WO2014087226A1 - Buprenorphine analogs as opiod receptor modulators - Google Patents
Buprenorphine analogs as opiod receptor modulators Download PDFInfo
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- WO2014087226A1 WO2014087226A1 PCT/IB2013/002705 IB2013002705W WO2014087226A1 WO 2014087226 A1 WO2014087226 A1 WO 2014087226A1 IB 2013002705 W IB2013002705 W IB 2013002705W WO 2014087226 A1 WO2014087226 A1 WO 2014087226A1
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- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 description 1
- OMOMUFTZPTXCHP-UHFFFAOYSA-N valpromide Chemical compound CCCC(C(N)=O)CCC OMOMUFTZPTXCHP-UHFFFAOYSA-N 0.000 description 1
- 229960001930 valpromide Drugs 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 229960005318 vigabatrin Drugs 0.000 description 1
- 201000002498 viral encephalitis Diseases 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- HUNXMJYCHXQEGX-UHFFFAOYSA-N zaleplon Chemical compound CCN(C(C)=O)C1=CC=CC(C=2N3N=CC(=C3N=CC=2)C#N)=C1 HUNXMJYCHXQEGX-UHFFFAOYSA-N 0.000 description 1
- 229960004010 zaleplon Drugs 0.000 description 1
- 229950007802 zidometacin Drugs 0.000 description 1
- 229960001360 zolmitriptan Drugs 0.000 description 1
- ULSDMUVEXKOYBU-ZDUSSCGKSA-N zolmitriptan Chemical compound C1=C2C(CCN(C)C)=CNC2=CC=C1C[C@H]1COC(=O)N1 ULSDMUVEXKOYBU-ZDUSSCGKSA-N 0.000 description 1
- 229960001475 zolpidem Drugs 0.000 description 1
- ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 description 1
- 229960003414 zomepirac Drugs 0.000 description 1
- ZXVNMYWKKDOREA-UHFFFAOYSA-N zomepirac Chemical compound C1=C(CC(O)=O)N(C)C(C(=O)C=2C=CC(Cl)=CC=2)=C1C ZXVNMYWKKDOREA-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- narcotic is often used to refer to opioids, the term is not specifically applicable to opioids.
- nociceptin also known as orphanin FQ (OFQ)
- OFQ orphanin FQ
- ORL-1 receptors activation of ORL-1 receptors in the brain can inhibit opioid-mediated analgesia (e.g. , D. Barlocco et al., "The opioid-receptor-like 1 (ORL-1 ) as a potential target for new analgesics.” Eur. J. Med Chem. , 2000, 35:275; J.S. Mogil et al., "Orphanin FQ is a functional anti-opioid peptide.” Neurosci., 1996, 75:333; K.
- opioid-mediated analgesia e.g. , D. Barlocco et al., "The opioid-receptor-like 1 (ORL-1 ) as a potential target for new analgesics.” Eur. J. Med Chem. , 2000, 35:275; J.S. Mogil et al., "Orphanin FQ is a functional anti-opioid peptide.” Neurosci., 1996, 75:
- ORL- 1 activation appears to have an inhibitory effect on the rewarding properties of several drugs of abuse, including ⁇ agonists.
- Constipation associated with the use of opioid analgesics is presumed to occur primarily and mechanistically as a result of the action of ⁇ opioid agonists directly upon ⁇ opioid receptors located in the bowel (Wood & Galligan (2004), Function of opioids in the enteric nervous system. Neurogastroenterology & Motility 16(Suppl.2): 17-28.).
- R 2 and R 8 are each independently selected from the group consisting of hydrogen, -(C
- -C )alkyl-, -(5- to 12- membered)heteroaryl, or ((5- to 12-membered)heteroaryl)-(Ci-C 6 )alkyl-; each of which is optionally substituted with 1 , 2, or 3 substituents each independently selected from the group consisting of -OH, ( 0), halo, -C(halo) 3 , -CH(halo) 2 , -CH 2 (halo), -(C C 6 )alkyl, hal
- R 4 is selected from the group consisting of -(C i-C 6 )alkyl, -(C 2 -C 6 )alkenyl, -(C 2 - C 6 )alkynyl, -C(halo) 3 , -CH(halo) 2 , -CH 2 (halo), hydroxy(C , -C 6 )alkyl-, -(C 3 - C] 2 )cycloalkyl,
- the present invention provides novel compounds of Formula II:
- the present invention provides novel compounds of Formula V:
- the present invention provides methods for preparing a composition, comprising the step of admixing a Compound of the Invention and a pharmaceutically acceptable carrier or excipient to form a pharmaceutical composition.
- the invention still further relates to a kit comprising a sterile container containing an effective amount of a Compound of the Invention, and instructions for therapeutic use.
- the other therapeutic agent can be, but is not limited to, a ⁇ -opioid agonist, a non-opioid analgesic, a non-steroidal antiinflammatory agent, a Cox-II inhibitor, an anti-emetic, a ⁇ -adrenergic blocker, an anticonvulsant, an antidepressant, a Ca 2+ -channel blocker, an anticancer agent, or a mixture thereof.
- R 4 is selected from the group consisting of -(Ci-C 6 )alkyl, -(C 2 -C 6 )alkenyl, -(C 2 - C 6 )alkynyl, -C(halo) 3 , -CH(halo) 2 , -CH 2 (halo), hydroxy(C , -C 6 )alkyl-, -(C 3 - Ci 2 )cycloalkyl,
- R 5 and R 6 are each independently selected from the group consisting of hydrogen, - (C i-C 6 )alkyl, -(C 3 -C 8 )cycloalkyl, ((C 3 -C 8 )cycloalkyl)-(C ,-C 6 )alkyl-, -COOR 7 , -(C r C 6 )alkyl-CO-OR 7 , -CONH 2 , and (C
- R 9 and R 10 are each independently selected from the group consisting of hydrogen, - (C,-C 6 )alkyl, -(C 2 -C 6 )alkenyl, -(C 2 -C 6 )alkynyl, -(Ci-C, 0 )alkoxy, -(C 3 -C, 2 )cycloalkyl, - (C 4 -Ci 2 )cycloalkenyl, ((C 3 -C i 2 )cycloalkyl)-(Ci-C6)alkyl-, and ((C 4 -Ci )cycloalkenyl)- (C ,-C 6 )alkyl-;
- G is selected from the group consisting of CH 2 , NR 16 , or O;
- X is selected from the group consisting of-(C
- -C io)alkoxy, OH, hydroxy(C r C 6 )alkyl-, dihydroxy(C,-C 6 )alkyl-, halogen, -NH 2 , -NR 2 (C 0)R 12 , and -CONR l 2 R 13 ;
- Item 3 In another embodiment Item 1 , the present invention provides novel compounds of Formula III:
- G is R 16 , wherein R 16 is hydrogen.
- Item 22 In one embodiment of Item 21 , at least one of R 2 or R 8 is phenyl.
- At least one of R 2 or R 8 is (6- to 14-membered)aryl- (C ,-C 6 )alkyl-.
- Item 25 In another embodiment of any one of Items 1 to 9, at least one of R 2 or R 8 is COOR 7 . Item 26. In certain embodiments of Item 25, R 2 is COOR 7 and R 8 is -(6- to 14- membered)aryl.
- Item 33 In one embodiment of any one of Items 1 to 28, X is halogen.
- Item 36 In another embodiment of Item 34, Q is ethoxy.
- Item 43 In one embodiment of any one of Items 1 to 5, at least one of R 2 or R 8 is -(6- to 14-membered)aryl, and at least one of R l 5a or R 15b is -(6- to 14-membered)aryl.
- At least one of R l 5a or R l 5b is -(6- to 14-membered)aryl.
- At least one of R l 5a or R l 5b is (6- to 14-membered)aryl-(C
- At least one of R 15a or R l 5b is hydrogen.
- At least one of R 2 or R 8 is -(C i -Cio)alkyl substituted with - CONR R .
- R and R are both hydrogen.
- At least one of R 2 or R 8 is (6- to 14-membered)aryl-(C
- R is COOR and R is -(6- to 14-membered)aryl.
- Q is ethoxy
- -(Ci-C io)alkyl refers to straight-chain and branched non-cyclic saturated hydrocarbons having from 1 to 10 carbon atoms.
- Representative straight chain -(Ci-C m) alkyl groups include methyl, -ethyl, -n-propyl, -n-butyl, -n- pentyl, -n-hexyl, n-heptyl, n-octyl, n-nonyl and n-decyl.
- Representative branched -(Ci- Cio)alkyl groups include isopropyl, sec-butyl, isobutyl, tert-butyl, isopentyl, neopentyl, 1 -methylbutyl, 2-methylbutyl, 3-methylbutyl, 1 , 1 -dimethylpropyl, 1 ,2- dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1 - ethylbutyl, 2-ethylbutyl, 3-ethylbutyl, 1 , 1 -dimethylbutyl, 1 ,2-dimethylbutyl, 1 ,3- dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 5-methylhexyl, 6-methylheptyl, and the like.
- Representative branched-chain -(C i -C6)alkyl groups include isopropyl, sec-butyl, isobutyl, tert-butyl, isopentyl, neopentyl, l -methylbutyl, 2- methylbutyl, 3-methylbutyl, 1 , 1 -dimethylpropyl, and 1 ,2-dimethylpropyl, methylpentyl,
- -(C2-C i 2 )alkynyl refers to straight chain and branched non-cyclic hydrocarbons having from 2 to 12 carbon atoms and including at least one carbon-carbon triple bond.
- Representative straight chain and branched -(C 2 - Ci 2 )alkynyl groups include -ethynyl, -propynyl, - I butynyl, -2-butynyl, - 1 -pentynyl, -2- pentynyl, -3-methyl- 1 -butynyl, -4-pentynyl, -1 -hexynyl, -2-hexynyl, -5-hexynyl, and the like.
- -(C8-C2o)tricycloalkenyl means a tri-cyclic hydrocarbon ring system having at least one carbon-carbon double bond in one of the rings and from 8 to 20 carbon atoms.
- Representative -(Cg-C 2 o)tricycloalkenyls include -anthracenyl, - phenanthrenyl, -phenalenyl, -acenaphthalenyl, as-indacenyl, s-indacenyl,
- the -(5- to 12- membered)heterocycle can be attached via a nitrogen or carbon atom.
- Representative -(5- to 12-membered)heterocycles include morpholinyl, piperidinyl, piperazinyl, 2,3- dihydrofuranyl, dihydropyranyl, hydantoinyl, valerolactamyl, oxiranyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, dihydropyridinyl, tetrahydropyridinyl, tetrahydropyrimidinyl, tetrahydrothiophenyl, tetrahydrothiopyranyl, and the like.
- -C6)alkyl means any of the above-mentioned Ci_ 6 alkyl groups substituted by one or more hydroxy groups.
- Representative hydroxy(C C 6 )alkyl groups include hydroxymethyi, hydroxyethyl, hydroxypropyl and
- the term “optionally substituted” refers to a group that is either unsubstituted or substituted.
- a typical, non-limiting, process of preparing a solvate would involve dissolving a compound of Formula I, Formula II, Formula HI, Formula I V, or Formula V in a desired solvent (organic, water, or a mixture thereof) at temperatures above about 20°C to about 25°C, then cooling the solution at a rate sufficient to form crystals, and isolating the crystals by known methods, e.g., filtration.
- a desired solvent organic, water, or a mixture thereof
- Analytical techniques such as infrared spectroscopy can be used to confirm the presence of the solvent in a crystal of the solvate.
- olefin E chlorochromate (PCC) in a suitable solvent such as dichloromethane (DCM).
- PCC dichloromethane
- DCM dichloromethane
- the ketone D can be reacted with an olefinic organometalic compound such as an olefinic Grignard reagent in a suitable solvent such as ether or THF to give olefin E.
- the double bond in compound E can be converted to a diol by reaction with a suitable reagent such as osmium tetroxide with or without a co-oxidant such as N-methylmorpholine " N-oxide (N O) in a suitable solvent such as an acetone/water mixture to give compound F.
- a suitable reagent such as osmium tetroxide with or without a co-oxidant such as N-methylmorpholine " N-oxide (N O) in a suitable solvent such as an acetone/water mixture to give compound F
- the prepared membrane solution (190 ⁇ /well) was transferred to 96- shallow well polypropylene plates containing 10 ⁇ of 20x concentrated stock solutions of the agonist [D-Ala 2 , N-methyl-Phe 4 Gly-oP]-enkephalin (DAMGO) prepared in dimethyl sulfoxide (DMSO). Plates were incubated for 30 min at about 25°C with shaking.
- DAMGO dimethyl sulfoxide
- Membranes from recombinant HEK.-293 cells expressing the human ⁇ opioid receptor were prepared by lysing cells in ice cold hypotonic buffer (2.5 mM MgCl 2 , 50 mM HEPES, pH 7.4) (10 mL/ 10 cm dish) followed by homogenization with a tissue grinder/Teflon pestle. Membranes were collected by centrifugation at 30,000 x g for 15 min at 4°C and pellets were resuspended in hypotonic buffer to a final concentration of l -3mg/mL. Protein concentrations were determined using the BioRad protein assay reagent with bovine serum albumen as standard. Aliquots of ⁇ receptor membranes were stored at -80 °C.
- K GTP E max (%) is the maximal effect elicited by a compound relative to the effect elicited by U69,593.
- Certain Compounds of the Invention will have a ⁇ GTP E max (%) of greater than about 1 %; or greater than about 5%; or greater than about 10%; or greater than about 20%.
- Compounds of the Invention will have a K GTP E max (%) of greater than about 50%; or greater than about 75%; or greater than about 90%; or greater than about 100%.
- the Compounds of the Invention will have a Ki (nM) for ⁇ receptors of about 10,000 or more (which, for the purposes of this invention, is interpreted as having no binding to the ⁇ receptors). Certain Compounds of the Invention will have a Ki (nM) of about 20,000 or less for 5 receptors. In one embodiment, the Compounds of the Invention will have a Ki (nM) of about 1 0,000 or less; or of about 9000 or less.
- the Compounds of the Invention will have a Ki (nM) of about 7500 or less; or of about 6500 or less; or of about 5000 or less; or of about 3000 or less; or of about 2500 or less. In another embodiment, the Compounds of the Invention will have a Ki (nM) of about 1000 or less; or of about 500 or less; or of about 350 or less; or of about 250 or less; or of about 1 00 or less; or of about 10 or less.
- ORL-1 Receptor Binding Assay Procedure Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL- 1 ) (Perkin Elmer, Shelton, CT) are prepared by lysing cells in ice-cold hypotonic buffer (2.5 mM MgCl 2 , 50 mM HEPES, pH 7.4) ( 10 ml/ 10 cm dish) followed by homogenization with a tissue grinder/Teflon pestle. Membranes are collected by centrifugation at 30,000 x g for 15 min at 4°C and pellets resuspended in hypotonic buffer to a final concentration of 1 -3 mg/ml. Protein concentrations are determined using the BioRad protein assay reagent with bovine serum albumen as standard. Al iquots of the ORL- 1 receptor membranes are stored at -80°C.
- ORL-1 Receptor Binding Data Certain Compounds of the Invention will have a i (nM) of about 1000 or less. In one embodiment, the Compounds of the invention will have a Ki (nM) of about 500 or less. In other embodiments, the
- Rats are tested using a hot plate apparatus consisting of a clear plexiglass cylinder with a heated metal floor maintained at a temperature of 48-52 °C (Model 7280, commercially available from Ugo Basile of Italy). A rat is placed into the cylinder on the hot plate apparatus for a maximum duration of 30 s, or until it exhibits a nocifensive behavior (behavioral endpoint), at which time it is removed from the hot plate, and response latency recorded. Hot plate latencies are measured immediately before (pre-treatment) and 1 , 3, and 5 hours following administration of a Compound of the Invention.
- the left hind paw of each animal is administered a 50 intraplantar injection of 50% FCA. Prior to injection of FCA (baseline) and 24 hours post injection, the animal is assessed for response to noxious mechanical stimuli by determining the PWT, as described below. Rats are then administered a single injection of 1 , 3, or 10 mg/kg of either a Compound of the Invention; 30mg/kg of a control drug selected from Celebrex, indomethacin or naproxen; or carrier. Responses to noxious mechanical stimuli are determined 1 , 3, 5 and 24 hours post administration. Percentage reversal of hyperalgesia for each animal is defined as: [ (post administration PWT) - (pre-administration PWT) ]
- the left thigh of the rat is shaved and the sciatic nerve exposed at high thigh level through a small incision and is carefully cleared of surrounding connective tissues at a site near the trocanther just distal to the point at which the posterior biceps semitendinosus nerve branches off of the common sciatic nerve.
- a 7-0 silk suture is inserted into the nerve with a 3/8 curved, reversed-cutting mini-needle and tightly l igated so that the dorsal '/ 3 to 1 ⁇ 2 of the nerve thickness is held within the ligature.
- the wound is closed with a single muscle suture (4-0 nylon (Vicryl)) and vetbond tissue glue.
- mice Following surgery animals are weighed, administered a subcutaneous (s.c.) injection of saline or ringers lactate, the wound area is dusted with antibiotic powder and they are kept on a warm pad until they recover from the anesthesia. Animals are then returned to their home cages unti l behavioral testing begins. The animals are assessed for response to noxious mechanical stimuli by determining PWT, as described below, prior to surgery (baseline), then immediately prior to and 1 , 3, and 5 hours after being administered a Compound of the Invention. The animal can also be assessed for response to noxious thermal stimuli or for tactile allodynia, as described below.
- the Chung model for neuropathic pain is described in S.H. Kim, "An Experimental Model for Peripheral Neuropathy Produced by Segmental Spinal Nerve Ligation in the Rat," Pain 50(3):355-363 ( 1992).
- the plantar test can be used to assess thermal hyperalgesia.
- hind paw withdrawal latencies to a noxious thermal stimulus are determined using a plantar test apparatus (commercially available from Ugo Basile of Italy) following the technique described by . Hargreaves et al, "A New and Sensitive Method for Measuring Thermal Nociception in Cutaneous Hyperalgesia," Pain 32( 0:77-88 ( 1 988).
- the maximum exposure time is set at 32 seconds to avoid tissue damage and any directed paw withdrawal from the heat source is taken as the end point.
- Three latencies are determined at each time point and averaged. Either only the affected (ipsilateral) paw is tested, or both the ipsilateral and contralateral (non-injured) paw are tested.
- rats can be prepared by implanting a femoral artery cannula via which blood samples are taken. Blood samples are taken prior to drug administration, then 1 , 3, 5 and 24 hours post-treatment. Blood samples are processed using an arterial blood gas analyzer (e.g., IDEXX VetStat with Respiratory/Blood Gas test cartridges). Comparable devices are a standard tool for blood gas analysis (e.g., D. Torbati et al., 2000 Intensive Care Med. (26) 585-591 ).
- an arterial blood gas analyzer e.g., IDEXX VetStat with Respiratory/Blood Gas test cartridges. Comparable devices are a standard tool for blood gas analysis (e.g., D. Torbati et al., 2000 Intensive Care Med. (26) 585-591 ).
- Methods of administration may include intradermal, intramuscular, intraperitoneal, parenteral, intravenous, subcutaneous, intranasal, epidural, oral, sublingual,
- the pharmaceutically acceptable excipient is sterile when administered to an animal.
- Water is a particularly useful excipient when a Compound of the Invention is administered intravenously.
- Saline solutions and aqueous dextrose and glycerol solutions can also be employed as liquid excipients, particularly for injectable solutions.
- a Compound of the Invention is administered locally. This can be achieved, for example, by local infusion during surgery, topical application, e.g., in conjunction with a wound dressing after surgery, by injection, by means of a catheter, by means of a suppository or enema, or by means of an implant, said implant being of a porous, non-porous, or gelatinous material, including membranes, such as sialastic membranes, or fibers.
- polymeric materials can be used (see Medical Applications of Controlled Release (Langer and Wise eds., 1 74); Controlled Drug Bioavailability, Drug Product Design and Performance (Smolen and Ball eds., 1984); Ranger and Peppas, J. Macromol. Sci. Rev. Macromol. Chem. 23 :61 ( 1983); Levy et al . Science 228: 190 ( 1985); During et al, Ann. Neurol. 25:351 (1989); and Howard et al, J. Neurosurg. T V. 105 (1 989)).
- a controlled- or sustained-release system can be placed in proximity of a target of a Compound of the Invention, e.g. , the spinal column, brain, or gastrointestinal tract, thus requiring only a fraction of the systemic dose.
- methods for treating or preventing a Condition in an animal in need thereof can further comprise co-administering to the animal an effective amount of a second therapeutic agent in addition to a Compound of the Invention (i.e. , a first therapeutic agent).
- a Compound of the Invention i.e. , a first therapeutic agent
- An effective amount of the second therapeutic agent will be known or determinable by a medical practitioner in view of this disclosure and published clinical studies.
- the minimal effective amount of the Compound of the Invention i.e., the first therapeutic agent
- the minimal effective amount of the Compound of the Invention i.e., the first therapeutic agent
- the second therapeutic agent can be, but is not limited to, an opioid agonist, a non-opioid analgesic, a non-steroidal anti-inflammatory agent, an antimigraine agent, a Cox-II inhibitor, a 5-lipoxygenase inhibitor, an anti-emetic, a ⁇ -adrenergic blocker, an anticonvulsant, an antidepressant, a Ca 2+ -channel blocker, an anti-cancer agent, an agent for treating or preventing UI, an agent for treating or preventing anxiety, an agent for treating or preventing a memory disorder, an agent for treating or preventing obesity, an agent for treating or preventing constipation, an agent for treating or preventing cough, an agent for treating or preventing diarrhea, an agent for treating or preventing high blood pressure, an agent for treating or preventing epilepsy, an agent for treating or preventing anorexia/cachexia, an agent for treating or preventing drug abuse, an agent for treating or preventing an ulcer, an agent for treating or preventing
- Examples of useful opioid agonists include, but are not limited to, alfentanil, allylprodine, alphaprodine, anileridine, benzylmorphine, bezitramide, buprenorphine, butorphanol, clonitazene, codeine, desomorphine, dextromoramide, dezocine, diampromide, diamorphone, dihydrocodeine, dihydromorphine, dimenoxadol, dimepheptanol, dimethylthiambutene, dioxaphetyl butyrate, dipipanone, eptazocine, ethoheptazine, ethylmethylthiambutene, ethylmorphine, etonitazene, fentanyl, heroin, hydrocodone, hydromorphone, hydroxypethidine, isomethadone, ketobemidone, levorphanol, levophenacylmorphan, lofentan
- Ca 2+ -channel blockers examples include, but are not limited to, bepridil, clentiazem, diltiazem, fendiline, gal lopamil, mibefradil, prenylamine, semotiadil, terodiline, verapamil, amlodipine, aranidipine, barnidipine, benidipine, cilnidipine, efonidipine, elgodipine, felodipine, isradipine, lacidipine, lercanidipine, manidipine, nicardipine, nifedipine, ni lvadipine, nimodipine, nisoldipine, nitrendipine, cinnarizine, flunarizine, lidoflazine, lomerizine, bencyclane, etafenone, fantofarone, perhexiline, a
- non-steroidal anti-inflammatory agents examples include 5-l ipoxygenase inhibitors, anti-emetics, ⁇ adrenergic blockers, antidepressants, and anti-cancer agents.
- useful therapeutic agents for treating or preventing memory disorder obesity, constipation, cough, high blood pressure, anorexia/cachexia, an ulcer, 1BD, IBS, addictive disorder, Parkinson's disease and parkinsonism, a stroke, a seizure, a pruritic condition, psychosis,
- Dess-Martin periodinane (2.1 g, 4.9 mmol) was added to a suspension of 3 ( 1 .2 g, 2.5 mmol) and sodium bicarbonate (NaHC0 3 ) (2.5 g, 29.5 mmol) at room temperature.
- the reaction mixture quenched with saturated aqueous sodium sulfite (Na 2 S0 ) after stirring at room temperature for l h.
- the resulting mixture was stirred vigorously for 15 min.
- Saturated aqueous sodium bicarbonate (NaHC0 3 ) was added, and the mixture was extracted with EtOAc.
- the organic layer was dried over Na 2 S0 4 , filtered and concentrated.
- the crude material was purified by flash chromatography (Si0 2 , 10-50% EtOAc/hexanes) to obtain compound 4 (0.8 g, 67% yield) as a pale yellow foam.
- Phenylmagnesium bromide (1 .15 mL, 3.4 mmol, 3.0 solution in ether) was added to a solution of 8 ( 1 .39 g, 3.4 mmol) in benzene (30 mL, anhydrous). The resulting mixture was heated to reflux overnight under a nitrogen atmosphere. A solution of ammonium acetate (5.9 g, 68.0 mmol) in methanol (20 mL) was added and the mixture was stirred at room temperature for lh. Sodium borohydride ( 1.2 g. 34.0 mmol) was added and the stirring continued for 2h. The mixture was concentrated. The residue was partitioned between saturated aqueous NaHC0 3 and CHC1 3 . The organic layer was dried over a 2 S0 , filtered and concentrated. Purification of the crude material by flash chromatography (Si0 2 , 10-50% EtOAc/hexanes) yielded 10 (0.49 g, 31% yield).
- Triethylamine (21 iL, 0.15 mmol) was added to a solution of 10 (25 mg, 0.05 mmol) and benzyl bromoacetate (16 ⁇ ,, 0.10 mmol) in THF (1 mL, anhydrous). The mixture was stirred at room temperature for 2h and concentrated. Purification of the crude material by flash chromatography (Si0 2 , 10-50% EtOAc/hexanes) yielded 11 (29 mg, 91% yield).
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Abstract
The present invention is directed to Buprenorphine Analog compounds of the Formula 1, Formula II, Formula III, Formula IV, and Formula V, wherein R1, R2, R3a, R3b, R,15a, R15b, X, Q, G, and Y are as defined herein. Compounds of the Invention are useful for treating pain and other conditions modulated by activity of opioid receptors.
Description
BUPRENORPHINE ANALOGS AS OPIOD RECEPTOR MODULATORS
The invention is in the field of medicinal chemistry. It relates to novel buprenorphine analogs having activity as opioid receptor agonists and/or antagonists. In certain embodiments compounds of the invention have dual activity as μ, δ, and/or κ opioid agonists and ORL- 1 receptor antagonists.
BACKGROUND OF THE INVENTION
Pain is the most common symptom for which patients seek medical advice and treatment. While acute pain is usually self-limited, chronic pain can persist for 3 months or longer and lead to significant changes in a patient's personality, lifestyle, functional ability and overall quality of life (K.M. Foley, Pain, in Cecil Textbook of Medicine 100- 107, J.C. Bennett and F. Plum eds., 20th ed. 1996).
Pain has traditionally been managed by administering either a non-opioid analgesic (such as acetyisaiicyhc acid, choline magnesium trisalicylate, acetaminophen, ibuprofen, fenoprofen, diflunisal or naproxen), or an opioid analgesic (such as morphine, hydromorphone, methadone, levorphanol, fentanyl, oxycodone or oxymorphone).
Although the term "narcotic" is often used to refer to opioids, the term is not specifically applicable to opioids. The term "narcotic", derived from the Greek word for "stupor", originally referred to any drug that induced sleep, only later being associated with opioids (Gutstein, Howard B., Akil, Huda, "Chapter 21. Opioid
Analgesics" (Chapter 21), Brunton, LL, Lazo, JS, Parker, Kl: Goodman & Gilman's The Pharmacological Basis of Therapeutics, 1 1 th Edition:
http://www.accessmedicine.com/content.aspx?aID=940653). In the legal context, the term "narcotic" refers to a variety of mechanistically unrelated substances with abuse or addictive potential (Gutstein, Howard B., Akil, Huda, "Chapter 21 . Opioid Analgesics" (Chapter 21 ), Brunton LL, Lazo JS, Parker Kl: Goodman & Gilman's The
Pharmacological Basis of Therapeutics, 1 1 th Edition:
http://www.accessmedicine.com/content.aspx?aID=940653). Thus, the term "narcotic" not only refers to opioids, but also refers to such drugs as cocaine, methamphetamine,
ecstasy, etc., which exert their pharmacological effects via different receptors than opioids. Furthermore, because the term "narcotic" refers to such a wide variety of unrelated drugs, many of which do not possess analgesic properties, it cannot be assumed that a drug that has "narcotic" properties is necessarily analgesic. For example, drugs such as ecstasy and methamphetamine are not analgesic, and are not used to treat pain.
Until recently, there was evidence of three major classes of opioid receptors in the central nervous system (CNS), with each class having subtype receptors. These receptor classes are known as μ, δ and κ. As opiates have a high affinity to these receptors while not being endogenous to the body, research followed in order to identify and isolate the endogenous ligands to these receptors. These ligands were identified as endorphins, enkephalins, and dynorphins, respectively. Additional experimentation has led to the identification of the opioid receptor-like (ORL-1 ) receptor, which has a high degree of homology to the known opioid receptor classes. This more recently discovered receptor was classified as an opioid receptor based only on structural grounds, as the receptor did not exhibit pharmacological homology. It was initially demonstrated that non-selective ligands having a high affinity for μ, δ and κ receptors had low affinity for the ORL- 1 receptor. This characteristic, along with the fact that an endogenous ligand had not yet been discovered, led to the ORL- 1 receptor being designated as an "orphan receptor".
The discovery of the ORL- 1 receptor and its endogenous ligand, nociceptin (also known as orphanin FQ (OFQ)) presents an opportunity for the discovery of novel compounds that can be administered for pain management or other syndromes influenced by this receptor.
Many publications in the ORL-l/nociceptin field provide evidence that activation of ORL-1 receptors in the brain can inhibit opioid-mediated analgesia (e.g. , D. Barlocco et al., "The opioid-receptor-like 1 (ORL-1 ) as a potential target for new analgesics." Eur. J. Med Chem. , 2000, 35:275; J.S. Mogil et al., "Orphanin FQ is a functional anti-opioid peptide." Neurosci., 1996, 75:333; K. Lutfy et al., "Tolerance develops to the inhibitory effect of orphanin FQ on morphine-induced antinociception in the rat." NeuroReport, 1999, 10: 103; M.M. Morgan et al., "Antinociception mediated
by the periaqueductal gray is attenuated by orphanin FQ." NeuroReport, 1997, 8:3431 ; and J. Tian et al., "Involvement of endogenous Orphanin FQ in electroacupuncture- induced analgesia." NeuroReport, 1997, 8:497).
A growing body of evidence supports a more generalized regulatory role for ORL-1 against the actions of the μ receptor, possibly contributing to the development of μ-agonist tolerance in patients being treated with classical opiates {e.g. , J. Tian et al., "Functional studies using antibodies against orphanin FQ/nociceptin." Peptides, 2000, 21 : 1047; and H. Ueda et al., "Enhanced Spinal Nociceptin Receptor Expression Develops Morphine Tolerance and Dependence." J. Neurosci. , 2000, 20:7640).
Moreover, ORL- 1 activation appears to have an inhibitory effect on the rewarding properties of several drugs of abuse, including μ agonists.
Certain compounds have been described as at least partial agonists for ORL-1 (e.g. , buprenorphine (IC5o of 8.4 nM), fentanyl (IC50 of about 10,000 nM), 7- benzylidenenaltrexone (IC50 about 10,000 nM) (S. Wnendt et al., "Agonistic effect of buprenorphine in a nociceptin/OFQ receptor-triggered reporter gene assay." Molec. Pharmacol , 1999, 56:334-338), and etorphine (IC50 of about 2000 nM) (Hawkinson et al., "Opioid activity profiles indicate similarities between the nociceptin/orphanin FQ and opioid receptors." Eur. J. Pharmacol, 2000, 389: 107- 1 14)). However,
buprenorphine's μ potency is disclosed to be much greater than its ORL-1 potency.
Recent data have shown that the analgesic efficacy of buprenorphine is enhanced by pre-treatment with an ORL- 1 receptor antagonist. Using the tail-flick test in mice, Lutfy et al. demonstrated that buprenorphine's typical bell-shaped dose- response curve (wherein low and high doses induce little analgesia, and mid-range doses produce maximal analgesia) is eliminated by pre-treatment with the ORL-1 antagonist J- 1 13397, and analgesic efficacy is improved at the higher range of doses (K. Lutfy et al., "Buprenorphine-induced antinociception is mediated by μ-opioid receptors and compromised by concomitant activation of opioid receptor-l ike receptors." J.
Neurosci. , 2003, 23 : 10331 - 10337).
Recently, a multidisciplinary group of experts in the fields of pharmacology, toxicology, pain management, and anesthesia have recommended buprenorphine as the best opioid for treating chronic severe pain in elderly patients (Pergolizzi, et al. (2008).
Opioids and the Management of Chronic Severe Pain in the Elderly: Consensus Statement of an International Expert Panel with Focus on the Six Clinically Most Often Used World Health Organization step IB Opioids (buprenorphine, Fentanyl,
Hydromorphone, Methadone, Morphine, Oxycodone. Pain Practice 8(4): 287-313)). It was found that of the opioids studied, buprenorphine provided the best analgesic-to-side effect profile. Buprenorphine was the most effective opioid for treating neuropathic pain. Buprenorphine was the only opioid for which metabolism was not affected by impaired renal function. Buprenorphine was the only opioid demonstrating a ceiling effect for respiratory depression, indicating that higher doses may be used. Also, buprenorphine was the least likely to induce immunosuppression. The panel of experts attributed the improved therapeutic efficacy of buprenorphine to its unique
pharmacological profile.
Buprenorphine has also been shown to have an improved side effect profile in animal models. A review of recent data in animal models of reward and addiction has shown that buprenorphine has a low addictive and dependence-inducing profile compared to other opioids (Tzschentike (2002). Behavioral pharmacology of buprenorphine, with a focus on preclinical models of reward and addiction.
Psychopharmacology 161 : 1 -16).
Use of opioid analgesics often leads to constipation as a side effect.
Constipation associated with the use of opioid analgesics is presumed to occur primarily and mechanistically as a result of the action of μ opioid agonists directly upon μ opioid receptors located in the bowel (Wood & Galligan (2004), Function of opioids in the enteric nervous system. Neurogastroenterology & Motility 16(Suppl.2): 17-28.).
Stimulation of the μ opioid receptors in the bowel causes inhibition of normal gastrointestinal (GI) motility, leading to constipation. The effect of μ opioid agonism on μ opioid receptors in the bowel can be observed via the action of loperamide (Imodium™) in treating diarrhea. Loperamide is a potent μ opioid agonist that is administered orally, but which has little to no absorption into the blood stream. As a result, loperamide exerts its action locally upon the μ opioid receptors in the bowel, and this results in inhibition of GI motility, which treats diarrhea.
There has been recent interest in developing combinations of μ receptor agonists and antagonists having defined biodistribution properties that might serve to limit opioid-induced constipation. For example, the co-administration of an orally bio- available μ opioid receptor agonist (such as morphine, codeine, oxycodone or hydormorphone) together with a potent μ opioid receptor antagonist (such as N- methylnaloxone or N-methylnaltrexone) that is not orally bio-available may serve to prevent or reduce the constipation otherwise associated with μ opioid receptor agonist therapy. The rationale is that the agonist component will be absorbed and distributed throughout the periphery and the central nervous system (CNS), resulting in the desired analgesia, while the antagonist component will remain in the bowel where it will prevent or reduce any agonist-induced constipation that might otherwise occur.
There remains a need in the art to identify and develop novel buprenorphine analogs having improved therapeutic efficacy while reducing adverse side effects.
BRIEF SUMMARY OF THE INVENTION
The present invention provides novel buprenorphine analog compounds useful for treating, preventing or ameliorating a variety of conditions, including pain, in particular chronic pain, and constipation. More specifical ly, the present invention provides compounds of Formula 1, Formula II, Formula III, Formula IV, and Formula V below, and the pharmaceutically acceptable salts, and solvates thereof, that exhibit affinity for one or more of the ORL- 1 , μ, δ, and/or κ opioid receptors. Such compounds, salts, and solvates are collectively referred to hereinafter as "Compounds of the Invention" (each is individually referred to hereinafter as a "Compound of the Invention").
In a particular aspect, the present invention provides novel compounds of Formula I:
wherein
R1 is selected from the group consisting of hydrogen, -(Ci -Cio)alkyl, -(C2- C i2)alkenyl, -(C2-C i2)alkynyl, -(Ci-C |0)alkoxy, -(C3-Ci2)cycloalkyl, -(C4- C12)cycloalkenyl, ((C3-Ci2)cycloalkyl)-(Ci-C6)alkyl-, ((C4-Ci2)cycloalkenyl)-(C r C6)alkyl-, -(6- to 14-membered)aryl, ((6- to l 4-membered)aryl)-(C| -C6)alkyl-, -(5- to 12-membered)heteroaryl, ((5- to 12-membered)heteroaryl)-(Ci-C6)aikyl-, -(3- to 12- membered)heterocycle, ((3- to 12 membered)heterocycle)-(Ci -C6)alkyl-, phenyl, and benzyl; any of which is optionally substituted with 1 , 2, or 3 substituents each independently selected from the group consisting of -(C] -C6)alkyl, OH, halo, -C(halo)3, -CH(halo)2, -CH2(halo), -(C,-C6)alkyl-COOR7, -COOR7, NH2, -NHCQ-Q alkyl, - NR9R10, -C1M, -CONR9R10, -NR9COR10, -SR9, -(5- to 12-membered)carbocyclic ring, - (5- to 12-membered)heterocycle, phenyl, and benzyl;
R2 and R8 are each independently selected from the group consisting of hydrogen, -(C |-Cl 0)alkyl, -(C2-C12)alkenyl, -(C2-C12)alkynyl, -CONR5R6, -COOR7, -(6- to 14-membered)aryl, ((6- to 14-membered)aryl)-(C|-C )alkyl-, -(5- to 12- membered)heteroaryl, or ((5- to 12-membered)heteroaryl)-(Ci-C6)alkyl-; each of which is optionally substituted with 1 , 2, or 3 substituents each independently selected from the group consisting of -OH, (=0), halo, -C(halo)3, -CH(halo)2, -CH2(halo), -(C
C6)alkyl, halo(Ci-C6)alkyl-, -(C2-C6)alkenyl, -(C2-C6)alkynyl, hydroxy(C,-C6)alkyl-, dihydroxy(C | -C6)alkyl-, -(Ct -C6)alkoxy, ((C i-C6)alkoxy)-CO-(Ci-C6)alkoxy-, phenyl, benzyl, -NH2, -NH(C ,-C6)alkyl, -(C1-C6)alkyl-NH(C, -C6)alkyl-R14, -CN, -SH, -OR4, -CONR5R6, -(Ci-C6alkyl)-CO-NR5R6, -COOR7, and -(CrQ^lkyl-CO-OR7;
R3a and R3b are each independently selected from the group consisting of hydrogen, -(C,-C,0)alkyl, -(C2-C ,0)alkenyl, -(C2-Ci0)alkynyl, -CONR5R6, and -COOR7, or together form (=0);
R4 is selected from the group consisting of -(C i-C6)alkyl, -(C2-C6)alkenyl, -(C2- C6)alkynyl, -C(halo)3, -CH(halo)2, -CH2(halo), hydroxy(C , -C6)alkyl-, -(C3- C]2)cycloalkyl,
((C3-Ci2)cycloalkyl)-(Ci-C6)alkyl-, -(6- to 14-membered)aryl, ((6- to 14- membered)aryl)-(C i-C6)alkyl-, -(5- to 12-membered)heteroaryl, and ((5- to 12- membered)heteroaryl)-(Ci -C6)alkyl-;
R5 and R6 are each independently selected from the group consisting of hydrogen, - (C,-C6)alkyl, -(C3-C8)cycloalkyl, ((C3-C8)cycloaIkyl)-(C,-C6)alkyl-, -COOR7, -(C C6)alkyl-CO-OR7, -CONH2, and (C C6)alkyl-CONH-, or R5 and R6 together with the nitrogen atom to which they are attached form a (4- to 8-membered)heterocycle;
R7 is selected from the group consisting of hydrogen, -(C i -C6)alkyl, -(C2-C6)alkenyl, - (C2-C6)alkynyl, -(C3-C12)cycloalkyl, -(C4-C,2)cycloalkenyl, ((C3-Ci2)cycloalkyl)-(C, - C6)alkyl-, and ((C4-Ci2)cycloalkenyl)-(C i-C6)aIkyl- ;
R9 and R10 are each independently selected from the group consisting of hydrogen, - (Ci-C6)alkyl, -(C2-C6)alkenyl, -(C2-C6)alkynyl, -(C i -Cio)alkoxy, -(C3-C,2)cycloalkyl, - (C4-Ci2)cycloalkenyl, ((C3-C) 2)cycloalkyl)-(Ci-C6)alkyl-, and ((C4-Ci2)cycloalkenyl)- (C,-C6)alkyl-;
R12 and R13 are each independently selected from the group consisting of hydrogen, - (Ci-Co)alkyl, -(C2-C,2)alkenyl, -(C2-C12)alkynyl, -(C, -C,0)alkoxy, -(OCH2CH2)s-0(C, - C6)alkyl, -(C3-C i2)cycloalkyl, ((C3-C ,2)cycloalkyl)-(Ci-C6)alkyl-, -(C4- C|2)cycloalkenyl, ((C4-C]2)cycloalkenyl)-(Ci-C6)alkyl-, -(C6-Ci4)bicycloalkyl, ((C6- C14)bicycloalkyI)-(C, -C6)alkyl-, -(C8-C20)tricycloalkyl, ((C8-C20)tricycloalkyl)-(C,- C6)alkyl-, -(C7-C,4)bicycloalkenyl, ((C7.C 14)bicycloalkenyl)-(C rC6)alkyl-, -(Q- C2o)tricycloalkenyl, ((C8-C2o)tricycloalkenyl)-(Ci-C6)alkyl-, -(6- to 14-membered)aryl,
((6- to l 4-membered)aryl)-(C] -C6)alkyl-, -(7- to 12-membered)bicyclic ring system, ((7- to 12-membered)bicyclic ring system)-(Ci-C6)alkyI-, -(7- to 12-membered)bicyclic aryl, ((7- to 12-membered)bicyclic aryl)-(C | -Ce)alkyl-, -(5- to 12-membered)heteroaryl, ((5- to 12-membered)heteroaryl)-(Ci-C6)alkyl-, -(3- to 12-membered)heterocycle, ((3- to 12- membered)heterocycle)-(Ci-C6)alkyl-, -(7- to 12-membered)bicycloheterocycle, ((7- to 12-membered)bicycloheterocycle)-(C]-C6)alkyl-, phenyl, benzyl and naphthyl; each of which is optionally substituted with I or 2 substituents each independently selected from the group consisting of OH, (=0), halo, -C(halo)3, -CH(halo)2, -CH2(halo), -(Ci- C6)alkyl, halo(C, -C6)alkyl-, -(C2-C5)alkenyl, -(C2-C6)alkynyl, hydroxy(C, -C6)alkyl-, phenyl, benzyl, NH2,
-NH(C|-C6)alkyl, CN, SH, OR4, -CONR5R6, -COOR7, -(C3-Ci2)cycloalkyl,
((C3-C12)cycloalkyl)-(Ci-C6)alkyl-, -(6- to 14-membered)aryl, ((6- to 14- membered)aryl)-(Ci-C6)alkyl-, -(5- to 12-membered)heteroaryl, ((5- to 12- membered)heteroaryl)-(Ci-C6)alkyl-, -(3- to 12-membered)heterocycle, ((3- to 12- membered)heterocycle)-(C i-C6)alkyl-, -(7- to 12-membered)bicycloheterocycle, and ((7- to 12-membered)bicycloheterocycle)-(Ci-C6)alkyl-;
R14 is selected from the group consisting of -COOR7, -(d-C6)alkyl-CO-OR7, -C(=0)- (C i-C6)alkyl-COOR7, -(C| -C6)alkyl-C(=0)-(C,-C6)alkyl-COOR7, -CONH2, and (C, - C6)alkyl-CONH-;
G is selected from the group consisting of CH2, NR16, and O;
X is selected from the group consisting of-(Ci-C i0)alkoxy, OH, hydroxy(Ci- C6)alkyl-, dihydroxy(C,-C6)alkyl-, halogen, -NH2, -NR2(C=0)R12, and -CONRl 2R13;
Q is selected from the group consisting of OH, -(Ci-C]0)alkoxy, -(Ci-Cio)alkyl, -O- (C|-C6)alkyl, -(6- to 14-membered)aryl, -0-((6- to l4-membered)aryl), ((6- to 14- membered)aryl)-(C |-C6)alkyl-, -0-((6- to 14-membered)aryl)-(Ci-C6)alkyl, (5- to 12- membered)heteroaryl, -0-((5- to 12-membered)heteroaryl), ((5- to 12- membered)heteroaryl)-(C|-C6)alkyl-, and -0-((5- to 12-membered)heteroaryl-(C i - C6)alkyl,;
Rl 5a and R15b are each independently selected from the group consisting of: hydrogen, OH;
b) saturated, unsaturated, or partially saturated -(C3-Ci2)cycloalkyl, ((C3-C)2)cycloalkyl)- (Ci-C6)alkyl-, ((C3-C,2)cycloalkyl)-(C2-C6)alkenyl-, and ((C3-C,2)cycloalkyI)-(C, - C6)alkoxy-;
c) -(6- to 14-membered)aryl, ((6- to 14-membered)aryl)-(Ci-C6)alkyl-, ((6- to 14- membered)aryl)-(Ci-C6)alkoxy-, and ((6- to 14-membered)aryl)-(C2-C6)alkenyl-;
d) -(5- to 12-membered)heteroaryl, ((5- to 12-membered)heteroaryl)-(Ci-C6)alkyl-, ((5- to 12-membered)heteroaryl)-(C i-C6)alkoxy-, and ((5- to 12-membered)heteroaryl)-(C2- C6)alkenyl-; and
e) -(3- to 12-membered)heterocycle, ((3- to 12-membered)heterocycle)-(Ci -C6)aIkyl-, ((3- to 12-membered)heterocycle)-(Ci-C6)alkoxy-, -(7- to 12- membered)bicycloheterocycle, ((7- to 12-membered)bicycloheterocycle)-(Ci-C6)alkyl-, and ((7- to 12-membered)bicycloheterocycle)-(C| -C6)alkoxy-;
provided that at least one of R15a and R15b is other than hydrogen;
R16 is selected from the group consisting of hydrogen and -(C i-C6)alkyl;
Y is -(CH2)n-CH or a direct bond, provided that when Y is a direct bond then
Q
R is absent;
n is an integer 0, 1 , 2, 3, 4, 5 or 6;
s is an integer 1 , 2, 3, 4, 5, 6, 7, 8, 9, 10, 1 1 , 12, or 13;
and the pharmaceutically acceptable salts, or solvates thereof.
In one embodiment, the present invention provides novel compounds of Formula II:
(III)
wherein R1, R2, R3a, R3b, R8, 15a, R15b, Q and X are as defined above for Formula I.
In another embodiment, the present invention provides novel compounds of Formula
(IV)
wherein R1, R2, R3a, R3b, R8, Rl 5a, Rl 5b, Q and X are as defined above for Formula I.
In another embodiment, the present invention provides novel compounds of Formula V:
(V) wherein R1 , R2, R3a, R3b, R8, Rl 5a, Rl 5b, Q and X are as defined above for Formula I.
It is an object of certain embodiments of the present invention to provide new compounds that are therapeutically effective at treating a Condition, while having reduced side effects (such as opioid-induced constipation) compared to compounds currently available.
Certain Compounds of the Invention have agonist activity at the μ, δ and/or κ receptors which is greater than currently available compounds, e.g. , morphine.
Certain Compounds of the Invention have both: (i) antagonist activity at the ORL- 1 receptor; and (ii) agonist activity at one or more of the μ, δ and/or κ receptors. Certain Compounds of the Invention have both: (i) antagonist activity at the ORL-1 receptor; and (ii) agonist activity at the μ receptor. Certain compounds of the invention will have both: (i) antagonist activity at the μ receptor; and (ii) agonist activity at the κ receptor. Certain compounds of the invention will have: (i) antagonist activity at the ORL- 1 receptor; (ii) antagonist activity at the μ receptor; and (iii) agonist activity at the K receptor. Certain compounds of the invention will have: (i) antagonist activity at the μ receptor; (ii) agonist activity at the κ receptor; and (iii) antagonist activity at the δ receptor.
Compounds of the Invention may be useful as analgesics to treat, ameliorate, or prevent pain; or as agents to treat, ameliorate, or prevent addictive disorders; or as agents to treat, ameliorate, or prevent withdrawal from alcohol and/or drugs of addiction; or as agents to treat, ameliorate, or prevent pruritic conditions; or as agents to treat or prevent constipation; or as agents to treat or prevent diarrhea (each of pain, alcohol withdrawal, drug withdrawal, addictive disorders, pruritis, constipation, and diarrhea being a "Condition").
In a further aspect, the present invention provides methods for treating a Condition, comprising administering to a subject in need thereof a therapeutically effective amount of a Compound of the Invention. In certain embodiments, the Condition is pain (chronic or acute pain). The Compounds of the Invention are particularly useful for treating chronic pain.
Compounds of the Invention can be used to treat, ameliorate, or prevent acute or chronic pain. Examples of pain that can be treated, ameliorated, or prevented using a
Compound of the Invention include, but are not limited to, cancer pain, neuropathic pain, labor pain, myocardial infarction pain, pancreatic pain, colic pain, post-operative pain, headache pain, migraine pain, muscle pain, arthritic pain, and pain associated with a periodontal disease, including gingivitis and periodontitis.
Compounds of the Invention can also be used to treat, ameliorate, or prevent pain associated with inflammation or with an inflammatory disease in an animal. Such pain can arise where there is an inflammation of the body tissue which can be a local inflammatory response or a systemic inflammation. For example, a Compound of the Invention can be used to treat, ameliorate, or prevent pain associated with inflammatory diseases including, but not limited to, organ transplant rejection; reoxygenation injury resulting from organ transplantation (see Grupp et al. , J. Mol, Cell Cardiol. 31 :297-303 (1999)) including, but not limited to, transplantation of the heart, lung, liver, or kidney; chronic inflammatory diseases of the joints, including arthritis, rheumatoid arthritis, osteoarthritis and bone diseases associated with increased bone resorption;
inflammatory bowel diseases, such as ileitis, ulcerative colitis, Barrett's syndrome, and Crohn's disease; inflammatory lung diseases, such as asthma, adult respiratory distress syndrome, and chronic obstructive airway disease; inflammatory diseases of the eye, including corneal dystrophy, trachoma, onchocerciasis, uveitis, sympathetic
ophthalmitis and endophthalmitis; chronic inflammatory disease of the gum, including gingivitis and periodontitis; tuberculosis; leprosy; inflammatory diseases of the kidney, including uremic complications, glomerulonephritis and nephrosis; inflammatory disease of the skin, including sclerodermatitis, psoriasis and eczema; inflammatory diseases of the central nervous system, including chronic demyelinating diseases of the nervous system, multiple sclerosis, AIDS-related neurodegeneration and Alzheimer 's disease, infectious meningitis, encephalomyelitis, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and viral or autoimmune encephalitis;
autoimmune diseases, including Type I and Type II diabetes mellitus; diabetic complications, including, but not limited to, diabetic cataract, glaucoma, retinopathy, nephropathy (such as microaluminuria and progressive diabetic nephropathy), gangrene of the feet, atherosclerotic coronary arterial disease, peripheral arterial disease, nonketotic hyperglycemic-hyperosmolar coma, foot ulcers, joint problems, and a skin or
mucous membrane complication (such as an infection, a shin spot, a candidal infection or necrobiosis lipoidica diabeticorum), immune-complex vasculitis, and systemic lupus erythematosus (SLE); inflammatory disease of the heart, such as cardiomyopathy, ischemic heart disease hypercholesterolemia, and artherosclerosis; as well as various other diseases that can have significant inflammatory components, including
preeclampsia, chronic liver failure, brain and spinal cord trauma, and cancer.
Compounds of the Invention can also be used to treat, ameliorate, or prevent pain associated with inflammatory disease that can, for example, be a systemic inflammation of the body, exemplified by gram-positive or gram negative shock, hemorrhagic or anaphylactic shock, or- shock induced by cancer chemotherapy in response to proinflammatory cytokines, e.g., shock associated with pro-inflammatory cytokines. Such shock can be induced, e.g. , by a chemotherapeutic agent that is administered as a treatment for cancer.
The Compounds of the Invention can also be used to treat, ameliorate, or prevent pain associated with nerve injury (i.e., neuropathic pain). Chronic neuropathic pain is a heterogenous disease state with an unclear etiology. In chronic neuropathic pain, the pain can be mediated by multiple mechanisms. This type of pain generally arises from injury to the peripheral or central nervous tissue. The syndromes include pain associated with spinal cord injury, multiple sclerosis, post-herpetic neuralgia, trigeminal neuralgia, phantom pain, causalgia, and reflex sympathetic dystrophy and lower back pain. The chronic pain is different from acute pain in that chronic neuropathic pain patients suffer the abnormal pain sensations that can be described as spontaneous pain, continuous superficial burning and/or deep aching pain. The pain can be evoked by heat-, cold-, and mechano-hyperalgesia, or by heat-, cold-, or mechano-allodynia.
Chronic neuropathic pain can be caused by injury or infection of peripheral sensory nerves. It includes, but is not limited to, pain from peripheral nerve trauma, herpes virus infection, diabetes mellitus, causalgia, plexus avulsion, neuroma, limb amputation, and vasculitis. Neuropathic pain can also be caused by nerve damage from chronic alcoholism, human immunodeficiency virus infection, hypothyroidism, uremia, or vitamin deficiencies. Stroke (spinal or brain) and spinal cord injury can also induce neuropathic pain. Cancer-related neuropathic pain results from tumor growth
compression of adjacent nerves, brain, or spinal cord. In addition, cancer treatments, including chemotherapy and radiation therapy, can cause nerve injury. Neuropathic pain includes but is not limited to pain caused by nerve injury such as, for example, the pain from which diabetics suffer.
Compounds of the Invention can be used to treat, ameliorate, or prevent pain associated with migraine including, but not limited to, migraine without aura ("common migraine"), migraine with aura ("classic migraine"), migraine without headache, basilar migraine, familial hemiplegic migraine, migrainous infarction, and migraine with prolonged aura.
Another object of the invention is to provide buprenorphine analog compounds useful for treating, ameliorating, or preventing constipation, preferably μ opioid receptor-induced constipation, by administering an effective amount of a Compound of the Invention to a patient in need of such treatment or prevention. In one embodiment, the Compound of the Invention is a μ antagonist that is substantially restricted to the GI tract. In another embodiment, the Compound of the Invention is both a μ antagonist and a K agonist, and is substantially restricted to the GI tract. In another embodiment, the method comprises co-administering to a patient both an effective amount of a
Compound of the Invention that is a μ antagonist and is substantially restricted to the GI tract, and an analgesically effective amount of a μ agonist. In another embodiment, the method comprises co-administration to a patient of both an effective amount of a Compound of the Invention that is both a μ antagonist and a κ agonist, and which is substantially restricted to the GI tract, and an analgesically effective amount of a μ agonist. Compounds of the Invention that have μ antagonist activity and are
substantially restricted to the GI tract will significantly reduce or prevent constipation that would otherwise occur in a patient as a resu lt of treatment with a μ agonist. In one embodiment, the reduction or prevention of constipation is obtained without substantially reducing the desired analgesic effect of the μ agonist. Compounds of the Invention that also exhibit κ agonist activity should additionally stimulate GI motility via a ηοη-μ receptor-mediated mechanism.
In certain non-limiting embodiments, the Compound of the Invention exhibits a substantially linear dose response curve, such that the bell-shaped dose response curve
observed for most opioid analgesics (i.e. low and high doses do not produce significant analgesia, whereas mid-range doses produce analgesia) is not observed for the
Compound of the Invention. It is expected, therefore, that it wi ll be easier to titrate to an effective dose of the Compound of the Invention in a patient than it is for conventional opioid analgesics. It is further expected that the Compound of the Invention will produce effective analgesia and/or anti-hyperalgesia in a patient who has become tolerant to conventional opioids, and for whom a conventional opioid is no longer an effective treatment. It is further expected that a Compound of the Invention will produce effective analgesia and/or anti-hyperalgesia at doses that do not induce side effects such as respiratory depression in patients for whom a dose of a conventional opioid that is high enough to be an effective treatment also induces significant side effects such as respiratory depression.
In a further aspect, the present invention provides methods for preventing a Condition, comprising administering to a subject in need thereof a Condition-preventing effective amount of a Compound of the Invention.
In a further aspect, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a Compound of the Invention admixed with a pharmaceutically acceptable carrier or excipient. Such compositions are useful for treating, ameliorating, or preventing a Condition in a subject. The pharmaceutical compositions of the present invention may be formulated as immediate release formulations, or as controlled or sustained release formulations. Pharmaceutical compositions of the present invention may be formulated for administration by any of a number of different routes known in the art, including but not limited to, oral, intradermal, intramuscular, intraperitoneal, parenteral, intravenous, subcutaneous, intranasal, epidural, sublingual, intracerebral, intravaginal, transdermal, transmucosal, rectal, by inhalation, or topical (particularly to the ears, nose, eyes, or skin).
In a further aspect, the present invention provides methods for preparing a composition, comprising the step of admixing a Compound of the Invention and a pharmaceutically acceptable carrier or excipient to form a pharmaceutical composition.
In a further aspect, the invention still further relates to a kit comprising a sterile container containing an effective amount of a Compound of the Invention, and instructions for therapeutic use.
DETAILED DESCRIPTION OF THE INVENTION
The Compounds of the Invention are novel buprenorphine analogs. They are useful for treating, ameliorating, or preventing one or more Conditions, such as pain or constipation. Compounds of the Invention may provide a reduced liability for developing analgesic tolerance and physical dependence.
The Compounds of the Invention are useful for modulating a pharmacodynamic response from one or more opioid receptors (μ, δ, κ, or ORL- 1) either centrally or peripherally, or both. The pharmacodynamic response may be attributed to the compound stimulating (agonizing) or inhibiting (antagonizing) the one or more receptors. Certain Compounds of the Invention may inhibit (or antagonize) the ORL- 1 receptor, while also stimulating (or agonizing) one or more other receptors (e.g. as a μ, δ and/or κ agonist). Compounds of the Invention having agonist activity may be either full or partial agonists.
In certain embodiments, Compounds of the Invention can be used in
combination with at least one other therapeutic agent. The other therapeutic agent can be, but is not limited to, a μ-opioid agonist, a non-opioid analgesic, a non-steroidal antiinflammatory agent, a Cox-II inhibitor, an anti-emetic, a β-adrenergic blocker, an anticonvulsant, an antidepressant, a Ca2+-channel blocker, an anticancer agent, or a mixture thereof.
Various objects and advantages of the present invention will become apparent from the following detailed description.
Item 1. The present invention provides novel compounds of Formula 1:
wherein
R1 is selected from the group consisting of hydrogen, -(Ci-C io)alkyl, -(C2- C,2)alkenyl, -(C2-C,2)alkynyl, -(C, -Ci0)alkoxy, -(C3-C,2)cycloalkyl, -(C4- Ci2)cycloalkenyl, ((C3-C i2)cycloalkyl)-(C|-C6)alkyl-, ((C4-C |2)cycloalkenyl)-(Cr C6)alkyl-, -(6- to 14-membered)aryl, ((6- tol 4-membered)aryl)-(C| -C6)alkyl-, -(5- to 12-membered)heteroaryl, ((5- to l 2-membered)heteroaryI)-(C i -C6)alkyl-, -(3- to 12- membered)heterocycle, ((3- to 12 membered)heterocycle)-(C i-C6)alkyl-, phenyl, and benzyl; any of which is optionally substituted with 1 , 2, or 3 substituents each independently selected from the group consisting of -(C| -C6)alkyl, OH, halo, -C(halo)3, -CH(halo)2, -CH2(halo), -(C,-C6)alkyl-COOR7, -COOR7, NH2, -NH(C rC6)alkyl, - NR9R10, -CN, -CONR9R10, -NR9COR10, -SR9, -(5- to 12-membered)carbocyclic ring, - (5- to 12-membered)heterocycle, phenyl, and benzyl;
R2 and R8 are each independently selected from the group consisting of hydrogen, -(C C|0)alkyl, -(C2-C12)alkenyl, -(C2-Ci2)alkynyl, -CONR5R6, -COOR7, -(6- to 14-membered)aryl, ((6- to 14-membered)aryl)-(C | -C6)alkyl-, -(5- to 12- membered)heteroaryl, and ((5- to 12-membered)heteroaryl)-(C] -C6)alkyl-; each of which is optionally substituted with 1 , 2, or 3 substituents independently selected from the group consisting of -OH, (=0), halo, -C(halo)3, -CH(halo)2, -CH2(halo), -(Cr
C6)alkyl, halo(C ,-C6)alkyl-, -(C2-C6)alkenyl, -(C2-C6)alkynyl, hydroxy(C,-C6)alkyl-, dihydroxy(Ci-C6)alkyl-, -(C i -C6)alkoxy, ((Ci -C6)alkoxy)-CO-(Ci-C6)alkoxy-, phenyl, benzyl, -NH2, -NH(C,-C6)alkyl, -(C1-C6)alkyl-NH(C ,-C6)alkyl-R14, -CN, -SH, -OR4, -CONR5R6, -(C,-C6alkyl)-CO-NR5R6, -COOR7, and -(C,-C6)aIkyl-CO-OR7;
R3a and R3b are each independently selected from the group consisting of hydrogen, -(C | -C ,0)alkyl, -(C2-C i0)alkenyl, -(C2-Ci0)alkynyl, -CONR5R6, -COOR7, or together form (=0);
R4 is selected from the group consisting of -(Ci-C6)alkyl, -(C2-C6)alkenyl, -(C2- C6)alkynyl, -C(halo)3, -CH(halo)2, -CH2(halo), hydroxy(C , -C6)alkyl-, -(C3- Ci2)cycloalkyl,
((C3-C|2)cycloalkyl)-(C,-C6)alkyl-, -(6- to 14-membered)aryl, ((6- to 14- membered)aryl)-(C | -C6)alkyl-, -(5- to 12-membered)heteroaryl, and ((5- to 12- membered)heteroaryl)-(Ci -C6)alkyl-;
R5 and R6 are each independently selected from the group consisting of hydrogen, - (C i-C6)alkyl, -(C3-C8)cycloalkyl, ((C3-C8)cycloalkyl)-(C ,-C6)alkyl-, -COOR7, -(C r C6)alkyl-CO-OR7, -CONH2, and (C| -C6)alkyl-CONH-, or R5 and R6 together with the nitrogen atom to which they are attached form a (4- to 8-membered)heterocycle;
R7 is selected from the group consisting of hydrogen, -(C i-C6)alkyl, -(C2-C6)alkenyl, - (C2-C6)alkynyl, -(C3-C]2)cycloalkyl, -(C4-C | 2)cycloalkenyl, ((C3-Ci2)cycloalkyl)-(C]- C6)alkyl-, and ((C -Ci2)cycloatkenyl)-(C i-C6)alkyl- ;
R9 and R10 are each independently selected from the group consisting of hydrogen, - (C,-C6)alkyl, -(C2-C6)alkenyl, -(C2-C6)alkynyl, -(Ci-C,0)alkoxy, -(C3-C,2)cycloalkyl, - (C4-Ci2)cycloalkenyl, ((C3-C i2)cycloalkyl)-(Ci-C6)alkyl-, and ((C4-Ci )cycloalkenyl)- (C ,-C6)alkyl-;
R12 and R13 are each independently selected from the group consisting of hydrogen, - (C,-C,o)alkyl. -(C2-Cl 2)alkenyl, -(C2-C12)alkynyl, -(C , -C 10)alkoxy, -(OCH2CH2)s-0(C ,- C6)alkyl, -(C3-C 12)cycloalkyl, ((C3-C l2)cycloalkyl)-(C,-C6)alkyl-, -(C4- C |2)cycloalkenyl, ((C4-Ci2)cycloalkenyl)-(C] -C6)alkyl-, -(C6-C i4)bicycloalkyl, ((C6- C ,4)bicycIoaIky 1)-(C i -C6)alky 1-, -(C8-C2o)tricycloalky 1, ((C8-C2o)tricycloalky l)-(C i - C6)alkyl-, -(C7-C| )bicycloalkenyl, ((C7-C|4)bicycloalkenyl)-(Ci-C6)alkyl-, -(C8- C o)tricycloalkenyl, ((C8-C2o)tricycloalkenyl)-(Ci-C6)alkyl-, -(6- to 14-membered)aryl,
((6- to l4-membered)aryl)-(Ci-C6)alkyl-, -(7- to 12-membered)bicyclic ring system, ((7- to 12-membered)bicyclic ring system)-(C i -C6)alkyl-, -(7- to 12-membered)bicyclic aryl, ((7- to 12-membered)bicyclic aryl)-(C rC6)alkyl-, -(5- to 12-membered)heteroaryl, ((5- to 12-membered)heteroaryl)-(C] -C6)alkyl-, -(3- to 12-membered)heterocycle, ((3- to 12- membered)heterocycle)-(C i-C6)alkyl-, -(7- to 12-membered)bicycloheterocycle, ((7- to 12-membered)bicycloheterocycle)-(C ] -C6)alkyl-, phenyl, benzyl and naphthyl; each of which is optionally substituted with 1 or 2 substituents independently selected from the group consisting of OH, (=0), halo, -C(halo)3, -CH(halo)2, -CH2(halo), -(C,-C6)alkyl, halo(C i -C6)alkyl-, -(C2-C6)alkenyl, -(C2-C6)alkynyl, hydroxy(C i-C6)aIkyl-, phenyl, benzyl, NH2,
-NH(C i-C6)alkyl, CN, SH, OR4, -CONR5R6, -COOR7, -(C3-C,2)cycloalkyl,
((C3-C i2)cycloalkyl)-(Ci-C6)alkyl-, -(6- to 14-membered)aryl, ((6- to 14- membered)aryl)-(Ci -C6)alkyl-, -(5- to 12-membered)heteroaryl, ((5- to 1 2- membered)heteroaryl)-(Ci -C6)alkyl-, -(3- to 12-membered)heterocycle, ((3- to 12- membered)heterocycle)-(C i -C6)alkyl-, -(7- to 12-membered)bicycloheterocycle, and ((7- to 12-membered)bicycloheterocycle)-(C i -C6)alkyl-;
R14 is selected from the group consisting of -COOR7, -(C| -C6)alkyl-CO-OR7, -C(=0)- (C|-C6)alkyl-COOR7, -(C, -C6)alkyl-C(=0)-(Cl -C6)alkyl-COOR7, -CONH2, and (C ,- C6)alkyl-CONH-;
G is selected from the group consisting of CH2, NR16, or O;
X is selected from the group consisting of-(C| -C io)alkoxy, OH, hydroxy(C r C6)alkyl-, dihydroxy(C,-C6)alkyl-, halogen, -NH2, -NR2(C=0)R12, and -CONRl 2R13;
Q is selected from the group consisting of OH, -(C i-Cio)alkoxy, -(C i-Cio)alkyl, -O- (C|-C6)alkyl, -(6- to 14-membered)aryl, -0-((6- to 14-membered)aryl), ((6- to 14- membered)aryl)-(C|-C6)alkyl-, -0-((6- to 14-membered)aryl)-(C rC6)alkyl, (5- to 12- membered)heteroaryl, -0-((5- to 12-membered)heteroaryl), ((5- to 12- membered)heteroaryl)-(C i-C6)alkyl-, -0-((5- to 12-membered)heteroaryl-(C| -C6)alkyl,;
Rl 5a and R15b are each independently selected from the group consisting of: hydrogen, OH;
b) saturated, unsaturated, or partially saturated -(C3-Ci2)cycloalkyl, ((C3-Ci2)cycloalkyl)- (C,-C6)alkyh ((C3-C ,2)cycloalkyl)-(C2-C6)aikenyl-, ((C3-C|2)cycloalkyl)-(C i- C6)alkoxy-;
c) -(6- to 14-membered)aryl, ((6- to 14-membered)aryl)-(C|-C6)alkyl-, ((6- to 14- membered)aryl)-(Ci-C6)alkoxy-, ((6- to 14-membered)aryl)-(C2-C )alkenyl-;
d) -(5- to 12-membered)heteroaryl, ((5- to 12-membered)heteroaryl)-(C| -C6)alkyl-, ((5- to 12-membered)heteroaryl)-(Ci -C6)alkoxy-, ((5- to 12-membered)heteroaryl)-(C2- C6)alkenyl-; and
e) -(3- to 12-membered)heterocycle, ((3- to 12-membered)heterocycle)-(Ci-C6)alkyl-, ((3- to 12-membered)heterocycle)-(C i-C6)alkoxy-, -(7- to 12- membered)bicycloheterocycle, ((7- to 12-membered)bicycloheterocycle)-(Ci-C6)alkyl-, and ((7- to 12-membered)bicycloheterocycle)-(C| -C6)alkoxy-.
provided that at least one of Kl yd and Rl 5b is other than hydrogen;
R16 is selected from the group consisting of hydrogen or -(Ci-C6)alkyl;
Y is -(CH2)n-CH or a direct bond, provided that when Y is a direct bond then R8 is absent;
n is an integer 0, 1 , 2, 3, 4, 5 or 6;
s is an integer.1 , 2, 3, 4, 5, 6, 7, 8, 9, 10, 1 1 , 12, or 13;
and the pharmaceutically acceptable salts, or solvates thereof.
Item 2. In one embodiment of Item 1 , the present invention provides novel compounds of Formula II:
wherein R1 , R2, R3a, R3b, R8, R15a, Rl 5b, Q and X are as defined above for Formula I.
Item 3. In another embodiment Item 1 , the present invention provides novel compounds of Formula III:
("I) wherein R1, R2, R3a, R3b, R8, RI 5a, R15b, Q and X are as defined above for Formula I.
Item 4. In another embodiment of Item 1 , the present invention provides novel compounds of Formula IV:
Item 5. In another embodiment of Item 1 , the present invention provides novel compounds of Formula V:
Item 7. In one embodiment of Item 6, G is R16, wherein R 16 is hydrogen.
Item 8. In another embodiment of any one of Items 1 to 5, G is CH2.
Item 9. In another embodiment of any one of Items 1 to 5, G is O.
Item 10. In one embodiment of any one of Items I to 9, at least one of Ri 5a or R15b is - (6- to 14-membered)aryl.
Item 1 1. In one embodiment of Item 10, at least one of R133 or Rl 5b is phenyl.
Item 12. In another embodiment of any one of Items 1 to 9, at least one of Rl 5a or R sb is (6- to 14-membered)aryl-(C| -C6)alkyl-.
item 13. In one embodiment of Item 12, at least one of R133 or Rl :)b is benzyl.
Item 14. In another embodiments of any one of Items 1 to 9, at least one of R15a or Rl 5b is hydrogen.
Item 1 5. In another embodiment of any one of Items 1 to 9, at least one of R133 or Rl 5b is OH.
Item 16. In one embodiment of any one of Items 1 to 9, at least one of R2 or R8 is - (C ,-C10)alkyl.
Item 1 7. In another embodiment of any one of Items I to 9 or 16, at least one of R2 or R8 is -(Ci-Cio)alkyl substituted with -COOR7.
Item 18. In certain embodiments of Item 17, R7 is hydrogen.
Item 19. In another embodiment of any one of Items 1 to 9<or 16, at least one of R2 or R8 is -(Ci -Cio)alkyl substituted with -CONR5R6.
Item 20. In certain embodiments of Item 19, R5 and R6 are both hydrogen.
Item 21. In another embod iment of any one of Items 1 to 9, at least one of R2 or R8 is -(6- to 14-membered)aryl.
Item 22. In one embodiment of Item 21 , at least one of R2 or R8 is phenyl.
Item 23. In another embodiment, at least one of R2 or R8 is (6- to 14-membered)aryl- (C ,-C6)alkyl-.
Item 24. In one embodiment of Item 23, at least one of R2 or R8 is benzyl.
Item 25. In another embodiment of any one of Items 1 to 9, at least one of R2 or R8 is COOR7.
Item 26. In certain embodiments of Item 25, R2 is COOR7 and R8 is -(6- to 14- membered)aryl.
Item 27. In certain embodiments of any one of Items 1 to 26, R1 is cyclopropylmethyl.
Item 28. In one embodiment of any one of Items I to 27, X is selected from the group consisting of-(C |-C i0)alkoxy, OH, hydroxy(Ci -C6)alkyl-, dihydroxy(Ci-C6)alkyl-, halogen, -NH2, and -NR2(C=0)R12.
Item 29. In certain embodiments of any one of Items 1 to 28, X is -(C i-Cio)alkoxy.
Item 30. In one embodiment of Item 29, X is methoxy.
Item 3 1 . In another embodiment of Item 29, X is ethoxy.
Item 32. In another embodiment of any one of Items 1 to 28, X is OH.
Item 33. In one embodiment of any one of Items 1 to 28, X is halogen.
Item 34. In certain embodiments of any one of Items 1 to 33, Q is -(C i-Cio)alkoxy.
Item 35. In one embodiment of Item 34, Q is methoxy.
Item 36. In another embodiment of Item 34, Q is ethoxy.
Item 37. In another embodiment of any one of Items 1 to 33, Q is OH.
Item 38. In certain embodiments of any one of Items 1 to 37, Y is CH2.
Item 39. In certain embodiments of any one of Items 1 to 5, Y is CH2, R8 is -(6- to 14-membered)aryl, and R2 is COOR7.
Item 40. In certain embodiments of any one of Items I to 5, Y is CH2, R8 is (6- to 14- membered)aryl-(Ci-C6)alkyl-, and R2 is COOR7.
Item 41. In certain embodiments of any one of Items 1 to 5, Y is CH2, R8 is -(6- to 14-membered)aryl, and R2 is -(Ci-Ct 0)alkyl substituted with -CONR5R6.
Item 42. In certain embodiments of any one of Items 1 to 5, Y is CH2, R8 is (6- to 14- membered)aryl-(Ci-C6)alkyl-, and R2 is -(C i-C|0)alkyl substituted with -CONR5R6.
Item 43. In one embodiment of any one of Items 1 to 5, at least one of R2 or R8 is -(6- to 14-membered)aryl, and at least one of Rl 5a or R15b is -(6- to 14-membered)aryl.
Item 44. In one embodiment of any one of Items 1 to 5, at least one of R2 or R8 is (6- to 14-membered)aryl-(C| -C6)alkyl-, and at least one of R15a or Rl 5b is -(6- to 14- membered)aryl.
Item 45. In one embodiment of any one of Items 1 to 5, at least one of R2 or R8 is to 14-membered)aryl, and at least one of R15a or R15b is (6- to 14-membered)aryl-(Ci Q alkyk
Item 46. In one embodiment of any one of Items 1 to 5, at least one of R2 or R8 is to 14-membered)aryl-(Ci-C6)alkyl-, and at least one of Rl 5a or Rl 5b is (6- to 14- membered)aryl-(Ci-C6)alkyl-.
Compounds of the invention include:
(4i?)-4-((4i?,4a5,,6i?,7^,7ai?, 12b5)-3-(cyclopropylmethyl)-7,9-dimethoxy- l ,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4, 12-methanobenzofuro[3,2-e]isoquinolin-6- 4-phenylbutane- l ,2,4-triol (Compound 6);
2-(((5)-((4i?,4a5,6i?;7i?,7ai?, 12b5)-3-(cyclopropylmethyl)-7,9-dimethoxy- l ,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4, 12-methanobenzofuro[3,2-e]isoquinolin-6- yl)(phenyl)methyl)amino)acetic acid (Compound 12);
2-(((5*)-((4i?,4a5',6i?,7i?,7ai?, 12b5)-3-(cyclopropylmethyl)-7,9-dimethoxy- 1 ,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4, 12-methanobenzofuro[3,2-e]isoquinolin-6- yl)(phenyl)methyl)arnino)propanoic acid (Compound 13);
2-(((5)-((4i?,4a5',6i?,7 ?,7ai?, 12b5)-3-(cyclopropylmethyl)-7,9-dimethoxy- 1 ,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4, 12-methanobenzofuro[3,2-e]isoquinolin-6- yl)(phenyl)methyl)amino)-2-phenylacetic acid (Compound 15);
2-(((5)-((4i?,4a5,6i?,7i?,7ai?, 12b5)-3-(cyclopropylmethyl)-7,9-dimethoxy- 1 ,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4, 12-methanobenzofuro[3,2-e]isoquinolin-6- yl)(phenyl)methyl)amino)propanamide (Compound 14);
( ?)-2-(((5)-((4i?,4a5,6i?,7i?,7ai?, 12b5)-3-(cyclopropylmethyl)-7,9-dimethoxy 1 ,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4, 12-methanobenzofuro[3,2-e]isoquinolin-6- yl)(phenyl)methyl)amino)-2-phenylacetamide (Compound 16); and
(5)-2-(((5)-((4i?,4aS,6i?,7i?,7ai?, 12b5)-3-(cyclopropylmethyl)-7,9-dimethoxy- 1 ,2, 3,4,5,6,7, 7a-octahydro-4a,7-ethano-4, 12-methanobenzofuro[3,2-e]isoquinolin-6- yl)(phenyl)methyl)amino)-2-phenylacetamide (Compound 17).
In one embodiment, G is NR16.
In another embodiment, G is NR.16, wherein R16 is hydrogen.
In another embodiment, G is CH2.
In another embodiment, G is O.
In one embodiment, at least one of Rl 5a or Rl 5b is -(6- to 14-membered)aryl.
In another embodiment, at least one of R15a or Rl 5b is phenyl.
In another embodiment, at least one of Rl 5a or Rl 5b is (6- to 14-membered)aryl-(C | - C6)alkyl-.
In another embodiment, at least one of R15a or Rl 5b is benzyl.
In another embodiments, at least one of R15a or Rl 5b is hydrogen.
In another embodiments, at least one of Rl 5a or R15b is OH.
In one embodiment, at least one of R" or R is -(Ci -C io)alkyl .
In another embodiment, at least one of R or R is -(C i -C io)alkyl substituted with - COOR7. In certain embodiments, R7 is hydrogen.
In another embodiment, at least one of R2 or R8 is -(C i -Cio)alkyl substituted with - CONR R . In certain embodiments, R and R are both hydrogen.
In another embodiment, at least one of R2 or R8 is -(6- to 14-membered)aryl.
In another embodiment, at least one of R2 or R8 is phenyl.
In another embodiment, at least one of R2 or R8 is (6- to 14-membered)aryl-(C | - C6)alkyl-.
In another embodiment, at least one of R2 or R8 is benzyl.
In another embodiment, at least one of R2 or R8 is COOR7.
2 7 8
In certain embodiments, R is COOR and R is -(6- to 14-membered)aryl.
In certain embodiments, R1 is cyclopropylmethyl.
In certain embodiments, X is -(C i -C io)alkoxy.
In another embodiment, X is methoxy.
In another embodiment, X is ethoxy.
In another embodiment, X is OH.
In certain embodiments, Q is -(C i -C io)alkoxy.
In another embodiment, Q is methoxy.
In another embodiment, Q is ethoxy.
In another embodiment, Q is OH.
In certain embodiments, Y is CH.
8 · 2 * 7
In certain embodiments, Y is CH, R is -(6- to 14-membered)aryl, and R is COOR .
8 2
In certain embodiments, Y is CH, R is (6- to l 4-membered)aryl-(Ci-C6)alkyl-, and R is COOR7.
8 · 2
In certain embodiments, Y is CH, R is -(6- to 14-membered)aryl, and R is -(C | - C,o)alkyl substituted with -CONR5R6.
8 ^
In certain embodiments, Y is CH, R is (6- to 14-membered)aryl-(C | -C6)alkyl-, and R~ is -(C,-Cl0)alkyl substituted with -CONR5R6.
2 8
In another embodiment, at least one of R or R is -(6- to 14-membered)aryl, and at least one of Rl 5a or R15b is -(6- to 14-membered)aryl.
2 8
In another embodiment, at least one of R or R is (6- to 14-membered)aryl-(Ci - C6)alkyl-, and at least one of R15a or R15b is -(6- to 14-membered)aryl.
In another embodiment, at least one of R2 or R8 is -(6- to 14-membered)aryl, and at least one of R15a or Rl 5b is (6- to 14-membered)aryl-(Ci -C6)alkyl-.
2 8
In another embodiment, at least one of R or R is (6- to 14-membered)aryl-(C | - C6)alkyl-, and at least one of R15a or Rl 5b is (6- to 14-membered)aryl-(C |-C6)alkyl-.
As used herein, the term "-(Ci-C io)alkyl" refers to straight-chain and branched non-cyclic saturated hydrocarbons having from 1 to 10 carbon atoms. Representative straight chain -(Ci-C m) alkyl groups include methyl, -ethyl, -n-propyl, -n-butyl, -n- pentyl, -n-hexyl, n-heptyl, n-octyl, n-nonyl and n-decyl. Representative branched -(Ci- Cio)alkyl groups include isopropyl, sec-butyl, isobutyl, tert-butyl, isopentyl, neopentyl, 1 -methylbutyl, 2-methylbutyl, 3-methylbutyl, 1 , 1 -dimethylpropyl, 1 ,2- dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1 - ethylbutyl, 2-ethylbutyl, 3-ethylbutyl, 1 , 1 -dimethylbutyl, 1 ,2-dimethylbutyl, 1 ,3- dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 5-methylhexyl, 6-methylheptyl, and the like.
As used herein, the term "-(Ci-C6)alkyl" refers to straight-chain and branched non-cyclic saturated hydrocarbons having from 1 to 6 carbon atoms. Representative straight chain -(C i -C6)alkyl groups include methyl, -ethyl, -n-propyl, -n-butyl, -n- pentyl, and -n-hexyl. Representative branched-chain -(C i -C6)alkyl groups include
isopropyl, sec-butyl, isobutyl, tert-butyl, isopentyl, neopentyl, l -methylbutyl, 2- methylbutyl, 3-methylbutyl, 1 , 1 -dimethylpropyl, and 1 ,2-dimethylpropyl, methylpentyl,
2- methylpentyl, 3-methyIpentyl, 4-mehtylpentyl, I -ethylbutyl, 2-ethylbutyl, 3- ethylbutyl, 1 , 1 -dimethylbutyl, 1 ,2-dimethylbutyl, 1 ,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, and the like.
As used herein, the term "-(C2-C i 2)alkenyl" refers to straight chain and branched non-cyclic hydrocarbons having from 2 to 12 carbon atoms and including at least one carbon-carbon double bond. Representative straight chain and branched -(C2- C|2)alkenyl groups include -vinyl, allyl, - 1 -butenyl, -2-butenyl, -isobutylenyl, - 1 - pentenyl, -2-pentenyl, -3-methyl- 1 -butenyl, -2-methyl-2-butenyl, -2,3-dimethyl-2- butenyl, - 1 -hexenyl, -2-hexenyl, 3-hexenyl, and the like.
As used herein, the term "-(C2-C6)alkenyl" refers to straight chain and branched non-cyclic hydrocarbons having from 2 to 6 carbon atoms and including at least one carbon-carbon double bond. Representative straight chain and branched -(C2- C6)alkenyl groups include -vinyl, allyl, - 1 -butenyl, -2-butenyl, -isobutylenyl, - 1 - pentenyl, -2-pentenyl, -3-methyl- 1 -butenyl, -2-methyl-2-butenyl, 1 -hexenyl, 2-hexenyl,
3- hexenyl and the like.
As used herein, the term "-(C2-C i2)alkynyl" refers to straight chain and branched non-cyclic hydrocarbons having from 2 to 12 carbon atoms and including at least one carbon-carbon triple bond. Representative straight chain and branched -(C2- Ci2)alkynyl groups include -ethynyl, -propynyl, - I butynyl, -2-butynyl, - 1 -pentynyl, -2- pentynyl, -3-methyl- 1 -butynyl, -4-pentynyl, -1 -hexynyl, -2-hexynyl, -5-hexynyl, and the like.
As used herein, the term "-(C2-C6)alkynyl" refers to straight chain and branched non-cyclic hydrocarbons having from 2 to 6 carbon atoms and including at least one carbon-carbon triple bond. Representative straight chain and branched -(C2-C6)alkynyl groups include -ethynyl, -propynyl, - 1 butynyl, -2-butynyl, - 1 -pentynyl, -2-pentynyl, - 3-methyl- 1 -butynyl, -4-pentynyl, and the like.
As used herein, "-(Ci-Cio)alkoxy" means a straight chain or branched non-cyclic hydrocarbon having one or more ether groups and from 1 to 10 carbon atoms. Representative straight chain and branched (Ci-C io)alkoxys include -methoxy, -
ethoxy, -propoxy, -butyloxy, -pentyloxy, -hexyloxy, -heptyloxy, -methoxymethyl, -2- methoxyethyl, -5-methoxypentyl, -3-ethoxybutyl and the like.
As used herein, "-(C | -C6)alkoxy" means a straight chain or branched non-cyclic hydrocarbon having one or more ether groups and from 1 to 6 carbon atoms.
Representative straight chain and branched (C|-C6)alkoxys include -methoxy, -ethoxy, - propoxy, -butyloxy, -pentyloxy, -hexyloxy, -methoxymethyl, -2-methoxyethyl, -5- methoxypentyl, -3-ethoxybutyl and the like.
As used herein, "-(Ci-C5)alkoxy" means a straight chain or branched non-cyclic hydrocarbon having one or more ether groups and from 1 to 5 carbon atoms. Representative straight chain and branched (Ci-C5)alkoxys include -methoxy, -ethoxy, - propoxy, -butyloxy, -pentyloxy, -methoxymethyl, -2-methoxyethyl, -5-methoxypentyl, - 3-ethoxybutyl and the like.
As used herein, the term "-(C3-C i2)cycloalkyl" refers to cyclic saturated hydrocarbon having from 3 to 12 carbon atoms. Representative (C3-C i2)cycloalkyls include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, and cyclononyl, cyclodecyl, cycloundecyl, cyclododecyl, and the like.
As used herein, "-(C6-C i4)bicycloalkyl" means a bicycl ic hydrocarbon ring system having from 6 to 14 carbon atoms and at least one saturated cyclic alkyl ring. Representative -(C6-Ci4)bicycloalkyls include -indanyl, -norbornyl, - 1 ,2,3,4- tetrahydronaphthalenyl, -5,6,7,8-tetrahydronaphthalenyl, -perhydronaphthalenyl, and the like.
As used herein, "-(Cg-C2o)tricycloalkyl" means a tricyclic hydrocarbon ring system having from 8 to 20 carbon atoms and at least one saturated cyclic alkyl ring. Representative -(C8-C2o)tricycloalkyls include -pyrenyl, -adamantyl, - 1 ,2,3,4- tetrahydroanthracenyl, -perhydroanthracenyl -aceanthrenyl, - 1 ,2,3,4- tetrahydropenanthrenyl, -5,6,7, 8-tetrahydrophenanthrenyl, -perhydrophenanthrenyl, tetradecahydro- lH-cyclohepta[a]naphthalenyl, tetradecahydro- l H-cycloocta[e]indenyl, tetradecahydro- lH-cyclohepta[e]azulenyl, hexadecahydrocycloocta[£]naphthalenyl, hexadecahydrocyclohepta[a]heptalenyl, tricyclo-pentadecanyl, tricyclo-octadecanyl, tricyclo-nonadecanyl, tricyclo-icosanyl, and the like.
As used herein, the term "-(C4-Ci2)cycloalkenyl" refers to a cyclic, preferably mono- or bicyclic, hydrocarbon having from 4 to 12 carbon atoms, and including at least one carbon-carbon double bond. Representative -(C3-C i2)cycloalkenyls include - cyclobutenyl, -cyclopentenyl, -cyclopentadienyl, -cyclohexenyl, -cyclohexadienyl, - cycloheptenyl, -cycloheptadienyl, -cycloheptatrienyl, -cyclooctenyl, -cyclooctadienyl, - cyclooctatrienyl, -cyclooctatetraenyl, -cyclononenyl, -cyclononadienyl, -cyclodecenyl, - cyclodecadienyl, -norbornenyl, and the like.
As used herein, "-(C7-C i4)bicycloalkenyl" means a bi-cyclic hydrocarbon ring system having at least one carbon-carbon double bond in at least one of the rings and from 7 to 14 carbon atoms. Representative -(C7-C i4)bicycloalkenyls include - bicyclo[3.2.0]hept-2-enyl, -indenyl, -pentalenyl, -naphthalenyl, -azulenyl, -heptalenyl, - 1 ,2,7,8-tetrahydronaphthalenyl, and the like.
As used herein, "-(C8-C2o)tricycloalkenyl" means a tri-cyclic hydrocarbon ring system having at least one carbon-carbon double bond in one of the rings and from 8 to 20 carbon atoms. Representative -(Cg-C2o)tricycloalkenyls include -anthracenyl, - phenanthrenyl, -phenalenyl, -acenaphthalenyl, as-indacenyl, s-indacenyl,
2,3,6,7,8,9, 10, 1 1 -octahydro- 1 H-cycloocta[e] indenyl, 2,3,4,7,8,9, 10, 1 1 -octahydro- 1 H- cyclohepta[a]naphthaIenyl, 8,9, 10, 1 1 -tetrahydro-7H-cycIohepta[a]naphthalenyl, 2,3,4,5,6,7,8,9, 10, 1 1 , 12, 13-dodecahydro- lH-cyclohepta[o]heptalenyl,
1 ,2,3,4,5,6,7,8,9, 10, 1 1 , 12, 13, 14-tetradecahydro-dicyclohepta[a,c]cyclooctenyl, 2,3,4,5,6,7,8,9, 10, 1 1 , 12, 13-dodecahydro- l H-dibenzo[a,i ]cyclononenyl, and the l ike.
As used herein, "-(3- to 12-membered)heterocycle" or "-(3- to 12- membered)heterocyclo" means a 3- to 12-membered monocyclic heterocyclic ring which is either saturated, partially unsaturated, or non-aromatic. A 3-membered heterocycle can contain up to 1 heteroatom; a 4-membered heterocycle can contain up to 2 heteroatoms; a 5-membered heterocycle can contain up to 4 heteroatoms; a 6- membered heterocycle can contain up to 4 heteroatoms; and a 7-membered heterocycle can contain up to 5 heteroatoms. Each heteroatom is independently selected from nitrogen (which can be quaternized), oxygen, and sulfur (including sulfoxide and sulfone). The -(3- to 12-membered)heterocycIe can be attached via a nitrogen or carbon atom. Representative -(3- to 12-membered)heterocycles include thiazolidinyl,
morpholinyl, pyrrolidinonyl, pyrrolidinyl, piperidinyl, piperazinyl, 2,3-dihydrofuranyl, dihydropyranyl, hydantoinyl, valerolactamyl, oxiranyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, dihydropyridinyl, tetrahydropyridinyl, tetrahydropyrimidinyl, tetrahydrothiophenyl, tetrahydrothiopyranyl, and the like.
As used herein, "-(4- to 8-membered)heterocycle" or "-(4- to 8- membered)heterocyclo" means a 4- to 8-membered monocyclic heterocyclic ring which is either saturated, partially unsaturated, or non-aromatic. A 4-membered heterocycle can contain up to 2 heteroatoms; a 5-membered heterocycle can contain up to 4 heteroatoms; a 6-membered heterocycle can contain up to 4 heteroatoms; and a 7- membered heterocycle can contain up to 5 heteroatoms. Each heteroatom is independently selected from nitrogen (which can be quaternized), oxygen, and sulfur (including sulfoxide and sulfone). The -(4- to 8-membered)heterocycle can be attached via a nitrogen or carbon atom. Representative -(4- to 8-membered)heterocycles include morpholinyl, piperidinyl, piperazinyl, 2,3-dihydrofuranyl, dihydropyranyl, hydantoinyl, valerolactamyl, oxiranyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl,
dihydropyridinyl, tetrahydropyridinyl, tetrahydropyrimidinyl, tetrahydrothiophenyl, tetrahydrothiopyranyl, and the like.
As used herein, "-(5- to l 2-membered)heterocycle" or "-(5- to 12- membered)heterocyclo" means a 5- to 12-membered monocyclic or bicyclic heterocyclic ring which is either saturated, partially unsaturated, or non-aromatic. A 5- membered heterocycle can contain up to 4 heteroatoms; a 6-membered heterocycle can contain up to 4 heteroatoms; and a 7-membered heterocycle can contain up to 5 heteroatoms. Each heteroatom is independently selected from nitrogen (which can be quaternized), oxygen, and sulfur (including sulfoxide and sulfone). The -(5- to 12- membered)heterocycle can be attached via a nitrogen or carbon atom. Representative -(5- to 12-membered)heterocycles include morpholinyl, piperidinyl, piperazinyl, 2,3- dihydrofuranyl, dihydropyranyl, hydantoinyl, valerolactamyl, oxiranyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, dihydropyridinyl, tetrahydropyridinyl, tetrahydropyrimidinyl, tetrahydrothiophenyl, tetrahydrothiopyranyl, and the like.
As used herein, "-(7- to 12-membered)bicycloheterocycle" or "-(7- to 12- membered)bicycloheterocyclo" means a 7- to 12-membered bicyclic, heterocyclic ring which is either saturated, partially unsaturated, ornon-aromatic. At least one ring of the bicycloheterocycle contains at least one heteroatom. A -(7- to 12- membered)bicycloheterocycle contains from 1 to 4 heteroatoms independently selected from nitrogen (which can be quaternized), oxygen, and sulfur (including sulfoxide and sulfone). The -(7- to 12-membered)bicycloheterocycle can be attached via a nitrogen or carbon atom. Representative -(7- to 10-membered)bicycloheterocycles include
-quinolinyl, -isoquinol inyl, -chromonyl, -coumarinyl, -indolyl, -indolizinyl,
-benzo[b]furanyl, -benzo[b]thiophenyl, -indazolyl, -purinyl, -4H-quinolizinyl,
-isoquinolyl, -quinolyl, -phthalazinyl, -naphthyridinyl, -carbazolyl, -β-carbolinyl, - indolinyl, isoindolinyl, - 1 ,2,3,4-tetrahydroquinolinyl, - 1 ,2,3,4-tetrahydroisoquinolinyl, pyrrolopyrrolyl and the like.
As used herein a "-(6- to 14- membered)aryl" means an aromatic carbocyclic ring containing 6 to 14 carbon atoms, including both mono-, bi-, and tricyclic ring systems. Representative -(6- to 14-membered)aryl groups include -indenyl, -phenyl, - naphthyl, anthracenyl and the like.
As used herein a "-(7- to 12- membered)bicyclic aryl" means a bicyclic aromatic carbocyclic ring containing 7 to 12 carbon atoms. Representative -(7- to 12-membered) bicyclic aryl groups include -indenyl, -naphthyl, and the like.
As used herein a "-(6- to 14- membered)aryloxy" means an oxygen substituted by an aromatic carbocycl ic ring containing 6 to 14 carbon atoms, including both mono-, bi- and tricyclic ring systems. Representative -(6- to 14-membered)aryloxy groups include phenoxy and 4-fluorophenoxy, and the like.
As used herein a "hydroxy(C| -C6)alkyl" means any of the above-mentioned Ci_6 alkyl groups substituted by one or more hydroxy groups. Representative hydroxy(C C6)alkyl groups include hydroxymethyi, hydroxyethyl, hydroxypropyl and
hydroxybutyl groups, and especially hydroxymethyi, 1 -hydroxyethyl, 2-hydroxyethyl, 1 ,2-dihydroxyethyl, 2-hydroxypropyl, 3-hydroxypropyl, 3-hydroxybutyl,
4-hydroxybutyl, 2-hydroxy- l -methyIpropyl, and l ,3-dihydroxyprop-2-yl.
As used herein a "dihydroxy(Ci-C6)alkyl" means any of the above-mentioned C i-6 alkyl groups substituted by two hydroxy groups. Representative dihydroxy(Ci- C6)alkyl groups include dihydroxyethyl, dihydroxypropyl and dihydroxybutyl groups, and especially 1 ,2-dihydroxyethyl, 1 ,3-dihydroxypropyl, 2,3-dihydroxypropyl, 1 ,3- dihydroxybutyl, 1 ,4-dihydroxybutyl, and l ,3-dihydroxyprop-2-yl.
As used herein a "-(5- to 12- membered)carbocyclic ring" means a mono- or bicyclic hydrocarbon ring system having from 5 to 12 carbon atoms, which is either saturated, unsaturated, or non-aromatic.
As used herein a "-(7- to 12- membered)bicyclic ring system" means a 7- to 12- membered a carbocyclic or heterocyclic ring, which may be either unsaturated, saturated, non-aromatic or aromatic.
As used herein, "-(5- to 12-membered)heteroaryl" means an aromatic heterocycle ring of 5 to 12 members, including both mono- and bicyclic ring systems, where at least one carbon atom (of one or both of the rings) is replaced with a heteroatom independently selected from nitrogen, oxygen, and sulfur, or at least two carbon atoms of one or both of the rings are replaced with a heteroatom independently selected from nitrogen, oxygen, and sulfur. In one embodiment, one of the bicyclic -(5- to 12-membered)heteroaryl rings contains at least one carbon atom. In another embodiment, both of the bicyclic -(5- to 12-membered)heteroaryl rings contain at least one carbon atom. Representative -(5- to 12-membered)heteroaryls include pyridyl, furyl, benzofuranyl, thiophenyl, benzothiophenyl, quinolinyl, isoquinolinyl, pyrrolyl, indolyl, oxazolyl, benzoxazolyl, imidazolyl, benzimidazolyl, thiazolyl, benzothiazolyl, isoxazolyl, oxadiazolinyl, pyrazolyl, isothiazolyl, pyridazinyl, pyrimidyl, pyrimidinyl, pyrazinyl, thiadiazolyl, triazinyl, thienyl, thiadiazolyl, cinnolinyl, phthalazinyl, quinazolinyl, and the like.
As used herein, the terms "halo" and "halogen" refer to fluoro, chloro, bromo or iodo.
As used herein, "-CH2(halo)" means a methyl group where one of the hydrogens of the methyl group has been replaced with a halogen. Representative -CH2(halo) groups include -CH2F, -CH2C1, -CH2Br, and -CH2I.
As used herein, "-CH(halo)2" means a methyl group where two of the hydrogens of the methyl group have been replaced with a halogen. Representative -CH(halo)2 groups include -CHF2, -CHCI2, -CHBr2, -CHBrCl, -CHCII, and -CHI2.
As used herein, "-C(halo)3 " means a methyl group where each of the hydrogens of the methyl group has been replaced with a halogen. Representative -C(halo)3 groups include -CF3, -CC I3, -CBr3, and -C I 3.
As used herein, the term "optionally substituted" refers to a group that is either unsubstituted or substituted.
Optional substituents on optionally substituted groups, when not otherwise indicated, include 1 , 2, or 3 groups each independently selected from the group consisting of -(Q - C6)alkyl, OH, halo, -C(halo)3, -CH(halo)2, -CH2(halo), NH2, -NH(C,-C6)alkyl, CN, SH, -(5- to 12-membered)carbocyclic ring, -(5- to 12-membered)heterocycle, phenyl, benzyl, (=0), halo(C i -C6)alkyl-, -(C2-C6)alkenyl, -(C2-C6)alkynyl, hydroxy(C i- C6)alkyl-, OR4 (such as -OC(halo)3 and -0(CrC6)alkyl), -C0NR5R6, and -COOR7, where R4 is selected from the group consisting of -(Ci-C6)aikyl, -(C2-C6)alkenyl, -(C2- C6)alkynyl, -C(halo)3, hydroxy(C | -C6)alkyl-, -(C3-Ci2)cycloalkyl, -(C6-C |4)bicycloalkyl, -(Cg-C20)tricycloalkyl, -(C4-Ci2)cycloalkenyl, -(C7-Ci4)bicycloalkenyl, -(C8- C2o)tricycloalkenyl, -(6- to 14-membered)aryl, -(5- to 12-membered)heteroaryl, -(3- to 12-membered)heterocycle, and -(7- to 12-membered)bicycloheterocycle; R5 and R6 are each independently selected from the group consisting of -(C|-C6)alkyl, -(C3- C8)cycIoalkyl, ((C3-C8)cycloalkyl)-(C |-C6)alkyl-, or together with the nitrogen atom to which they are attached form a (4- to 8- membered)heterocycle; and R7 is selected from the group consisting of hydrogen, -(C) -C6)alkyl, -(C2-C6)alkenyl, -(C2-C6)alkynyl, -(C3- C,2)cycloalkyl, -(C4-C ,2)cycloalkenyl, ((C3-C|2)cycloalkyl)-(Ci-C6)alkyl-, ((C4- C,2)cycloalkenyl)-(Ci -C6)alkyl-, -(C,-C6)alkoxy-COOR7 > -NH-C(=0)-NH-(C, -C6)alkyl, -NH-C(=0)-(6- to 14- membered)aryl, -NH-C(=0)-(C, -C6)alkyl-(6- to 14- membered)aryl, -NH-(C , -C6)alkyl-C0-0R7, -NH-C(=0)-(C,-C6)alkyl-C0-0R7, -NH- C(=0)-CH( H2)-(C| -C6)alkyl-C0-0R7, -(C3-C 12)cycloalkyl, -(6- to 14-membered)aryl, -(6- to 14-membered)aryloxy, -(C rC6)alkoxy-C(0)-NR5R6, -NH-(C i-C6)alkyl-C(0)- NR5R6, -C(0)NH-(C ,-C6)alkyl-C00R7, -(C,-C6)alkyl-C(=0)-(Ci-C6)alkoxy, -(C , - C6)alkoxy-C(=0)-(C ,-C6)alkyl, -(C, -C6)alkyl-CN, -(C,-C6)alkyl-COOR7, -(C,-
C6)alkoxy-COOR7, -(C3-C12)cycloalkyl, ((C3-Ci2)cycloalkyl)-(C C6)alkyl-, ((C3- C,2)cycloalkyl)-(C , -C6)alkoxy-, ((C3-C i2)cycloalkyl)-(C,-C6)alkoxy-(C , -C6)alkyl-, - (C4-C 12)cycloalkeny 1, ((C4-C , 2)cycloalkeny l)-(C , -C6)alkyl-, ((C4-C , 2)cycloalkenyl)-(C , - C6)alkoxy-, ((C4-Ci2)cycloalkenyl)-(C i-C6)alkoxy-(C i -C6)alkyl-, -(6- to 14- membered)ary], ((6- to l 4-membered)aryl)-(C | -C6)alkyl-, ((6- to l 4-membered)aryl)- (C rC6)alkoxy-, ((6- to l 4-membered)aryl)-(C rC6)alkoxy-(C | -C6)alkyl-, -(5- to 12- membered)heteroaryl, ((5- to 12-membered)heteroaryl)-(C| -C6)alkyl-, ((5- to 12- membered)heteroaryl)-(Ci-C6)alkoxy-, ((5- to 12-membered)heteroaryl)-(Ci-C6)alkoxy- (C i-C6)alkyl-, -(3- to 12-membered)heterocycle, ((3- to 12 membered)heterocycle)-(Ci- C6)alkyl-, ((3- to 12 membered)heterocycle)-(C ] -C6)alkoxy-, and ((3- to 12
membered)hetetOcycle)-(C | -C6)aIkoxy-(C | -C6)alkyl-.
As used herein, compounds that bind to receptors and mimic the regulatory effects of endogenous ligands are defined as "agonists". Compounds that bind to receptors and are only partly effective as agonists are defined as "partial agonists". Compounds that bind to a receptor without producing any regulatory effect, but rather block the binding of ligands to the receptor are defined as "antagonists". (Ross and Kenakin, "Ch. 2: Pharmacodynamics: Mechanisms of Drug Action and the
Relationship Between Drug Concentration and Effect", pp. 3 1 -32, in Goodman & Oilman 's the Pharmacological Basis of Therapeutics, 10th Ed. (J.G. Hardman, L.E. Limbird and A.Goodman-Gilman eds., 2001 ).
Compounds of the Invention can be isotopically-labeled {i.e. , radio-labeled). Examples of isotopes that can be incorporated into the disclosed compounds include isotopes of hydrogen, carbon, nitrogen, oxygen, phosphorous, fluorine and chlorine, such as 2H, 3H, " C, l 3C, l 4C, 15N, l 80, l 70, 3 1 P, 32P, 35S, l 8F and 36CI, respectively, and preferably 3H, " C, and 14C. Isotopically-labeled Compounds of the Invention can be prepared by methods known in the art in view of this disclosure. For example, tritiated Compounds of the Invention can be prepared by introducing tritium into the particular compound by catalytic dehalogenation with tritium. This method may include reacting a suitable halogen-substituted precursor of a Compound of the Invention with tritium gas in the presence of an appropriate catalyst such as Pd/C in the presence of a base. Other suitable methods for preparing tritiated compounds are generally described in
Filer, Isotopes in the Physical and Biomedical Sciences, Vol. 1 , Labeled Compounds (Part A), Chapter 6 ( 1987). l 4C-labeled compounds can be prepared by employing starting materials having a l 4C carbon.
Isotopically labeled Compounds of the Invention, as well as the
pharmaceutically acceptable salts, and solvates thereof, can be used as radioligands to test for the binding of compounds to an opioid or ORL- 1 receptor. For example, a radio-labeled Compound of the Invention can be used to characterize specific binding of a test or candidate compound to the receptor. Binding assays utilizing such radiolabeled compounds can provide an alternative to animal testing for the evaluation of chemical structure-activity relationships. In a non-limiting embodiment, the present invention provides a method for screening a candidate compound for the ability to bind to an opioid or ORL- 1 receptor, comprising the steps of: a) introducing a fixed concentration of the radio-labeled compound to the receptor under conditions that permit binding of the radio-labeled compound to the receptor to form a complex; b) titrating the complex with a candidate compound; and c) determining the binding of the candidate compound to said receptor.
Compounds of the Invention disclosed herein may contain one or more asymmetric centers, thus giving rise to enantiomers, diastereomers, and other stereoisomeric forms. The present invention encompasses all such possible forms, as well as their racemic and resolved forms and mixtures thereof, and the uses thereof. The individual enantiomers may be separated according to methods known to those of ordinary skill in the art in view of the present disclosure. When the compounds described herein contain olefinic double bonds or other centers of geometric asymmetry, and unless specified otherwise, they include' both E and Z geometric isomers. All tautomers are intended to be encompassed by the present invention as well.
As used herein, the term "stereoisomer" is a general term for all isomers of individual molecules that differ only in the orientation of their atoms in space. It includes enantiomers and isomers of compounds with more than one chiral center that are not mirror images of one another (diastereoisomers).
The term "chiral center" refers to a carbon atom to which four different groups are attached.
The terms "enantiomer" and "enantiomeric" refer to a molecule that cannot be superimposed on its mirror image and hence is optically active such that the enantiomer rotates the plane of polarized light in one direction and its mirror image compound rotates the plane of polarized light in the opposite direction.
The term "racemic" refers to a mixture of equal parts of enantiomers and which mixture is optically inactive.
The term "resolution" refers to the separation or concentration or depletion of one of the two enantiomeric forms of a molecule.
The terms "a" and "an" refer to one or more.
Compounds of the Invention encompass all salts of the disclosed compounds of Formula I. The present invention preferably includes any and all non-toxic, pharmaceutically acceptable salts of the disclosed compounds. Examples of pharmaceutically acceptable salts include inorganic and organic acid addition salts and basic salts. The pharmaceutically acceptable salts include, but are not limited to, metal salts such as sodium salt, potassium salt, cesium salt, and the like; alkaline earth metals such as calcium salt, magnesium salt and the like; organic amine salts such as triethylamine salt, pyridine salt, picoline salt, ethanolamine salt, triethanolamine salt, dicylohexylamine salt, Ν,Ν'-dibenzylethylenediamine salt and the like; inorganic acid salts such as hydrochloride, hydrobromide, phosphate, sulphate and the like; organic acid salts such as citrate, lactate, tartrate, maleate, fumarate, mandelate, acetate, dichloroacetate, trifluoroacetate, oxalate, formate and the like; sulfonates such as methanesulfonate, benzenesulfonate, p-toluenesulfonate and the like; and amino acid salts such as arginate, glutamate and the like.
Acid addition salts can be formed by mixing a solution of the particular compound of the present invention with a solution of a pharmaceutically acceptable non-toxic acid such as hydrochloric acid, fumaric acid, maleic acid, succinic acid, acetic acid, citric acid, tartaric acid, carbonic acid, phosphoric acid, oxalic acid, dichloroacetic acid, and the like. Basic salts can be formed by mixing a solution of the particular compound of the present invention and a pharmaceutically acceptable non-toxic base such as sodium hydroxide, potassium hydroxide, choline hydroxide, sodium carbonate and the like.
Compounds of the Invention also encompass solvates of the disclosed compounds of Formula I, Formula II, Formula II I, Formula IV, and Formula V. The term "solvate" as used herein is a combination, physical association and/or solvation of a compound of Formula I, Formula II, Formula III, Formula IV, or Formula V with a solvent molecule such as, e.g. a disolvate, monosolvate or hemisolvate, where the ratio of solvent molecule to compound of Formula I, Formula II, Formula III, Formula IV, or Formula V is 2: 1 , 1 : 1 or 1 :2, respectively. This physical association involves varying degrees of ionic and covalent bonding, including hydrogen bonding. In certain instances, the solvate can be isolated, such as when one or more solvent molecules are incorporated into the crystal lattice of a crystalline solid. Thus, "solvate" encompasses both solution-phase and isolatable solvates. A compound of Formula I, Formula I f, Formula I I I, Formula IV, or Formula V may be present as a solvated form with a pharmaceutically acceptable solvent, such as water, methanol, ethanol, and the like, and it is intended that the invention include both solvated and unsolvated forms of Formula I, Formula I I, Formula I I I, Formula IV, or Formula V compounds. One type of solvate is a hydrate. A "hydrate" relates to a particular subgroup of solvates where the solvent molecule is water. Solvates typically can function as pharmacological equivalents. Preparation of solvates is known in the art. See, for example, M. Caira et al, J.
Pharmaceut. Sci. , 93(3):601 -61 1 (2004), which describes the preparation of solvates of fluconazole with ethyl acetate and with water. Similar preparation of solvates, hemisolvates, hydrates, and the like are described by E.C. van Tonder et al., AAPS Pharm. Sci. Tech. , 5( 1 ):Article 12 (2004), and A.L. Bingham et al, Chem. Commun., 603-604 (2001 ). A typical, non-limiting, process of preparing a solvate would involve dissolving a compound of Formula I, Formula II, Formula HI, Formula I V, or Formula V in a desired solvent (organic, water, or a mixture thereof) at temperatures above about 20°C to about 25°C, then cooling the solution at a rate sufficient to form crystals, and isolating the crystals by known methods, e.g., filtration. Analytical techniques such as infrared spectroscopy can be used to confirm the presence of the solvent in a crystal of the solvate.
The present invention also provides the use of a Compound of the Invention in the manufacture of a medicament for treating or preventing a Condition. In one
embodiment, the Condition is pain, such as acute or chronic pain. In one embodiment, a Compound of the Invention has agonist activity at the μ, δ and/or κ receptors. In another embodiment a Compound of the Invention has agonist activity at the μ receptor. In another embodiment, a Compound of the Invention has antagonist activity at the ORL- 1 receptor. In another embodiment, certain Compounds of the invention can stimulate one receptor (e.g., a μ, 5 and/or κ agonist) and inhibit a different receptor (e.g. , an ORL- 1 antagonist). In another embodiment, the Compound of the Invention is an agonist at the μ receptor, and an antagonist at the ORL- 1 receptor.
Synthesis of Compounds
Compounds of Formula I can be made using conventional organic synthesis in view of this disclosure, or by the illustrative methods shown in the schemes below.
Scheme A
Compound A is reacted with an organometalic compound such as a Grignard reagent in a suitable solvent such as ether or THF to give alcohol B. The double bond in compound B is reduced to a single bond by appropriate reducing conditions such as hydrogenation in a suitable solvent such as ethanol or methanol with a suitable catalyst such as palladium on carbon (Pd/C) to give compound C. The alcohol group in compound C can be oxidized to the ketone D with a suitable oxidizing reagent such as Dess-Martin periodane [Org. Synth., Coll. Vol. 10, 2004, 696] or pyridinium
chlorochromate (PCC) in a suitable solvent such as dichloromethane (DCM). The ketone D can be reacted with an olefinic organometalic compound such as an olefinic Grignard reagent in a suitable solvent such as ether or THF to give olefin E. The double bond in compound E can be converted to a diol by reaction with a suitable reagent such as osmium tetroxide with or without a co-oxidant such as N-methylmorpholine "N-oxide (N O) in a suitable solvent such as an acetone/water mixture to give compound F.
Compound G is reacted with an unsaturated nitrile in a suitable solvent such as toluene at an elevated temperature such as 60 - 1 00 °C to give compound H. The nitrile in compound H is reacted with an organometalic compound such as a Grignard reagent in a suitable solvent such as benzene, ether or THF to give ketone I. Reductive amination with a suitable source of ammonia such as ammonium acetate and a suitable reducing agent such as sodium borohydride in a suitable solvent such as methanol gives amine J. Alkylation with a suitable halo benzyl ester in the presence of a suitable base such as triethyl amine (TEA) in an appropriate solvent such as ether or THF gives compound . Reduction of the double bond and hydrogenolysis of the benzyl ester by hydrogenation in a suitable solvent such as ethanol or methanol with a suitable catalyst such as palladium on carbon (Pd/C) gives compound L.
Scheme C
Compound M is converted to amide N by coupling with a suitable amine such as ammonium chloride in the presence of a peptide coupl ing reagent such as 0-(7- azabenzotriazol-l -yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (HATU) in the presence of a suitable base such as diisopropylethyl amine (DIPEA) in a suitable solvent such as ether or THF.
Testing of Compounds
μ-opioid Receptor Binding Assay Procedures: Radioligand dose- displacement binding assays for μ-opioid receptors used 0.3 nM [3H]-diprenorphine
(Perkin Elmer, Shelton, CT), with 5 mg membrane protein/well in a final volume of 500 μΙ binding buffer ( 10 mM MgCl2, 1 mM EDTA, 5% DMSO, 50 mM HEPES, pH 7.4). Reactions were carried out in the absence or presence of increasing concentrations of unlabeled naloxone. All reactions were conducted in 96-deep well polypropylene plates for 2 hr at room temperature. Binding reactions were terminated by rapid filtration onto 96-well Unifilter GF/C filter plates (Perkin Elmer, Shelton, CT), presoaked in 0.5% polyethylenimine using a 96-well tissue harvester (Perkin Elmer, Shelton, CT) followed by performing three filtration washes with 500 μΙ of ice-cold binding buffer. Filter plates were subsequently dried at 50°C for 2-3 hours. BetaScint scintillation cocktail (Perkin Elmer, Shelton, CT) was added (50 μΙ/well), and plates were counted using a Packard Top-Count for 1 min/well. The data were analyzed using the one-site competition curve fitting functions in GraphPad PRISM™ v. 3.0 or higher (San Diego, Calif), or an in-house function for one-site competition curve-fitting.
μ-opioid Receptor Binding Data: Generally, the lower the Ki value, the mot e effective the Compounds of the Invention will be at treating or preventing pain or another Condition. Typically, the Compounds of the Invention will have a Ki (nM) of about 1000 or less for binding to μ-opioid receptors. In one embodiment the
Compounds of the Invention wi ll have a Ki (nM) of about 300 or less for binding to μ- opioid receptors. In one embodiment, Compounds of the Invention will have a Ki (nM) of about 100 or less. In another embodiment, Compounds of the Invention will have a Ki (nM) of about 10 or less. In still another embodiment, Compounds of the Invention will have a Ki (nM) of about 1 or less. In still another embodiment, Compounds of the Invention will have a Ki (nM) of about 0.1 or less.
μ-Opioid Receptor Functional Assay Procedures: [33S]GTPyS functional assays were conducted using freshly thawed μ-receptor membranes prepared in-hoiise from a cel l line expressing recombinant μ opioid receptor in a HEK-293, CHO or U-2 OS cell background, or purchased from a commercial source (Perkin Elmer, Shelton, CT; or DiscovRx, Fremont, CA).. Assay reactions were prepared by sequentially adding the following reagents to binding buffer ( 100 mM aCl, 10 mM MgCl2, 20 mM HEPES, pH 7.4) on ice (final concentrations indicated): membrane protein (0.026 mg/mL), saponin ( 10 mg/mL), GDP (3mM) and [35S]GTPyS (0.20 nM; Perkin Elmer,
Shelton, CT). The prepared membrane solution (190 μΐ/well) was transferred to 96- shallow well polypropylene plates containing 10 μΙ of 20x concentrated stock solutions of the agonist [D-Ala2, N-methyl-Phe4 Gly-oP]-enkephalin (DAMGO) prepared in dimethyl sulfoxide (DMSO). Plates were incubated for 30 min at about 25°C with shaking. Reactions were terminated by rapid filtration onto 96-well Unifilter GF/B filter plates (Perkin Elmer, Shelton, CT) using a 96-well tissue harvester (Perkin Elmer, Shelton, CT.) followed by three filtration washes with 200 μΐ of ice-cold wash buffer ( 10 inM NaH2P04, 10 mM Na2HP04, pH 7.4). Filter plates were subsequently dried at 50°C for 2-3 hr. BetaScint scintillation cocktail (Perkin Elmer, Shelton, CT) was added (50 μΐ/well) and plates were counted using a Packard Top-Count for 1 min/well. Data were analyzed using the sigmoidal dose-response curve fitting functions in GraphPad PRISM v. 3.0, or an in-house function for non-linear, sigmoidal dose-response curve- fitting.
U-Opioid Receptor Functional Data: μ GTP EC50 is the concentration of a compound providing 50% of the maximal response for the compound at a μ-opioid receptor. Compounds of the Invention will typically have a μ GTP EC50 (nM) of about 5000 or less. In certain embodiments, Compounds of the Invention will have a μ GTP EC50 (nM) of about 2000 or less; or about 1000 or less; or about 100 or less; or about 10 or less; or about 1 or less; or about 0.1 or less.
μ GTP Emax (%) is the maximal effect elicited by a compound relative to the effect elicited by DAMGO, a standard μ agonist. General ly, the μ GTP Emax (%) value measures the efficacy of a compound to treat or prevent pain or other Conditions.
Typically, Compounds of the Invention will have a μ GTP Emax (%) of greater than about 10%; or greater than about 20%. In certain embodiments, Compounds of the Invention will have a μ GTP Emax (%) of greater than about 50%; or greater than about' 65%; or greater than about 75%; or greater than about 85%; or greater than about 100%.
K-opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK.-293 cells expressing the human κ opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypotonic buffer (2.5 mM MgCl2, 50 mM HEPES, pH 7.4) (10 mL/ 10 cm dish) followed by homogenization with a tissue grinder/Teflon pestle. Membranes were collected by centrifugation at 30,000 x g for 15 min at 4°C and pellets
were resuspended in hypotonic buffer to a final concentration of l -3mg/mL. Protein concentrations were determined using the BioRad protein assay reagent with bovine serum albumen as standard. Aliquots of κ receptor membranes were stored at -80 °C.
Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE
Healthcare, Piscataway, NJ; 40 Ci/mmole) with 15 μg membrane protein (recombinant K opioid receptor expressed in HE 293 cells; in-house prep) in a final volume of 200 μΐ binding buffer (5% DMSO, 50 mM Trizma base, pH 7.4). Non-specific binding was determined in the presence of 10 μΜ unlabeled naloxone or U69,593. All reactions were performed in 96-well polypropylene plates for 1 hr at a temperature of about 25°C. Binding reactions were terminated by rapid filtration onto 96-well Unifilter GF/C filter plates (Perkin Elmer, Shelton, CT) presoaked in 0.5% polyethylenimine (Sigma).
Harvesting was performed using a 96-well tissue harvester (Perkin Elmer, Shelton, CT) followed by five fi ltration washes with 200 μΐ ice-cold binding buffer. Filter plates were subsequently dried at 50°C for 1 -2 hours. Fifty μΐ/well scintillation cocktail (Perkin Elmer, Shelton, CT) was added and plates were counted in a Packard Top- Count for 1 min/well.
κ-opioid Receptor Bindine Data: In certain embodiments, the Compounds of the Invention will have a i (nM) for κ receptors of about 10,000 or more (which, for purposes of this invention, is interpreted as having no binding to the κ receptors).
Certain Compounds of the Invention will have a Ki (nM) of about 20,000 or less for κ receptors. In certain embodiments, Compounds of the Invention will have a Ki (nM) of about 10,000 or less; or about 5000 or less; or about 1000 or less; or about 500 or less; or about 450 or less; or about 350 or less; or about 200 or less; or about 100 or less; or about 50 or less; or about 10 or less; or about 1 or less; or about 0.1 or less.
K-Opioid Receptor Functional Assay Procedures: Membranes from recombinant HEK-293 cells, CHO or U-2 OS cells expressing the recombinant human κ opioid receptor (κ) were prepared by lysing cells in ice cold hypotonic buffer (2.5 mM MgCl2, 50 mM HEPES, pH 7.4) ( 10 mL/ 10 cm dish) followed by homogenization with a tissue grinder/Teflon pestle. Functional [35S]GTPyS binding assays were conducted as follows. K opioid receptor membrane solution was prepared by sequentially adding final concentrations of 0.026 μg/μl κ membrane protein (in-house), 1 0 μg/mL saponin,
3 μΜ GDP and 0.20 nM [J5S]GTPyS to binding buffer ( 100 mM NaCl, 10 mM MgCl2, 20 mM HEPES, pH 7.4) on ice. The prepared membrane solution ( 190 μΐ/well) was transferred to 96-shallow well polypropylene plates containing 10 μΐ of 20x
concentrated stock solutions of agonist prepared in DMSO. Plates were incubated for 30 min at a temperature of about 25°C with shaking. Reactions were terminated by rapid filtration onto 96-wel l Unifilter GF/B filter plates (Perkin Elmer, Shelton, CT) using a 96-well tissue harvester (Packard) and fol lowed by three filtration washes with 200 μΐ ice-cold binding buffer ( 10 mM NaH2P04, 10 mM Na2HP04, pH 7.4). Filter plates were subsequently dried at 50°C for 2-3 hours. Fifty μΙ/well scintillation cocktail (Perkin Elmer, Shelton, CT) was added and plates were counted in a Packard Top- Count for 1 min/well.
-Opioid Receptor Functional Data: κ GTP EC50 is the concentration of a compound providing 50% of the maximal response for the compound at a κ receptor. Certain Compounds of the Invention w ill have a κ GTP EC50 (nM) of about 20,000 or less to stimulate κ opioid receptor function. In certain embodiments, Compounds of the Invention will have a K GTP EC50 (nM) of about 1 0,000 or less; or about 5000 or less; or about 2000 or less; or about 1500 or less; or about 1 000 or less; or about 600 or less; or about 100 or less; or about 50 or less; or about 25 or less; or about 10 or less; or about 1 or less; or about 0. 1 or less.
K GTP Emax (%) is the maximal effect elicited by a compound relative to the effect elicited by U69,593. Certain Compounds of the Invention will have a κ GTP Emax (%) of greater than about 1 %; or greater than about 5%; or greater than about 10%; or greater than about 20%. In certain embodiments, Compounds of the Invention will have a K GTP Emax (%) of greater than about 50%; or greater than about 75%; or greater than about 90%; or greater than about 100%.
δ-opioid Receptor Binding Assay Procedures: δ-opioid Receptor Binding Assay Procedures can be conducted as follows. Radioligand dose-displacement assays use 0.3 nM [3H]-Naltrindole (Perkin Elmer, Shelton, CT; 33.0 Ci/mmole) with 5 μg membrane protein (Perkin Elmer, Shelton, CT) in a final volume of 500 μΐ binding buffer (5 mM MgCl2, 5% DMSO, 50 mM Trizma base, pH 7.4). Non-specific binding is determined in the presence of 25 μΜ unlabeled naloxone. All reactions are
performed in 96-deep well polypropylene plates for 1 hr at a temperature of about 25°C. Binding reactions are terminated by rapid fi ltration onto 96-well Unifi lter GF/C filter plates (Perkin Elmer, Shelton, CT) presoaked in 0.5% polyethylenimine (Sigma).
Harvesting is performed using a 96-well tissue harvester (Perkin Elmer, Shelton, CT) followed by five fi ltration washes with 500 μΐ ice-cold binding buffer. Filter plates are subsequently dried at 50°C for 1 -2 hours. Fifty μΐ/well scintillation cocktail (Perkin Elmer, Shelton, CT) is added and plates are counted in a Packard Top-Count for 1 min/well.
δ-opioid Receptor Binding Data: In certain embodiments, the Compounds of the Invention will have a Ki (nM) for δ receptors of about 10,000 or more (which, for the purposes of this invention, is interpreted as having no binding to the δ receptors). Certain Compounds of the Invention will have a Ki (nM) of about 20,000 or less for 5 receptors. In one embodiment, the Compounds of the Invention will have a Ki (nM) of about 1 0,000 or less; or of about 9000 or less. In another embodiment, the Compounds of the Invention will have a Ki (nM) of about 7500 or less; or of about 6500 or less; or of about 5000 or less; or of about 3000 or less; or of about 2500 or less. In another embodiment, the Compounds of the Invention will have a Ki (nM) of about 1000 or less; or of about 500 or less; or of about 350 or less; or of about 250 or less; or of about 1 00 or less; or of about 10 or less.
δ-Opioid Receptor Functional Assay Procedures: Functional [35S]GTPyS binding assays are conducted as follows, δ opioid receptor membrane solution is prepared by sequentially adding final concentrations of 0.026 μg/μ δ membrane protein (Perkin Elmer, Shelton, CT), 10 μg/mL saponin, 3 μΜ GDP and 0.20 nM [ 5S]GTPyS to binding buffer ( l OOmM NaCl, l OmM MgCI2, 20mM HEPES, pH 7.4) on ice. The prepared membrane solution ( 190 μΐ/well) is transferred to 96-shallow well
polypropylene plates containing 10 μΐ of 20x concentrated stock solutions of agonist prepared in DMSO. Plates are incubated for 30 min at a temperature of about 25°C with shaking. Reactions are terminated by rapid filtration onto 96-well Unifilter GF/B filter plates (Perkin Elmer, Shelton, CT) using a 96-well tissue harvester (Packard) and fol lowed by three filtration washes with 200 μΙ ice-cold binding buffer ( 10 mM
NaH2P04, 10 mM Na2HP04, pH 7.4). Filter plates are subsequently dried at 50°C for 1 -
2 hours. Fifty μΙ/well scintillation cocktail (Perkin Elmer, Shelton, CT) is added and plates are counted in a Packard Top-count for 1 m in/well.
δ-Opioid Receptor Functional Data: δ GTP EC50 is the concentration of a compound providing 50% of the maximal response for the compound at a δ receptor. Certain Compounds of the Invention will have a δ GTP EC50 (nM) of about 20,000 or less; or about 10,000 or less. In certain embod iments, the Compounds of the Invention will have a δ GTP EC50 (nM) of about 3500 or less; or of about 1000 or less; or of about 500 or less; or of about 100 or less; or of about 90 or less; or of about 50 or less; or of about 25 or less; or of about 10 or less.
δ GTP Emax (%) is the maximal effect elicited by a compound relative to the effect elicited by met-enkephalin. Certain Compounds of the Invention of the invention will have a δ GTP Emax (%) of greater than about 1 %; or of greater than about 5%; or of greater than about 10%. In one embodiment, the Compounds of the Invention will have a δ GTP Emax (%) of greater than about 30%. In other embodiments, the Compounds of the Invention will have a δ GTP Emax (%) of greater than about 50%; or of greater than about 75%; or of greater than about 90%. In another embodiment, the Compounds of the Invention will have a δ GTP Emax (%) of about 1 00% or greater.
ORL-1 Receptor Binding Assay Procedure: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL- 1 ) (Perkin Elmer, Shelton, CT) are prepared by lysing cells in ice-cold hypotonic buffer (2.5 mM MgCl2, 50 mM HEPES, pH 7.4) ( 10 ml/ 10 cm dish) followed by homogenization with a tissue grinder/Teflon pestle. Membranes are collected by centrifugation at 30,000 x g for 15 min at 4°C and pellets resuspended in hypotonic buffer to a final concentration of 1 -3 mg/ml. Protein concentrations are determined using the BioRad protein assay reagent with bovine serum albumen as standard. Al iquots of the ORL- 1 receptor membranes are stored at -80°C.
Radioligand binding assays (screening and dose-displacement) use 0. 1 nM [3H]- nociceptin (Perkin Elmer, Shelton, CT; 87.7 Ci/mmole) with 12 μg membrane protein in a final volume of 500 μΐ binding buffer ( 10 mM MgCl2, 1 mM EDTA, 5% DMSO, 50 mM HEPES, pH 7.4). Non-specific binding is determined in the presence of 10 nM unlabeled nociceptin (American Peptide Company). All reactions are performed in 96-
deep well polypropylene plates for 1 h at room temperature. Binding reactions are terminated by rapid filtration onto 96-well Unifilter GF/C filter plates (Perkin Elmer, Shelton, CT) presoaked in 0.5% polyethylenimine (Sigma). Harvesting is performed using a 96-well tissue harvester (Perkin Elmer, Shelton, CT) followed by three filtration washes with 500 μΐ ice-cold binding buffer. Filter plates are subsequently dried at 50°C for 2-3 hours. Fifty μΙ/well scintillation cocktail (Perkin Elmer, Shelton, CT) is added and plates are counted in a Packard Top-Count for 1 min/well. The data from screening and dose-displacement experiments are analyzed using Microsoft Excel and the curve fitting functions in GraphPad PRISM™, v. 3.0 or higher, respectively, or an in-house function for one-site competition curve-fitting.
ORL-1 Receptor Binding Data: Certain Compounds of the Invention will have a i (nM) of about 1000 or less. In one embodiment, the Compounds of the invention will have a Ki (nM) of about 500 or less. In other embodiments, the
Compounds of the Invention will have a Ki (nM) of about 300 or less; or of about 100 or less; or of about 50 or less; or of about 20 or less. In yet other embodiments, the Compounds of the Invention will have a Ki (nM) of about 10 or less; or of about 1 or less; or of about 0.1 or less.
ORL-1 Receptor Functional Assay Procedure: Membranes from
recombinant HEK-293 cells expressing the human opioid receptor-like (ORL- 1 ) (Perkin Elmer, Shelton, CT) are prepared by lysing cells in ice-cold hypotonic buffer (2.5 mM Mg Cl2, 50 m HEPES, pH 7.4) ( 10 ml/10 cm dish) followed by homogenization with a tissue grinder/Teflon pestle. Membranes are collected by centrifugation at 30,000 x g for 15 min at 4°C, and pellets resuspended in hypotonic buffer to a final concentration of 1 -3 mg/ml. Protein concentrations are determined using the BioRad protein assay reagent with bovine serum albumen as standard. Aliquots of the ORL- 1 receptor membranes are stored at -80°C.
Functional [35S]GTPyS binding assays are conducted as follows. ORL- 1 membrane solution is prepared by sequentially adding final concentrations of 0.026 μg/μl ORL-1 membrane protein, 10 μg/ml saponin, 3 μΜ GDP and 0.20 nM
[35S]GTPyS to binding buffer ( 100 mM NaCl, 10 mM MgCl2, 20 mM HEPES, pH 7.4) on ice. The prepared membrane solution ( 190 μΐ/well) is transferred to 96-shallow well
polypropylene plates containing 10 μΐ of 20x concentrated stock solutions of agonist/nociceptin prepared in DMSO. Plates are incubated for 30 min at room temperature with shaking. Reactions are terminated by rapid filtration onto 96-well Unifilter GF/B filter plates (Perkin Elmer, Shelton, CT) using a 96-well tissue harvester (Packard) and followed by three filtration washes with 200 μΐ ice-cold binding buffer ( 10 mM NaH2P04, 10 mM Na2HP04, pH 7.4). Fi lter plates are subsequently dried at 50°C for 2-3 hours. Fifty μΐ/well scintil lation cocktail (Perkin Elmer, Shelton, CT) is added and plates are counted in a Packard Top-Count for 1 min/well. Data are analyzed using the sigmoidal dose-response curve fitting functions in GraphPad PRISM v. 3.0 or higher, or an in-house function for non-linear, sigmoidal dose-response curve-fitting.
ORL-1 Receptor Functional Data: ORL- 1 GTP EC50 is the concentration of a compound providing 50% of the maximal response for the compound at an ORL- 1 receptor. In certain embodiments, the Compounds of the Invention that have a high binding affinity (i.e. low j value) will have an ORL- 1 GTP EC50 (nM) of greater than about 10,000 (i.e. will not stimulate at therapeutic concentrations) In certain
embodiments Compounds of the Invention wil l have an ORL- 1 GTP EC50 (nM) of about 20,000 or less. In one embodiment, the Compounds of the Invention will have an ORL- 1 GTP EC50 (nM) of about 10,000 or less; or of about 5000 or less; or of about 1000 or less. In still other embodiments, the Compounds of the Invention will have an ORL-1 GTP EC50 (nM) of about 100 or less; or of about 10 or less; or of about 1 or less; or of about 0.1 or less. .
ORL-1 GTP Emax % is the maximal effect elicited by a compound relative to the effect elicited by nociceptin, a standard ORL- 1 agonist. In certain embodiments, Compounds of the Invention will have an ORL- 1 GTP Emax of less than 10% (which, for the purposes of this invention, is interpreted as having antagonist activity at ORL- 1 receptors). Certain Compounds of the Invention will have an ORL- 1 GTP Emax (%) of greater than 1 %; or of greater than 5%; or of greater than 10%. In other embodiments the Compounds of the Invention will have an ORL- 1 GTP Emax of greater than 20%; or of greater than 50%; or of greater than 75%; or of greater than 88%; or of greater than 100%.
In Vivo Assays for Prevention or Treatment of Pain Test Animals: Each experiment uses rats weighing between 200-260 g at the start of the experiment. The rats are group-housed and have free access to food and water at all times, except prior to oral administration of a Compound of the Invention when food is removed for about 16 hours before dosing. A control group acts as a comparison to rats treated with a Compound of the Invention. The control group is administered the carrier for the Compound of the Invention. The volume of carrier administered to the control group is the same as the volume of carrier and Compound of the Invention administered to the test group.
Acute Pain: To assess the actions of a Compound of the Invention for the treatment or prevention of acute pain, the rat tai l fl ick test can be used. Rats are gently restrained by hand and the tail exposed to a focused beam of radiant heat at a point 5 cm from the tip using a tail flick unit (Model 7360, commercially available from Ugo Basile of Italy). Tail flick latencies are defined as the interval between the onset of the thermal stimulus and the flick of the tail. Animals not responding within 20 seconds are removed from the tai l flick unit and assigned a withdrawal latency of 20 seconds. Tail flick latencies are measured immediately before (pre-treatment) and 1 , 3, and 5 hours following administration of a Compound of the Invention. Data are expressed as tail flick latency(s) and the percentage of the maximal possible effect (% MPE), i.e. , 20 seconds, is calculated as follows:
[ (post administration latency) - (pre-administration latenc
% MPE = " x 100
(20 s - pre-administration latency)
The rat tail fl ick test is described in F.E. D'Amour et al , "A Method for Determining Loss of Pain Sensation," J. Pharmacol Exp. Ther. 72:74-79 ( 1941 ).
To assess the actions of a Compound of the Invention for the treatment or prevention of acute pain, the rat hot plate test can also be used. Rats are tested using a hot plate apparatus consisting of a clear plexiglass cylinder with a heated metal floor maintained at a temperature of 48-52 °C (Model 7280, commercially available from Ugo Basile of Italy). A rat is placed into the cylinder on the hot plate apparatus for a
maximum duration of 30 s, or until it exhibits a nocifensive behavior (behavioral endpoint), at which time it is removed from the hot plate, and response latency recorded. Hot plate latencies are measured immediately before (pre-treatment) and 1 , 3, and 5 hours following administration of a Compound of the Invention. The nocifensive behavioral endpoint is defined as any of the following: 1 ) paw withdrawal, either as a sustained lift or with shaking or licking; 2) alternating foot lifting; 3) escape or attempted escape from the testing device; or 4) vocalization. Data are expressed as response latency(s) and the percentage of the maximal possible effect is calculated as described above for the tail flick test. The hot plate test is described in G. Woolfe and A.D. Macdonald, J. Pharmacol. Exp. Ther. 80:300-307 ( 1944).
Inflammatory Pain: To assess the actions of a Compound of the Invention for the treatment or prevention of inflammatory pain, the Freund's complete adjuvant ("FCA") model of inflammatory pain can be used. FCA-induced inflammation of the rat hind paw is associated with the development of persistent inflammatory mechanical hyperalgesia and provides reliable prediction of the anti-hyperalgesic action of clinically useful analgesic drugs (L. Bartho et ai , "Involvement of Capsaicin-sensitive Neurones in Hyperalgesia and Enhanced Opioid Antinociception in Inflammation," Naunyn- Schmiedeberg's Archives of Pharmacol. 342:666-670 ( 1990)). The left hind paw of each animal is administered a 50 intraplantar injection of 50% FCA. Prior to injection of FCA (baseline) and 24 hours post injection, the animal is assessed for response to noxious mechanical stimuli by determining the PWT, as described below. Rats are then administered a single injection of 1 , 3, or 10 mg/kg of either a Compound of the Invention; 30mg/kg of a control drug selected from Celebrex, indomethacin or naproxen; or carrier. Responses to noxious mechanical stimuli are determined 1 , 3, 5 and 24 hours post administration. Percentage reversal of hyperalgesia for each animal is defined as:
[ (post administration PWT) - (pre-administration PWT) ]
% Reversal = x 100
[ (baseline PWT) - (pre-administration PWT) ]
Neuropathic Pain: To assess the actions of a Compound of the Invention for the treatment or prevention of neuropathic pain, either the Seltzer model or the Chung model can be used.
In the Seltzer model, the partial sciatic nerve ligation model of neuropathic pain is used to produce neuropathic hyperalgesia in rats (Z. Seltzer et al. , "A Novel Behavioral Model of Neuropathic Pain Disorders Produced in Rats by Partial Sciatic Nerve Injury," Pain 43 :205-218 ( 1990)). Partial ligation of the left sciatic nerve is performed under isoflurane/02 inhalation anaesthesia. Following induction of anesthesia, the left thigh of the rat is shaved and the sciatic nerve exposed at high thigh level through a small incision and is carefully cleared of surrounding connective tissues at a site near the trocanther just distal to the point at which the posterior biceps semitendinosus nerve branches off of the common sciatic nerve. A 7-0 silk suture is inserted into the nerve with a 3/8 curved, reversed-cutting mini-needle and tightly l igated so that the dorsal '/3 to ½ of the nerve thickness is held within the ligature. The wound is closed with a single muscle suture (4-0 nylon (Vicryl)) and vetbond tissue glue. Following surgery, the wound area is dusted with antibiotic powder. Sham- treated rats undergo an identical surgical procedure except that the sciatic nerve is not manipulated. Following surgery, animals are weighed and placed on a warm pad until they recover from anesthesia. Animals are then returned to their home cages until behavioral testing begins. The animal is assessed for response to noxious mechanical stimuli by determining PWT, as described below, prior to surgery (baseline), then immediately prior to and 1 , 3, and 5 hours after drug administration. Percentage reversal of neuropathic hyperalgesia is defined as:
[ (post administration PWT) - (pre-administration PWT) ]
% Reversal = x 100
[ (baseline PWT) - (pre-administration PWT) ]
In the Chung model, the spinal nerve ligation model of neuropathic pain is used to produce mechanical hyperalgesia, thermal hyperalgesia and tactile allodynia in rats. Surgery is performed under isoflurane/02 inhalation anaesthesia. Following induction of anaesthesia, a 3 cm incision is made and the left paraspinal muscles are separated from the spinous process at the L4 - S2 levels. The L6 transverse process is carefully removed with a pair of small rongeurs to identify visually the L4 - L6 spinal nerves. The left L5 (or L5 and L6) spinal nerve(s) is isolated and tightly ligated with silk thread. A complete hemostasis is confirmed and the wound is sutured using non-absorbable sutures, such as nylon sutures or stainless steel staples. Sham-treated rats undergo an identical surgical procedure except that the spinal nerve(s) is not manipulated.
Following surgery animals are weighed, administered a subcutaneous (s.c.) injection of saline or ringers lactate, the wound area is dusted with antibiotic powder and they are kept on a warm pad until they recover from the anesthesia. Animals are then returned to their home cages unti l behavioral testing begins. The animals are assessed for response to noxious mechanical stimuli by determining PWT, as described below, prior to surgery (baseline), then immediately prior to and 1 , 3, and 5 hours after being administered a Compound of the Invention. The animal can also be assessed for response to noxious thermal stimuli or for tactile allodynia, as described below. The Chung model for neuropathic pain is described in S.H. Kim, "An Experimental Model for Peripheral Neuropathy Produced by Segmental Spinal Nerve Ligation in the Rat," Pain 50(3):355-363 ( 1992).
Response to Mechanical Stimuli as an Assessment of Mechanical
Hyperalgesia: The paw pressure assay can be used to assess mechanical hyperalgesia. For this assay, hind paw withdrawal thresholds (PWT) to a noxious mechanical stimulus are determined using an analgesymeter (Model 7200, commercially available from Ugo Basile of Italy) as described in C. Stein, "Unilateral Inflammation of the Hindpaw in Rats as a Model of Prolonged Noxious Stimulation: Alterations in Behavior and
Nociceptive Thresholds," Pharmacol. Biochem. and Behavior 3 1 :451 -455 (1988). The maximum weight that is applied to the hind paw is set at 250 g and the end point is taken as complete withdrawal of the paw. PWT is determined once for each rat at each time point and either only the affected (ipsilateral; same side as the injury) rear paw is tested, or both the ipsilateral and contralateral (non-injured; opposite to the injury) rear paw are tested.
Response to Thermal Stimuli as an Assessment of Thermal Hyperalgesia:
The plantar test can be used to assess thermal hyperalgesia. For this test, hind paw withdrawal latencies to a noxious thermal stimulus are determined using a plantar test apparatus (commercially available from Ugo Basile of Italy) following the technique described by . Hargreaves et al, "A New and Sensitive Method for Measuring Thermal Nociception in Cutaneous Hyperalgesia," Pain 32( 0:77-88 ( 1 988). The maximum exposure time is set at 32 seconds to avoid tissue damage and any directed paw withdrawal from the heat source is taken as the end point. Three latencies are determined at each time point and averaged. Either only the affected (ipsilateral) paw is tested, or both the ipsilateral and contralateral (non-injured) paw are tested.
Assessment of Tactile Allodynia: To assess tactile allodynia, rats are placed in clear, plexiglass compartments with a wire mesh floor and allowed to habituate for a period of at least 1 5 minutes. After habituation, a series of von Frey monofilaments are presented to the plantar surface of the affected (ipsilateral) foot of each rat. The series of von Frey monofilaments consists of six monofilaments of increasing diameter, with the smallest diameter fiber presented first. Five trials are conducted with each filament with each trial separated by approximately 2 minutes. Each presentation lasts for a period of 4-8 seconds or until a nociceptive withdrawal behavior is observed.
Flinching, paw withdrawal or licking of the paw are considered nociceptive behavioral responses.
Assessment of Respiratory Depression: To assess respiratory depression, rats can be prepared by implanting a femoral artery cannula via which blood samples are taken. Blood samples are taken prior to drug administration, then 1 , 3, 5 and 24 hours post-treatment. Blood samples are processed using an arterial blood gas analyzer (e.g., IDEXX VetStat with Respiratory/Blood Gas test cartridges). Comparable devices are a
standard tool for blood gas analysis (e.g., D. Torbati et al., 2000 Intensive Care Med. (26) 585-591 ).
Assessment of Gastric Motility: Animals are treated with vehicle, reference compound or test article by oral gavage at a volume of 10 mL/kg. At one hour post- dose, all animals are treated with charcoal meal solution (5% non-activated charcoal powder in a solution of 1 % carboxymethylcellulose in water) at a volume of 10 mL/kg. At two hours post-dose (one hour post-charcoal), animals are sacrificed by carbon dioxide inhalation or isofiurane overdose and the transit of charcoal meal identified. The stomach and small intestine are removed carefully and each placed on a saline-soaked absorbent surface. The distance between the pylorus and the furthest progression of charcoal meal is measured and compared to the distance between the pylorus and the ileocecal junction. The charcoal meal transit is expressed as a percentage of small intestinal length traveled.
Pharmaceutical Compositions
Due to their activity, the Compounds of the Invention are advantageously useful in human and veterinary medicine. As described above, the Compounds of the
Invention are useful for treating or preventing a Condition in an animal (a human patient or non-human subject) in need thereof. The Compounds of the Invention can be administered to any animal requiring modulation of the opioid and/or ORL- 1 receptors.
When administered to an animal, a Compound of the Invention can be administered as a component of a pharmaceutical composition that comprises a pharmaceutically acceptable carrier or excipient. A Compound of the Invention can be administered by any appropriate route, as determined by the medical practitioner.
Methods of administration may include intradermal, intramuscular, intraperitoneal, parenteral, intravenous, subcutaneous, intranasal, epidural, oral, sublingual,
intracerebral, intravaginal, transdermal, transmucosal, rectal, by inhalation, or topical (particularly to the ears, nose, eyes, or skin). Delivery can be either local or systemic. In certain embodiments, administration will result in the release of a Compound of the Invention into the bloodstream.
Pharmaceutical compositions of the invention can take the form of solutions, suspensions, emulsions, tablets, pills, pellets, multi-particulates, capsules, capsules containing liquids, capsules containing powders, capsules containing multi-particulates, lozenges, sustained-release formulations, controlled-release formulations, suppositories, aerosols, sprays, or any other form suitable for use. In one embodiment, the composition is in the form of a capsule (see, e.g., U.S. Patent No. 5,698, 155).
Pharmaceutical compositions of the invention preferably comprise a suitable amount of a pharmaceutically acceptable excipient so as to provide the form for proper administration to the animal . Such a pharmaceutical excipient can be a diluent, suspending agent, solubilizer, binder, disintegrant, preservative, coloring agent, lubricant, and the like. The pharmaceutical excipient can be a liquid, such as water or an oil, including those of petroleum, animal, vegetable, or synthetic origin, such as peanut oi l, soybean oil, mineral oil, sesame oil, and the like. The pharmaceutical excipient can be saline, gum acacia, gelatin, starch paste, talc, keratin, colloidal sil ica, urea, and the like. In addition, auxiliary, stabilizing, thickening, lubricating, and coloring agents can be used. In one embodiment, the pharmaceutically acceptable excipient is sterile when administered to an animal. Water is a particularly useful excipient when a Compound of the Invention is administered intravenously. Saline solutions and aqueous dextrose and glycerol solutions can also be employed as liquid excipients, particularly for injectable solutions. Suitable pharmaceutical excipients also include starch, glucose, lactose, sucrose, gelatin, malt, rice, flour, chalk, silica gel, sodium stearate, glycerol monostearate, talc, sodium chloride, dried skim milk, glycerol, propylene glycol, water, ethanol, and the like. The invention compositions, if desired, can also contain minor amounts of wetting or emulsifying agents, or pH buffering agents. Specific examples of pharmaceutically acceptable carriers and excipients that can be used to formulate oral dosage forms are described in the Handbook of
Pharmaceutical Excipients, American Pharmaceutical Association ( 1 986). Other examples of suitable pharmaceutical excipients are described in Remington's
Pharmaceutical Sciences 1447- 1676 (Alfonso R. Gennaro ed., 19th ed. 1995), incorporated herein by reference.
In certain embodiments, the Compounds of the Invention are formulated for oral administration. A Compound of the Invention to be orally delivered can be in the form of tablets, capsules, gelcaps, caplets, lozenges, aqueous or oily solutions, suspensions, granules, powders, emulsions, syrups, or elixirs, for example. When a Compound of the Invention is incorporated into oral tablets, such tablets can be compressed, tablet triturates, enteric-coated, sugar-coated, fi lm-coated, multiply compressed or multiply layered.
An orally administered Compound of the Invention can contain one or more additional agents such as, for example, sweetening agents such as fructose, aspartame or saccharin; flavoring agents such as peppermint, oil of wintergreen, or cherry; coloring agents; and preserving agents, and stabil izers, to provide stable, pharmaceutically palatable dosage forms. Techniques and compositions for making solid oral dosage forms are described in Pharmaceutical Dosage Forms: Tablets (Lieberman, Lachman and Schwartz, eds., 2nd ed.) publ ished by Marcel Dekker, Inc. Techniques and compositions for making tablets (compressed and molded), capsules (hard and soft gelatin) and pills are also described in Remington's Pharmaceutical Sciences 1553- 1593 (Arthur Osol, ed., 16th ed., Mack Publishing, Easton, PA 1980). Liquid oral dosage forms include aqueous and nonaqueous solutions, emulsions, suspensions, and solutions and/or suspensions reconstituted from non-effervescent granules, optionally containing one or more suitable solvents, preservatives, emulsifying agents, suspending agents, diluents, sweeteners, coloring agents, flavoring agents, and the like. Techniques and compositions for making liquid oral dosage forms are described in Pharmaceutical Dosage Forms: Disperse Systems, (Lieberman, ieger and Banker, eds.) published by Marcel Dekker, Inc.
When a Compound of the Invention is formulated for parenteral administration by injection (e.g., continuous infusion or bolus injection), the formulation can be in the form of a suspension, solution, or emulsion in an oily or aqueous vehicle, and such formulations can further comprise pharmaceutically necessary additives such as one or more stabilizing agents, suspending agents, dispersing agents, and the like. When a Compound of the Invention is to be injected parenterally, it can be, e.g. , in the form of
an isotonic sterile solution. A Compound of the Invention can also be in the form of a powder for reconstitution as an injectable formulation.
In certain embodiments, a Compound of the Invention is formulated into a pharmaceutical composition for intravenous administration. Typically, such compositions comprise sterile isotonic aqueous buffer. Where necessary, the compositions can also include a solubilizing agent. A Compound of the Invention for intravenous administration can optionally include a local anesthetic such as benzocaine or prilocaine to lessen pain at the site of the injection. General ly, the ingredients are suppl ied either separately or mixed together in unit dosage form, for example, as a dry lyophilized powder or water free concentrate in a hermetically sealed container such as an ampule or sachette indicating the quantity of active agent. Where a Compound of the Invention is to be administered by infusion, it can be dispensed, for example, with an infusion bottle containing sterile pharmaceutical grade water or saline. Where a Compound of the Invention is administered by injection, an ampule of sterile water for injection or saline can be provided so that the ingredients can be mixed prior to administration.
When a Compound of the Invention is to be administered by inhalation, it can be formulated into a dry aerosol, or an aqueous or partially aqueous solution.
In another embodiment, a Compound of the Invention can be delivered in a vesicle, in particular a liposome (see Langer, Science 249: 1527-1 533 (1990); and Treat ei al. , Liposomes in the Therapy of Infectious Disease and Cancer 3 17-327 and 353-365 ( 1989)).
In certain embodiments, a Compound of the Invention is administered locally. This can be achieved, for example, by local infusion during surgery, topical application, e.g., in conjunction with a wound dressing after surgery, by injection, by means of a catheter, by means of a suppository or enema, or by means of an implant, said implant being of a porous, non-porous, or gelatinous material, including membranes, such as sialastic membranes, or fibers.
In certain embodiments, a Compound of the Invention can be delivered in an immediate release form. In other embodiments, a Compound of the Invention can be delivered in a controlled-release system or sustained-release system. Controlled- or
sustained-release pharmaceutical compositions can have a common goal of improving drug therapy over the results achieved by their non-controlled or non-sustained-release counterparts. In one embodiment, a controlled- or sustained-release composition comprises a minimal amount of a Compound of the Invention to treat or prevent the Condition (or a symptom thereof) in a minimum amount of time. Advantages of controlled- or sustained-release compositions include extended activity of the drug, reduced dosage frequency, and increased compliance. In addition, controlled- or sustained-release compositions can favorably affect the time of onset of action or other characteristics, such as blood levels of the Compound of the Invention, and can thus reduce the occurrence of adverse side effects.
Controlled- or sustained-release compositions can initially release an amount of a Compound of the Invention that promptly produces the desired therapeutic or prophylactic effect, and gradually and continually release other amounts of the
Compound of the Invention to maintain a level of therapeutic or prophylactic effect over an extended period of time. To maintain a constant level of the Compound of the Invention in the body, the Compound of the Invention can be released from the dosage form at a rate that will replace the amount of Compound of the Invention being metabolized and excreted from the body. Controlled- or sustained-release of an active ingredient can be stimulated by various conditions, including but not limited to, changes in pH, changes in temperature, concentration or availability of enzymes, concentration or availability of water, or other physiological conditions or compounds.
Controlled-release and sustained-release means for use according to the present invention may be selected from those known in the art. Examples include, but are not limited to, those described in U.S. Patent Nos.: 3,845,770; 3,916,899; 3,536,809;
3,598, 123; 4,008,71 9; 5,674,533; 5,059,595; 5,591 ,767; 5, 120,548; 5,073,543;
5,639,476; 5,354,556; and 5,733,566, each of which is incorporated herein by reference. Such dosage forms can be used to provide controlled- or sustained-release of one or more active ingredients using, for example, hydropropylmethyl cellulose, other polymer matrices, gels, permeable membranes, osmotic systems, multilayer coatings, microparticles, multiparticulates, liposomes, microspheres, or a combination thereof to provide the desired release profile in varying proportions. Suitable controlled- or
sustained-release formulations known in the art, including those described herein, can be readily selected for use with the active ingredients of the invention in view of this disclosure. See also Goodson, "Dental Applications" (pp. 1 1 5- 1 38) in Medical Applications of Controlled Release, Vol. 2, Applications and Evaluation, R.S. Langer and D.L. Wise eds., CRC Press (1984). Other controlled- or sustained-release systems that are discussed in the review by Langer, Science 249: 1527- 1533 ( 1990) can be selected for use according to the present invention. In one embodiment, a pump can be used (Langer, Science 249: 1 527- 1533 ( 1990); Sefton, CRC Crit. Ref. Biomed. Eng. 14:201 ( 1987); Buchwald et al , Surgery 88:507 ( 1980); and Saudek et al , N. Engl. J. Med. 32 1 :574 ( 1 989)). In another embodiment, polymeric materials can be used (see Medical Applications of Controlled Release (Langer and Wise eds., 1 74); Controlled Drug Bioavailability, Drug Product Design and Performance (Smolen and Ball eds., 1984); Ranger and Peppas, J. Macromol. Sci. Rev. Macromol. Chem. 23 :61 ( 1983); Levy et al . Science 228: 190 ( 1985); During et al, Ann. Neurol. 25:351 (1989); and Howard et al, J. Neurosurg. T V. 105 (1 989)). In yet another embodiment, a controlled- or sustained-release system can be placed in proximity of a target of a Compound of the Invention, e.g. , the spinal column, brain, or gastrointestinal tract, thus requiring only a fraction of the systemic dose.
When in tablet or pill form, a pharmaceutical composition of the invention can be coated to delay disintegration and absorption in the gastrointestinal tract thereby providing a sustained action over an extended period of time. Selectively permeable membranes surrounding an osmotically active driving compound are also suitable for orally administered compositions. In these latter platforms, fluid from the environment surrounding the capsule is imbibed by the driving compound, which swells to displace the agent or agent composition through an aperture. These delivery platforms can provide an essentially zero order delivery profile as opposed to the spiked profiles of immediate release formulations. A time-delay material such as glycerol monostearate or glycerol stearate can also be used. Oral compositions can include standard excipients such as mannitol, lactose, starch, magnesium stearate, sodium saccharin, cellulose, and magnesium carbonate. In one embodiment, the excipients are of pharmaceutical grade.
Pharmaceutical compositions of the invention include single unit dosage forms suitable for oral administration such as, but not limited to, tablets, capsules, gelcaps, and caplets that are adapted for controlled- or sustained-release.
The amount of the Compound of the Invention that is effective for the treatment or prevention of a condition can be determined by standard clinical techniques. In addition, in vitro and/or in vivo assays can optionally be employed to help identify optimal dosage ranges. The precise dose to be employed will also depend on, e.g. , the route of administration and the extent of the Condition to be treated, and can be decided according to the judgment of a practitioner and/or each animal's circumstances.
Variations in dosing may occur depending upon typical factors such as the weight, age, gender and physical condition (e.g., hepatic and renal function) of the animal being treated, the affliction to be treated, the severity of the symptoms, the frequency of the dosage interval, the presence of any deleterious side-effects, and the particular compound utilized, among other things.
Suitable effective dosage amounts can range from about O.O l mg/kg of body weight to about 3000 mg/kg of body weight of the animal per day, although they are typically from about O.O l mg/kg of body weight to about 2500 mg/kg of body weight of the animal per day or from about O.O l mg/kg of body weight to about 1000 mg/kg of body weight of the animal per day. In one embodiment, the effective dosage amount is about 100 mg/kg of body weight of the animal per day or less. In another embodiment, the effective dosage amount ranges from about O.O l mg/kg of body weight to about 100 mg/kg of body weight of the animal per day of a Compound of the Invention, in another embodiment, about 0.02 mg/kg of body weight to about 50 mg/kg of body weight of the animal per day, and in another embodiment, about 0.025 mg/kg of body weight to about 20 mg/kg of body weight of the animal per day.
Administration can be as a single dose or as a divided dose. In one embodiment, an effective dosage amount is administered about every 24h until the Condition is abated. In another embodiment, an effective dosage amount is administered about every \ 2h until the Condition is abated. In another embodiment, an effective dosage amount is administered about every 8h until the Condition is abated. In another embodiment, an effective dosage amount is administered about every 6h until the Condition is abated.
In another embodiment, an effective dosage amount is administered about every 4h until the Condition is abated. The effective dosage amounts described herein refer to total amounts administered; that is, if more than one Compound of the Invention is administered, the effective dosage amounts correspond to the total amount administered.
Where a cell capable of expressing the ORL-1 receptor is contacted with a Compound of the Invention in vitro, the amount effective for inhibiting or activating the ORL- 1 receptor function in a cell will typically range from about 10~ 12 mol/L to about 10~4 mol/L, or from about 10"12 mol/L to about l O"5 mol/L, or from about 10" 12 mol/L to about 10"6 mol/L, or from about 10"'2 mol/L to about 10"9 mol/L of a solution or suspension of the compound in a pharmaceutically acceptable carrier or excipient. In one embodiment, the volume of solution or suspension comprising the Compound of the , Invention will be from about 0.0 \ iL to about I mL. In another embodiment, the volume of solution or suspension will be about 200 iL.
Where a cell capable of expressing the μ-opioid receptors is contacted with a Compound of the Invention in vitro, the amount effective for inhibiting or activating the μ-opioid receptors function in a cell will typically range from about 10"' 2 mol/L to about 10"4 mol/L, or from about 10" 12 mol/L to about 10° mol/L, or from about 10" 12 mol/L to about 1 0"6 mol/L, or from about 10" 12 mol/L to about I 0"9 mol/L of a solution or suspension of the Compound of the Invention in a pharmaceutically acceptable carrier or excipient. In one embodiment, the volume of solution or suspension comprising the Compound of the Invention will be from about 0.0
to about 1 mL. In another embodiment, the volume of solution or suspension will be about 200 iL.
Where a cell capable of expressing the δ-opioid receptors is contacted with a Compound of the Invention in vitro, the amount effective for inhibiting or activating the δ-opioid receptors function in a cell will typically range from about 1 0" 12 mol/L to about 10"4 mol/L, or from about 10" 12 mol/L to about 10"5 mol/L, or from about 1 0" ] 2 mol/L to about 10"6 mol/L, or from about l O" 12 mol/L to about 10"9 mol/L of a solution or suspension of the Compound of the Invention in a pharmaceutically acceptable carrier or excipient. In one embodiment, the volume of solution or suspension comprising the Compound of the Invention will be from about 0.0 \
to about I mL. In another embodiment, the volume of solution or suspension will be about 200 \iL.
Where a cell capable of expressing the κ-opioid receptors is contacted with a Compound of the Invention in vitro, the amount effective for inhibiting or activating the K-opioid receptors function in a cell will typical ly range from about 10" 12 mol/L to about 10"4 mol/L,or from about l O" 12 mol/L to about 10"5 mol/L, or from about 10~ 12 mol/L to about 10"6 mol/L, or from about 10"'2 mol/L to about l O"9 mol/L of a solution or suspension of the Compound of the Invention in a pharmaceutically acceptable carrier or excipient. In one embodiment, the volume of solution or suspension comprising the Compound of the Invention will be from about 0.01 to about 1 mL. In another embodiment, the volume of solution or suspension will be about 200 μί.
The Compounds of the Invention can be assayed in vitro or in vivo for the desired therapeutic or prophylactic activity prior to use in humans. Animal model systems can be used to demonstrate safety and efficacy. Certain Compounds of the Invention will have an ED50 for treating inflammatory pain ranging from about 0.5 mg/kg to about 20 mg/kg. Certain Compounds of the Invention will produce significant analgesia and/or anti-hyperalgesia at doses that do not induce respiratory depression. In contrast, oxygen tension, oxygen saturation and pH are significantly decreased, while carbon dioxide is significantly increased, in blood samples from rats given effective doses of conventional opioids, such as morphine.
According to the invention, methods for treating or preventing a Condition in an animal in need thereof can further comprise co-administering to the animal an effective amount of a second therapeutic agent in addition to a Compound of the Invention (i.e. , a first therapeutic agent). An effective amount of the second therapeutic agent will be known or determinable by a medical practitioner in view of this disclosure and published clinical studies. In one embodiment of the invention, where a second therapeutic agent is administered to an animal for treatment of a Condition (e.g. , pain), the minimal effective amount of the Compound of the Invention (i.e., the first therapeutic agent) will be less than its minimal effective amount would be in
circumstances where the second therapeutic agent is not administered. In this embodiment, the Compound of the Invention and the second therapeutic agent can act either additively or synergistically to treat or prevent a Condition. Alternatively, the second therapeutic agent may be used to treat or prevent a disorder that is different from
the Condition for which the first therapeutic agent is being administered, and which disorder may or may not be a Condition as defined hereinabove. In one embodiment, a Compound of the Invention is administered concurrently with a second therapeutic agent as a single composition comprising an effective amount of a Compound of the invention and an effective amount of the second therapeutic agent. Alternatively, a composition comprising an effective amount of a Compound of the Invention and a second composition comprising an effective amount of the second therapeutic agent are concurrently administered. In another embodiment, an effective amount of a
Compound of the Invention is administered prior or subsequent to administration of an effective amount of the second therapeutic agent. In this embodiment, the Compound of the Invention is administered while the second therapeutic agent exerts its therapeutic effect, or the second therapeutic agent is administered while the Compound of the Invention exerts its therapeutic effect for treating or preventing a Condition.
The second therapeutic agent can be, but is not limited to, an opioid agonist, a non-opioid analgesic, a non-steroidal anti-inflammatory agent, an antimigraine agent, a Cox-II inhibitor, a 5-lipoxygenase inhibitor, an anti-emetic, a β-adrenergic blocker, an anticonvulsant, an antidepressant, a Ca2+-channel blocker, an anti-cancer agent, an agent for treating or preventing UI, an agent for treating or preventing anxiety, an agent for treating or preventing a memory disorder, an agent for treating or preventing obesity, an agent for treating or preventing constipation, an agent for treating or preventing cough, an agent for treating or preventing diarrhea, an agent for treating or preventing high blood pressure, an agent for treating or preventing epilepsy, an agent for treating or preventing anorexia/cachexia, an agent for treating or preventing drug abuse, an agent for treating or preventing an ulcer, an agent for treating or preventing IBD, an agent for treating or preventing IBS, an agent for treating or preventing addictive disorder, an agent for treating or preventing Parkinson's disease and parkinsonism, an agent for treating or preventing a stroke, an agent for treating or preventing a seizure, an agent for treating or preventing a pruritic condition, an agent for treating or preventing psychosis, an agent for treating or preventing Huntington's chorea, an agent for treating or preventing ALS, an agent for treating or preventing a cognitive disorder, an agent for treating or preventing a migraine, an agent for treating, preventing or inhibiting
vomiting, an agent for treating or preventing dyskinesia, an agent for treating or preventing depression, or any mixture thereof.
Examples of useful opioid agonists include, but are not limited to, alfentanil, allylprodine, alphaprodine, anileridine, benzylmorphine, bezitramide, buprenorphine, butorphanol, clonitazene, codeine, desomorphine, dextromoramide, dezocine, diampromide, diamorphone, dihydrocodeine, dihydromorphine, dimenoxadol, dimepheptanol, dimethylthiambutene, dioxaphetyl butyrate, dipipanone, eptazocine, ethoheptazine, ethylmethylthiambutene, ethylmorphine, etonitazene, fentanyl, heroin, hydrocodone, hydromorphone, hydroxypethidine, isomethadone, ketobemidone, levorphanol, levophenacylmorphan, lofentanil, meperidine, meptazinol, metazocine, methadone, metopon, morphine, myrophine, nalbuphine, narceine, nicomorphine, norlevorphanol, normethadone, nalorphine, normorphine, norpipanone, opium, oxycodone, oxymorphone, papaveretum, pentazocine, phenadoxone, phenomorphan, phenazocine, phenoperidine, piminodine, piritramide, proheptazine, promedol, properidine, propiram, propoxyphene, sufentani l, tilidine, tramadol, pharmaceutically acceptable derivatives thereof, or any mixture thereof.
In certain embodiments, the opioid agonist is selected from codeine,
hydromorphone, hydrocodone, oxycodone, dihydrocodeine, dihydromorphine, morphine, tramadol, oxymorphone, pharmaceutically acceptable derivatives thereof, or any mixture thereof.
Examples of useful non-opioid analgesics include, but are not limited to, non-steroidal anti-inflammatory agents, such as aspirin, ibuprofen, diclofenac, naproxen, benoxaprofen, flurbiprofen, fenoprofen, flubufen, ketoprofen, indoprofen, piroprofen, carprofen, oxaprozin, pramoprofen, muroprofen, trioxaprofen, suprofen, aminoprofen, tiaprofenic acid, fluprofen, bucloxic acid, indomethacin, sulindac, tolmetin, zomepirac, tiopinac, zidometacin, acemetacin, fentiazac, clidanac, oxpinac, mefenamic acid, meclofenamic acid, flufenamic acid, niflumic acid, tolfenamic acid, diflurisal, flufenisal, piroxicam, sudoxicam, isoxicam, a pharmaceutically acceptable derivative thereof, or any mixture thereof. Other suitable non-opioid analgesics include the following, non-limiting, chemical classes of analgesic, antipyretic, nonsteroidal antiinflammatory drugs: salicylic acid derivatives, including aspirin, sodium salicylate,
choline magnesium trisal icy late, salsalate, diflunisal, salicylsalicylic acid, sulfasalazine, and olsalazin; para-am inophenol derivatives including acetaminophen and phenacetin; indole and indene acetic acids, including indomethacin, sulindac, and etodolac;
heteroaryl acetic acids, including tolmetin, diclofenac, and ketorolac; anthranilic acids (fenamates), including mefenamic acid and meclofenamic acid; enolic acids, including oxicams (piroxicam, tenoxicam), and pyrazolidinediones (phenylbutazone,
oxyphenthartazone); alkanones, including nabumetone; a pharmaceutically acceptable derivative thereof; or any mixture thereof. For a more detailed description of the NSAIDs, see Paul A. Insel, Analgesic-Antipyretic and Anti-inflammatory Agents and Drugs Employed in the Treatment of Gout, in Goodman & Gilman's The
Pharmacological Basis of Therapeutics 617-57 (Perry B. Molinhoff and Raymond W. Ruddon eds., 9th ed 1996); and Glen R. Hanson, Analgesic, Antipyretic and
Anti-Inflammatory Drugs in Remington: The Science and Practice of Pharmacy Vol IA 1 196- 1221 (A.R. Gennaro ed. 1 9th ed. 1995), which are hereby incorporated by reference in their entireties.
Examples of useful Cox-II inhibitors and 5-lipoxygenase inhibitors, as well as combinations thereof, are described in U.S. Patent No. 6, 136,839, which is hereby incorporated by reference in its entirety. Examples of useful Cox-II inhibitors include, but are not limited to, celecoxib, DUP-697, flosulide, meloxicam, 6-MNA, L-745337, rofecoxib, nabumetone, nimesulide, NS-398, SC-5766, T-614, L-768277, GR-253035, JTE-522, RS-57067-000, SC-58125, SC-078, PD- 138387, NS-398, flosulide, D- 1367, SC-5766, PD- 164387, etoricoxib, valdecoxib, parecoxib, a pharmaceutically acceptable derivative thereof, or any mixture thereof.
Examples of useful antimigraine agents include, but are not limited to, alpiropride, bromocriptine, dihydroergotamine, dolasetron, ergocornine, ergocorninine, ergocryptine, ergonovine, ergot, ergotamine, flumedroxone acetate, fonazine, ketanserin, lisuride, lomerizine, methylergonovine, methysergide, metoprolol, naratriptan, oxetorone, pizotyline, propranolol, risperidone, rizatriptan, sumatriptan, timolol, trazodone, zolmitriptan, a pharmaceutically acceptable derivative thereof, or any mixture thereof.
Examples of useful anticonvulsants include, but are not limited to,
acetylpheneturide, albutoin, aloxidone, aminoglutethimide, 4-amino-3-hydroxybutyric acid, atrolactamide, beclamide, buramate, calcium bromide, carbamazepine, cinromide, clomethiazole, clonazepam, decimemide, diethadione, dimethadione, doxenitroin, eterobarb, ethadione, ethosuximide, ethotoin, felbamate, fluoresone, gabapentin, 5-hydroxytryptophan, lamotrigine, magnesium bromide, magnesium sulfate, mephenytoin, mephobarbital, metharbital, methetoin, methsuximide, 5-methyl- 5-(3-phenanthryl)-hydantoin, 3-methyl-5-phenylhydantoin, narcobarbital, nimetazepam, nitrazepam, oxcarbazepine, paramethadione, phenacemide, phenetharbital, pheneturide, phenobarbital, phensuximide, phenylmethylbarbituric acid, phenytoin, phethenylate sodium, potassium bromide, pregabaline, primidone, progabide, sodium bromide, solanum, strontium bromide, suclofenide, sulthiame, tetrantoin, tiagabine, topiramate, trimethadione, valproic acid, valpromide, vigabatrin, zonisamide, a pharmaceutically acceptable derivative thereof, or any mixture thereof.
Examples of useful Ca2+-channel blockers include, but are not limited to, bepridil, clentiazem, diltiazem, fendiline, gal lopamil, mibefradil, prenylamine, semotiadil, terodiline, verapamil, amlodipine, aranidipine, barnidipine, benidipine, cilnidipine, efonidipine, elgodipine, felodipine, isradipine, lacidipine, lercanidipine, manidipine, nicardipine, nifedipine, ni lvadipine, nimodipine, nisoldipine, nitrendipine, cinnarizine, flunarizine, lidoflazine, lomerizine, bencyclane, etafenone, fantofarone, perhexiline, a pharmaceutically acceptable derivative thereof, or any mixture thereof.
Examples of useful therapeutic agents for treating or preventing UI include, but are not limited to, propantheline, imipramine, hyoscyamine, oxybutynin, dicyclomine, a pharmaceutically acceptable derivative thereof, or any mixture thereof.
Examples of useful therapeutic agents for treating or preventing anxiety include, but are not limited to, benzodiazepines, such as alprazolam, brotizolam,
chlordiazepoxide, clobazam, clonazepam, clorazepate, demoxepam, diazepam, estazolam, flumazenil, flurazepam, halazepam, lorazepam, midazolam, nitrazepam, nordazepam, oxazepam, prazepam, quazepam, temazepam, and triazolam; non- benzodiazepine agents, such as buspirone, gepirone, ipsapirone, tiospirone, zolpiclone, Zolpidem, and zaleplon; tranquilizers, such as barbituates, e.g., amobarbital,
aprobarbital, butabarbital, butalbital, mephobarbital, methohexital, pentobarbital, phenobarbital, secobarbital, and thiopental; propanediol carbamates, such as meprobamate and tybamate; a pharmaceutically acceptable derivative thereof; or any mixture thereof.
Examples of useful therapeutic agents for treating or preventing diarrhea include, but are not limited to, diphenoxylate, loperamide, a pharmaceutically acceptable derivative thereof, or any mixture thereof.
Examples of useful therapeutic agents for treating or preventing epilepsy include, but are not l imited to, carbamazepine, ethosuximide, gabapentin, lamotrigine, phenobarbital, phenytoin, primidone, valproic acid, trimethadione, benzodiazepines, γ vinyl GABA, acetazolamide, felbamate, a pharmaceutically acceptable derivative thereof, or any mixture thereof.
Examples of useful therapeutic agents for treating or preventing drug abuse include, but are not l imited to, methadone, desipramine, amantadine, fluoxetine, buprenorphine, an opiate agonist, 3-phenoxypyridine, levomethadyl acetate
hydrochloride, serotonin antagonists, a pharmaceutically acceptable derivative thereof, or any mixture thereof.
Examples of non-steroidal anti-inflammatory agents, 5-l ipoxygenase inhibitors, anti-emetics, β adrenergic blockers, antidepressants, and anti-cancer agents are known in the art and can be selected by those skilled in the art. Examples of useful therapeutic agents for treating or preventing memory disorder, obesity, constipation, cough, high blood pressure, anorexia/cachexia, an ulcer, 1BD, IBS, addictive disorder, Parkinson's disease and parkinsonism, a stroke, a seizure, a pruritic condition, psychosis,
Huntington's chorea, ALS, a cognitive disorder, a migraine, dyskinesia, depression, and/or treating, preventing or inhibiting vomiting include those that are known in the art and can be selected by those skilled in the art.
A composition of the invention is prepared by a method comprising admixing a Compound of the Invention (or a pharmaceutically acceptable salt, prodrug or solvate thereof) with a pharmaceutically acceptable carrier or excipient. Admixing can be accomplished using methods known for admixing a compound (or derivative) and a pharmaceutically acceptable carrier or excipient. In one embodiment, the Compound of
the Invention (or pharmaceutically acceptable salt, prodrug or solvate thereof) is present in the composition in an effective amount.
Examples
EXAMPLE 1
(4^)-4-((4i?,4a5,6i?,7i?,7ai?,12b5)-3-(cyclopropylmethyl)-7,9-dimethoxy-
1,2, 3,4,5, 6,7, 7a-octahydro-4a,7-ethano-4, 12-methanobenzofuro[3,2-e]isoquinolin-6-yl)-
4-phenylbutane- l ,2,4-triol (Compound 6).
Phenylmagnesium bromide (2.7 mL, 8.1 mmol, 3.0 M solution in ether) was added to a solution of 1 (2.2 g, 5.4 mmol) in THF (25 mL, anhydrous) at -10°C under a nitrogen atmosphere. The resulting mixture was allowed to warm to room temperature overnight.
The reaction mixture was quenched with ice water, extracted with ethyl acetate (EtOAc), dried over sodium sulfate (Na2S04), filtered and concentrated. The crude 2 (2.8 g, quantitative yield, as a mixture of diastereomers) was used for the next reaction. LC/MS, m/z = 486 [M + H]+ (Calc: 485).
A mixture of 2 (2.8 g, 5.4 mmol) and 5% Palladium on carbon (5% Pd/C) in absolute ethanol (EtOH) (30 mL) was hydrogenated at 50 psi of hydrogen overnight. The mixture was filtered through a Celite pad and concentrated. The crude 3 (2.9 g, quantitative yield, as a mixture of diastereomers) was used for the next reaction.
LC/MS, m/z = 488 [M + H]+ (Calc: 487).
Dess-Martin periodinane (2.1 g, 4.9 mmol) was added to a suspension of 3 ( 1 .2 g, 2.5 mmol) and sodium bicarbonate (NaHC03) (2.5 g, 29.5 mmol) at room temperature. The reaction mixture quenched with saturated aqueous sodium sulfite (Na2S0 ) after stirring at room temperature for l h. The resulting mixture was stirred vigorously for 15 min. Saturated aqueous sodium bicarbonate (NaHC03) was added, and the mixture was extracted with EtOAc. The organic layer was dried over Na2S04, filtered and concentrated. The crude material was purified by flash chromatography (Si02, 10-50% EtOAc/hexanes) to obtain compound 4 (0.8 g, 67% yield) as a pale yellow foam.
LC/MS, m/z = 486 [M + H]+ (Calc: 485).
Aliylmagnesium bromide (0.23 mL, 0.45 mmol, 2.0 M solution in THF) was added to a solution of 4 (0.2 g, 0.41 mmol) in THF (5 mL) at -40°C under a nitrogen atmosphere. The mixture was allowed to warm to room temperature over 6h. The mixture was cooled in an ice-bath, quenched with saturated aqueous ammonium chloride (NH4C1) and extracted with EtOAc. The organic layer was dried over Na2S04, filtered and concentrated. The crude 5 (0.24 g, quantitative yield) was used for the next reaction. LC/MS, m/z = 528 [M + H]+ (Calc: 527).
Osmium tetraoxide (0.24 mL, 0.04 mmol, 2% aqueous solution) was added to a solution of 5 (0.2 g, 0.38 mmol) in acetone/water (10:2 mL). After 10 min N-methylmorpholine-
N-oxide (0.06 g, 0.46 mmol) was added. The reaction was stirred at room temperature for 4h. Most of the acetone was evaporated and the mixture was partitioned between chloroform (CHC13) and saturated NaHC03. The organic layer was dried overNa2S04, filtered and concentrated. The crude material was purified twice by flash
chromatography (Si02, 10-100% EtOAc/hexanes). Final purification was achieved by reverse phase chromatography (CI 8, acetonitrile/water with 0.1% TFA, 0-95%) to obtain Compound 6 (24.7 mg) as the trifluoroacetate (TFA) salt.
Ή NMR (300 MHz, OMSO-d6) δ ppm 8.42 (br s, IH), 7.52 (d, J= 7.4 Hz, 2H), 7.26 (m,2H), 7.14(m, IH), 6.81 (2d,J=7.2 hz, IH), 6.64 (d,J=7.2 Hz, IH), 5.52 and 5.41 (bs, IH), 4.51 (s, 1H),3.88 (d,J=6.3 Hz, IH), 3.73 (s, 3H), 3.54-3.10 (m, 6H), 2.92- 2.58 (m., 5H), 2.54 (m, IH), 2.40 (m, IH), 2.34-2.17 (m, 2H), 2.11 (m, IH), 1.95-1.80 (m, 2H), 1.60 (m, I H); 1.18-0.84 (m, 2H), 0.77-0.58 (m, 2H), 0.54-0.32 (m, 3H).
LC/MS, m/z = 562 [M + H]+ (Calc: 561).
EXAMPLE 2
2-(((5)-((4?,4a5,6i?,7i?,7a^,12b5 -3-(cyclopropylmethyl)-7,9-dimethoxy-
1 ,2,3,4,5, 6,7, 7a-octahydro-4a,7-ethano-4, 12-methanobenzofuro[3,2-e]isoquinolin-6- yl)(phenyl)methyl)amino)acetic acid (Compound 12).
Acrylonitrile (20 mL) was added to a solution of 2 (5.3 g, 15.0 mmol) in toluene ( 1 00 mL, anhydrous). The mixture was heated at 50°C overnight. The reaction mixture was concentrated. Purification of the crude material by flash chromatography (Si02, 10-25% EtOAc/hexanes) yielded 8 (2.3 g, 37% yield) and 9 (1 .92 g, 31 % yield).
LC/MS, m/z = 404 [M + H]+ (Calc: 403).
Phenylmagnesium bromide (1 .15 mL, 3.4 mmol, 3.0 solution in ether) was added to a solution of 8 ( 1 .39 g, 3.4 mmol) in benzene (30 mL, anhydrous). The resulting mixture was heated to reflux overnight under a nitrogen atmosphere. A solution of ammonium acetate (5.9 g, 68.0 mmol) in methanol (20 mL) was added and the mixture was stirred at room temperature for lh. Sodium borohydride ( 1.2 g. 34.0 mmol) was added and the stirring continued for 2h. The mixture was concentrated. The residue was partitioned between saturated aqueous NaHC03and CHC13. The organic layer was dried over a2S0 , filtered and concentrated. Purification of the crude material by flash
chromatography (Si02, 10-50% EtOAc/hexanes) yielded 10 (0.49 g, 31% yield).
Ή NMR (300 MHz, CDC13) δ ppm: 7.34-7.16 (m, 5H), 6.58 (d, J = 7.4 Hz, IH), 6.44 (m, 1 H), 5.79 and 5.62 (2d, J= 7.4 Hz, 1 H), 5.32 and 5.26 (2d, J = 7.4 Hz, 1 H), 4.60 (s, 1H), 3.84-3.62 (m, 9H), 3.51-3.42 (m, 2H), 3.28 (d, J = 6.2 Hz, 1H), 3.10 and 2.82 (2m, lH),3.00(d,J= 14.1 Hz, 1H),2.62 (m., 1H), 2.54-2.20 (m, 6H), 2.01-1.40 (m, 5H), 1.21 and 1.13 (2d, J = 6.9 and 7.1 Hz, 3H), 0.69 (m, 2H), 0.41 (m, 2H), 0.002 (m, 2H). LC/MS, m/z = 485 [M + H]+ (Calc: 484).
Triethylamine (21 iL, 0.15 mmol) was added to a solution of 10 (25 mg, 0.05 mmol) and benzyl bromoacetate (16 μΐ,, 0.10 mmol) in THF (1 mL, anhydrous). The mixture was stirred at room temperature for 2h and concentrated. Purification of the crude material by flash chromatography (Si02, 10-50% EtOAc/hexanes) yielded 11 (29 mg, 91% yield).
LC/MS, m/z = 633 [M + H]+ (Calc: 632).
A mixture of 5 (29 mg, 0.05 mmol) and 5% Pd/C in absolute ethanol (5 mL) was hydrogenated at room temperature overnight under 50 psi of hydrogen. The mixture filtered through a Celite pad. The filtrate was concentrated and the crude material was purified by reverse phase chromatography (CI 8, acetonitrile/water with 0.1% TFA, 0- 95%) to obtain Compound 12 (12.4 mg) as the di-TFA salt.
1 H NMR (300 MHz, D20) δ ppm: 7.50 (bs, 5H), 6.98 (m, IH), 6.79 (m, 1H), 4.84 (s, IH), 4.51 (m, IH), 3.86 (m, 4H), 3.60 (s, 3H), 3.40-2.68 (m, 8H), 2.22 (m, 2H), 2.04 (m, IH), 1.85 (m,2H), 1.30 (m, IH), 1.05 (m, IH), 0.81 (m, 2H), 0.61-0.52 (m, 2H), 0.29-0.18 (m,2H).
LC/MS, m/z = 545 [M + H]+ (Calc: 544).
In a similar manner, 2-(((5)-((4^,4a1S,67?,7i?,7ai?,12b5)-3-(cyclopropylmethyl)-7,9- dimethoxy- 1,2, 3,4, 5,6,7, 7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2- e]isoquinolin-6-yl)(phenyl)methyl)amino)propanoic acid (Compound 13) was prepared from 10 using benzyl 2-bromopropionate rather than benzyl bromoacetate.
Ή NMR (300 MHz, D20) δ ppm: (mixture of diastereomers) 9.40 (bs, IH), 8.41 (bs,
1H), 7.73-7.41 (m, 5H), 6.91 (d, J= 8.4 Hz, ΓΗ), 6.69 (d, J= 8.4 Hz, 1H), 4.71-4.61 (m, 3H), 3.87 (m, 3H), 3.75 (m, 2H), 3.58 (s, 3H), 3.56 (m, 2H), 3.32-3.22 (m., 3H), 3.00- 2.64 (m, 4H), 2.35-2.14 (m, 2H), 2.00-1.71 (m, 2H), 1.62 (m, I H), 1.45 (d,J= 7.0 Hz, IH), 1.23 (m, IH), 0.89 (m, 3H), 0.73-0.47 (m, 3H), 0.29 (m, 2H).
LC/MS, m/z = 599 [M + H]+ (Calc: 598).
In a similar manner, 2-(((5 -((4i?,4a5,6i?,77?,7ai?, 12b5)-3-(cyclopropylmethyl)-7,9- dimethoxy-l,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2- e]isoquinolin-6-yl)(phenyl)methyl)amino)-2-phenylacetic acid (Compound 15) was prepared from 10 using benzyl 2-phenyl-2-bromoacetate rather than benzyl
bromoacetate.
Ή NMR (301 MHz, D20) δ ppm: (mixture of diastereomers) 8.30 (bs, 1 H), 7.60-7.51 (m, 2H), 7.46-7.37 (m, 3H), 7.35-7.24 (m, 3H), 7.01-6.90 (m, 2H), 6.90 (d, J= 8.5 Hz, IH), 6.69 (d,J = 8.0 Hz, IH), 4.72 (s, IH), 4.50 (m, IH), 4.20 (m, 2H), 3.82 (s, 3H), 3.74 (m, IH), 3.58 (s, 3H), 3.32-3.15 (m, 3H), 3.00-2.66 (m., 4H), 2.45 (m, IH), 2.26- 2.10 (m,2H), 1.91-1.80 (m,2H), 1.50 (m, IH), 1.32-0.84 (m, 4H), 0.74-0.50 (m, 3H), 0.28 (m, 2H).
LC/MS, m/z = 621 [M + H]+ (Calc: 620).
EXAMPLE 3
2-(((5)-((4i?,4aS,6?,7R,7ai?,12b5)-3-(cyclopi pylmethyl)-7,9-dimethoxy- 1 ,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4, 12-methanobenzofuro[3,2-e]isoq
yl)(phenyl)methyl)amino)propanamide (Compound 14).
MeO Ό' O
2-(7-Aza- 1 H-benzotriazole- 1 -yl)- 1 , 1 ,3,3-tetramethyluroniiim hexafluorophosphate (HATU) (Sigma Aldrich) (86 mg, 0.23 mmol) was added to a solution of 13 (82 mg, 0. 15 mmol) in TH F (6.0 mL). After 10 min NH4Cl (32 mg, 0.6 mmol) and
diisopropylethylamine (DIPEA) (131 μΐ, 0.75 mmol) was added. The resulting mixture was stirred overnight at room temperature. The reaction was quenched with water and extracted with CHCI3. The organic layer was dried over Na2S04, filtered and concentrated. The crude material was purified by reverse phase chromatography (C I 8, acetonitrile/water with 0. 1 % TFA, 0-95%) to obtain Compound 14 (30 mg) as the di- TFA salt.
Ή NMR (300 MHz, D20) δ ppm : 9.34 (bs, 2H), 8.70 and 8.48 (2bs, l H), 7.89-7.49 (m, 7H), 6.90(d, J = 8.3 Hz, 1 H), 6.69 (d, J = 8.2 Hz, 1 H), 4.75-4.53 (m, 2H), 3.82 (m, 3H), 3.73 (m, l H), 3.58 (s, 3H), 3.48 (m, l H), 3.40-3.1 5 (m., 3H), 2.93-2.72 (m, 4H), 2.49- 2.14 (m, 2H), 1.94-1 .80 (m, 2H), 1.62 (m, l H), 1 .43 (d, J = 6.9 Hz, 1 H), 1 .29 (m, l H), 0.97 and 0.95 (2s, 3H), 0.89 (m, 2H), 0.78-0.42 (m, 3H), 0.28 (m, 2H).
LC/MS, m/z = 558 [M + H]+ (Calc: 557).
In a similar manner, (J/?)-2-(((5)-((47?,4a5',6R,7i?,7a7?,12b5 -3-(cyclopropylmethyl)-7,9- dimethoxy- 1 ,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4, 12-methanobenzofuro[3,2- e]isoquinol in-6-yl)(phenyl)methyI)amino)-2-phenylacetamide (Compound 16) and (5)- 2-(((5*)-((4^,4a5,6^,7i?,7a^, 12bS)-3-(cyclopropylmethyI)-7,9-dimethoxy- 1 ,2, 3,4, 5,6,7, 7a-octahydro-4a,7-ethano-4, 12-methanobenzofuro[3,2-e]isoquinolin-6- yl)(phenyl)methyl)amino)-2-phenylacetamide (Compound 17) were prepared from 15 and separated by reverse phase chromatography (C I 8, acetonitrile/water with 0.1 % TFA, 0-95%)) to obtain Compound 16 (20.1 mg) and Compound 17 (6.5 mg) as their di- TFA salts.
Compound 16;
'HNMR (300 MHz, OMSO-D6) δ ppm: 9.87 (bs, IH), 9.70 (bs, 1H), 8.47 (bs, 1H), 8.03 (bs, IH), 7.87 (bs, 1H), 7.66-7.38 (m, 8H), 6.98 (m, 2H), 6.93(d,J= 8.3 Hz, IH), 6.70 (d,J=7.7 Hz, IH), 4.66 (s, IH), 4.57 (m, IH), 4.30 (m, 1H),3.84 (s, 3H), 3.76 (m, IH), 3.67 (s, 3H), 3.32-3.16 (m, 3H), 2.92-2.72 (m., 4H), 2.33-2.07 (m, 2H), 2.00-1.84 (m, 2H), 1.71 (m, IH), 1.38 (m, IH), 1.01-0.88 (m, 2H), 0.80-0.43 (m, 3H), 0.28 (m, 2H).
LC/MS, m/z = 620 [M + H]+ (Calc: 619).
Compound 17;
Ή NMR (300 MHz, DMSO-D6) δ ppm: 10.30 (bs, IH), 9.50 (bs, IH), 8.31 (bs, IH), 7.90 (bs, IH), 7.80 (bs, IH), 7.51 (m, 7H), 7.28 (m, 2H), 6.90 (d,J= 8.2 Hz, IH), 6.69 (d, J= 8.2 Hz, 1 H), 4.82 (s, IH), 4.24 (m, 1 H), 3.82 (s, 3H), 3.76 (m, 1 H), 3.67 (s, 3H), 3.60 (m, 1 H), 3.31 -3.22 (m, 3H), 2.97-2.81 (m., 2H), 2.78-2.62 (m, 2H), 2.29-2.13 (m, 2H), 1.91 (m, IH), 1.52 (m, IH), 1.24-1.00 (m, 2H), 0.82-0.69 (m, 2H), 0.60-0.31 (m, 3H), 0.28 (m, 2H).
LC/MS, mz = 620 [M + H]+ (Calc: 619).
EXAMPLE 4
The following Tables provide results on the efficacy of binding and activity response of exemplified Compounds of the Invention at the μ- and κ-opioid receptors.
In TABLE 1, binding affinity of certain Compounds of the Invention to the μ-, and κ- opioid receptors in HEK-293 or CHO cells was determined as described above.
In TABLE 2, activity response of certain Compounds of the Invention at the μ- and κ- opioid receptors using HEK-293 or CHO cells was determined as described above for functional assays.
In TABLE 2A, activity response of certain Compounds of the Invention at the μ- and K-opioid receptors using U-2 OS cells was determined as described above for functional assays.
In TABLE 3, the structure of the exemplified compounds is shown.
TABLE 1 : Binding Affinity of Buprenorphine Analog Compounds
TABLE 2: Activity Response of Buprenorphine Analog Compounds in HEK-293 or CHO Cells
Cells
Other embodiments of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the invention disclosed herein. It
is intended that the specification and examples be considered as exemplary only, with a true scope and spirit of the invention being indicated by the following claims.
All patents and publications cited herein are fully incorporated by reference in their entirety.
Claims
1. A compound of Formula I:
(I)
wherein
R1 is selected from the group consisting of hydrogen, -(C i-C io)alkyl, -(C2- Ci2)alkenyl, -(C2-C]2)alkynyl, -(Ci-Cio)alkoxy, -(C3-C|2)cycloalkyl, -(C4- C |2)cycloalkenyl, ((C3-C i2)cycloalkyl)-(C i-C6)alkyl-, ((C4-C|2)cycloalkenyl)-(C| - C6)alkyl-, -(6- to 14-membered)aryl, ((6- to l 4-membered)aryl)-(Ci-C6)alkyl-, -(5- to 12-membered)heteroaryl, ((5- to 12-membered)heteroaryl)-(Ci-C6)alkyl-, -(3- to 12- membered)heterocycle, ((3- to 12 membered)heterocycle)-(C | -C6)alkyl-, phenyl, and benzyl; any of which is optionally substituted with 1 , 2, or 3 substituents each independently selected from the group consisting of -(Ci-C6)alkyl, OH, halo, -C(halo)3, -CH(halo)2, -CH2(halo), -(C 1-C6)alkyl-COOR7, -COOR7, NH2, -NH(C rC6)alkyl, - NR9R10, -CN, -CONR9R10, -NR9COR10, -SR9, -(5- to 12-membered)carbocyclic ring, - (5- to 12-membered)heterocycle, phenyl, and benzyl;
2 8
R and R are each independently selected from the group consisting of hydrogen, -(C ,-Cl 0)alkyl, -(C2-C |2)alkenyl, -(C2-C i2)alkynyl, -CONR5R6, -COOR7, -(6-
to 14-membered)aryl, ((6- to 14-membered)aryl)-(Ci-C6)alkyl-, -(5- to 12- membered)heteroaryl, and ((5- to 12-membered)heteroaryl)-(C| -C6)alkyl-; each of which is optionally substituted with I , 2, or 3 substituents independently selected from the group consisting of -OH, (=0), halo, -C(halo)3, -CH(halo)2, -CH2(halo), -(C i- C6)alkyl, halo(C| -C6)alkyl-, -(C2-C6)alkenyl, -(C2-C6)alkynyl, hydroxy(C| -C6)alkyl-, dihydroxy(C |-C6)alkyl-, -(Ci -C6)alkoxy, ((C | -C6)alkoxy)-CO-(C i -C6)alkoxy-, phenyl, benzyl, -NH2, -NH(C-C6)alkyl, -(C] -C6)alkyl-NH(Ci-C6)alkyl-R14, -CN, -SH, -OR4, -CONR5R6, -(C i-C6alkyl)-CO-NR5R6, -COOR7, and -(C C6)alkyl-CO-OR7;
R3a and R3b are each independently selected from the group consisting of hydrogen, -(C 1-C ] 0)alkyl, -(C2-C,o)alkenyl, -(C2-C,0)alkynyl, -CONR5R6, and -COOR7, or together form (=0);
R4 is selected from the group consisting of -(C i-C6)alkyl, -(C2-C6)alkenyl, -(C2- C6)alkynyl, -C(halo)3, -CH(halo)2, -CH2(halo), hydroxy(Ci -C6)a!kyl-, -(C3- Ci2)cycloalkyl,
((C3-C i 2)cycloalkyl)-(C,-C6)alkyl-, -(6- to 14-membered)aryl, ((6- to 14- membered)aryl)-(C | -C6)alkyl-, -(5- to 12-membered)heteroaryl, and ((5- to 12- membered)heteroaryl)-(C| -C6)alkyl-;
R5 and R6 are each independently selected from the group consisting of hydrogen, - (C,-C6)alkyl, -(C3-C8)cycloalkyl, ((C3-C8)cycloalkyl)-(C , -C6)alkyl-, -COOR7, -(C, - C6)alkyl-CO-OR7, -CONH2, and (C, -C6)alkyl-CONH-, or R5 and R6 together with the nitrogen atom to which they are attached form a (4- to 8-membered)heterocycle;
R7 is selected from the group consisting of hydrogen, -(C | -C6)alkyl, -(C2-C6)alkenyl, - (C2-C6)alkynyl, -(C3-C|2)cycloalkyl, -(C4-C i2)cycloalkenyl, ((C3-Ci2)cycloalkyl)-(C | - C6)alkyl-, and ((C4-C ,2)cycloalkenyl)-(C| -C5)alkyl- ;
R9 and R10 are each independently selected from the group consisting of hydrogen, - (C| -C6)alkyl, -(C2-C6)alkenyl, -(C2-C6)alkynyl, -(C| -Cio)alkoxy, -(C3-C) 2)cycloalkyl, - (C3-C i2)cycloalkenyl, ((C -Ci2)cycIoalkyl)-(C i-C6)alkyl-, and ((C3-C |2)cycloalkenyl)- (C, -C6)alkyl-;
R12 and R13 are each independently selected from the group consisting of hydrogen, - (C ,-C,o)alkyl, -(C2-C12)alkenyl, -(C2-C,2)alkynyl, -(C,-C10)alkoxy, -(OCH2CH2)s-0(C1- C6)alkyl, -(C3-C12)cycloalkyl, ((C3-CI2)cycloalkyl)-(C1-C6)alkyl-, -(C4-
Ci2)cycloalkenyl, ((C4-Ci2)cycloalkenyl)-(Ci-C6)alkyl-, -(C6-Ci4)bicycloalkyl, ((C6- C i4)bicycloalkyl)-(C| -C6)alkyl-, -(C8-C20)tricycloalkyl, ((C8-C2o)tricycloalky!)-(C|- C6)alkyl-, -(C7-C|4)bicycloalkenyl, ((C7-C|4)bicycloalkenyl)-(C| -C6)alkyl-, -(C8- C2o)tricycloalkenyl, ((C8-C2o)tricycloalkenyl)-(C, -C6)alkyl-, -(6- to 14-membered)aryl, ((6- to l 4-membered)aryl)-(Ci-C6)alkyl-, -(7- to 12-membered)bicyclic ring system, ((7- to 12-membered)bicyclic ring system)-(C i -C6)alkyl-, -(7- to 12-membered)bicyclic aryl, ((7- to 12-membered)bicyclic aryl)-(C i-C6)alkyl-, -(5- to 12-membered)heteroaryl, ((5- to 12-membered)heteroaryl)-(Ci-C6)alkyl-, -(3- to 12-membered)heterocycle, ((3- to 12- membered)heterocycle)-(C | -C6)alkyl-, -(7- to 12-membered)bicycloheterocycle, ((7- to 12-membered)bicycloheterocycle)-(C|-C6)alkyl-, phenyl, benzyl and naphthyl; each of which is optional ly substituted with 1 or 2 substituents independently selected from the group consisting of OH, (=0), halo, -C(halo)3, -CH(halo)2, -CH2(halo), -(C ] -C6)alkyl, halo(C |-C6)alkyl-, -(C2-C6)alkenyl, -(C2-C6)alkynyl, hydroxy(Ci-C6)alkyl-, phenyl, benzyl, NH2, -NH(C ,-C6)alkyl, -CN, -SH, -OR4, -CONR5R6, -COOR7, -(C3- C i2)cycloalkyl, ((C3-C i2)cycloalkyl)-(C i -C6)alkyl-, -(6- to 14-membered)aryl, ((6- to 14-membered)aryl)-(C i -C6)alkyl-, -(5- to 12-membered)heteroaryI, ((5- to 12- membered)heteroaryl)-(Ci -C6)alkyl-, -(3- to 12-membered)heterocycle, ((3- to 12- membered)heterocycle)-(C | -C6)alkyl-, -(7- to 12-membered)bicycloheterocycle, and ((7- to 12-membered)bicycloheterocycle)-(Ci -C6)alkyl-;
R14 is selected from the group consisting of -COOR7, -(d-C6)alkyl-CO-OR7, -C(=0)- (C |-C6)alkyl-COOR7,
,-C6)alkyl-COOR7, -CONH2, and (C ,- C6)alkyl-CONH-;
G is selected from the group consisting of CH , NR16, and O;
X is selected from the group consisting of -(C i-C io)alkoxy, OH, hydroxy(Ci- Q alkyl-, dihydroxy(C , -C6)alkyl-, halogen, -NH2, -NR2(C=0)R12, -CONRl 2R13,
Q is selected from the group consisting of OH, -(C] -C,o)alkoxy, -(Ci -Cio)alkyl, -O- (Ci-C6)alkyl, -(6- to 14-membered)aryl, -0-((6- to 14-membered)aryl), ((6- to 14- membered)aryl)-(Ci -C6)alkyl-, -0-((6- to 14-membered)aryl)-(Ci-C6)alkyl, (5- to 12- membered)heteroaryl, -0-((5- to 12-membered)heteroaryl), ((5- to 12- membered)heteroaryl)-(C| -C6)alkyl-, and -0-((5- to 12-membered)heteroaryl-(C] - C6)alkyl;
R15a and Rl ;>b are each independently selected from the group consisting of: a) hydrogen, OH;
b) saturated, unsaturated, or partial ly saturated -(C3-C | 2)cycloal kyl, ((C3-C |2)cycloal kyl)- (C,-C6)alkyh ((C3-C, 2)cycloalkyl)-(C2-C6)alkenyl-, ((C3-C12)cycloalkyl)-(C, - C6)alkoxy-;
c) -(6- to 14-membered)aryl, ((6- to 14-membered)aryl)-(C | -C6)alkyl-, ((6- to 14- membered)aryl)-(Ci -C6)alkoxy-, ((6- to 14-membered)aryl)-(C2-C6)alkenyl-; or d) -(5- to 12-membered)heteroaryl, ((5- to 12-membered)heteroaryl)-(Ci-C6)alkyl-, ((5- to 12-membered)heteroaryl)-(Ci-C6)alkoxy-, ((5- to 12-membered)heteroaryl)-(C2- C6)alkenyl-; and
e) -(3- to 12-membered)heterocycle, ((3- to 12-membered)heterocycle)-(Ci -C6)alkyl-, ((3- to I 2-membered)heterocycle)-(Ci-C6)alkoxy-, -(7- to 12- membered)bicycloheterocycle, ((7- to 12-membered)bicycloheteiOcycle)-(Ci-C6)alkyl-, and ((7- to 12-membered)bicycloheterocycle)-(Ci-C6)alkoxy-;
provided that at least one of Rl 5a and Rl 5b is other than hydrogen ;
R16 is selected from hydrogen and -(C i -C6)alkyl;
Y is -(CH2)n-CH or a d irect bond, provided that when Y is a direct bond then R8 is absent;
n is an integer 0, 1 , 2, 3, 4, 5 or 6;
s is an integer 1 , 2, 3, 4, 5, 6, 7, 8, 9, 10, 1 1 , 12, or 13;
or a pharmaceutical ly acceptable salt, or solvate thereof.
2. A compound of claim 1 having Formula II:
(Π) wherein R1, R2, R3a, R3b, R8, Rl5a, Rl5b, Q and X are as defmed above for Formula I, or a pharmaceutically acceptable salt or solvate thereof.
3. A compound of claim 1 having Formula III:
(III) wherein R1, R2, R3a, R3b, R8, R15a, R15b, Q and X are as defmed above for Formula I, or a pharmaceutically acceptable salt or solvate thereof.
4. A compound of claim 1 having Formula IV:
5. A compound of claim 1 having Formula V:
6. The compound of any one of claims 1 to 5, wherein G is R16.
7. The compound of any one of claims 1 to 6, wherein R16 is hydrogen.
8. The compound of any one of claims 1 to 5, wherein G is CH2.
9. The compound of any one of claims 1 to 5, wherein G is O.
10. The compound of any one of claims 1 to 9, wherein at least one of RI 5a or Rl :>b is - (6- to 14-membered)aryl.
1 1 . The compound of any one of claims 1 to 10, wherein at least one of Rl 5a or Rl 3 is phenyl.
12. The compound of any one of claims 1 to 9, wherein at least one of RI 5a or R, 5b is (6- to 14-membered)aryl-(C i -C6)alkyl-.
13. The compound of any one of claims 1 to 9 and 12, wherein at least one of R15a or R15b is benzyl.
14. The compound of any one of claims 1 to 13, wherein at least one of R15a or Rl5b is hydrogen.
15. The compound of any one of claims 1 to 13, wherein at least one of R, 5a or R, Db is OH.
16. The compound of any one of claims 1 to 1 5 , wherein at least one of R2 or R8 is - (C,-Cl 0)alkyl.
^ 8
17. The compound of any one of claims 1 to 16, wherein at least one of or R is - (Ci -Co)alkyl substituted with -COOR7.
1 8. The compound of claim 1 7, wherein R7 is hydrogen.
19. The compound of any one of claims 1 to 16, wherein at least one of R2 or R8 is - (C,-CJ0)alkyl substituted with -CONR5R6.
20. The compound of claim 19, wherein R3 and R6 are both hydrogen.
21 . The compound of any one of claims 1 to 20, wherein at least one of R2 or R8 is -(6- to 14-membered)aryl.
22. The compound of any one of claims 1 to 21 , wherein at least one of R2 or R8 is phenyl.
23. The compound of any one of claims 1 to 20, wherein at least one of R2 or R8 is (6- to 14-membered)aryl-(Ci-C6)alkyl-.
24. The compound of any one of claims 1 to 20, wherein at least one of R2 or R8 is benzyl.
25. The compound of any one of claims 1 to 1 5, wherein at least one of R2 or R8 is COOR7.
26. The compound of any one of claims 1 to 1 5, wherein R2 is COOR7 and R8 is -(6- to 14-membered)aryl.
27. The compound of any one of claims 1 to 15, wherein at least one of R2 and R8 is selected from the group consisting of -(Ci-Cio)alkyl, -(C2-C i2)alkenyl, -(C2-Ci2)alkynyl, -CONR5R6, -COOR7, -(6- to 14-membered)aryl, ((6- to 14-membered)aryl)-(C i-
C6)alkyl-, -(5- to 12-membered)heteroaryl, and ((5- to 12-membered)heteroaryl)-(Ci- C6)alkyl-; each of which is optional ly substituted with 1 , 2, or 3 substituents independently selected from the group consisting of -OH, (=0), halo, -C(halo)3, -CH(halo)2, -CH2(halo), -(C,-C6)alkyl, halo(C,-C6)alkyl-, -(C2-C6)alkenyl, -(C2- C6)alkynyl, hydroxy(C,-C6)alkyl-, dihydroxy(C , -C6)alkyl-, -(d-C6)alkoxy, ((C , - C6)alkoxy)-CO-(C , -C6)alkoxy-, phenyl, benzyl, -NH2, -NH(C,-C6)alkyl,
-(Ci-C6)alkyl-NH(C i-C6)alkyl-R 14, -CN, -SH, -OR4, -CONR5R6, -(CrC6alky])-CO- NR5R6, -COOR7, and -(C,-C6)alkyl-CO-OR7.
28. The compound of any one of claims 1 to 27, wherein R1 is cyclopropylmethyl.
29. The compound of any one of claims 1 to 28, wherein X is selected from the group consisting of -(Ci -C io)alkoxy, -OH, and halo.
30. The compound of any one of claims 1 to 29, wherein X is -(C i-Cio)alkoxy.
3 1 . The compound of claim 29 or 30, wherein X is methoxy.
32. The compound of claim 29 or 30, wherein X is ethoxy.
33. The compound of any one of claims 1 to 29, wherein X is OH.
34. The compound of any one of claims 1 to 33, wherein Q is selected from the group consting of-(Ci-Cio)alkoxy or -OH.
35. The compound of any one of claims I to 34, wherein Q is methoxy.
36. The compound of any one of claims 1 to 34, wherein Q is ethoxy.
The compound of any one of claims 1 to 34, wherein Q is OH.
38. The compound of any one of claims 1 to 37, wherein n is 0 and Y is CH.
39. The compound of any one of claims 1 to 37, wherein Y is a direct bond.
40. The compound of any one of claims 1 to 15, wherein Y is CH, R is -(6- to 14- membered)aryl, and R2 is COOR7.
41 . The compound of any one of claims 1 to 15, wherein Y is CH, R8 is (6- to 14- membered)aryl-(C| -C6)alkyl-, and R2 is COOR7.
42. The compound of any one of claims 1 to 15, wherein Y is CH, R8 is -(6- to 14- membered)aryl, and R2 is— (C , -C ,o)alkyl substituted with -CONR5R6.
43. The compound of any one of claims 1 to 15, wherein Y is CH, R8 is (6- to 14- membered)aryl-(Ci-C6)alkyl-, and R2 is -(Ci -Chalky I substituted with -CONR5R6.
44. The compound of any one of claims 1 to 1 5, wherein Y is CH, R8 is -CONR5R6, and R2 is -(C , -C |0)alkyl.
45. The compound of any one of claims 1 to 1 5, wherein Y is CH, R8 is -COOR7, and R2 is -(C, -C10)alkyl.
46. The compound of any one of claims 1 to 15, wherein Y is a direct bond, and R2 is - (Ci-Cio)alkyl optionally subsituted with 1 , 2, or 3 substituents independently selected from the group consisting of OH, (=0), halo, -C(halo)3, COOR7, and CONR5R6.
47. The compound of any one of claims 1 to 9, 28 to 38, 40 and 42, wherein at least one of R2 or R8 is -(6- to 14-membered)aryl, and at least one of R15a or Rl b is -(6- to 14- membered)aryl.
48. The compound of any one of claims 1 to 9, 28 to 38, 41 and 43, wherein at least one of R2 or R8 is (6- to 14-membered)aryl-(C, -C6)alkyl-, and at least one of Rl 5a or Rl 5b is -(6- to 14-membered)aryl.
49. The compound of any one of claims 1 to 9, 28 to 38, 40 and 42, wherein at least one of R2 or R8 is -(6- to 14-membered)aryl, and at least one of R15a or Rl 5b is (6- to 14- membered)ary 1-(C i -C6)alkyl-.
50. The compound of any one of claims 1 to 9, 28 to 38, 41 and 43, wherein at least one of R2 or R8 is (6- to 14-membered)aryl-(C,-C6)alkyl-, and at least one of R15a or Rl 5h is (6- to 14-membered)aryl-(C i-C6)alkyl-.
5 1 . A compound selected from the group consisting of:
(4i?)-4-((4i?,4a5,6/?,77?,7a7?, 12b5)-3-(cyclopropylmethyl)-7,9-dimethoxy- 1 ,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4, 12-methanobenzofuro[3,2-e]isoquinolin-6-yl)- 4-phenylbutane- l ,2,4-triol (Compound 6);
2-(((5)-((4i?,4a5,6/?,7i?,7a7?, 12b5 -3-(cyclopropylmethyl)-7,9-dimethoxy- l ,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4, 12-methanobenzofuro[3,2-e]isoquinolin-6- yl)(phenyl)methyl)amino)acetic acid (Compound 12);
2-(((5)-((4i?,4a5,67?,7i?,7a/ , 12b^)-3-(cyclopropylmethyl)-7,9-dimethoxy- l ,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4, 12-methanobenzofuro[3,2-e]isoquinolin-6- yl)(phenyl)methyl)amino)propanoic acid (Compound 13);
2-(((5)-((4i?,4a5,6i?,7R,7ai?, 12b5)-3-(cyclopropylmethyl)-7,9-dimethoxy- l ,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4, 12-methanobenzofuro[3,2-e] isoquinolin-6- yl)(phenyl)methyl)amino)-2-phenylacetic acid (Compound 15);
2-(((5)-((4i?,4a5,6^,7 ?,7a^, 12b5)-3-(cyclopropylmethyl)-7,9-dimethoxy- l ,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4, l 2-methanobenzofuro[3,2-e]isoquinolin-6- yl)(phenyl)methyl)amino)propanamide (Compound 14);
(7?)-2-(((1¾-((4J/?,4a5,6i?,7i?,7ai?, 12b5)-3-(cyclopropylmethyl)-7,9-dimethoxy- 1 ,2, 3,4, 5,6,7, 7a-octahydro-4a,7-ethano-4, 12-methanobenzofuro[3,2-e]isoquinolin-6- yl)(phenyl)methyl)amino)-2-phenylacetamide (Compound 16); and
(5)-2-(((5)-((4i?,4a5,6 ?,7i?,7a^, 12b5)-3-(cyclopropylmethyl)-7,9-dimethoxy-
yl)(phenyl)methyl)amino)-2-phenylacetamide (Compound 17); and
the pharmaceutically acceptable salts and solvates thereof.
52. A pharmaceutical composition comprising an effective amount of a compound of any one of claims 1 to 51 , or a pharmaceutically salt or solvate thereof, and a pharmaceutically acceptable carrier or excipient.
53. A method for modulating opioid receptor function in a cell, comprising contacting a cell capable of expressing an opioid receptor with an effective amount of a compound of any one of claims 1 to 51 , or a pharmaceutically acceptable salt or solvate thereof.
54. The method of claim 53, wherein the compound modulates μ-opioid receptor function.
55. The method of claim 53 or 54, wherein the compound acts as an agonist at the μ- opioid receptor.
56. The method of claim 53 or 54, wherein the compound acts as an antagonist at the μ- opioid receptor.
57. The method of claim 53, wherein the compound acts as an agonist at the κ-opioid receptor.
58. The method of claim 53, wherein the compound modulates ORL-1 receptor function.
59. The method of claim 53, wherein the compound acts as an antagonist at the ORL- 1 receptor.
60. A method of treating a Condition in a mammal, comprising administering to such - mammal in need thereof an effective amount of a compound of any one of claims 1 to 51 , or a pharmaceutically acceptable salt or solvate thereof.
61 . The method of claim 60, wherein the Condition is pain.
62. The method of claim 60, wherein the Condition is constipation.
63. A method for preparing a composition, comprising the step of admixing a compound according to any one of claims 1 to 51 , or a pharmaceutically acceptable salt or solvate thereof, with a pharmaceutically acceptable carrier or excipient.
64. A compound of any one of claims 1 to 51 or a pharmaceutically acceptable salt or solvate thereof, for use in the treatment, prevention, or amelioration of a Condition.
65. The compound for use of claim 64 wherein the Condition is pain.
66. The compound for use of claim 64 wherein the Condition is constipation.
67. Use of a compound according to any one of claims 1 to 51 or a pharmaceutically acceptable salt or solvate thereof in the manufacture of a medicament useful for treating or preventing a Condition.
68. The use of claim 67, wherein the Condition is pain.
69. The use of claim 67, wherein the Condition is constipation.
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