WO2014186804A3 - Aminoglycoside and azole compositions and methods - Google Patents

Aminoglycoside and azole compositions and methods Download PDF

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Publication number
WO2014186804A3
WO2014186804A3 PCT/US2014/038649 US2014038649W WO2014186804A3 WO 2014186804 A3 WO2014186804 A3 WO 2014186804A3 US 2014038649 W US2014038649 W US 2014038649W WO 2014186804 A3 WO2014186804 A3 WO 2014186804A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
aminoglycoside
compounds
present
azole compositions
Prior art date
Application number
PCT/US2014/038649
Other languages
French (fr)
Other versions
WO2014186804A2 (en
Inventor
Jon Takemoto
Cheng-Wei Chang
Sanjib SHRESTHA
Michelle Grilley
Original Assignee
Utah State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Utah State University filed Critical Utah State University
Priority to JP2016514162A priority Critical patent/JP2016520086A/en
Priority to EP14797052.9A priority patent/EP2996471A4/en
Publication of WO2014186804A2 publication Critical patent/WO2014186804A2/en
Publication of WO2014186804A3 publication Critical patent/WO2014186804A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Abstract

The present invention relates to novel fungicidal compound including an aminoglycoside analog having certain substituents at the 6 position of ring III that exhibit improved antifungal activity but possess minimal antibacterial properties in combination with fungicidal azoles. The aminoglycoside compounds are analogues of kanamycin A. Also provided are methods of synthesizing and methods of using the compounds of the present invention. The compounds of the present invention are useful in treating or preventing fungal disease.
PCT/US2014/038649 2013-05-17 2014-05-19 Aminoglycoside and azole compositions and methods WO2014186804A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2016514162A JP2016520086A (en) 2013-05-17 2014-05-19 Aminoglycoside and azole compositions and methods
EP14797052.9A EP2996471A4 (en) 2013-05-17 2014-05-19 Aminoglycoside and azole compositions and methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361824847P 2013-05-17 2013-05-17
US61/824,847 2013-05-17

Publications (2)

Publication Number Publication Date
WO2014186804A2 WO2014186804A2 (en) 2014-11-20
WO2014186804A3 true WO2014186804A3 (en) 2015-01-08

Family

ID=51899031

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/038649 WO2014186804A2 (en) 2013-05-17 2014-05-19 Aminoglycoside and azole compositions and methods

Country Status (3)

Country Link
EP (1) EP2996471A4 (en)
JP (1) JP2016520086A (en)
WO (1) WO2014186804A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030091510A1 (en) * 1997-10-22 2003-05-15 Jens Ponikau Methods for treating and preventing asthma and non-invasive fungus-induced rhinosinusitis
US20110190233A1 (en) * 2008-10-03 2011-08-04 Glycan Biosciences Pty Ltd Anionic conjugates of glycosylated bacterial metabolite
US20120316125A1 (en) * 2010-12-14 2012-12-13 Cheng-Wei Tom Chang Aminoglycosides: synthesis and use as antifungals

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR76519B (en) * 1981-04-29 1984-08-10 Pfizer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030091510A1 (en) * 1997-10-22 2003-05-15 Jens Ponikau Methods for treating and preventing asthma and non-invasive fungus-induced rhinosinusitis
US20110190233A1 (en) * 2008-10-03 2011-08-04 Glycan Biosciences Pty Ltd Anionic conjugates of glycosylated bacterial metabolite
US20120316125A1 (en) * 2010-12-14 2012-12-13 Cheng-Wei Tom Chang Aminoglycosides: synthesis and use as antifungals

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ROSENBOHM ET AL.: "Parallel synthesis of a small library of novel aminoglycoside analogs based on 2-amino-2-deoxy-d-glucose and d-ribose scaffolds", TETRAHEDRON, vol. 57, 2001, pages 627 - 6287, XP004305817 *
See also references of EP2996471A4 *

Also Published As

Publication number Publication date
JP2016520086A (en) 2016-07-11
WO2014186804A2 (en) 2014-11-20
EP2996471A2 (en) 2016-03-23
EP2996471A4 (en) 2016-12-28

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