WO2014114615A1

WO2014114615A1 - Process for the preparation of 4-methylpent-3-en-1-ol derivatives

Info

Publication number: WO2014114615A1
Application number: PCT/EP2014/051081
Authority: WO
Inventors: Jean-Jacques Riedhauser; Oliver Knopff; Luigi MARINONI
Original assignee: Firmenich Sa
Priority date: 2013-01-23
Filing date: 2014-01-21
Publication date: 2014-07-31
Also published as: US20150353463A1; JP6345189B2; IL239815B; EP2948245B1; EP2948245A1; US9381507B2; CN104994949A; JP2016505632A; IL239815A0; CN104994949B; MX2015008354A

Abstract

The present invention concerns a process for the preparation with high selectivity of a compound of formula (I) by isomerization at room temperature of compound of formula (II) in the presence of a complex of formula [Ru(dienyl)₂H]X.

Description

PROCESS FOR THE PREPARATION OF 4-METHYLPENT-3-EN-1-OL

DERIVATIVES

Technical field

The present invention relates to the field of organic synthesis and more specifically it concerns a process for the preparation of 4-methylpent-3-en-l-ol derivatives as defined in formula (I) via an isomerization presenting a good selectivity.

Prior art

Many 4-methylpent-3-en-l-ol derivatives as defined in formula (I) are useful products as such or useful intermediates of the preparation of other important raw materials. The compounds of formula (I), which are poly-isoprenoid derivatives, are of particular interest for the perfumery industry, and in particular 4,8-dimethylnona-3,7- dien-l-ol or 4,8,12-trimethyltrideca-3,7,l l-trien-l-ol. The latter compound is described as an important intermediate for the preparation of industrially relevant compounds such as Cetalox^® (dodecahydro-3a,6,6,9a-tetramethyl-naphtho[2,l-b]furan; origin: Firmenich SA, Geneva, Switzerland).

The compound of formula (I) 4,8,12-trimethyltrideca-3,7,l l-trien-l-ol has been prepared by many different processes, such as reduction of the corresponding carboxylic derivatives (e.g. see K.Ishihara et al in JACS, 2002, 3647), or by other exotic methods such as the ones based on boron chemistry (e.g. see D.S.Dodd et al in JOC, 1992, 2794). All these methods are complexes or long syntheses and are rarely feasible on an industrial scale.

None of the prior art reports the preparation of a derivative of formula (I) by isomerization of a compound of formula (II), which is in general of easy access.

It is known to this art, from US7250536, to isomerize in a presence of [RuCOD(2-methallyl)2] and BF₃.(AcOH)₂ (Ru complex and Lewis acid) a disubstituted double bond toward a trisubstituted one. However, the temperature at which the process is carried out at about 100 °C or more suggesting that the catalyst used is not effective on soft conditions required for the kind of substrates described in this application to avoid formation of by-products. Furthermore, this patent is focused on cyclic substrates for which the selectivity issue is less challenging compared to linear ones possibly leading to conjugated products and having several double bonds which could migrate. The problem of the invention's approach is of reaching a sufficient selectivity in favor of the desired product (see Examples), while having reaction conditions which can be applicable at an industrial scale. Description of the invention

We have now found that the derivatives of formula (I) can be produced in an advantageous manner by means of a new catalytic isomerization allowing a high selectivity and minimal by-products formation.

Therefore, a first object of the present invention is a process for the preparation of a compound of formula (I)

wherein X represents a CHO, CHCOR¹^, COOH, COOR², CON(R³)₂ or a CH₂OH group, R¹ representing when taken separately a Ci_₄ alkyl or when taken together a C₂-8 alkanediyl group, R² representing a C_1-5 alkyl group, R³ representing when taken separately a C_1-4 alkyl or when taken together a C3-8 alkanediyl group optionally comprising an ether functional group; and

R represents a C_1-12 alkyl or C_5-12 cycloalkyl group, a C_2-12 alkenyl or C_5-12 cycloalkenyl group, or a C_6-i₂ alkandienyl or C_6-i₂ cycloalkandienyl group;

by the isomerization of the corresponding compound of the formula (II)

wherein R and X have the same meaning as in formula (I);

said isomerization being performed in the presence of a complex of formula:

[Ru(dienyl)₂H]A (III)

wherein

dienyl represents a Cs-C₂₂ hydrocarbon group comprising a carbon-carbon double bond and a moiety C=C-C^"; and

A is a weakly or non-coordinating anion. For the sake of clarity, it is understood that by the expression "hydrocarbon" it is meant the usual meaning in the art, i.e. a group comprising only carbon or hydrogen atoms and which can be linear, branched or cyclic.

For the sake of clarity, it is understood that by the expression "complex" it is intended a specie which could be a catalyst or a precursor thereof.

According to a particular embodiment of the invention, said X represent a COOH, COOR² or a CH₂OH group, R² representing a Ci_₅ alkyl group.

According to any one of the above embodiments of the invention, said R is a linear or branched alkyl, alkenyl or non conjugated alkadienyl group. According to any one of the above embodiments of the invention, said R is C_2-12 group or even a C₄_i2 group.

According to any one of the above embodiments of the invention, said R can be a group of formula

wherein m is 0, 1 or 2. According to any one of the above embodiments of the invention, said m is 1 or 2.

According to any one of the above embodiments of the invention, the compound of formula (I) is 4,8-dimethylnona-3,7-dien-l-ol and the corresponding compound (II) is 8-methyl-4-methylene-non-7-en-l-ol, or the compound of formula (I) is 4,8,12- trimethyltrideca-3,7,l l-trien-l-ol and the corresponding compound (II) is 8,12-dimethyl- 4-methylene-trideca-7, 11 -dien- 1 -ol.

The compounds of formula (II) are known compounds and can be obtained according to the literature.

The compounds (I) and (II) may have one or two carbon-carbon double bonds which can have different stereochemistry (i.e. can be in a E or Z configuration). Each of said carbon-carbon double bond of said compounds, independently from each other, can be in a configuration Z or E or a mixture thereof, or in other worlds each carbon-carbon double bond can be in the form of an essentially pure isomer (i.e. the (3E) when R of compound of formula (I) is the group of formula (i) with m is 0 or 1 or the (3E,7E) when R of compound of formula (I) is the group of formula (i) with m is 2) or in the form of a mixture of isomers, e.g. in the case wherein two carbon-carbon double bonds can have different stereochemistry as with 4,8,12-trimethyltrideca-3,7,l l-trien-l-ol a mixture comprising the isomers (3E,7E) and (3Z,7E) in various w/w ratio.

According to any one of the above embodiments of the invention, the starting compound (II) is 8,12-dimethyl-4-methylenetrideca-7,l l-dien-l-ol, e.g. in the form of a mixture of isomers of conformation (E) and (Z) wherein the (E) isomer represent at least 50% w/w, or even 80% w/w, or even 90% w/w relative to the total weight of the starting material. In such a case the compound (I) obtained is a mixture of isomers of various double bonds conformation, such as (3E,7E)-4,8,12-trimethyltrideca-3,7,l l-trien-l-ol, (3E,7Z)-4,8,12-trimethyltrideca-3,7,ll-trien-l-ol and (3Z,7E)-4,8,12-trimethyltrideca- 3,7,11-trien-l-ol. According to a particular embodiment of the invention, when compound (I) is 4,8, 12-trimethyltrideca-3,7,l 1-trien-l-ol, said compound is in the form a mixture of the (3E,7E), (3E,7Z), (3Z,7E) and (3Z,7Z) isomers wherein the isomer (3E,7E) represent at least 50% w/w, or even 60% w/w, or even 80 % w/w, or even 90% w/w of said mixture.

The invention's process is carried out in the presence of a complex of formula [Ru(dienyl)₂H]A.

According to any one of the above embodiments of the invention, said A is a weakly or non coordinative mono anion. In particular said A represents NO₃ ^", HSO4^", BF₄ ^", PF₆ ^~, SbF₆ ^~, AsF₆ ^~, F^" or R^XSC>3^~ wherein R^x is a fluoride atom or a Ci_8 alkyl or Ci-₁0 aromatic group optionally substituted by one to three C₁-4 alkyl group or Ci_8 fluoroalkylgroup. By fluoroalkyl group it is meant a partially or totally fluorinated alkyl group such CF₃.

According to any one of the above embodiments of the invention, said A is a mono anion. In particular said A represents NO₃ ^", BF₄ ^~, PF₆ ^~, SbF₆ ^~, AsF6^~, F^" or R^XSC>3^~ wherein R^x is a fluoride atom or a Ci_s alkyl or Ci_s fluoroalkyl group.

According to any one of the above embodiments of the invention, said A is a mono anion. In particular said A represents BF4^", PF5^", SbF ^~, ASF5^", F^" or R^XS(V wherein R^x is a fluoride atom or a CH₃ or a CF₃ or a phenyl or a para-toluyl.

According to any one of the above embodiments of the invention, said A is BF₄ ^". According to any one of the above embodiments of the invention, said dienyl is a deprotonated diene, wherein by diene it is meant a C5-C22 hydrocarbon group comprising two carbon-carbon double bonds and which is not aromatic. Therefore said "dienyl" comprises a carbon-carbon double bond and a moiety C=C-C^".

According to any one of the above embodiments of the invention, said dienyl, and the diene generating it, is a linear, branched or cyclic group. According to any one of the above embodiments of the invention, said dienyl is a C_5-12 group.

As non-limiting examples of suitable "dienyl" one may cite compounds such as a cyclooctadienyl, also known as "codyl" (e.g. 1,3- or 1,4- or 1,5-cyclooctadienyl), norbornadienyl, a 2,4-dimethyl-pentadienyl, a 2,3,4-trimethylpenta-l,3-dienyl, a 2,7- dimethyl-octadienyl or a cycloheptadienyl, and the respective diene from which the dienyl is derived are COD (cyclooctadiene) or NBD (norbornadiene), 2,4-dimethyl-l,3- pentadiene, 2,3,4-trimethylpenta-l,3-diene, 2,7-dimethyl-2,6-octadiene or yet cyclohepta- 1 ,4-diene respectively.

According to any one of the above embodiments of the invention, said complex of formula (III) is [Ru(codyl)₂H]A, [Ru(cycloheptadienyl)₂H]A, [Ru(2,3,4- trimethylpenta- 1 ,3-dienyl)₂H] A or [Ru(2,4-dimethyl-pentadienyl)₂H] A.

Complexes of formula (III) are known compounds and can be obtained by applying prior art procedures as for example described in FR 2887253, in EP 1283843, in Salzer et al., OM 2000, (19),5471 or in Cox and Roulet in Chem. Commun., 1988, 951 or in F. Bouachir et al, Nouv. J. Chim., 1987, 11, 527 or in a combination of said documents. The complex could be formed in situ. Practical examples are shown in the Example section.

The complex can be added into the reaction medium of the invention's process in a large range of concentrations. As non-limiting examples, one can cite as complex concentration values those ranging from 0.01 % to 15 %, relative to the molar amount of substrate (II). Preferably, the complex concentration will be comprised between 0.2 % and 2 %. It goes without saying that the optimum concentration of complex will depend, as the person skilled in the art knows, on the nature of the latter, on the nature of the substrate, of the temperature used during the process, as well as the desired time of reaction. The reaction is preferably carried out under an inert atmosphere, e.g. under N₂, Ar or a mixture thereof. According to any one of the above embodiments of the invention, said inert atmosphere may further comprise up to 5% volume/volume of ¾.

The reaction can be carried out in the presence or absence of a solvent. When a solvent is required or used for practical reasons, then any solvent current in such reaction type can be used for the purposes of the invention. Non-limiting examples include C₆-io aromatic solvents such as benzene or toluene or xylene, C3-9 esters such as AcOEt, C_1-2 chlorinated solvents such as CH2CI2 or dichloro ethane, C2-9 ethers as tetrafydrofuran, methyl-tetrahydrofuran, dimethoxye thane, diethylether, C2-9 alcohol such as methanol, or mixtures thereof. According to any one of the above embodiments of the invention, the preferred solvent is aromatic solvents such as benzene or toluene or xylene, C3-9 esters such as AcOEt, C_1-2 chlorinated solvents such as CH2CI2 or dichloro ethane. The choice of the solvent is a function of the nature of the substrate and of the complex and the person skilled in the art is well able to select the solvent most convenient in each case to optimize the reaction.

The temperature at which the isomerization can be carried out is comprised between -20 °C and 95 °C more preferably in the range of between 20 °C and 60 °C. Of course, a person skilled in the art is also able to select the preferred temperature as a function of the melting and boiling point of the starting and final products as well as the desired time of reaction or conversion.

Examples

The invention, in all its embodiments, will now be described in further detail by way of the following examples, wherein the abbreviations have the usual meaning in the art, the temperatures are indicated in degrees centigrade (°C) ; the NMR spectral data were recorded in CDCI₃ with a 360 MHz or 100 MHz machine for ^]H or ¹³C respectively, the chemical displacements δ are indicated in ppm with respect to TMS as standard, the coupling constants J are expressed in Hz. The following abbreviations used herein below have the following meaning:

COD: 1,5-cyclooctadiene eaction scheme: for the compound wherein R is Et

Both product (I) and one of the two by-products have a triply-substituted double bond, fact which renders the selectivity difficult to be achieved. Moreover when X is not an alcohol the double bond of (I) can still migrate to become a much more stable conjugated double bond.

Preparation of the complexes (III) (in the form of a solution)

General procedure:

Use a precursor of:

- Solution Complex (1) - ([Ru(77⁵-C₈Hn)2H]BF₄)

In the glovebox, a Schlenk tube was charged with the [RuCOD(methylallyl)2] complex (0.08 mmol), COD (0.1 ml) and EtOAc (1 ml). After having stirred the mixture for 5 minutes BF₃.2CH₃COOH (0.035 mmol) was added, to give a slightly yellow solution containing the complex of formula (III).

- Solution Complex (2) - ([Ru( ⁵-C₈Hn)₂H]F)

In the glovebox, a Schlenk tube was charged with the [RuCOD(methylallyl)₂] complex (0.07 mmol), COD (0.1 ml) and CH₂C1₂ (1 ml). After having stirred the mixture for 15 minutes HF (48 % in water, 0.138 mmol) was added, to give a slightly yellow solution containing the complex of formula (III).

- Solution Complex (3) - ([Ru( ⁵-C₈H₁₁)₂H]BF₄)

In the glovebox, a Schlenk tube was charged with the {Ru(r|³:r|³-CioHi6)Cl₂}₂ complex (0.011 mmol), COD (0.1 ml) and CH₂C1₂ (2 ml) to give a purple solution. Then the silver tetrafluoroborate (0.058 mmol) was added, forming a suspension. Filtration of the suspension gave a solution containing the complex of formula (III). Example 1

Catalytic isomerization of (E)-8J2-dimethyl-4-methylenetrideca-7J l-dien-l-ol using Solution Complex (1)

In the glovebox, a Schlenk tube was charged with Solution Complex 1 (1.8 mol relative to compound (II)) before adding a solution of (E)-8, 12-dimethyl-4- methylenetrideca-7, l l-dien-l-ol (4.4 mmol) in EtOAc (4 ml). The reaction mixture was stirred 27 hours and then was quenched with aqueous NaOH IN (0.5 ml) and stirred half an hour. The aqueous layer was decanted, the organic layer dried over anhydrous Na₂S0₄ and concentrated to give 993 mg of a crude residue. Purification by bulb to bulb distillation afforded 727 mg of a colorless liquid. GLC analysis of this colorless liquid indicated a conversion of 94 % and a selectivity toward the formation of (3E,7E)-4,8, 12- trimethyltrideca-3,7, l l-trien-l-ol superior at 97 %. Example 2

Catalytic isomerization of (E)-8, 12-dimethyl-4-methylenetrideca-7, l l-dien-l-ol using Solution Complex (3)

In the glovebox, a Schlenk tube was charged with Solution Complex (3) (8.3 mol relative to compound (II)), as obtained above, and a solution of (E)-8, 12-dimethyl-4- methylenetrideca-7, l l-dien-l-ol (0.77 mmol) in CH₂C1₂ (1 ml).

After 2 hours, the reaction was quenched with aqueous hydroxylamine (0.2 ml)/Florisil^® (100 mg)/Na₂S0₄ (400 mg). The mixture was stirred 1 hour, filtered and concentrated to give 319 mg of a crude residue. Then, the crude was filtered through a small pad of Si0₂ to give, after concentration, 150 mg of a transparent liquid. GLC analysis of this liquid indicated a conversion of 95 % and a selectivity toward the formation of (3E,7E)-4,8, 12- trimethyltrideca-3,7, l l-trien-l-ol superior at 97 %.

Example 3

Catalytic isomerization of (E)-8, 12-dimethyl-4-methylenetrideca-7, l l-dien-l-ol using Solution Complex (2)

In the glovebox, a Schlenk tube was charged with Solution Complex (3) (9 mol relative to compound (II)), CH₂C1₂ (1 ml) and the (E)-8,12-dimethyl-4-methylenetrideca- 7, 11-dien-l-ol (0.831 mmol). The reaction mixture was stirred for 22 hours at room temperature, before being quenched with Ca(OH)2/Florisil /Na₂SC>4, filtered and concentrated. GLC analysis of the crude indicated a conversion of 96 % and a selectivity toward the formation of (3E,7E)-4,8, 12-trimethyltrideca-3,7, l l-trien- l-ol of 50 %. Example 4

Catalytic isomerization of (E)-methyl-8, 12-dimethyl-4-methylenetrideca-7,l l-dienoate using Solution Complex (1)

In the glovebox, a Schlenk tube was charged with Solution Complex (1) (10.3 mol relative to compound (II)), and a solution of (E)-methyl 8, 12-dimethyl-4- methylenetrideca-7, l l-dienoate (>99 , 0.677 mmol) in EtOAc (1 ml). The reaction mixture was stirred 8 hours. Then, the reaction was quenched with aqueous hydroxylamine/Florisil^®/ Na₂S0₄. Thereafter, the mixture was filtered, concentrated to give 126 mg of a residue. GLC analysis of the crude indicated a conversion of 90 % and a selectivity toward the formation of (3E,7E)-methyl-4,8,12-trimethyltrideca-3,7, I ltrienoate superior at 99 %.

Example 5

Catalytic isomerization of 8-methyl-4-methylenenon-7-enal using Solution Complex (1) In the glovebox, a Schlenk tube was charged with Solution Complex (1) (5.4 mol relative to compound (II)), and a solution of 8-methyl-4-methylenenon-7-enal (1.19 mmol) in EtOAc (1 ml). The reaction mixture was stirred 1 hour. Then, the reaction mixture was filtered through a Si0₂ pad and concentrated to give 180 mg of a residue. GLC analysis of the crude indicated a conversion of 84 % and a selectivity toward the formation of (E)-4,8-dimethylnona-3,7-dienal of 60 %. The low selectivity observed in this case is most probably due to some degradation of the homogeranial on the Si0₂ pad.

Example 6

Catalytic isomerization of (E)-8, 12-dimethyl-4-methylenetrideca-7, l l-dien-l-ol using Complex ( \Ru( if -2 ,4-dimethyl-pentadienyl)_?Hl A)

In the glovebox, a solution with the ([Ru(^⁵-2,4-dimethyl-pentadienyl)₂] (1.75 mg, 6 μιηοΐ, 0.24mol ) in CH₂C1₂ (0.5 ml) was added to a mixture of 2,4-dimethylpenta-l ,3- diene (17 μΐ, 12.25mg) and (E)-8, 12-dimethyl-4-methylenetrideca-7, l l-dien- l-ol (600 mg, 2.47 mmol) in CH₂C1₂ (2.5 ml). This final solution was split into six 4 ml vials each containing CH₂CI₂ (1.5 ml). To the thus prepared vials was then added a solution of one of the following acids (see Table 1). Table 1 : Isomerization of (E)-8,12-dimethyl-4-methylenetrideca-7,ll-dien-l-ol using various acids

1) Product selectivity based on converted starting (E)-8,12-dimethyl-4- methylenetrideca-7, 11 -dien- 1 -ol.

Example 7

Catalytic isomerization of (E)-8,12-dimethyl-4-methylenetrideca-7,l l-dien-l-ol using

The same procedure described in Example 1 was repeated. A solution of complex 1 containing 1 mol (relative to compound (II)) of catalyst was used and the (E)-8,12- dimethyl-4-methylenetrideca-7,l l-dien-l-ol was diluted in the appropriate solvent.

In toluene, GLC analysis after 5 h indicated a conversion of 55 % and a selectivity toward the formation of (3E,7E)-4,8,12-trimethyltrideca-3,7,l l-trien- l-ol of 95%.

In benzene, GLC analysis after 5 h indicated a conversion of 76 % and a selectivity toward the formation of (3E,7E)-4,8,12-trimethyltrideca-3,7,l l-trien- l-ol of 99%.

If a solution of complex 1 containing 9.7 mol% (relative to compound (II)) of catalyst was used:

In toluene, GLC analysis after 5 h indicated a conversion of 95 % and a selectivity toward the formation of (3E,7E)-4,8,12-trimethyltrideca-3,7,l l-trien- l-ol of 89%.

In benzene, GLC analysis after 5 h indicated a conversion of 96 % and a selectivity toward the formation of (3E,7E)-4,8,12-trimethyltrideca-3,7,l l-trien- l-ol of 76%.

In methyl-tetrahydrofuran, GLC analysis after 5 h indicated a conversion of 94 % and a selectivity toward the formation of (3E,7E)-4,8,12-trimethyltrideca-3,7,l l- trien-l-ol of 85%.

In ether, GLC analysis after 5 h indicated a conversion of 95 % and a selectivity toward the formation of (3E,7E)-4,8,12-trimethyltrideca-3,7,l l-trien-l-ol of 93%. In dimethoxyethane, GLC analysis after 5 h indicated a conversion of 94 % and a selectivity toward the formation of (3E,7E)-4,8,12-trimethyltrideca-3,7,l l-trien- l-ol of 83%.

In methanol, GLC analysis after 5 h indicated a conversion of 68 % and a selectivity toward the formation of (3E,7E)-4,8,12-trimethyltrideca-3,7,l l-trien- l-ol of 86%.

In tetrahydrofuran, GLC analysis after 5 h indicated a conversion of 94 % and a selectivity toward the formation of (3E,7E)-4,8,12-trimethyltrideca-3,7,l l-trien- l-ol of 87%. Example 8

Catalvtic isomerization of (E)-8,12-dimethyl-4-methylenetrideca-7,l l-dien-l-ol using Complex (rRu( ^-cycloheptadienyl^HlBFa

In the glovebox, a Schlenk tube was charged with [Ru^ -cycloheptadienyl)2H]BF4 (21 mg, 0.056mmol, 6.3mol ), cyclohepta-l,3-diene (87mg, 0.9mmol, 0.1 ml) and CH₂C1₂ (1 ml). This solution was added to a solution of (E)-8,12-dimethyl-4- methylenetrideca-7,l l-dien-l-ol (0.215g, 0.9mmol, 97.5%) in CH₂C1₂ (1 ml). The reaction mixture was stirred under Argon at room temperature for 21.5h. GLC analysis of this reaction mixture indicated a conversion of 92 % and a selectivity toward the formation of (3E,7E)-4,8,12-trimethyltrideca-3,7,ll-trien-l-ol superior at 92 %.

Claims

1. A process for the preparation of a compound of formula (I)

wherein X represents a CHO, CH(OR¹)₂, COOH, COOR², CON(R³)₂ or a CH₂OH group, R¹ representing when taken separately a C_1-4 alkyl or when taken together a C₂-8 alkanediyl group, R² representing a C_1-5 alkyl group, R³ representing when taken separately a C_1-4 alkyl or when taken together a C3-8 alkanediyl group optionally comprising an ether functional group; and

by the isomerization of the corresponding compound of the formula (II)

wherein R and X have the same meaning as in formula (I);

said isomerization being performed in the presence of a complex of formula:

[Ru(dienyl)₂H]A (III)

wherein

A is a weakly or non-coordinating anion.

2. A process according to claim 1, characterized in that said R is a group of formula

wherein m is 0, 1 or 2.

3. A process according to claim 1, characterized in that said X represents a CH₂OH group.

4. A process according to claim 1, characterized in that said A represents

N0₃ ^", HSO4^", BF₄ ^", PF₆ ^", SbF₆ ^", AsF₆ ^", F^" or R^xS0₃ ^" wherein R^x is a fluoride atom or a Ci_ 8 alkyl or Ci_io aromatic group optionally substituted by one to three C₁-4 alkyl groups or Ci-8 fluoroalkylgroup.

5. A process according to claim 1, characterized in that said A represents

N0₃ ^", BF₄ ^", PF₆ ^", SbF₆ ^", AsF₆ ^", F^" or R^xS0₃ ^" wherein R^x is a fluoride atom or a Ci_₈ alkyl or Ci-8 fluoroalkylgroup.

6. A process according to claim 1, characterized in that said dienyl is cyclooctadienyl, or norbornadienyl, or 2,4-dimethyl-pentadienyl, or 2,7-dimethyl- octadienyl or cycloheptadienyl or 2,3,4-trimethypenta-l,3-dienyl.