WO2014184365A1 - Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b - Google Patents
Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b Download PDFInfo
- Publication number
- WO2014184365A1 WO2014184365A1 PCT/EP2014/060132 EP2014060132W WO2014184365A1 WO 2014184365 A1 WO2014184365 A1 WO 2014184365A1 EP 2014060132 W EP2014060132 W EP 2014060132W WO 2014184365 A1 WO2014184365 A1 WO 2014184365A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methyl
- compound
- mmol
- fluoro
- hydrogen
- Prior art date
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- 0 *c([s]c(S(N(*)*)(=O)=O)c1)c1C(Nc1cc(*)c(*)c(*)c1)=O Chemical compound *c([s]c(S(N(*)*)(=O)=O)c1)c1C(Nc1cc(*)c(*)c(*)c1)=O 0.000 description 2
- WQMPJXOMNDDTPK-UHFFFAOYSA-N CC(C)(C)NS(c1cc(C(Nc(cc2Cl)ccc2F)=O)c(C)[s]1)(=O)=O Chemical compound CC(C)(C)NS(c1cc(C(Nc(cc2Cl)ccc2F)=O)c(C)[s]1)(=O)=O WQMPJXOMNDDTPK-UHFFFAOYSA-N 0.000 description 1
- FDFNMZYGPAIBFP-UHFFFAOYSA-N CC1(COC1)NS(c1cc(C(Nc(cc2F)cc(Cl)c2F)=O)c(C)[s]1)(=O)=O Chemical compound CC1(COC1)NS(c1cc(C(Nc(cc2F)cc(Cl)c2F)=O)c(C)[s]1)(=O)=O FDFNMZYGPAIBFP-UHFFFAOYSA-N 0.000 description 1
- WWTYNHVOCYHMJD-UHFFFAOYSA-N Cc([s]c(S(NC1(CC1)C(F)(F)F)(=O)=O)c1)c1C(Nc(cc1C)ccc1F)=O Chemical compound Cc([s]c(S(NC1(CC1)C(F)(F)F)(=O)=O)c1)c1C(Nc(cc1C)ccc1F)=O WWTYNHVOCYHMJD-UHFFFAOYSA-N 0.000 description 1
- KMQJTEIZANJSSX-UHFFFAOYSA-N Cc([s]c(S(NC1SC1C(F)(F)F)(=O)=O)c1)c1C(Nc(cc1Cl)cc(F)c1F)=O Chemical compound Cc([s]c(S(NC1SC1C(F)(F)F)(=O)=O)c1)c1C(Nc(cc1Cl)cc(F)c1F)=O KMQJTEIZANJSSX-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Description
Claims
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2909742A CA2909742C (en) | 2013-05-17 | 2014-05-16 | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
LTEP14724109.5T LT2997019T (en) | 2013-05-17 | 2014-05-16 | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
EP14724109.5A EP2997019B1 (en) | 2013-05-17 | 2014-05-16 | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
EA201592198A EA035500B1 (en) | 2013-05-17 | 2014-05-16 | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
JP2016513394A JP6441315B2 (en) | 2013-05-17 | 2014-05-16 | Sulfamoylthiophenamide derivatives and their use as pharmaceuticals for treating hepatitis B |
SI201430958T SI2997019T1 (en) | 2013-05-17 | 2014-05-16 | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
US14/891,895 US10160743B2 (en) | 2013-05-17 | 2014-05-16 | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
BR112015028538A BR112015028538A2 (en) | 2013-05-17 | 2014-05-16 | sulfamoylthiophenamide derivatives and their use as medicines for the treatment of hepatitis b |
MX2015015771A MX366787B (en) | 2013-05-17 | 2014-05-16 | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b. |
PL14724109T PL2997019T3 (en) | 2013-05-17 | 2014-05-16 | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
AU2014267235A AU2014267235B2 (en) | 2013-05-17 | 2014-05-16 | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
DK14724109.5T DK2997019T3 (en) | 2013-05-17 | 2014-05-16 | SULFAMOYLTHIOPHENAMIDE DERIVATIVES AND USE THEREOF AS MEDICINES FOR TREATING HEPATITIS B |
CN201480028318.9A CN105960400B (en) | 2013-05-17 | 2014-05-16 | Sulfamoylthiophene amide derivatives and its purposes for being used to treat hepatitis B as drug |
ES14724109T ES2695182T3 (en) | 2013-05-17 | 2014-05-16 | Derivatives of sulfamoyl thiophenamide and its use as medicines to treat hepatitis B |
RS20181358A RS57999B1 (en) | 2013-05-17 | 2014-05-16 | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
IL242141A IL242141B (en) | 2013-05-17 | 2015-10-18 | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
HRP20181863TT HRP20181863T1 (en) | 2013-05-17 | 2018-11-07 | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
CY20181101182T CY1122337T1 (en) | 2013-05-17 | 2018-11-08 | SULPHAMOYLTHIOPHANAMIDE DERIVATIVES AND THEIR USE AS DRUGS FOR THE THERAPEUTIC TREATMENT OF HEPATITIS B |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13168295.7 | 2013-05-17 | ||
EP13168295 | 2013-05-17 | ||
EP13185227 | 2013-09-19 | ||
EP13185227.9 | 2013-09-19 | ||
EP14157917 | 2014-03-05 | ||
EP14157917.7 | 2014-03-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2014184365A1 true WO2014184365A1 (en) | 2014-11-20 |
Family
ID=50729521
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2014/060132 WO2014184365A1 (en) | 2013-05-17 | 2014-05-16 | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
Country Status (22)
Country | Link |
---|---|
US (1) | US10160743B2 (en) |
EP (1) | EP2997019B1 (en) |
JP (1) | JP6441315B2 (en) |
CN (1) | CN105960400B (en) |
AU (1) | AU2014267235B2 (en) |
BR (1) | BR112015028538A2 (en) |
CA (1) | CA2909742C (en) |
CY (1) | CY1122337T1 (en) |
DK (1) | DK2997019T3 (en) |
EA (1) | EA035500B1 (en) |
ES (1) | ES2695182T3 (en) |
HK (1) | HK1225387A1 (en) |
HR (1) | HRP20181863T1 (en) |
HU (1) | HUE040446T2 (en) |
IL (1) | IL242141B (en) |
LT (1) | LT2997019T (en) |
MX (1) | MX366787B (en) |
PL (1) | PL2997019T3 (en) |
PT (1) | PT2997019T (en) |
RS (1) | RS57999B1 (en) |
SI (1) | SI2997019T1 (en) |
WO (1) | WO2014184365A1 (en) |
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WO2017048962A1 (en) | 2015-09-15 | 2017-03-23 | Assembly Biosciences, Inc. | Hepatitis b core protein modulators |
WO2017155844A1 (en) | 2016-03-07 | 2017-09-14 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
WO2017205078A1 (en) | 2016-05-27 | 2017-11-30 | Gilead Sciences, Inc. | Methods for treating hepatitis b virus infections using ns5a, ns5b or ns3 inhibitors |
US9873671B2 (en) | 2014-01-16 | 2018-01-23 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
US9884818B2 (en) | 2013-05-17 | 2018-02-06 | Janssen Sciences Ireland Uc | Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
US9895349B2 (en) | 2013-04-03 | 2018-02-20 | Janssen Sciences Ireland Us | N-phenyl-carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
WO2018039531A1 (en) | 2016-08-26 | 2018-03-01 | Gilead Sciences, Inc. | Substituted pyrrolizine compounds and uses thereof |
WO2018045144A1 (en) | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
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EA201592198A1 (en) | 2016-03-31 |
PL2997019T3 (en) | 2019-03-29 |
EA035500B1 (en) | 2020-06-25 |
DK2997019T3 (en) | 2018-12-03 |
MX2015015771A (en) | 2016-03-15 |
US10160743B2 (en) | 2018-12-25 |
AU2014267235A1 (en) | 2015-11-12 |
HK1225387A1 (en) | 2017-09-08 |
PT2997019T (en) | 2018-11-21 |
US20160115149A1 (en) | 2016-04-28 |
HRP20181863T1 (en) | 2018-12-28 |
CN105960400B (en) | 2019-05-31 |
CA2909742C (en) | 2020-08-04 |
AU2014267235A8 (en) | 2015-12-10 |
BR112015028538A2 (en) | 2017-07-25 |
CA2909742A1 (en) | 2014-11-20 |
IL242141B (en) | 2019-09-26 |
RS57999B1 (en) | 2019-01-31 |
ES2695182T3 (en) | 2019-01-02 |
LT2997019T (en) | 2018-11-26 |
HUE040446T2 (en) | 2019-03-28 |
MX366787B (en) | 2019-07-23 |
CN105960400A (en) | 2016-09-21 |
EP2997019A1 (en) | 2016-03-23 |
AU2014267235B2 (en) | 2017-10-05 |
JP6441315B2 (en) | 2018-12-19 |
JP2016518437A (en) | 2016-06-23 |
SI2997019T1 (en) | 2018-12-31 |
EP2997019B1 (en) | 2018-08-08 |
CY1122337T1 (en) | 2020-07-31 |
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