, a micro-processor, a micro-controller, or any other form of programmable hardware.
8. A computer program product according to claim 7, further comprising program code means adapted to perform a fourth measurements Sum R-Top equal to the sum of R- half-VHS and top-half-VHS.
9. Method for determining enlargement of specific heart chambers from heart radiographic measurements, comprising:
- obtaining thoracic radiographs;
- performing on said thoracic radiographs, measurements using as a reference the long L and short S cardiac axes;
- comparing some of these radiographic measurements in healthy subjects and subjects with degenerative mitral valve disease (DMVD);
- analysing similarities and differences between the compared measurements, and
- storing the results.
characterized in that said size measurement on said thoracic radiographs comprise at least following three measurements:
R-half-VHS equal to the distance from the intersection of the L and S axis of the heart to caudal heart limit;
top-half-VHS equal to the distance from the intersection of the L and S axis of the heart to ventral border of carina; and
LA roof equal to the distance from midpoint of R-half-VHS to LA roof.
10. Method according to claim 9, wherein said individual heart chambers pertain to a dog and the method allowing to detect left atrial enlargement.
1 1. Method according to claim 9, wherein said individual heart chambers pertain to a human being and the method allowing to detect cardiomegaly.
12. Use of the measurements obtained according to claim 1 or 9 to detect enlargement of left atrial chamber of the heart in dogs
13. Use of the measurements obtained according to claim 1 or 9 to diagnose degenerative mitral valve disease in dogs
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Cited By (3)
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| WO2020257592A1 (en) * | 2019-06-21 | 2020-12-24 | The Regents Of The University Of California | Application of artificial intelligence on detecting canine left atrial enlargement on thoracic radiographs |
| KR20220161990A (en) * | 2021-05-31 | 2022-12-07 | 주식회사 우리엔 | Method and apparatus for quantifying a size of a tissue of interest of a sick animal using an X-ray image thereof |
| KR20240153741A (en) * | 2023-04-17 | 2024-10-24 | 에스케이텔레콤 주식회사 | Method and Device for Measuring Heart Size using Radiographic Image |
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2014
- 2014-06-11 WO PCT/EP2014/062097 patent/WO2014198753A1/en not_active Ceased
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020257592A1 (en) * | 2019-06-21 | 2020-12-24 | The Regents Of The University Of California | Application of artificial intelligence on detecting canine left atrial enlargement on thoracic radiographs |
| US12068077B2 (en) | 2019-06-21 | 2024-08-20 | The Regents Of The University Of California | Application of artificial intelligence on detecting canine left atrial enlargement on thoracic radiographs |
| KR20220161990A (en) * | 2021-05-31 | 2022-12-07 | 주식회사 우리엔 | Method and apparatus for quantifying a size of a tissue of interest of a sick animal using an X-ray image thereof |
| KR102610046B1 (en) | 2021-05-31 | 2023-12-05 | 주식회사 우리엔 | Method and apparatus for quantifying a size of a tissue of interest of a sick animal using an X-ray image thereof |
| US12307665B2 (en) | 2021-05-31 | 2025-05-20 | Woorien Co. | Method and device for quantifying size of tissue of interest of animal by using X-ray image of animal |
| KR20240153741A (en) * | 2023-04-17 | 2024-10-24 | 에스케이텔레콤 주식회사 | Method and Device for Measuring Heart Size using Radiographic Image |
| KR102837777B1 (en) | 2023-04-17 | 2025-07-22 | 에스케이텔레콤 주식회사 | Method and Device for Measuring Heart Size using Radiographic Image |
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