WO2014108218A8 - Microfluidics systems with waste hollow - Google Patents

Microfluidics systems with waste hollow Download PDF

Info

Publication number
WO2014108218A8
WO2014108218A8 PCT/EP2013/060723 EP2013060723W WO2014108218A8 WO 2014108218 A8 WO2014108218 A8 WO 2014108218A8 EP 2013060723 W EP2013060723 W EP 2013060723W WO 2014108218 A8 WO2014108218 A8 WO 2014108218A8
Authority
WO
WIPO (PCT)
Prior art keywords
waste
electrode
hollow
gap
microfluidics system
Prior art date
Application number
PCT/EP2013/060723
Other languages
French (fr)
Other versions
WO2014108218A1 (en
Inventor
Tiffany Lay
Thomas D. Perroud
Michael Benjamin Franklin
Anne R. Kopf-Sill
Original Assignee
Tecan Trading Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2013/050326 external-priority patent/WO2014108185A1/en
Priority claimed from PCT/EP2013/060585 external-priority patent/WO2014187488A1/en
Application filed by Tecan Trading Ag filed Critical Tecan Trading Ag
Priority to EP13725632.7A priority Critical patent/EP2768613B1/en
Priority to CN201380011888.2A priority patent/CN104136124B/en
Publication of WO2014108218A1 publication Critical patent/WO2014108218A1/en
Publication of WO2014108218A8 publication Critical patent/WO2014108218A8/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427—Electrowetting

Abstract

A digital microfluidics system (1) is configured for manipulating samples in liquid droplets within a gap (6) of at least one disposable cartridge (2). For providing additional space for collecting and/or storing waste fluids in this digital microfluidics system (1), it is provided at least one waste hollow (50) which is fluidly connected with a gap (6) of a disposable cartridge (2) that comprises a bottom layer (3) with a first hydrophobic surface (17') and a top layer (4) with a second hydrophobic surface (17"). The waste hollow (50) is located next to at least one individual waste electrode (52) that is positioned next to at least one individual electrode (10) of an electrode array 9 of the microfluidics system (1). Each individual waste electrode (52) is operatively connected to a central control unit (14) of the microfluidics system (1) and covers in each case a waste electrode area. The waste hollow (50) covers a waste area that is equal to a multitude of said waste electrode area and said waste hollow (50) has a height (51) that is equal to a multitude of a gap height (53) of the gap (6) of a disposable cartridge (2).
PCT/EP2013/060723 2013-01-09 2013-05-24 Microfluidics systems with waste hollow WO2014108218A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP13725632.7A EP2768613B1 (en) 2013-01-09 2013-05-24 Microfluidics systems with waste hollow
CN201380011888.2A CN104136124B (en) 2013-01-09 2013-05-24 Microfluid system with waste cavity

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EPPCT/EP2013/050326 2013-01-09
PCT/EP2013/050326 WO2014108185A1 (en) 2013-01-09 2013-01-09 Disposable cartridge for microfluidics systems
EPPCT/EP2013/060585 2013-05-23
PCT/EP2013/060585 WO2014187488A1 (en) 2013-05-23 2013-05-23 Digital microfluidics system with swappable pcb`s

Publications (2)

Publication Number Publication Date
WO2014108218A1 WO2014108218A1 (en) 2014-07-17
WO2014108218A8 true WO2014108218A8 (en) 2014-12-18

Family

ID=48536839

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2013/060723 WO2014108218A1 (en) 2013-01-09 2013-05-24 Microfluidics systems with waste hollow

Country Status (2)

Country Link
CN (1) CN104136124B (en)
WO (1) WO2014108218A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016162505A1 (en) 2015-04-08 2016-10-13 F-Star Biotechnology Limited Her2 binding agent therapies
CN115582155A (en) * 2017-09-01 2023-01-10 米罗库鲁斯公司 Digital microfluidic device and method of use thereof
CN107727838B (en) * 2017-09-30 2019-10-25 西南大学 A kind of micro waste collecting device suitable for micro-fluidic chip

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486337A (en) * 1994-02-18 1996-01-23 General Atomics Device for electrostatic manipulation of droplets
US6565727B1 (en) 1999-01-25 2003-05-20 Nanolytics, Inc. Actuators for microfluidics without moving parts
FR2871076A1 (en) * 2004-06-04 2005-12-09 Univ Lille Sciences Tech DEVICE FOR LASER RADIATION DESORPTION INCORPORATING HANDLING OF THE LIQUID SAMPLE IN THE FORM OF INDIVIDUAL DROPS ENABLING THEIR CHEMICAL AND BIOCHEMICAL TREATMENT
JP2006058031A (en) * 2004-08-17 2006-03-02 Hitachi High-Technologies Corp Chemical analyzer
PL1883474T3 (en) 2005-05-25 2021-10-18 Boehringer Ingelheim Vetmedica Gmbh System for the integrated and automated analysis of dna or protein and method for operating said type of system
WO2008106678A1 (en) * 2007-03-01 2008-09-04 Advanced Liquid Logic, Inc. Droplet actuator structures
AU2008237017B2 (en) * 2007-04-10 2013-10-24 Advanced Liquid Logic, Inc. Droplet dispensing device and methods
CH700127A1 (en) 2008-12-17 2010-06-30 Tecan Trading Ag System and apparatus for processing biological samples and for manipulating liquids with biological samples.
WO2011002957A2 (en) 2009-07-01 2011-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods
US8734628B2 (en) * 2010-03-10 2014-05-27 Empire Technology Development, Llc Microfluidic channel device with array of drive electrodes
US8470153B2 (en) 2011-07-22 2013-06-25 Tecan Trading Ag Cartridge and system for manipulating samples in liquid droplets

Also Published As

Publication number Publication date
CN104136124A (en) 2014-11-05
WO2014108218A1 (en) 2014-07-17
CN104136124B (en) 2017-07-25

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