WO2014089385A2 - Methods of synthesizing a prostacyclin analog - Google Patents
Methods of synthesizing a prostacyclin analog Download PDFInfo
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- WO2014089385A2 WO2014089385A2 PCT/US2013/073474 US2013073474W WO2014089385A2 WO 2014089385 A2 WO2014089385 A2 WO 2014089385A2 US 2013073474 W US2013073474 W US 2013073474W WO 2014089385 A2 WO2014089385 A2 WO 2014089385A2
- Authority
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- WIPO (PCT)
- Prior art keywords
- compound
- formula
- generate
- reacting
- organic solvent
- Prior art date
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- 238000000034 method Methods 0.000 title claims abstract description 247
- 150000003815 prostacyclins Chemical class 0.000 title abstract description 7
- 230000002194 synthesizing effect Effects 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 994
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 45
- 150000003839 salts Chemical class 0.000 claims abstract description 42
- 239000000126 substance Substances 0.000 claims abstract description 36
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 297
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims description 244
- 239000003960 organic solvent Substances 0.000 claims description 188
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 176
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 162
- -1 borane compound Chemical class 0.000 claims description 144
- 125000000217 alkyl group Chemical group 0.000 claims description 142
- 239000007800 oxidant agent Substances 0.000 claims description 115
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 105
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 87
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Inorganic materials O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 claims description 58
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 57
- 238000010992 reflux Methods 0.000 claims description 53
- 239000000203 mixture Substances 0.000 claims description 48
- NKLCNNUWBJBICK-UHFFFAOYSA-N dess–martin periodinane Chemical compound C1=CC=C2I(OC(=O)C)(OC(C)=O)(OC(C)=O)OC(=O)C2=C1 NKLCNNUWBJBICK-UHFFFAOYSA-N 0.000 claims description 47
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 44
- 239000003638 chemical reducing agent Substances 0.000 claims description 39
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 claims description 34
- DCGLONGLPGISNX-UHFFFAOYSA-N trimethyl(prop-1-ynyl)silane Chemical compound CC#C[Si](C)(C)C DCGLONGLPGISNX-UHFFFAOYSA-N 0.000 claims description 33
- PUPAWTXNPAJCHR-UHFFFAOYSA-N oxazaborole Chemical compound O1C=CB=N1 PUPAWTXNPAJCHR-UHFFFAOYSA-N 0.000 claims description 31
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 30
- 239000002244 precipitate Substances 0.000 claims description 30
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 claims description 28
- 239000003054 catalyst Substances 0.000 claims description 27
- 229910052723 transition metal Inorganic materials 0.000 claims description 25
- 150000003624 transition metals Chemical class 0.000 claims description 25
- UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 claims description 24
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 22
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 21
- 229910000085 borane Inorganic materials 0.000 claims description 21
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 18
- 125000005843 halogen group Chemical group 0.000 claims description 16
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 16
- WGOPGODQLGJZGL-UHFFFAOYSA-N lithium;butane Chemical group [Li+].CC[CH-]C WGOPGODQLGJZGL-UHFFFAOYSA-N 0.000 claims description 15
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims description 13
- 239000002904 solvent Substances 0.000 claims description 12
- NNOHXABAQAGKRZ-UHFFFAOYSA-N 3,5-dinitrobenzoyl chloride Chemical compound [O-][N+](=O)C1=CC(C(Cl)=O)=CC([N+]([O-])=O)=C1 NNOHXABAQAGKRZ-UHFFFAOYSA-N 0.000 claims description 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
- 230000003647 oxidation Effects 0.000 claims description 10
- 238000007254 oxidation reaction Methods 0.000 claims description 10
- OHENQANLQNOMAO-UHFFFAOYSA-N oxaborole Chemical compound O1B=CC=C1 OHENQANLQNOMAO-UHFFFAOYSA-N 0.000 claims description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical group CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 8
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 8
- HRBGUGQWTMBDTR-UHFFFAOYSA-N 2,3,4-tri(propan-2-yl)benzenesulfonyl chloride Chemical compound CC(C)C1=CC=C(S(Cl)(=O)=O)C(C(C)C)=C1C(C)C HRBGUGQWTMBDTR-UHFFFAOYSA-N 0.000 claims description 7
- 239000010949 copper Substances 0.000 claims description 7
- 229910052736 halogen Inorganic materials 0.000 claims description 7
- KFUAVDKJOGDOFI-UHFFFAOYSA-N 4,5-dihydrooxazaborole Chemical compound C1CB=NO1 KFUAVDKJOGDOFI-UHFFFAOYSA-N 0.000 claims description 6
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 6
- 238000004440 column chromatography Methods 0.000 claims description 6
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical group N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims description 5
- 229910002651 NO3 Inorganic materials 0.000 claims description 5
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical group [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 5
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical group OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 5
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 5
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 2
- 229910052802 copper Inorganic materials 0.000 claims description 2
- 238000006646 Dess-Martin oxidation reaction Methods 0.000 claims 1
- 230000008569 process Effects 0.000 abstract description 15
- 239000000543 intermediate Substances 0.000 abstract description 8
- 239000006227 byproduct Substances 0.000 abstract description 4
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 abstract description 4
- 238000011210 chromatographic step Methods 0.000 abstract description 3
- 231100001231 less toxic Toxicity 0.000 abstract description 2
- 230000001590 oxidative effect Effects 0.000 abstract description 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical class CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 265
- 235000019439 ethyl acetate Nutrition 0.000 description 108
- 238000006243 chemical reaction Methods 0.000 description 95
- 239000000243 solution Substances 0.000 description 83
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 74
- 125000001072 heteroaryl group Chemical group 0.000 description 69
- 125000003118 aryl group Chemical group 0.000 description 64
- 125000001931 aliphatic group Chemical group 0.000 description 61
- 239000002585 base Substances 0.000 description 60
- 238000005481 NMR spectroscopy Methods 0.000 description 49
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 46
- 0 **C[C@@](CCC#CC(c1c(CC=C)c(O*)ccc1)O)** Chemical compound **C[C@@](CCC#CC(c1c(CC=C)c(O*)ccc1)O)** 0.000 description 45
- 239000003921 oil Substances 0.000 description 44
- 235000019198 oils Nutrition 0.000 description 44
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 40
- 239000007787 solid Substances 0.000 description 40
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 39
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 38
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 description 36
- 229910052757 nitrogen Inorganic materials 0.000 description 36
- 238000003756 stirring Methods 0.000 description 35
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 33
- 238000004587 chromatography analysis Methods 0.000 description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 30
- 239000012074 organic phase Substances 0.000 description 28
- 229910000027 potassium carbonate Inorganic materials 0.000 description 28
- 125000001424 substituent group Chemical group 0.000 description 28
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 27
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 27
- 239000000706 filtrate Substances 0.000 description 26
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 24
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 23
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 description 21
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 20
- 125000003545 alkoxy group Chemical group 0.000 description 20
- 125000000592 heterocycloalkyl group Chemical group 0.000 description 20
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 20
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 19
- 125000003342 alkenyl group Chemical group 0.000 description 19
- 235000011181 potassium carbonates Nutrition 0.000 description 19
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 18
- 239000012230 colorless oil Substances 0.000 description 18
- 125000000753 cycloalkyl group Chemical group 0.000 description 18
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 17
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 17
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 17
- 125000003368 amide group Chemical group 0.000 description 17
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 17
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 description 16
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 15
- 125000000304 alkynyl group Chemical group 0.000 description 15
- 230000015572 biosynthetic process Effects 0.000 description 15
- 239000000463 material Substances 0.000 description 15
- 239000011736 potassium bicarbonate Substances 0.000 description 15
- 235000015497 potassium bicarbonate Nutrition 0.000 description 15
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 15
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 14
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 14
- 125000004093 cyano group Chemical group *C#N 0.000 description 14
- 125000003396 thiol group Chemical group [H]S* 0.000 description 14
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 13
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium on carbon Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 13
- 125000002252 acyl group Chemical group 0.000 description 13
- 125000002619 bicyclic group Chemical group 0.000 description 13
- 238000004809 thin layer chromatography Methods 0.000 description 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 12
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 12
- 125000003435 aroyl group Chemical group 0.000 description 12
- 238000005984 hydrogenation reaction Methods 0.000 description 12
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 12
- PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 description 12
- 125000004104 aryloxy group Chemical group 0.000 description 11
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 11
- 125000005553 heteroaryloxy group Chemical group 0.000 description 11
- 238000004128 high performance liquid chromatography Methods 0.000 description 11
- 229920006395 saturated elastomer Polymers 0.000 description 11
- NVBFHJWHLNUMCV-UHFFFAOYSA-N sulfamide Chemical compound NS(N)(=O)=O NVBFHJWHLNUMCV-UHFFFAOYSA-N 0.000 description 11
- 239000012267 brine Substances 0.000 description 10
- 239000010410 layer Substances 0.000 description 10
- 125000004043 oxo group Chemical group O=* 0.000 description 10
- 239000011780 sodium chloride Substances 0.000 description 10
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 10
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 10
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 9
- 235000019270 ammonium chloride Nutrition 0.000 description 9
- 125000004122 cyclic group Chemical group 0.000 description 9
- 125000001188 haloalkyl group Chemical group 0.000 description 9
- 230000014759 maintenance of location Effects 0.000 description 9
- 239000002002 slurry Substances 0.000 description 9
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 9
- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 9
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 description 8
- 125000003710 aryl alkyl group Chemical group 0.000 description 8
- 125000004432 carbon atom Chemical group C* 0.000 description 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 8
- 239000011541 reaction mixture Substances 0.000 description 8
- 229960005032 treprostinil Drugs 0.000 description 8
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- 125000000392 cycloalkenyl group Chemical group 0.000 description 7
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- 239000012071 phase Substances 0.000 description 7
- 239000011734 sodium Substances 0.000 description 7
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 description 7
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- 125000003806 alkyl carbonyl amino group Chemical group 0.000 description 6
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 6
- 125000004414 alkyl thio group Chemical group 0.000 description 6
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- 125000002102 aryl alkyloxo group Chemical group 0.000 description 6
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- 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 description 3
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- 238000004296 chiral HPLC Methods 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 150000004699 copper complex Chemical class 0.000 description 1
- 150000001880 copper compounds Chemical class 0.000 description 1
- GBRBMTNGQBKBQE-UHFFFAOYSA-L copper;diiodide Chemical compound I[Cu]I GBRBMTNGQBKBQE-UHFFFAOYSA-L 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 150000001924 cycloalkanes Chemical class 0.000 description 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000001162 cycloheptenyl group Chemical group C1(=CCCCCC1)* 0.000 description 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000000522 cyclooctenyl group Chemical group C1(=CCCCCCC1)* 0.000 description 1
- 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
- DEZRYPDIMOWBDS-UHFFFAOYSA-N dcm dichloromethane Chemical compound ClCCl.ClCCl DEZRYPDIMOWBDS-UHFFFAOYSA-N 0.000 description 1
- 125000004856 decahydroquinolinyl group Chemical group N1(CCCC2CCCCC12)* 0.000 description 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229910052805 deuterium Inorganic materials 0.000 description 1
- 125000004663 dialkyl amino group Chemical group 0.000 description 1
- IIJREXIVDSIOFR-UHFFFAOYSA-N dichloromethane;heptane Chemical compound ClCCl.CCCCCCC IIJREXIVDSIOFR-UHFFFAOYSA-N 0.000 description 1
- UXGNZZKBCMGWAZ-UHFFFAOYSA-N dimethylformamide dmf Chemical compound CN(C)C=O.CN(C)C=O UXGNZZKBCMGWAZ-UHFFFAOYSA-N 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
- CETRZFQIITUQQL-UHFFFAOYSA-N dmso dimethylsulfoxide Chemical compound CS(C)=O.CS(C)=O CETRZFQIITUQQL-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229960001123 epoprostenol Drugs 0.000 description 1
- OCLXJTCGWSSVOE-UHFFFAOYSA-N ethanol etoh Chemical compound CCO.CCO OCLXJTCGWSSVOE-UHFFFAOYSA-N 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- PQJJJMRNHATNKG-UHFFFAOYSA-N ethyl bromoacetate Chemical compound CCOC(=O)CBr PQJJJMRNHATNKG-UHFFFAOYSA-N 0.000 description 1
- FAMRKDQNMBBFBR-UHFFFAOYSA-N ethyl n-ethoxycarbonyliminocarbamate Chemical compound CCOC(=O)N=NC(=O)OCC FAMRKDQNMBBFBR-UHFFFAOYSA-N 0.000 description 1
- OJCSPXHYDFONPU-UHFFFAOYSA-N etoac etoac Chemical compound CCOC(C)=O.CCOC(C)=O OJCSPXHYDFONPU-UHFFFAOYSA-N 0.000 description 1
- 238000011066 ex-situ storage Methods 0.000 description 1
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N guanidine group Chemical group NC(=N)N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 1
- 125000000262 haloalkenyl group Chemical group 0.000 description 1
- 125000003106 haloaryl group Chemical group 0.000 description 1
- 125000005114 heteroarylalkoxy group Chemical group 0.000 description 1
- RTIAQOLKVLAEAU-UHFFFAOYSA-N hexan-3-yl acetate Chemical compound CCCC(CC)OC(C)=O RTIAQOLKVLAEAU-UHFFFAOYSA-N 0.000 description 1
- 150000002431 hydrogen Chemical group 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000005020 hydroxyalkenyl group Chemical group 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 description 1
- LPAGFVYQRIESJQ-UHFFFAOYSA-N indoline Chemical compound C1=CC=C2NCCC2=C1 LPAGFVYQRIESJQ-UHFFFAOYSA-N 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001786 isothiazolyl group Chemical group 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-M isovalerate Chemical compound CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 description 1
- 125000000842 isoxazolyl group Chemical group 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- QDLAGTHXVHQKRE-UHFFFAOYSA-N lichenxanthone Natural products COC1=CC(O)=C2C(=O)C3=C(C)C=C(OC)C=C3OC2=C1 QDLAGTHXVHQKRE-UHFFFAOYSA-N 0.000 description 1
- CETVQRFGPOGIQJ-UHFFFAOYSA-N lithium;hexane Chemical compound [Li+].CCCCC[CH2-] CETVQRFGPOGIQJ-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- BCVXHSPFUWZLGQ-UHFFFAOYSA-N mecn acetonitrile Chemical compound CC#N.CC#N BCVXHSPFUWZLGQ-UHFFFAOYSA-N 0.000 description 1
- DVSDBMFJEQPWNO-UHFFFAOYSA-N methyllithium Chemical compound C[Li] DVSDBMFJEQPWNO-UHFFFAOYSA-N 0.000 description 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 125000006578 monocyclic heterocycloalkyl group Chemical group 0.000 description 1
- 125000002757 morpholinyl group Chemical group 0.000 description 1
- 125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 125000006574 non-aromatic ring group Chemical group 0.000 description 1
- 125000005593 norbornanyl group Chemical group 0.000 description 1
- 125000002868 norbornyl group Chemical group C12(CCC(CC1)C2)* 0.000 description 1
- 125000001736 nosyl group Chemical group S(=O)(=O)(C1=CC=C([N+](=O)[O-])C=C1)* 0.000 description 1
- 125000005889 octahydrochromenyl group Chemical group 0.000 description 1
- 125000005060 octahydroindolyl group Chemical group N1(CCC2CCCCC12)* 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 description 1
- FIYYMXYOBLWYQO-UHFFFAOYSA-N ortho-iodylbenzoic acid Chemical compound OC(=O)C1=CC=CC=C1I(=O)=O FIYYMXYOBLWYQO-UHFFFAOYSA-N 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 229950000688 phenothiazine Drugs 0.000 description 1
- 125000005936 piperidyl group Chemical group 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 description 1
- 125000005412 pyrazyl group Chemical group 0.000 description 1
- 125000005495 pyridazyl group Chemical group 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- ZDYVRSLAEXCVBX-UHFFFAOYSA-N pyridinium p-toluenesulfonate Chemical compound C1=CC=[NH+]C=C1.CC1=CC=C(S([O-])(=O)=O)C=C1 ZDYVRSLAEXCVBX-UHFFFAOYSA-N 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229940118867 remodulin Drugs 0.000 description 1
- 239000011369 resultant mixture Substances 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 230000000707 stereoselective effect Effects 0.000 description 1
- 125000005017 substituted alkenyl group Chemical group 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 1
- 125000000565 sulfonamide group Chemical group 0.000 description 1
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
- 125000000037 tert-butyldiphenylsilyl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1[Si]([H])([*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 125000006168 tricyclic group Chemical group 0.000 description 1
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 description 1
- 125000004385 trihaloalkyl group Chemical group 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/34—Separation; Purification; Stabilisation; Use of additives
- C07C41/44—Separation; Purification; Stabilisation; Use of additives by treatments giving rise to a chemical modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/32—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/14—Benz[f]indenes; Hydrogenated benz[f]indenes
Definitions
- the present invention relates to processes and intermediates for the preparation of prostacyclin analog that are useful for treating hypertension and other diseases.
- Prostacyclin derivatives and analogs are useful pharmaceutical compounds possessing activities such as platelet aggregation inhibition, gastric secretion reduction, lesion inhibition, vasodilation, and bronchodilation.
- Treprostinil is a synthetic prostacyclin derivative currently marketed as an active pharmaceutical ingredient (API) for its ability to inhibit pulmonary arterial hypertension under the trade name Remodulin ® .
- API active pharmaceutical ingredient
- Prostacyclin derivatives are traditionally synthesized using a variety of methods that are described in /. Org. Chem. 2004, 69, 1890-1902, Drug of the Future, 2001, 26(4), 364-374, U.S. patent nos. 4,306,075; 6,441 ,245; 6,528,688; 6,700,025; 6,765, 117; 6,809,223 and U.S. patent application publication nos. 2009/0163738, 2011/0319641 Al, as well as Canadian patent application publication no. 2710726 Al. The entire teachings of these documents are incorporated herein by reference in their entireties. Also disclosed in these publications are processes and intermediates useful for the preparation of Treprostinil.
- the present invention provides processes for preparing a prostacyclin analogue of Formula IA:
- R is a linear or branched Ci_6 alkyl.
- the processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods.
- the processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride).
- reagents e.g., the oxidizing reagent
- Many of the processes of the present invention do not require additional chromatography for purification of intermediates and generate intermediates with improved e.e. and chemical purity.
- the processes of the present invention are scalable to generate commercial quantities of the final compound.
- One aspect of the present invention provides a method of generating a compound of Formula I
- R 1 is Ci_6 alkyl and the oxidizing agent comprises Mn0 2 or Dess-Martin periodinane; ii) reacting the compound of Formula 10 with a compound of Formula 5 in the presence of a base and an organic solvent to generate a compound of Formula 11, wherein each R 2 is independently selected from Ci_6 alkyl or phenyl; and
- the organic solvent of step i) comprises a halogenated organic solvent.
- the organic solvent of step i) comprises dichloromethane, chloroform, or any combination thereof.
- the base of step ii) comprises an alkyllithium reagent.
- the base of step ii) comprises seobutyllithium.
- the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1 ,4-dioxane, diethyl ether, petro ether,
- methyl-ieri-butylether or any combination thereof.
- the organic solvent of step ii) comprises methyl-ieri-butylether.
- Some methods further comprise the steps of: iv) refluxing the compound of Formula la in the presence of methanol to generate a compound of Formula 1 having an e.e. of greater than about 98%;
- Another aspect of the present invention provides a method of generating a compound of
- Formula I or a pharmaceutically acceptable salt thereof comprising the steps of: viii) reacting a compound of Formula 11 with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 12
- R 1 is Ci_6 alkyl
- each R 2 is independently selected from Ci_6 alkyl or phenyl
- the oxidizing agent comprises Mn0 2 ; and ix) converting the compound of Formula 12 to the compound of Formula I.
- each of the -OSi(R 2 )3 groups in the compounds of Formulae 11 and 12 is independently
- the organic solvent of step viii) comprises a halogenated organic solvent.
- the halogenated organic solvent of step viii) comprises dichloromethane, chloroform, or any combination thereof.
- Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 10
- R is Ci_6 alkyl and the oxidizing agent comprises Mn0 2 or Dess-Martin periodinane; and ii) reacting the compound of Formula 10 with a compound of Formula 5
- the base of step ii) comprises an alkyllithium reagent.
- the alkyllithium reagent of step ii) comprises sec-butyllithium.
- the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-ieri- butylether, or any combination thereof.
- the organic solvent of step ii) comprises methyl-ieri-butylether.
- Another aspect of the present invention provides a method of generating a compound of Formula I
- organic solvent comprises THF
- R 1 is Ci_6 alkyl
- each R 2 is independently Ci_6 alkyl or phenyl
- the reducing agent of step x) comprises a chiral borane compound.
- the chiral borane compound is selected from (R)-l-methyl- 3,3-diphenylhexahydropyrrolo[l,2-c][l,3,2]oxazaborole, (R)-3,3-diphenylhexahydropyrrolo[l,2- c][l,3,2]oxazaborole, (R)-l-butyl-3,3-diphenylhexahydropyrrolo[l,2-c][l,3,2]oxazaborole, (R)- tetrahydro-l,3,3-triphenyl-lH,3H-pyrrolo[l,2-c][l,3,2]oxaborole, (4S)- 2-methyl-4,5,5-triphenyl- 1,3,2-oxazaborolidine, or any combination thereof. [0021] In some implementations
- Some methods further comprise the step of: viii) reacting a compound of Formula 11 with an oxidizing agent to generate the compound of Formula 12, wherein the oxidizing agent comprises Mn0 2
- Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and
- the oxidizing agent comprises Mn0 2 or Dess-Martin periodinane.
- the base of step ii) comprises an alkyllithium reagent.
- the alkyllithium reagent of step ii) comprises sec-butyllithium.
- the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-ieri- butylether, or any combination thereof.
- the organic solvent of step ii) comprises methyl- ieri-butylether .
- Some methods further comprise the steps of: iv) refluxing the compound of Formula la in the presence of methanol to generate a compound of Formula 1 having an e.e. of greater than about 98%;
- Another aspect of the present invention provides a method of generating a compound of Formula I
- an organic solvent e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof
- R 1 is Ci_6 alkyl and each R 2 is independently selected from Ci_6 alkyl or phenyl; and xiii) converting the compound of Formula 16 to the compound of Formula I.
- Some methods further comprise the steps of: x) reacting a compound of Formula 12 with a reducing agent in the presence of an organic solvent to generate a compound of Formula 13
- organic solvent comprises THF; and xiv) converting the compound of Formula 13 to the compound of Formula 15.
- the reducing agent of step x) comprises a chiral borane compound.
- the chiral borane compound is selected from (R)-l-methyl- 3,3-diphenylhexahydropyrrolo[l,2-c][l,3,2]oxazaborole, (R)-3,3-diphenylhexahydropyrrolo[l,2- c][l,3,2]oxazaborole, (R)-l-butyl-3,3-diphenylhexahydropyrrolo[l,2-c][l,3,2]oxazaborole, (R)- tetrahydro-l,3,3-triphenyl-lH,3H-pyrrolo[l,2-c][l,3,2]oxaborole, (4S)- 2-methyl-4,5,5-triphenyl- 1,3,2-oxazaborolidine, or any combination thereof.
- Some methods further comprise the steps of: viii) reacting a compound of Formula 11 with an oxidizing agent to generate the compound of Formula 12, wherein the oxidizing agent comprises Mn0 2
- Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and
- the oxidizing agent of step i) comprises Mn0 2 or Dess-Martin periodinane.
- the base of step ii) comprises an alkyllithium reagent.
- the alkyllithium reagent of step ii) comprises sec-butyllithium.
- the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-ieri- butylether, or any combination thereof.
- the organic solvent of step ii) comprises methyl-ieri-butylether.
- Some methods further comprise the steps of: iv) refluxing the compound of Formula la in the presence of methanol to generate a compound of Formula 1 having an e.e. of greater than about 98%;
- Another aspect of the present invention provides a method of generating a compound of Formula I
- the transition metal catalyst of step xv) comprises a compound or complex either of which comprises Cu having a +1 oxidation state.
- the transition metal catalyst of step xv) comprises CuX, wherein X is selected from halogen, acetate, benzoate, cyanide, hydroxide, nitrate, or any combination thereof.
- the transition metal catalyst of step xv) comprises Cul.
- Some methods further comprise the steps of: xvii) reacting a compound of Formula 19 with R 4 -substituted benzenesulfonyl chloride under basic conditions to generate a compound of Formula
- Some methods further comprise the steps of: xix) reacting a compound of Formula 16 with a reducing agent to generate a compound of Formula 17;
- Some methods further comprise the steps of: xii) hydrogenating a compound of Formula
- an organic solvent e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof) to generate the compound of Formula 16.
- an organic solvent e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof
- the hydrogenation of the compound of Formula 15 also occurs in the presence of a base (e.g., potassium carbonate or potassium bicarbonate).
- a base e.g., potassium carbonate or potassium bicarbonate.
- Some methods further comprise the steps of: x) reacting a compound of Formula 12 with a reducing agent to generate a compound of Formula 13;
- the reducing agent of step x) comprises a chiral borane compound.
- the chiral borane compound is selected from (R)-l-methyl- 3,3-diphenylhexahydropyrrolo[l,2-c][l,3,2]oxazaborole, (R)-3,3-diphenylhexahydropyrrolo[l,2- c][l,3,2]oxazaborole, (R)-l-butyl-3,3-diphenylhexahydropyrrolo[l,2-c][l,3,2]oxazaborole, (R)-tetrahydro-l,3,3-triphenyl-lH,3H-pyrrolo[l,2-c][l,3,2]oxaborole, (4S)- 2-methyl-4,5,5- triphenyl-l,3,2-oxazaborolidine, or any combination thereof.
- Some methods further comprise the step of: viii) reacting a compound of Formula 11
- the oxidizing agent comprises Mn0 2 .
- Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and
- the oxidizing agent of step i) comprises Mn0 2 or Dess-Martin periodinane.
- the base of step ii) comprises an alkyllithium reagent.
- the alkyllithium reagent of step ii) comprises sec-butyllithium.
- the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-ieri- butylether, or any combination thereof.
- the organic solvent of step ii) comprises methyl-ieri-butylether.
- Some methods further comprise the steps of: iv) refluxing the compound of Formula la in the presence of methanol to generate a compound of Formula 1 having greater than about 99% e.e.;
- Some methods further comprise the steps of: xxii) reacting a compound of Formula 7 with a 3-haloprop- l-ene in the presence of a base and an organic solvent to generate a compound of Formula 8; and
- Another aspect of the present invention provides a method of generating a compound of Formula I
- step xxii) comprises sec -butyl lithium.
- Another aspect of the present invention provides a method of generating a compound of Formula I
- R 1 is Ci alkyl and the oxidizing agent comprises Mn0 2 or Dess-Martin periodinane; ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a; and
- the organic solvent of step i) comprises a halogenated organic solvent.
- the organic solvent of step i) comprises dichloromethane, chloroform, or any combination thereof.
- the base of step ii) comprises an alkyllithium reagent.
- the base of step ii) comprises seobutyllithium.
- the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-ieri- butylether, or any combination thereof.
- the organic solvent of step ii) comprises methyl-ieri-butylether.
- Some methods further comprise the steps of: iv) refluxing the compound of Formula la in the presence of methanol to generate a compound of Formula 1 having an e.e. of greater than about 98%;
- Another aspect of the present invention provides a method of generating a compound of Formula I
- R 1 is Ci_6 alkyl and the oxidizing agent comprises Mn0 2 ; and ix) converting the compound of Formula 12a to the compound of Formula I.
- the organic solvent of step viii) comprises a halogenated organic solvent.
- the halogenated organic solvent of step viii) comprises dichloromethane, chloroform, or any combination thereof.
- Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 10
- the oxidizing agent comprises Mn0 2 or Dess-Martin periodinane; and ii) reacting the compound of Formula 10 with a compound of Formula 5a
- the organic solvent of step i) comprises a halogenated organic solvent.
- the organic solvent of step i) comprises dichloromethane, chloroform, or any combination thereof.
- the base of step ii) comprises an alkyllithium reagent.
- the base of step ii) comprises seobutyllithium.
- the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1 ,4-dioxane, diethyl ether, petro ether,
- methyl-ieri-butylether or any combination thereof.
- the organic solvent of step ii) comprises methyl-ieri-butylether.
- Another aspect of the present invention provides a method of generating a compound of Formula I
- organic solvent comprises THF
- R 1 is Ci_6 alkyl
- each R 2 is independently selected from Ci_6 alkyl or phenyl
- the reducing agent of step x) comprises a chiral borane compound.
- the chiral borane compound is selected from (R)- l-methyl- 3,3-diphenylhexahydropyrrolo[l ,2-c] [l ,3,2]oxazaborole, (R)-3,3-diphenylhexahydropyrrolo[l ,2- c][l ,3,2]oxazaborole, (R)- l-butyl-3,3-diphenylhexahydropyrrolo[l ,2-c] [l ,3,2]oxazaborole, (R)- tetrahydro-l ,3,3-triphenyl- lH,3H-pyrrolo[l ,2-c][l ,3,2]oxaborole, (4S)- 2-methyl-4,5,5-triphenyl- 1 ,3,2-oxazaborolidine
- the organic solvent of step x) comprises THF.
- the organic solvent of step x) further comprises toluene.
- Some methods further comprise the step of: viii) reacting a compound of Formula 11a with an oxidizing agent to generate the compound of Formula 12a, wherein the oxidizing agent comprises Mn0 2
- Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and
- the oxidizing agent of step i) comprises Mn0 2 or Dess-Martin periodinane.
- the base of step ii) comprises an alkyllithium reagent.
- the alkyllithium reagent of step ii) comprises sec-butyllithium.
- the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-ieri- butylether, or any combination thereof.
- the organic solvent of step ii) comprises methyl-ieri-butylether.
- Some methods further comprise the steps of: iv) refluxing the compound of Formula la in the presence of methanol to generate a compound of Formula 1 having an e.e. of greater than about 98%;
- Another aspect of the present invention provides a method of generating a compound of Formula I
- an organic solvent e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof
- R is Ci_6 alkyl; and xiii) converting the compound of Formula 16a to the compound of Formula I.
- the hydrogenation of the compound of Formula 15a also occurs in the presence of a base (e.g., potassium carbonate or potassium bicarbonate).
- a base e.g., potassium carbonate or potassium bicarbonate.
- Some methods further comprise the steps of: x) reacting a compound of Formula 12a with a reducing agent in the presence of an organic solvent to generate a compound of Formula
- organic solvent comprises THF; and xiv) converting the compound of Formula 13a to the compound of Formula 15a.
- Some methods further comprise the steps of: viii) reacting a compound of Formula 11a with an oxidizing agent to generate the compound of Formula 12a, wherein the oxidizing agent comprises Mn0 2
- Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and
- Some methods further comprise the steps of: iv) refluxing the compound of Formula la in the presence of methanol to generate a compound of Formula 1 having an e.e. of greater than about 98%;
- Another aspect of the present invention provides a method of generating a compound of Formula I
- R 1 is Ci_6 alkyl; and xvi) converting the compound of Formula 22a to the compound of Formula I.
- the transition metal catalyst of step xv) comprises a compound or complex either of which comprises Cu having a +1 oxidation state.
- the transition metal catalyst of step xv) comprises CuX, wherein X is selected from halogen, acetate, benzoate, cyanide, hydroxide, nitrate, or any combination thereof.
- the transition metal catalyst of step xv) comprises Cul.
- Some methods further comprise the steps of: xvii) reacting a compound of Formula 19a with triisopropylbenzenesulfonyl chloride under basic conditions to generate a compound of Formula 20a;
- Some methods further comprise the steps of: xix) reacting a compound of Formula 16a with a reducing agent to generate a compound of Formula 17a;
- Some methods further comprise the step of: xii) hydrogenating a compound of Formula 15a
- an organic solvent e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof) to generate the compound of Formula 16a.
- an organic solvent e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof
- the organic solvent of step xii) is anhydrous (e.g., anhydrous methanol or anhydrous THF).
- the hydrogenation of the compound of Formula 15a occurs in the presence of a base (e.g., potassium carbonate or potassium bicarbonate).
- a base e.g., potassium carbonate or potassium bicarbonate.
- Some methods further comprise the steps of: x) reacting a compound of Formula 12a with a reducing agent to generate a compound of Formula 13a;
- Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and
- Some methods further comprise the steps of: iv) refluxing the compound of Formula la in the presence of methanol to generate a compound of Formula 1 having an e.e. of greater than about 98%;
- Some methods further comprise the steps of: xxii) reacting a compound of Formula 7a with a 3-haloprop-l-ene in the presence of a base and an organic solvent to generate a compound of Formula 8a; and
- Another aspect of the present invention provides a method of generating a compound of Formula I
- Formula 12a wherein the oxidizing agent comprises Mn0 2 ;
- xii) hydrogenating a compound of Formula in the presence of an organic solvent (e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2- methyl-THF or THF), EtOAc, or any combination thereof) to generate the compound of Formula 16a;
- an organic solvent e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2- methyl-THF or THF), EtOAc, or any combination thereof
- Some methods further comprise the step of: xxiv) reacting the compound of Formula I with diethanolamine in the presence of an organic solvent to generate the diethanolamine salt of the compound of Formula I.
- R 1 is Ci_6 alkyl and each R 3 is independently Ci_6 alkyl or phenyl.
- R 1 is methyl, ethyl, propyl, wo-propyl, butyl, sec-butyl, or tert- butyl.
- the -OSi R 3 3 rou is selected from
- R is methyl and the -OSi(R ) 3 group is
- Another aspect of the present invention provides a compound of Formula la
- Another aspect of the present invention provides a method of purifying a compound of Formula 1
- xxx reacting a compound of Formula 1 with a derivatizing reagent to generate a precipitate that is substantially insoluble in dichloromethane or mixtures thereof (e.g., a mixture of dichloromethane and an alkane (e.g., heptane)); xxxi) collecting the precipitate and refluxing the precipitate in a solvent comprising an alcohol to generate the compound of Formula 1 having a chemical purity of about 98% or greater and an e.e. of about 98% or greater; wherein the method excludes the use of any column chromatography.
- a derivatizing reagent to generate a precipitate that is substantially insoluble in dichloromethane or mixtures thereof (e.g., a mixture of dichloromethane and an alkane (e.g., heptane)
- xxxi) collecting the precipitate and refluxing the precipitate in a solvent comprising an alcohol to generate the compound of Formula 1 having a chemical purity of about 98% or greater and an
- the derivitizing reagent comprises 3,5-dinitrobenzoyl chloride and the alcohol comprises methanol.
- Another aspect of the present invention provides a method of purifying a compound of Formula 9 comprising the steps of: xl) reacting a compound of Formula 9, wherein R 1 is Ci_6 alkyl, with
- Some methods further comprise the step of: xlii) recrystallizing the precipitate of step xli).
- Another aspect of the present invention provides a method of generating a compound of Formula 5 wherein each of R 2 is independently selected from a Ci_6 alkyl or phenyl, comprising the steps of: iv) refluxing the compound of Formula la in the presence of methanol to generate a compound of Formula 1 having an e.e. of greater than about 98%;
- Another aspect of the present invention provides a method of generating a compound of Formula 13
- R 1 is Ci_6 alkyl and each R 2 is independently selected from Ci_6 alkyl or phenyl, comprising the step of: x) reacting a compound of Formula 12 with (R)-l-methyl-3,3- diphenylhexahydropyrrolo[l,2-c][l,3,2]oxazaborole in the presence of an organic solvent comprising THF and toluene to generate a compound of Formula 13
- the compound of Formula 13 has a chemical purity of about 97% or greater and a d.e. of about 97% or greater.
- the present invention provides a method of generating a compound of Formula I
- the present invention also provides novel intermediates that are useful for the synthesis of the compound of Formula I.
- Teprostinil refers to (lR,2R,3aS,9aS)-[[2,3,3a,4,9,9a- hexahydro-2-hydroxy-l-[(3S)-3-hydroxyoctyl]-lH-benz[f]inden-5-yl]oxy]acetic acid having the chemical structure, illustrated belo la I
- Treprostinil is a synthetic analog of prostacyclin (PGI 2 ) that is indicated for the treatment of pulmonary arterial hypertension and other diseases in patients.
- Treprostinil is formulated into a variety of dosage forms including forms suited for i.v. infusion and inhalation.
- compounds of the invention may optionally be substituted with one or more substituents, such as are illustrated generally above, or as exemplified by particular classes, subclasses, and species of the invention.
- hydroxyl or "hydroxy” refers to an -OH moiety.
- aliphatic encompasses the terms alkyl, alkenyl, alkynyl, each of which being optionally substituted as set forth below.
- an "alkyl” group refers to a saturated aliphatic hydrocarbon group containing 1-12 (e.g., 1-8, 1-6, or 1-4) carbon atoms.
- An alkyl group can be straight or branched. Examples of alkyl groups include, but are not limited to, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, n-heptyl, or 2-ethylhexyl.
- An alkyl group can be substituted (i.e., optionally substituted) with one or more substituents such as halo, phospho, cycloaliphatic [e.g., cycloalkyl or cycloalkenyl], heterocycloaliphatic [e.g., heterocycloalkyl or heterocycloalkenyl], aryl, heteroaryl, alkoxy, aroyl, heteroaroyl, acyl [e.g., (aliphatic)carbonyl, (cycloaliphatic)carbonyl, or (heterocycloaliphatic)carbonyl], nitro, cyano, amido [e.g.,
- heteroarylcarbonylamino heteroaralkylcarbonylamino alkylaminocarbonyl
- heteroarylaminocarbonyl amino [e.g., aliphaticamino, cycloaliphaticamino, or heterocycloaliphaticamino], sulfonyl [e.g., aliphatic-S0 2 -], sulfinyl, sulfanyl, sulfoxy, urea, thiourea, sulfamoyl, sulfamide, oxo, carboxy, carbamoyl, cycloaliphaticoxy,
- substituted alkyls include carboxyalkyl (such as HOOC-alkyl, alkoxycarbonylalkyl, and alkylcarbonyloxyalkyl), cyanoalkyl, hydroxyalkyl, alkoxyalkyl, acylalkyl, aralkyl, (alkoxyaryl)alkyl,
- an "alkenyl” group refers to an aliphatic carbon group that contains 2-8 (e.g., 2-12, 2-6, or 2-4) carbon atoms and at least one double bond. Like an alkyl group, an alkenyl group can be straight or branched. Examples of an alkenyl group include, but are not limited to allyl, 1- or 2-isopropenyl, 2-butenyl, and 2-hexenyl.
- An alkenyl group can be optionally substituted with one or more substituents such as halo, phospho, cycloaliphatic [e.g., cycloalkyl or cycloalkenyl], heterocycloaliphatic [e.g., heterocycloalkyl or heterocycloalkenyl], aryl, heteroaryl, alkoxy, aroyl, heteroaroyl, acyl [e.g., (aliphatic)carbonyl,
- heteroarylcarbonylamino heteroaralkylcarbonylamino alkylaminocarbonyl
- heteroarylaminocarbonyl amino [e.g., aliphaticamino, cycloaliphaticamino,
- sulfonyl e.g., alkyl-S0 2 -, cycloaliphatic- S0 2 -, or aryl-S0 2 -
- sulfinyl e.g., alkyl-S
- substituted alkenyls include cyanoalkenyl, alkoxyalkenyl, acylalkenyl, hydroxyalkenyl, aralkenyl, (alkoxyaryl)alkenyl, (sulfonylamino)alkenyl (such as (alkyl-S0 2 - amino)alkenyl), aminoalkenyl, amidoalkenyl, (cycloaliphatic)alkenyl, or haloalkenyl.
- an "alkynyl” group refers to an aliphatic carbon group that contains 2-8 (e.g., 2-12, 2-6, or 2-4) carbon atoms and has at least one triple bond.
- An alkynyl group can be straight or branched. Examples of an alkynyl group include, but are not limited to, propargyl and butynyl.
- An alkynyl group can be optionally substituted with one or more substituents such as aroyl, heteroaroyl, alkoxy, cycloalkyloxy, heterocycloalkyloxy, aryloxy, heteroaryloxy, aralkyloxy, nitro, carboxy, cyano, halo, hydroxy, sulfo, mercapto, sulfanyl [e.g., aliphaticsulfanyl or cycloaliphaticsulfanyl], sulfinyl [e.g., aliphaticsulfinyl or cycloaliphaticsulfinyl], sulfonyl [e.g., aliphatic-SC>2-, aliphaticamino-SC>2-, or cycloaliphatic-SC>2-], amido [e.g., aminocarbonyl, alkylaminocarbonyl, alkylcarbonylamino, cycloalkylaminocarbonyl,
- alkylcarbonyloxy cycloaliphatic, heterocycloaliphatic, aryl, heteroaryl, acyl [e.g.,
- cycloaliphaticcarbonyl or (heterocycloaliphatic)carbonyl amino [e.g., aliphaticamino], sulfoxy, oxo, carboxy, carbamoyl, (cycloaliphatic)oxy, (heterocycloaliphatic)oxy, or
- an “amido” encompasses both “aminocarbonyl” and “carbonylamino”. These terms when used alone or in connection with another group refer to an amido group such as -N(R x )-C(0)-R Y or -C(0)-N(R x ) 2 , when used terminally, and -C(0)-N(R x )- or -N(R x )-C(0)- when used internally, wherein R x and R Y can be aliphatic, cycloaliphatic, aryl, araliphatic, heterocycloaliphatic, heteroaryl or heteroaraliphatic.
- amido groups include alkylamido (such as alkylcarbonylamino or alkylaminocarbonyl), (heterocycloaliphatic)amido, (heteroaralkyl)amido, (heteroaryl)amido, (heterocycloalkyl)alkylamido, arylamido, aralkylamido, (cycloalkyl)alkylamido, or cycloalkylamido.
- alkylamido such as alkylcarbonylamino or alkylaminocarbonyl
- heterocycloaliphatic such as alkylcarbonylamino or alkylaminocarbonyl
- heteroaryl heteroaryl
- an "amino" group refers to -NR X R Y wherein each of R x and R Y is independently hydrogen, aliphatic, cycloaliphatic, (cycloaliphatic)aliphatic, aryl, araliphatic, heterocycloaliphatic, (heterocycloaliphatic)aliphatic, heteroaryl, carboxy, sulfanyl, sulfinyl, sulfonyl, (aliphatic)carbonyl, (cycloaliphatic)carbonyl, ((cycloaliphatic)aliphatic)carbonyl, arylcarbonyl, (araliphatic)carbonyl, (heterocycloaliphatic)carbonyl,
- amino groups include alkylamino, dialkylamino, or arylamino.
- amino is not the terminal group (e.g., alkylcarbonylamino), it is represented by -NR X -, where R x has the same meaning as defined above.
- an "aryl” group used alone or as part of a larger moiety as in “aralkyl”, “aralkoxy”, or “aryloxyalkyl” refers to monocyclic (e.g., phenyl); bicyclic (e.g., indenyl, naphthalenyl, tetrahydronaphthyl, tetrahydroindenyl); and tricyclic (e.g., fluorenyl
- tetrahydrofluorenyl, or tetrahydroanthracenyl, anthracenyl) ring systems in which the monocyclic ring system is aromatic or at least one of the rings in a bicyclic or tricyclic ring system is aromatic.
- the bicyclic and tricyclic groups include benzofused 2-3 membered carbocyclic rings.
- a benzofused group includes phenyl fused with two or more C 4 _s carbocyclic moieties.
- An aryl is optionally substituted with one or more substituents including aliphatic [e.g., alkyl, alkenyl, or alkynyl]; cycloaliphatic; (cycloaliphatic)aliphatic; heterocycloaliphatic;
- heterocycloaliphatic aliphatic
- aryl heteroaryl
- alkoxy (cycloaliphatic)oxy
- heterocycloaliphatic oxy; aryloxy; heteroaryloxy; (araliphatic)oxy; (heteroaraliphatic)oxy; aroyl; heteroaroyl; amino; oxo (on a non-aromatic carbocyclic ring of a benzofused bicyclic or tricyclic aryl); nitro; carboxy; amido; acyl [e.g., (aliphatic)carbonyl; (cycloaliphatic)carbonyl; ((cycloaliphatic)aliphatic)carbonyl; (araliphatic)carbonyl; (heterocycloaliphatic)carbonyl;
- sulfamide sulfamide
- carbamoyl Alternatively, an aryl can be unsubstituted.
- Non-limiting examples of substituted aryls include haloaryl [e.g., mono-, di (such as p,m- dihaloaryl), and (trihalo)aryl] ; (carboxy)aryl [e.g., (alkoxycarbonyl)aryl,
- alkylsulfonyl alkyl
- cyanoalkyl aryl
- hydroxy alkyl alkyl
- alkylcarbonyl alkylaryl
- trihaloalkyl trihaloalkyl
- p-amino-m-alkoxycarbonylaryl p-amino-m-cyanoaryl
- p-halo-m-aminoaryl or (m-(heterocycloaliphatic)-o-(alkyl))aryl.
- an "araliphatic” such as an “aralkyl” group refers to an aliphatic group (e.g., a Ci_ 4 alkyl group) that is substituted with an aryl group.
- "Aliphatic,” “alkyl,” and “aryl” are defined herein.
- An example of an araliphatic such as an aralkyl group is benzyl.
- an "aralkyl” group refers to an alkyl group (e.g., a C 1-4 alkyl group) that is substituted with an aryl group. Both “alkyl” and “aryl” have been defined above.
- An example of an aralkyl group is benzyl.
- An aralkyl is optionally substituted with one or more substituents such as aliphatic [e.g., alkyl, alkenyl, or alkynyl, including carboxyalkyl, hydroxyalkyl, or haloalkyl such as trifluoromethyl], cycloaliphatic [e.g., cycloalkyl or cycloalkenyl],
- cycloalkyl alkyl, heterocycloalkyl, (heterocycloalkyl)alkyl, aryl, heteroaryl, alkoxy, cycloalkyloxy, heterocycloalkyloxy, aryloxy, heteroaryloxy, aralkyloxy, heteroaralkyloxy, aroyl, heteroaroyl, nitro, carboxy, alkoxycarbonyl, alkylcarbonyloxy, amido [e.g., aminocarbonyl, alkylcarbonylamino, cycloalkylcarbonylamino, (cycloalkylalkyl)carbonylamino,
- heterocycloalkylalkyl carbonylamino, heteroarylcarbonylamino, or
- heteroaralkylcarbonylamino cyano, halo, hydroxy, acyl, mercapto, alkylsulfanyl, sulfoxy, urea, thiourea, sulfamoyl, sulfamide, oxo, or carbamoyl.
- a "bicyclic ring system” includes 6-12 (e.g., 8-12 or 9, 10, or 11) membered structures that form two rings, wherein the two rings have at least one atom in common (e.g., 2 atoms in common).
- Bicyclic ring systems include bicycloaliphatics (e.g., bicycloalkyl or bicycloalkenyl), bicycloheteroaliphatics, bicyclic aryls, and bicyclic heteroaryls.
- a "cycloaliphatic” group encompasses a “cycloalkyl” group and a “cycloalkenyl” group, each of which being optionally substituted as set forth below.
- a "cycloalkyl” group refers to a saturated carbocyclic mono- or bicyclic (fused or bridged) ring of 3-10 (e.g., 5-10) carbon atoms.
- Examples of cycloalkyl groups include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, adamantyl, norbornyl, cubyl, octahydro-indenyl, decahydro-naphthyl, bicyclo[3.2.1]octyl, bicyclo[2.2.2]octyl,
- a "cycloalkenyl” group refers to a non-aromatic carbocyclic ring of 3-10 (e.g., 4-8) carbon atoms having one or more double bonds.
- Examples of cycloalkenyl groups include cyclopentenyl, 1 ,4-cyclohexa-di-enyl, cycloheptenyl, cyclooctenyl, hexahydro-indenyl, octahydro-naphthyl, cyclohexenyl, bicyclo[2.2.2]octenyl, or bicyclo[3.3.1]nonenyl.
- a cycloalkyl or cycloalkenyl group can be optionally substituted with one or more substituents such as phospho, aliphatic [e.g., alkyl, alkenyl, or alkynyl], cycloaliphatic,
- cycloaliphatic aliphatic, heterocycloaliphatic, (heterocycloaliphatic) aliphatic, aryl, heteroaryl, alkoxy, (cycloaliphatic)oxy, (heterocycloaliphatic)oxy, aryloxy, heteroaryloxy, (araliphatic)oxy, (heteroaraliphatic)oxy, aroyl, heteroaroyl, amino, amido [e.g., (aliphatic)carbonylamino, (cycloaliphatic)carbonylamino, ((cycloaliphatic)aliphatic)carbonylamino, (aryl)carbonylamino, (araliphatic)carbonylamino, (heterocycloaliphatic)carbonylamino,
- alkylcarbonyloxy acyl [e.g., (cycloaliphatic)carbonyl, ((cycloaliphatic) aliphatic)carbonyl, (araliphatic)carbonyl, (heterocycloaliphatic)carbonyl, ((heterocycloaliphatic)aliphatic)carbonyl, or (heteroaraliphatic)carbonyl], cyano, halo, hydroxy, mercapto, sulfonyl [e.g., alkyl-SC>2- and aryl-S0 2 -], sulfinyl [e.g., alkyl-S(O)-], sulfanyl [e.g., alkyl-S-], sulfoxy, urea, thiourea, sulfamoyl, sulfamide, oxo, or carbamoyl.
- acyl e.g., (cycloaliphatic)carbonyl,
- heterocycloaliphatic encompasses heterocycloalkyl groups and heterocycloalkenyl groups, each of which being optionally substituted as set forth below.
- heterocycloalkyl refers to a 3-10 membered mono- or bicylic (fused or bridged) (e.g., 5- to 10-membered mono- or bicyclic) saturated ring structure, in which one or more of the ring atoms is a heteroatom (e.g., N, O, S, or combinations thereof).
- heterocycloalkyl group examples include piperidyl, piperazyl, tetrahydropyranyl, tetrahydrofuryl, 1,4- dioxolanyl, 1 ,4-dithianyl, 1,3-dioxolanyl, oxazolidyl, isoxazolidyl, morpholinyl, thiomorpholyl, octahydrobenzofuryl, octahydrochromenyl, octahydrothiochromenyl, octahydroindolyl, octahydropyrindinyl, decahydroquinolinyl, octahydrobenzo[ ⁇ ]thiopheneyl, 2-oxa- bicyclo[2.2.2]octyl, l-aza-bicyclo[2.2.2]octyl, 3-aza-bicyclo[3.2.1]octyl, and 2,6-di
- a "heterocycloalkenyl” group refers to a mono- or bicylic (e.g., 5- to 10- membered mono- or bicyclic) non-aromatic ring structure having one or more double bonds, and wherein one or more of the ring atoms is a heteroatom (e.g., N, O, or S).
- Monocyclic and bicyclic heterocycloaliphatics are numbered according to standard chemical nomenclature.
- a heterocycloalkyl or heterocycloalkenyl group can be optionally substituted with one or more substituents such as phospho, aliphatic [e.g., alkyl, alkenyl, or alkynyl], cycloaliphatic, (cycloaliphatic)aliphatic, heterocycloaliphatic, (heterocycloaliphatic)aliphatic, aryl, heteroaryl, alkoxy, (cycloaliphatic)oxy, (heterocycloaliphatic)oxy, aryloxy, heteroaryloxy, (araliphatic)oxy, (heteroaraliphatic)oxy, aroyl, heteroaroyl, amino, amido [e.g., (aliphatic)carbonylamino, (cycloaliphatic)carbonylamino, ((cycloaliphatic) aliphatic)carbonylamino, (aryl)carbonylamino, (araliphatic)carbonylamino, (heterocyclo
- sulfonyl e.g., alkylsulfonyl or arylsulfonyl
- sulfinyl e.g., alkylsulfinyl
- sulfanyl e.g., alkylsulfanyl
- sulfoxy urea, thiourea, sulfamoy
- a “heteroaryl” group refers to a monocyclic, bicyclic, or tricyclic ring system having 4 to 15 ring atoms wherein one or more of the ring atoms is a heteroatom (e.g., N, O, S, or combinations thereof) and in which the monocyclic ring system is aromatic or at least one of the rings in the bicyclic or tricyclic ring systems is aromatic.
- a heteroaryl group includes a benzofused ring system having 2 to 3 rings.
- a benzofused group includes benzo fused with one or two 4 to 8 membered heterocycloaliphatic moieties (e.g., indolizyl, indolyl, isoindolyl, 3H-indolyl, indolinyl, benzo[ ⁇ ]furyl, benzo[ ⁇ ]thiophene-yl, quinolinyl, or
- heteroaryl isoquinolinyl).
- heteroaryl are azetidinyl, pyridyl, lH-indazolyl, furyl, pyrrolyl, thienyl, thiazolyl, oxazolyl, imidazolyl, tetrazolyl, benzofuryl, isoquinolinyl, benzthiazolyl, xanthene, thioxanthene, phenothiazine, dihydroindole, benzo[l,3]dioxole, benzo[b]furyl, benzo[b]thiophenyl, indazolyl, benzimidazolyl, benzthiazolyl, puryl, cinnolyl, quinolyl, quinazolyl,cinnolyl, phthalazyl, quinazolyl, quinoxalyl, isoquinolyl, 4H-quinolizyl, benzo
- monocyclic heteroaryls include furyl, thiophene-yl, 2H-pyrrolyl, pyrrolyl, oxazolyl, thazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, 1 ,3,4-thiadiazolyl, 2H-pyranyl, 4-H-pranyl, pyridyl, pyridazyl, pyrimidyl, pyrazolyl, pyrazyl, or 1,3,5-triazyl.
- Monocyclic heteroaryls are numbered according to standard chemical nomenclature.
- bicyclic heteroaryls include indolizyl, indolyl, isoindolyl, 3H-indolyl, indolinyl, benzo[ ⁇ ]furyl, benzo[ ⁇ ]thiophenyl, quinolinyl, isoquinolinyl, indolizyl, isoindolyl, indolyl, benzo[ ⁇ ]furyl, bexo[ ⁇ ]thiophenyl, indazolyl, benzimidazyl, benzthiazolyl, purinyl, 4H- quinolizyl, quinolyl, isoquinolyl, cinnolyl, phthalazyl, quinazolyl, quinoxalyl, 1,8-naphthyridyl, or pteridyl.
- Bicyclic heteroaryls are numbered according to standard chemical nomenclature.
- a heteroaryl is optionally substituted with one or more substituents such as aliphatic [e.g., alkyl, alkenyl, or alkynyl]; cycloaliphatic; (cycloaliphatic)aliphatic; heterocycloaliphatic;
- substituents such as aliphatic [e.g., alkyl, alkenyl, or alkynyl]; cycloaliphatic; (cycloaliphatic)aliphatic; heterocycloaliphatic;
- heterocycloaliphatic aliphatic
- aryl heteroaryl
- alkoxy (cycloaliphatic)oxy
- heterocycloaliphatic oxy; aryloxy; heteroaryloxy; (araliphatic)oxy; (heteroaraliphatic)oxy; aroyl; heteroaroyl; amino; oxo (on a non-aromatic carbocyclic or heterocyclic ring of a bicyclic or tricyclic heteroaryl); carboxy; amido; acyl [ e.g., aliphaticcarbonyl; (cycloaliphatic)carbonyl; ((cycloaliphatic)aliphatic)carbonyl; (araliphatic)carbonyl; (heterocycloaliphatic)carbonyl;
- aliphaticsulfanyl ] ; nitro; cyano; halo; hydroxy; mercapto; sulfoxy; urea; thiourea; sulfamoyl; sulfamide; or carbamoyl.
- a heteroaryl can be unsubstituted.
- Non-limiting examples of substituted heteroaryls include (halo)heteroaryl [e.g., mono- and di-(halo)heteroaryl]; (carboxy)heteroaryl [e.g., (alkoxycarbonyl)heteroaryl]; cyanoheteroaryl; aminoheteroaryl [e.g., ((alkylsulfonyl)amino)heteroaryl and ((dialkyl)amino)heteroaryl];
- aminocarbonylheteroaryl e.g., aminocarbonylheteroaryl, ((alkylcarbonyl)amino)heteroaryl,
- alkylcarbonyl heteroaryl
- alkyl heteroaryl
- haloalkyl heteroaryl
- heteroaralkyl refers to an aliphatic group (e.g., a Ci_ 4 alkyl group) that is substituted with a heteroaryl group.
- aliphatic group e.g., a Ci_ 4 alkyl group
- heteroaryl group refers to an alkyl group (e.g., a C 1-4 alkyl group) that is substituted with a heteroaryl group. Both “alkyl” and “heteroaryl” have been defined above.
- a heteroaralkyl is optionally substituted with one or more substituents such as alkyl (including carboxyalkyl, hydroxyalkyl, and haloalkyl such as trifluoromethyl), alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, (heterocycloalkyl)alkyl, aryl, heteroaryl, alkoxy, cycloalkyloxy, heterocycloalkyloxy, aryloxy, heteroaryloxy, aralkyloxy, heteroaralkyloxy, aroyl, heteroaroyl, nitro, carboxy, alkoxycarbonyl, alkylcarbonyloxy, aminocarbonyl,
- substituents such as alkyl (including carboxyalkyl, hydroxyalkyl, and haloalkyl such as trifluoromethyl), alkenyl, alkynyl, cycloalkyl, (cycloalkyl)
- alkylcarbonylamino cycloalkylcarbonylamino, (cycloalkylalkyl)carbonylamino
- heterocycloalkylalkyl carbonylamino, heteroarylcarbonylamino, heteroaralkylcarbonylamino, cyano, halo, hydroxy, acyl, mercapto, alkylsulfanyl, sulfoxy, urea, thiourea, sulfamoyl, sulfamide, oxo, or carbamoyl.
- cyclic moiety and “cyclic group” refer to mono-, bi-, and tri-cyclic ring systems including cycloaliphatic, heterocycloaliphatic, aryl, or heteroaryl, each of which has been previously defined.
- bridged bicyclic ring system refers to a bicyclic heterocyclicalipahtic ring system or bicyclic cycloaliphatic ring system in which the rings are bridged.
- bridged bicyclic ring systems include, but are not limited to, adamantanyl, norbornanyl, bicyclo[3.2.1]octyl, bicyclo[2.2.2]octyl, bicyclo[3.3.1]nonyl, bicyclo[3.3.2]decyl, 2- oxabicyclo[2.2.2]octyl, l-azabicyclo[2.2.2]octyl, 3-azabicyclo[3.2.1]octyl, and 2,6-dioxa- tricyclo[3.3.1.0 3 ' 7 ]nonyl.
- a bridged bicyclic ring system can be optionally substituted with one or more substituents such as alkyl (including carboxyalkyl, hydroxyalkyl, and haloalkyl such as trifluoromethyl), alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl,
- substituents such as alkyl (including carboxyalkyl, hydroxyalkyl, and haloalkyl such as trifluoromethyl), alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl,
- heterocycloalkyl alkyl
- aryl, heteroaryl alkoxy, cycloalkyloxy, heterocycloalkyloxy, aryloxy, heteroaryloxy, aralkyloxy, heteroaralkyloxy, aroyl, heteroaroyl, nitro, carboxy, alkoxycarbonyl, alkylcarbonyloxy, aminocarbonyl, alkylcarbonylamino, cycloalkylcarbonylamino,
- heteroarylcarbonylamino heteroaralkylcarbonylamino, cyano, halo, hydroxy, acyl, mercapto, alkylsulfanyl, sulfoxy, urea, thiourea, sulfamoyl, sulfamide, oxo, or carbamoyl.
- an "acyl” group refers to a formyl group or R x -C(0)- (such as alkyl-C(O)-, also referred to as “alkylcarbonyl”) where R x and "alkyl” have been defined previously.
- R x and "alkyl” have been defined previously.
- Acetyl and pivaloyl are examples of acyl groups.
- an "aroyl” or “heteroaroyl” refers to an aryl-C(O)- or a heteroaryl-C(O)-.
- the aryl and heteroaryl portion of the aroyl or heteroaroyl is optionally substituted as previously defined.
- alkoxy refers to an alkyl-O- group where “alkyl” has been defined previously.
- a “carbamoyl” group refers to a group having the structure
- R x and R Y have been defined above and R z can be aliphatic, aryl, araliphatic, heterocycloaliphatic, heteroaryl, or heteroaraliphatic.
- a "carboxy” group refers to -COOH, -COOR x , -OC(0)H, -OC(0)R x , when used as a terminal group; or -OC(O)- or -C(0)0- when used as an internal group.
- haloaliphatic refers to an aliphatic group substituted with 1-3 halogen.
- haloalkyl includes the group -CF 3 .
- mercapto refers to -SH.
- a "sulfo" group refers to -SO 3 H or -SC>3R X when used terminally or -S(0)3- when used internally.
- a "sulfamide” group refers to the structure -NR X -S(0)2-NR Y R Z when used terminally and -NR X -S(0)2-NR Y - when used internally, wherein R x , R Y , and R z have been defined above.
- a "sulfamoyl” group refers to the structure -0-S(0)2-NR Y R z wherein R Y and R z have been defined above.
- a "sulfonamide” group refers to the structure -S(0) 2 -NR x R Y or
- sulfanyl group refers to -S-R x when used terminally and -S- when used internally, wherein R x has been defined above.
- sulfanyls include aliphatic-S-, cycloaliphatic-S-, aryl-S-, or the like.
- sulfinyl refers to -S(0)-R x when used terminally and -S(O)- when used internally, wherein R x has been defined above.
- exemplary sulfinyl groups include aliphatic-S(O)-, aryl-S(O)-, (cycloaliphatic(aliphatic))-S(0)-, cycloalkyl-S(O)-,
- heterocycloaliphatic-S(O)- heteroaryl-S(O)-, or the like.
- a "sulfonyl” group refers to-S(0) 2 -R x when used terminally and
- Exemplary sulfonyl groups include aliphatic-S(0) 2 -, aryl-S(0) 2 -, (cycloaliphatic(aliphatic))-S(0) 2 -, cycloaliphatic-S(0) 2 -, heterocycloaliphatic-S(0) 2 -, heteroaryl-S(0) 2 -, (cycloaliphatic(amido(aliphatic)))-S(0) 2 -or the like.
- a "sulfoxy" group refers to -0-S(0)-R x or -S(0)-0-R x , when used terminally and -O-S(O)- or -S(0)-0- when used internally, where R x has been defined above.
- halogen or halo group refers to fluorine, chlorine, bromine or iodine.
- alkoxycarbonyl which is encompassed by the term carboxy, used alone or in connection with another group refers to a group such as alkyl-O-C(O)-.
- alkoxyalkyl refers to an alkyl group such as alkyl-O-alkyl-, wherein alkyl has been defined above.
- a "carbonyl” refers to -C(O)-.
- phospho refers to phosphinates and phosphonates.
- phosphinates and phosphonates include -P(0)(R P ) 2 , wherein R p is aliphatic, alkoxy, aryloxy, heteroaryloxy, (cycloaliphatic)oxy, (heterocycloaliphatic)oxy aryl, heteroaryl, cycloaliphatic or amino.
- aminoalkyl refers to the structure (R x ) 2 N-alkyl-.
- a "cyanoalkyl” refers to the structure (NC)-alkyl-.
- a "urea” group refers to the structure -NR x -CO-NR Y R z and a "thiourea” group refers to the structure -NR X -CS-NR Y R Z when used terminally and -NR x -CO-NR Y - or -NR X -CS-NR Y - when used internally, wherein R x , R Y , and R z have been defined above.
- the term "vicinal” refers to the placement of substituents on a group that includes two or more carbon atoms, wherein the substituents are attached to adjacent carbon atoms.
- the term “geminal” refers to the placement of substituents on a group that includes two or more carbon atoms, wherein the substituents are attached to the same carbon atom.
- terminal refers to the location of a group within a substituent.
- a group is terminal when the group is present at the end of the substituent not further bonded to the rest of the chemical structure.
- Carboxyalkyl i.e., R x O(0)C-alkyl is an example of a carboxy group used terminally.
- a group is internal when the group is present in the middle of a substituent of the chemical structure.
- Alkylcarboxy e.g., alkyl-C(0)0- or alkyl- OC(O)-
- alkylcarboxyaryl e.g., alkyl-C(0)0-aryl- or alkyl-O(CO)-aryl-
- an "aliphatic chain” refers to a branched or straight aliphatic group (e.g., alkyl groups, alkenyl groups, or alkynyl groups).
- a straight aliphatic chain has the structure -[CH 2 ] V -, where v is 1-12.
- a branched aliphatic chain is a straight aliphatic chain that is substituted with one or more aliphatic groups.
- a branched aliphatic chain has the structure
- aliphatic chain includes alkyl chains, alkenyl chains, and alkynyl chains, where alkyl, alkenyl, and alkynyl are defined above.
- DMP Dess-Martin periodinane
- DMP refers to l,l,l-triacetoxy-l,l-dihydro-l,2-benziodoxol-3(lH)-one having the structure
- the phrase "optionally substituted” is used interchangeably with the phrase “substituted or unsubstituted.”
- compounds of the invention can optionally be substituted with one or more substituents, such as are illustrated generally above, or as exemplified by particular classes, subclasses, and species of the invention.
- variables R 1 , R 2 , R 3 , R 4 , R 10 , and other variables contained in Formulae IA and I described herein encompass specific groups, such as alkyl and aryl. Unless otherwise noted, each of the specific groups for the variables R 1 , R 2 , R 3 , R 4 , R 10 , and other variables contained therein can be optionally substituted with one or more substituents described herein. Each substituent of a specific group is further optionally substituted with one to three of halo, cyano, oxo, alkoxy, hydroxy, amino, nitro, aryl, cycloaliphatic, heterocycloaliphatic, heteroaryl, haloalkyl, and alkyl.
- an alkyl group can be substituted with alkylsulfanyl and the alkylsulfanyl can be optionally substituted with one to three of halo, cyano, oxo, alkoxy, hydroxy, amino, nitro, aryl, haloalkyl, and alkyl.
- the cycloalkyl portion of a (cycloalkyl)carbonylamino can be optionally substituted with one to three of halo, cyano, alkoxy, hydroxy, nitro, haloalkyl, and alkyl.
- substituted refers to the replacement of hydrogen atoms in a given structure with the radical of a specified substituent.
- substituents are described above in the definitions and below in the description of compounds and examples thereof.
- an optionally substituted group can have a substituent at each substitutable position of the group, and when more than one position in any given structure can be substituted with more than one substituent selected from a specified group, the substituent can be either the same or different at every position.
- a ring substituent such as a heterocycloalkyl
- substituents envisioned by this invention are those combinations that result in the formation of stable or chemically feasible compounds.
- stable or chemically feasible refers to compounds that are not substantially altered when subjected to conditions to allow for their production, detection, and preferably their recovery, purification, and use for one or more of the purposes disclosed herein.
- a stable compound or chemically feasible compound is one that is not substantially altered when kept at a temperature of 40 °C or less, in the absence of moisture or other chemically reactive conditions, for at least a week.
- chemical purity refers to the degree to which a substance, i.e., the desired product or intermediate, is undiluted or unmixed with extraneous material such as chemical byproducts.
- structures depicted herein are also meant to include all isomeric (e.g., enantiomeric, diastereomeric, and geometric (or conformational)) forms of the structure; for example, the R and S configurations for each asymmetric center, (Z) and (E) double bond isomers, and (Z) and (E) conformational isomers. Therefore, single stereochemical isomers as well as enantiomeric, diastereomeric, and geometric (or conformational) mixtures of the present compounds are within the scope of the invention. Unless otherwise stated, all tautomeric forms of the compounds of the invention are within the scope of the invention.
- structures depicted herein are also meant to include compounds that differ only in the presence of one or more isotopically enriched atoms.
- compounds having the present structures except for the replacement of hydrogen by deuterium or tritium, or the replacement of a carbon by a 13 C- or 14 C-enriched carbon are within the scope of this invention.
- Such compounds are useful, for example, as analytical tools or probes in biological assays, or as therapeutic agents.
- One aspect of the present invention provides a method of generating a compound of Formula I
- R 1 is Ci_6 alkyl and the oxidizing agent comprises Mn0 2 or Dess-Martin periodinane; ii) reacting the compound of Formula 10 with a compound of Formula 5 in the presence of a base and an organic solvent to generate a compound of Formula 11, wherein each R 2 is independently selected from Ci_6 alkyl or phenyl; and
- Step i) comprises reacting a compound of Formula 9 with an oxidizing agent in the presence of an organic so
- R 1 is Ci_6 alkyl
- R 1 is methyl, ethyl, propyl, wo-propyl, butyl, sec-butyl, or tert- butyl.
- R 1 is methyl.
- the oxidizing agent of step i) comprises manganese(IV)oxide, i.e., Mn0 2 , DMP, or IBX.
- the oxidizing agent comprises Mn0 2 or DMP.
- the oxidizing agent comprises Mn0 2 .
- the organic solvent of step i) is any suitable solvent that is capable of substantially dissolving the compound of Formula 9 and is substantially inert when combined with the oxidizing agent and the compound of Formula 9.
- the organic solvent of step i) comprises a halogenated organic solvent.
- the halogenated organic solvent comprises dichloromethane, i.e., methylene chloride, chloroform, or any combination thereof.
- the organic solvent e.g., dichloromethane
- the reaction of step i) is performed at a temperature from about 10° C to about 40° C.
- the reaction of step i) is performed at room temperature.
- step i) is performed under agitation, e.g., stirring.
- step i) the reaction of step i) is performed under an inert gas (e.g., nitrogen gas).
- an inert gas e.g., nitrogen gas
- the reaction of step i) is about 99% complete (e.g., from about 95% to about 99.9% complete after about 15 hrs (e.g. from about 14 to about 18 hrs).
- step i) generates the compound of Formula 10, having a yield of greater than about 95% (e.g., from about 95% to about 99.9% or about 99%).
- Step ii) comprises reacting the compound of Formula 10 with a compound of Formula 5 in the presence of a base and an organic solvent to generate a compound of Formula 11, wherein each R 2 is independently selected from Ci_6 alkyl or phenyl.
- the base comprises an alkyllithium reagent.
- alkyllithium reagents include butyllithium, hexyllithium, seobutyllithium, and methyllithium.
- the base comprises seobutyllithium.
- Organic solvents that are useful in the reaction of step ii) comprise alkanes, cyclic alkanes, heterocycles (e.g., THF, 1,4-dioxane, or any combination thereof), ethers, or any combination thereof.
- the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, THF, 1,4-dioxane, diethyl ether, petro ether, MTBE, or any combination thereof.
- the organic solvent of step ii) comprises MTBE.
- the organic solvent of step ii) is anhydrous (e.g., anhydrous
- the base of step ii) comprises sec-butyllithium
- the organic solvent of step ii) comprises MTBE.
- the compound of Formula 5 has an e.e. of about 98% or greater
- the compound of Formula 5 has a chemical purity of about 95% or greater (e.g., from about 97% to about 99.9%).
- step ii) is performed at a temperature from about
- step ii) is performed under agitation, e.g., stirring.
- step ii) the reaction of step ii) is performed under an inert gas (e.g., nitrogen gas).
- an inert gas e.g., nitrogen gas
- Steps iv)-vii) may optionally be performed with other steps described herein to generate the compound of Formula I.
- Some methods further comprise the steps of: iv) refluxing the compound of Formula la in the presence of methanol to generate a compound of Formula 1 having an e.e. of greater than about 98%;
- Step iv) is an efficient stereoselective method for generating the compound of Formula 1 having an e.e. of greater than 98% that does not require additional chromatography. Moreover, in some implementations, step iv) generates the compound of Formula 1 with a yield of at least about 90% (e.g., at least about 91%, or about 92%).
- the refluxing of the compound of Formula la occurs in the presence of an alcohol (e.g., methanol, ethanol, or any combination thereof).
- an alcohol e.g., methanol, ethanol, or any combination thereof.
- the compound of Formula la undergoes reflux in the presence of methanol (e.g., anhydrous methanol).
- the compound of Formula la is heated to reflux under an inert gas (e.g., nitrogen).
- an inert gas e.g., nitrogen
- the compound of Formula la is heated to reflux for a period of about 1 to about 3 hrs (e.g., about 2 hrs).
- Step v) comprises the protection of the hydroxy functional group of the compound of Formula 1 under basic conditions to generate the alkylsilyl ether compound of Formula 2.
- the base of step v) comprises a nitrogen base.
- the nitrogen base comprises Et 3 N, imidazole, piperidine, piperazine, any combination thereof, or the like.
- the base of step v) comprises imidazole.
- the SiCl(R 2 ) 3 reagent of step v) comprises chloro-ieri- butyldimethylsilane (TBS-C1), ieri-butylchlorodiphenyl silane (TBDPS-C1), chlorotrimethylsilane (TMS-C1), triisopropylsilyloxymethyl chloride (TOM-C1), or chlorotriisopropylsilane (TIPS-Cl).
- the 1-TMS-l-propyne of step vi) is first reacted with an alkyllithium reagent followed by the reaction with the compound of Formula 2.
- the present invention provides a method of generating a compound of Formula 5 wherein each R is independently selected from a C e alkyl or phenyl, comprising the steps of: iv) refluxing the compound of Formula la in the presence of methanol to generate a compound of Formula 1 having an e.e. of greater than about 98% (e.g., greater than about 98.5%, greater than about 99% or from about 98.5% to about 99.9%);
- the compound of Formula 5 has a chemical purity of about 95% or greater (e.g., from about 97% to about 99.9% or about 99% or greater) and an e.e. of about 98% or greater (e.g., about 99% or greater). In some implementations, the compound of Formula 5 has an e.e. of -100%, e.g., about 98% or greater, about 99% or greater, or greater than 99%.
- Another aspect of the present invention provides a method of generating a compound of Formula I
- R 1 is Ci_ 6 alkyl
- each R 2 is independently selected from Ci_ 6 alkyl or phenyl
- the oxidizing agent comprises Mn0 2 ; and ix) converting the compound of Formula 12 to the compound of Formula I.
- step viii) accomplishes the oxidation of the compound of Formula 11 to generate the compound of Formula 12 using an oxidizing agent that possesses a reduced toxicity than traditional chromium based oxidation agents (e.g., PCC).
- an oxidizing agent that possesses a reduced toxicity than traditional chromium based oxidation agents (e.g., PCC).
- each of the -OSi(R 2 )3 groups in the compounds of Formulae 11 and 12 is independently selected from
- the organic solvent of step viii) comprises a halogenated organic solvent.
- the halogenated organic solvent of step viii) comprises dichloromethane, chloroform, or any combination thereof.
- the organic solvent of step viii) e.g., dichloromethane
- Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 10
- R 1 is Ci_6 alkyl and the oxidizing agent comprises Mn0 2 or Dess-Martin periodinane; and ii) reacting the compound of Formula 10 with a compound of Formula 5
- Another aspect of the present invention provides a method of generating a compound of Formula I
- organic solvent comprises THF
- R 1 is Ci_6 alkyl
- R 2 is independently selected from Ci-6 alkyl or phenyl
- the reducing agent of step x) comprises a chiral borane compound.
- the chiral borane compound of step x) reacts with the compound of Formula 12 to generate the compound of Formula 13 with a d.e. of about 97% or greater (e.g., about 97.5% of greater).
- the chiral borane reducing agent is formed in situ or ex situ.
- the chiral borane compound is selected from (R)-l-methyl-3,3-diphenylhexahydropyrrolo[l,2-c][l,3,2]oxazaborole, (R)-3,3- diphenylhexahydropyrrolo[l,2-c][l,3,2]oxazaborole, (R) -1 -butyl- 3,3 - diphenylhexahydropyrrolo[l,2-c][l,3,2]oxazaborole, (R)-tetrahydro-l ,3,3-triphenyl-lH,3H- pyrrolo[l,2-c][l,3,2]oxaborole, (4S)- 2-methyl-4,5,5-triphenyl-l ,3,2-oxazaborolidine, or any combination thereof.
- the organic solvent of step x) further comprises toluene.
- the organic solvent of step x) is anhydrous.
- Some methods further comprise the step of: viii) reacting a compound of Formula 11 with an oxidizing agent to generate the compound of Formula 12, wherein the oxidizing agent comprises Mn0 2
- Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and
- Some methods further comprise the steps of: iv) refluxing the compound of Formula la in the presence of methanol to generate a compound of Formula 1 having an e.e. of greater than about 98%;
- Another aspect of the present invention provides a method of generating a compound of Formula I
- an organic solvent e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof
- R 1 is Ci_6 alkyl and each R 2 is independently selected from Ci_6 alkyl or phenyl; and xiii) converting the compound of Formula 16 to the compound of Formula I.
- Step xii) comprises the improved hydrogenation of the compound of Formula 15 to generate the compound of Formula 16.
- Some implementations comprise the hydrogenation of the compound of Formula 15 in the presence of an alcohol (e.g., methanol or ethanol), optionally substituted THF (e.g., THF or 2-Me-THF), or any combination thereof to generate the compound of Formula 16.
- the hydrogenation of the compound of Formula 15 occurs in the presence of an alcohol (e.g., methanol or ethanol), optionally substituted THF (e.g., THF or 2-Me-THF), or any combination thereof and a base (e.g., potassium carbonate or potassium bicarbonate).
- step xii The substitution of methanol for the traditional ethanol in step xii) produces an improved yield (e.g., at least about 88%) and improved chemical purity for the compound of Formula 16.
- Some methods further comprise the steps of: x) reacting a compound of Formula 12 with a reduc 13
- organic solvent comprises THF; and xiv) converting the compound of Formula 13 to the compound of Formula 15.
- Some methods further comprise the steps of: viii) reacting a compound of Formula 11 with an oxidizing agent to generate the compound of Formula 12, wherein the oxidizing agent comprises Mn0 2
- Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and
- the oxidizing agent of step i) comprises Mn0 2 or Dess-Martin periodinane.
- Some methods further comprise the steps of: iv) refluxing the compound of Formula la in the presence of methanol to generate a compound of Formula 1 having an e.e. of greater than about 98%;
- Another aspect of the present invention provides a method of generating a compound of Formula I
- R 3 is Ci_ 6 alkyl or phenyl; and xvi) converting the compound of Formula 22 to the compound of Formula I.
- Step xv) generates a yield of at least about 70% (e.g., at least about 75%, at least about 80%, or about 82%) for the compound of Formula 22.
- the reaction of step xv) is conducted at a temperature of from about -80° C to about -20° C (e.g., from about -78° C to about -30°C).
- the transition metal catalyst of step xv) comprises copper having a +1 oxidation state.
- the transition metal catalyst comprises a copper compound or a copper complex wherein the Cu has a +1 oxidation state.
- the transition metal catalyst of step xv) comprises CuX, wherein X is selected from halogen, acetate, benzoate, cyanide, hydroxide, nitrate, or any combination thereof.
- the transition metal catalyst of step xv) comprises Cul.
- Some methods further comprise the steps of: xvii) reacting a compound of Formula 19 with R 4 -substituted benzenesulfonyl chloride under basic conditions to generate a compound of Formula 20, wherein each R 4 is independently selected from -H or C 1-3 alkyl; and '"OSi(R 3 ) 3 OSi(R 3 ) 3
- the R 4 -substituted benzenesulfonyl chloride of step xvii) is 2-mesitylenesulfonyl chloride (2,4,6-trimethylbenzenesulfonyl chloride) or tosyl chloride (TsCl).
- Some methods further comprise the steps of: xix) reacting a compound of Formula 16 with a reducing agent to generate a compound of Formula 17;
- Some methods further comprise the steps of: xii) hydrogenating a compound of Formula
- an organic solvent e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof) to generate the compound of Formula 16.
- an organic solvent e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof
- the hydrogenation of the compound of Formula 15 occurs in the presence of a base (e.g., potassium carbonate or potassium bicarbonate).
- a base e.g., potassium carbonate or potassium bicarbonate.
- Some methods further comprise the steps of: x) reacting a compound of Formula 12 with a reducing agent to generate a compound of Formula 13;
- Some methods further comprise the step of: viii) reacting a compound of Formula 11
- the oxidizing agent comprises ⁇ 0 2 .
- Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and
- Some methods further comprise the steps of: iv) refluxing the compound of Formula la in the presence of methanol to generate a compound of Formula 1 having greater than about 99% e.e.;
- the present invention also provides a method of generating a compound of Formula I
- step xxiv) converting the compound of Formula 9 to the compound of Formula I, wherein the base of step xxii) comprises sec -butyl lithium.
- step xxii) generates the compound of Formula 8 with improved chemical purity without additional chromatography steps.
- step xxii) is conducted at room temperature (e.g., from about 20° C to about 30° C) for a period of about 2 hrs (e.g., from about 1.5 to about 2.5 hrs) then cooled to a temperature of about 0° C (e.g., from about -5° C to about 5° C) under stirring.
- room temperature e.g., from about 20° C to about 30° C
- 2 hrs e.g., from about 1.5 to about 2.5 hrs
- a temperature of about 0° C e.g., from about -5° C to about 5° C
- the organic solvent of step xxii) comprises one or more alkanes.
- the organic solvent of step xxii) comprises heptanes, cyclohexane, or any combination thereof.
- the organic solvent of step xxii) comprises MTBE.
- Another aspect of the present invention provides a method of generating a compound of Formula I
- R 1 is Ci_6 alkyl and the oxidizing agent comprises Mn0 2 or Dess-Martin periodinane; ii) reacting the compound of Formula 10 with a compound of Formula 5a in the presence of a base and an organic solvent to generate a compound of Formula 11a; and
- Some methods further comprise the steps of: iv) refluxing the compound of Formula la in the presence of methanol to generate a compound of Formula 1 having an e.e. of greater than about 98%;
- Another aspect of the present invention provides a method of generating a compound of Formula I
- R 1 is Ci_6 alkyl and the oxidizing agent comprises Mn0 2 ; and ix) converting the compound of Formula 12a to the compound of Formula I.
- Step viii) is discussed above.
- Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent in the presence of an organic solvent to generate a compound of Formula 10
- the oxidizing agent comprises Mn0 2 or Dess-Martin periodinane; and ii) reacting the compound of Formula 10 with a compound of Formula 5a
- Another aspect of the present invention provides a method of generating a compound of Formula I
- organic solvent comprises THF
- R 1 is Ci_6 alkyl
- each R 2 is independently selected from Ci_6 alkyl or phenyl
- Steps x) and xi) are discusses in detail above.
- Some methods further comprise the step of: viii) reacting a compound of Formula lla with an oxidizing agent to generate the compound of Formula 12a, wherein the oxidizing agent comprises Mn0 2
- Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and
- the oxidizing agent of step i) comprises Mn0 2 or Dess-Martin periodinane.
- the base of step ii) comprises an alkyllithium reagent.
- the alkyllithium reagent of step ii) comprises sec-butyllithium.
- the organic solvent of step ii) comprises pentane, hexane, cyclohexane, heptane, tetrahydrofuran, 1,4-dioxane, diethyl ether, petro ether, methyl-ieri- butylether, or any combination thereof.
- the organic solvent of step ii) comprises methyl-ieri-butylether.
- Some methods further comprise the steps of: iv) refluxing the compound of Formula la in the presence of methanol to generate a compound of Formula 1 having an e.e. of greater than about 98%;
- Another aspect of the present invention provides a method of generating a compound of Formula I
- an organic solvent e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof
- R 1 is Ci_6 alkyl
- the hydrogenation of the compound of Formula 15a occurs in the presence of a base (e.g., potassium carbonate or potassium bicarbonate).
- a base e.g., potassium carbonate or potassium bicarbonate.
- Some methods further comprise the steps of: x) reacting a compound of Formula 12a with a reducing agent in the presence of an organic solvent to generate a compound of Formula
- organic solvent comprises THF; and xiv) converting the compound of Formula 13a to the compound of Formula 15a.
- Some methods further comprise the steps of: viii) reacting a compound of Formula 11a with an oxidizing agent to generate the compound of Formula 12a, wherein the oxidizing agent comprises Mn0 2
- Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and
- Some methods further comprise the steps of: iv) refluxing the compound of Formula la in the presence of methanol to generate a compound of Formula 1 having an e.e. of greater than about 98%;
- Another aspect of the present invention provides a method of generating a compound of Formula I
- the transition metal catalyst of step xv) comprises a compound or complex either of which comprises Cu having a +1 oxidation state.
- the transition metal catalyst of step xv) comprises CuX, wherein X is selected from halogen, acetate, benzoate, cyanide, hydroxide, nitrate, or any combination thereof.
- the transition metal catalyst of step xv) comprises Cul.
- Some methods further comprise the steps of: xvii) reacting a compound of Formula 19a with triisopropylbenzenesulfonyl chloride under basic conditions to generate a compound of Formula 20a;
- Some methods further comprise the steps of: xix) reacting a compound of Formula 16a with a reducing agent to generate a compound of Formula 17a;
- Some methods further comprise the step of: xii) hydrogenating a compound of Formula 15a
- an organic solvent e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof) to generate the compound of Formula 16a.
- an organic solvent e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof
- the hydrogenation of the compound of Formula 15a occurs in the presence of a base (e.g., potassium carbonate or potassium bicarbonate).
- a base e.g., potassium carbonate or potassium bicarbonate.
- Some methods further comprise the steps of: x) reacting a compound of Formula 12a with a reducing agent to generate a compound of Formula 13a;
- the oxidizing agent comprises Mn0 2 .
- Some methods further comprise the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10; and
- Some methods further comprise the steps of: iv) refluxing the compound of Formula la in the presence of methanol to generate a compound of Formula 1 having an e.e. of greater than about 98%;
- Some methods further comprise the steps of: xxii) reacting a compound of Formula 7a with a 3-haloprop-l-ene in the presence of a base and an organic solvent to generate a compound of Formula 8a; and
- Another aspect of the present invention provides a method of generating a compound of Formula I or a pharmaceutically acceptable salt thereof, comprising the steps of: i) reacting a compound of Formula 9 with an oxidizing agent to generate a compound of Formula 10;
- xii) hydrogenating a compound of Formula 15a in the presence of an organic solvent (e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof) to generate the compound of Formula 16a;
- an organic solvent e.g., an alcohol (e.g., methanol, ethanol, or any combination thereof), an optionally substituted THF (e.g., 2-methyl-THF or THF), EtOAc, or any combination thereof
- the hydrogenation of the compound of Formula 15a occurs in the presence of a base (e.g., potassium carbonate or potassium bicarbonate).
- a base e.g., potassium carbonate or potassium bicarbonate.
- Some methods further comprise the step of: xxiv) reacting the compound of Formula I with diethanolamine in the presence of an organic solvent to generate the diethanolamine salt of the compound of Formula I.
- Some methods further comprise the step of: xxva) treating the compound of Formula I with an alkali metal hydroxide (e.g., NaOH, KOH, or like, or any combination thereof) in the presence of an alcohol (e.g., ethanol, methanol, wo-propanol, or any combination thereof) to generate the alkali metal salt (e.g., Na salt) of the compound of Formula I.
- an alkali metal hydroxide e.g., NaOH, KOH, or like, or any combination thereof
- an alcohol e.g., ethanol, methanol, wo-propanol, or any combination thereof
- the alkali metal hydroxide comprises NaOH.
- the alcohol comprises ethanol.
- some methods further comprise the step of: xxvi) treating the compound of Formula 25
- R 2 is defined above, with an alkali metal hydroxide (e.g., NaOH, KOH, or like, or any combination thereof), in the presence of an alcohol and water to generate the alkali metal salt (e.g., Na salt) of the compound of Formula I.
- an alkali metal hydroxide e.g., NaOH, KOH, or like, or any combination thereof
- the alcohol comprises methanol.
- Some methods further comprise the step of: xxvii) recrystallizing the diethanolamine salt of the compound of Formula I to generate a first pure form of the diethanolamine salt of the compound of Formula I. (e.g., about 90% or greater chemical purity, about 95% or greater chemical purity, or about 97.5% or greater chemical purity). Some methods further comprise the step of: xxviii) reacting the first pure form of the diethanolamine salt of the compound of Formula I with an acid to generate a second pure form of the compound of Formula I (e.g., about 98% or greater chemical purity, about 98.5% or greater chemical purity, or about 99% or greater chemical purity). And, some methods further comprise the step of: xxvb) converting the second pure form of the compound of Formula I to an alkali metal salt.
- a first pure form of the diethanolamine salt of the compound of Formula I e.g., about 90% or greater chemical purity, about 95% or greater chemical purity, or about 97.5% or greater chemical purity.
- Some methods further comprise the step of
- Another aspect of the present invention provides a compound of Formula 21
- R 1 is Ci_6 alkyl and each R 3 is independently Ci_6 alkyl or phenyl.
- R 1 is methyl, ethyl, propyl, wo-propyl, butyl, sec-butyl, or tert- butyl.
- R is methyl Si(R 3 )3 group is
- Another aspect of the present invention provides a compound of Formula la
- Another aspect of the present invention provides a compound of Formula 5
- each of R 2 is independently selected from a Ci_6 alkyl or phenyl.
- Another aspect of the present invention provides a compound of Formula 9a
- R is Ci_6 alkyl
- Another aspect of the present invention provides a compound of Formula 13
- R 1 is Ci_6 alkyl and each R 2 is independently selected from Ci_6 alkyl or phenyl.
- Another aspect of the present invention provides a method of purifying a compound of Formula 1
- ⁇ OH comprising the steps of: xxx) reacting a compound of Formula 1 with a derivatizing reagent to generate a precipitate that is substantially insoluble in dichloromethane or mixture thereof (e.g., a mixture comprising dicloromethane and an alkane (e.g., heptane) (e.g., a mixture comprising dichloromethane and about 50% or more by volume heptane)); xxxi) collecting the precipitate and refluxing the precipitate in a solvent comprising an alcohol to generate the compound of Formula 1 having a chemical purity of about 98% or greater (e.g., about 98.5% or greater, about 99% or greater, or about 99.5% or greater) and an e.e. of about 98% or greater (e.g., about 98.5% or greater, about 99% or greater, or about 99.5% or greater); wherein the method excludes the use of any column chromatography (e.g., HPLC).
- the derivitizing reagent comprises 3,5-dinitrobenzoyl chloride and the alcohol comprises methanol.
- Another aspect of the present invention provides a method of purifying a compound of Formula 9
- Some methods further comprise the step of: xlii) recrystallizing the precipitate of step xli).
- Another aspect of the present invention provides a method of generating a compound of Formula 5 wherein each of R 2 is independently selected from a Ci_6 alkyl or phenyl, comprising the steps of: iv) refluxing the compound of Formula la in the presence of methanol to generate a compound of Formula 1 having an e.e. of greater than about 98%;
- the compound of Formula 5 has a chemical purity of about 98% or greater (e.g., about 98.5% or greater, about 99% or greater, or about 99.5% or greater) and an e.e. of about 98% or greater (e.g., about 98.5% or greater, about 99% or greater, or about 99.5% or greater).
- Another aspect of the present invention provides a method of generating a compound of Formula 13
- R 1 is Ci_6 alkyl and each R 2 is independently selected from Ci_6 alkyl or phenyl, comprising the step of: x) reacting a compound of Formula 12 with (R)-l-methyl-3,3- diphenylhexahydropyrrolo[l,2-c][l,3,2]oxazaborole in the presence of an organic solvent comprising THF and toluene to generate a compound of Formula 13
- the compound of Formula 13 has a chemical purity of greater than about 97% (e.g., about 97.5% or greater, about 98% or greater) and a d.e. of greater than about 97% (e.g., about
- Step x) is described in detail above.
- R 1 , R 2 , and R 3 are as defined above.
- Some methods of the present invention comprise one or more of the following reaction conditions:
- Step xl 1. 3,5-dinitrobenzoyl chloride, DMAP, NEt 3 , CH 2 C1 2 , 0 °C to r.t.
- Step xix NaBH 4 , aq. NaOH, EtOH, -10 °C
- the present invention also provides the following synthetic steps, wherein one or more of the following steps may be optionally substituted for one or more steps described above.
- Step A2) Step A2)
- Example 1 (/f)-oxiran-2-ylmethyl 3,5-dinitrobenzoate (la).
- Triethylamine (8.52 g mL, 84.2 mmol, 1.25 equiv) and 4-dimethylaminopyridine (100 mg, 0.818 mmol, 0.01 equiv) were added to a solution of (5)-(-)-glycidol 1 (5.00 g, 67.5 mmol, 1.0 equiv, 99.5% ee) in anhydrous methylene chloride (100 mL) while stirring under nitrogen. The reaction was then warmed to 30 °C and 3,5-dinitrobenzoyl chloride (16.3 g, 70.9 mmol, 1.05 equiv) added drop-wise over 20 minutes as a solution in anhydrous methylene chloride (50 mL).
- Example 2 (S)-(-)-glycidol (1, -100% ee).
- Example 3 (/f)-tert-butyldimethyl(oxiran-2-ylmethoxy)silane (2a).
- Example 4 (/f)-l-((tert-butyldimethylsilyl)oxy)-6-(trimethylsilyl)hex-5-yn-2-ol (3a).
- thermocouple and addition funnel To a 3-neck flask fitted with a mechanical stirrer, a thermocouple and addition funnel was charged l-(trimethylsilyl)-l-propyne (120.0 g, 1.07 mol, 2.2 equiv) followed by ieri-butyl methyl ether (600 mL) while being kept under nitrogen. The solution was cooled to 0 + 5 °C while stirring and sec-butyllithium (696 mL, mmol, 2.0 equiv, 2 M in cyclohexane) was added slowly while maintaining the reaction temperature below 5 °C. After complete addition, the resulting mixture was stirred at 0 + 5 °C under nitrogen for three hours. In a separate 3-neck flask fitted with a mechanical stirrer, a thermocouple, and addition funnel was charged epoxide 2a (92.5 g,
- Example 6 (/f)-5-(but-3-yn-l-yl)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8- disiladecane (5a).
- Example 7 fert-butyl((3-methoxybenzyl)oxy)dimethylsilane (7b).
- dichloromethane (20 L, 8 volumes) was added imidazole (1466 g, 21.53 mol, 1.19 equiv) and the solution cooled to 15 °C while stirring under nitrogen. Once cooled, the solution was charged with ieri-butyl(chloro)dimethyl-silane (3164 g, 20.99 mol, 1.16 equiv) over the next 9 minutes during which time an exotherm of 42.9 °C was observed. The reaction was then cooled to room temperature while stirring for 17 hours. The reaction was then quenched with 5% aqueous citric acid (20 L, 8 volumes) and the lower organic phase concentrated to give 4958 g of a pale yellow oil.
- Vacuum distillation done in two batches afforded 2336 g and 1964 g of a clear colorless oil, which totaled 4300 g (94%) of the title compound.
- Example 8 (( -allyl-3-methoxybenzyl)oxyXtert-butyl)dimethylsilane (8b).
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US14/650,234 US20150315114A1 (en) | 2012-12-07 | 2013-12-06 | Methods of Synthesizing a Prostacyclin Analog |
CN201380064046.3A CN104837806A (en) | 2012-12-07 | 2013-12-06 | Methods of synthesizing prostacyclin analog |
NZ708130A NZ708130A (en) | 2012-12-07 | 2013-12-06 | Methods of synthesizing a prostacyclin analog |
SG11201504430TA SG11201504430TA (en) | 2012-12-07 | 2013-12-06 | Methods of synthesizing a prostacyclin analog |
EP18154039.4A EP3398931B1 (en) | 2012-12-07 | 2013-12-06 | Methods of synthesizing a prostacyclin analog |
AU2013355130A AU2013355130B2 (en) | 2012-12-07 | 2013-12-06 | Methods of synthesizing a prostacyclin analog |
CA2893604A CA2893604A1 (en) | 2012-12-07 | 2013-12-06 | Methods of synthesizing a prostacyclin analog |
JP2015545860A JP6342414B2 (en) | 2012-12-07 | 2013-12-06 | Method for synthesizing prostacyclin analogs |
EP13812336.9A EP2928858B1 (en) | 2012-12-07 | 2013-12-06 | Methods of synthesizing a prostacyclin analog |
DK13812336.9T DK2928858T3 (en) | 2012-12-07 | 2013-12-06 | METHODS OF SYNTHESIS OF A PROSTACYCLINE ANALOGUE |
ES13812336.9T ES2664026T3 (en) | 2012-12-07 | 2013-12-06 | Methods to synthesize a prostacyclin analog |
MX2015006972A MX369094B (en) | 2012-12-07 | 2013-12-06 | Methods of synthesizing a prostacyclin analog. |
EA201591093A EA034309B1 (en) | 2012-12-07 | 2013-12-06 | Processes and intermediate compounds for preparing a prostacyclin analog |
KR1020157018095A KR20150091170A (en) | 2012-12-07 | 2013-12-06 | Methods of synthesizing a prostacyclin analog |
BR112015013085A BR112015013085A2 (en) | 2012-12-07 | 2013-12-06 | synthesis methods of a prostacyclin analog |
PH12015501258A PH12015501258A1 (en) | 2012-12-07 | 2015-06-03 | Methods of synthesizing a prostacyclin analog |
IL239172A IL239172B (en) | 2012-12-07 | 2015-06-03 | Methods of synthesizing a postacyclin analog |
HK16100175.9A HK1212323A1 (en) | 2012-12-07 | 2016-01-08 | Methods of synthesizing a prostacyclin analog |
US15/583,457 US9908834B2 (en) | 2012-12-07 | 2017-05-01 | Methods of synthesizing a prostacyclin analog |
US15/874,093 US10450257B2 (en) | 2012-12-07 | 2018-01-18 | Methods of synthesizing a prostacyclin analog |
PH12018500562A PH12018500562A1 (en) | 2012-12-07 | 2018-03-15 | Methods of synthesizing a prostacyclin analog |
AU2018233009A AU2018233009B2 (en) | 2012-12-07 | 2018-09-21 | Methods of synthesizing a prostacyclin analog |
US16/567,471 US20200002261A1 (en) | 2012-12-07 | 2019-09-11 | Methods of synthesizing a prostacyclin analog |
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JP2017531661A (en) * | 2014-10-08 | 2017-10-26 | キノイン・ジヨージセル・エーシユ・ベジエーセテイ・テルメーケク・ジヤーラ・ゼー・エル・テー | Method for producing treprostinil |
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Publication number | Priority date | Publication date | Assignee | Title |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4306075A (en) | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
US6441245B1 (en) | 1997-10-24 | 2002-08-27 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
US6700025B2 (en) | 2001-01-05 | 2004-03-02 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
US20090163738A1 (en) | 2007-12-17 | 2009-06-25 | United Therapeutics Corporation | Process to prepare treprostinil, the active ingredient in remodulin |
US20110319641A1 (en) | 2010-06-03 | 2011-12-29 | United Therapeutics Corporation | Treprostinil production |
CA2710726A1 (en) | 2010-07-22 | 2012-01-22 | Alphora Research Inc. | Synthesis of treprostinil and intermediates useful therein |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2039857A1 (en) * | 1990-04-26 | 1991-10-27 | Wilfred Po-Sum Shum | Process for producing epoxyalcohols of high optical purity |
ES2622471T5 (en) * | 2003-05-22 | 2020-07-23 | United Therapeutics Corp | Compounds and procedures for the administration of prostacyclin analogs |
JPWO2009019868A1 (en) * | 2007-08-06 | 2010-10-28 | 大正製薬株式会社 | 10a, 12-position cross-linked 10a-azalide compound |
WO2010039531A1 (en) * | 2008-09-23 | 2010-04-08 | Resolvyx Pharmaceuticals, Inc. | Therapeutic compounds |
CN101891596B (en) * | 2009-05-22 | 2013-12-11 | 上海天伟生物制药有限公司 | New compound and preparation method and application thereof |
WO2012041334A1 (en) | 2010-10-01 | 2012-04-05 | Rigshospitalet | Compounds capable of modulating/preserving endothelial integrity for use in prevention or treatment of acute traumatic coagulopathy and resuscitated cardiac arrest |
JP5199519B2 (en) * | 2010-11-30 | 2013-05-15 | 独立行政法人科学技術振興機構 | Nucleoside analogs or salts thereof, oligonucleotide analogs, gene expression inhibitors, and nucleic acid probes for gene detection |
US8524939B2 (en) | 2011-08-24 | 2013-09-03 | Chirogate International Inc. | Intermediates for the synthesis of benzindene prostaglandins and preparations thereof |
CN102796134B (en) * | 2012-08-31 | 2015-07-01 | 甘肃皓天化学科技有限公司 | Preparation method for Maxacalcitol intermediate |
US20150315114A1 (en) * | 2012-12-07 | 2015-11-05 | Cayman Chemical Company Incorporated | Methods of Synthesizing a Prostacyclin Analog |
EP3068752A1 (en) * | 2013-11-13 | 2016-09-21 | Cayman Chemical Company Incorporated | Amine salts of a prostacyclin analog |
-
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Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4306075A (en) | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
US6441245B1 (en) | 1997-10-24 | 2002-08-27 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
US6528688B2 (en) | 1997-10-24 | 2003-03-04 | United Therapeutics Corporation | Prostacyclin derivatives |
US6765117B2 (en) | 1997-10-24 | 2004-07-20 | United Therapeutic Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
US6700025B2 (en) | 2001-01-05 | 2004-03-02 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
US6809223B2 (en) | 2001-01-05 | 2004-10-26 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
US20090163738A1 (en) | 2007-12-17 | 2009-06-25 | United Therapeutics Corporation | Process to prepare treprostinil, the active ingredient in remodulin |
US20110319641A1 (en) | 2010-06-03 | 2011-12-29 | United Therapeutics Corporation | Treprostinil production |
CA2710726A1 (en) | 2010-07-22 | 2012-01-22 | Alphora Research Inc. | Synthesis of treprostinil and intermediates useful therein |
Non-Patent Citations (5)
Title |
---|
DRUG OF THE FUTURE, vol. 26, no. 4, 2001, pages 364 - 374 |
J. ORG. CHEM., vol. 69, 2004, pages 1890 - 1902 |
SMITH, M.B. AND MARCH, J.,: "March's Advanced Organic Chemistry, 5th Ed.,", 2001, JOHN WILEY & SONS |
THOMAS SORRELL: "Organic Chemistry", 1999 |
UNKNOWN: "Handbook of Chemistry and Physics 75th Ed.", UNKNOWN |
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