WO2014044794A3 - Pharmaceutical composition - Google Patents

Pharmaceutical composition Download PDF

Info

Publication number
WO2014044794A3
WO2014044794A3 PCT/EP2013/069570 EP2013069570W WO2014044794A3 WO 2014044794 A3 WO2014044794 A3 WO 2014044794A3 EP 2013069570 W EP2013069570 W EP 2013069570W WO 2014044794 A3 WO2014044794 A3 WO 2014044794A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical composition
treatment
activated carbon
provides
oral administration
Prior art date
Application number
PCT/EP2013/069570
Other languages
French (fr)
Other versions
WO2014044794A2 (en
Inventor
Soren Halskov
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Bv filed Critical Ferring Bv
Priority to CN201380060120.4A priority Critical patent/CN104797243A/en
Priority to CA2885278A priority patent/CA2885278A1/en
Priority to JP2015532423A priority patent/JP6456830B2/en
Priority to EP13771084.4A priority patent/EP2897594B1/en
Priority to US14/429,806 priority patent/US10449158B2/en
Priority to ES13771084T priority patent/ES2801801T3/en
Priority to DK13771084.4T priority patent/DK2897594T3/en
Priority to US14/779,412 priority patent/US9682101B2/en
Priority to PCT/EP2014/055937 priority patent/WO2014154677A1/en
Priority to EP14713807.7A priority patent/EP2978413A1/en
Publication of WO2014044794A2 publication Critical patent/WO2014044794A2/en
Publication of WO2014044794A3 publication Critical patent/WO2014044794A3/en
Priority to US15/598,819 priority patent/US20170319617A1/en
Priority to US16/123,175 priority patent/US20190134081A1/en
Priority to US17/117,599 priority patent/US11712422B2/en
Priority to US18/208,658 priority patent/US20240016753A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/44—Elemental carbon, e.g. charcoal, carbon black
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Addiction (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides a pharmaceutical composition comprising activated carbon particles, for oral administration. The pharmaceutical composition may be for (use in) the treatment of gastrointestinal fistula.
PCT/EP2013/069570 2012-09-21 2013-09-20 Pharmaceutical composition WO2014044794A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
CN201380060120.4A CN104797243A (en) 2012-09-21 2013-09-20 Pharmaceutical composition
CA2885278A CA2885278A1 (en) 2012-09-21 2013-09-20 Pharmaceutical composition
JP2015532423A JP6456830B2 (en) 2012-09-21 2013-09-20 Pharmaceutical composition
EP13771084.4A EP2897594B1 (en) 2012-09-21 2013-09-20 Pharmaceutical composition
US14/429,806 US10449158B2 (en) 2012-09-21 2013-09-20 Pharmaceutical activated carbon composition
ES13771084T ES2801801T3 (en) 2012-09-21 2013-09-20 Pharmaceutical composition
DK13771084.4T DK2897594T3 (en) 2012-09-21 2013-09-20 PHARMACEUTICAL COMPOSITION
US14/779,412 US9682101B2 (en) 2013-03-25 2014-03-25 Composition for the treatment of disease
PCT/EP2014/055937 WO2014154677A1 (en) 2013-03-25 2014-03-25 Composition for the treatment of disease
EP14713807.7A EP2978413A1 (en) 2013-03-25 2014-03-25 Composition for the treatment of disease
US15/598,819 US20170319617A1 (en) 2013-03-25 2017-05-18 Composition for the treatment of disease
US16/123,175 US20190134081A1 (en) 2013-03-25 2018-09-06 Composition for the treatment of disease
US17/117,599 US11712422B2 (en) 2012-09-21 2020-12-10 Pharmaceutical compositions comprising activated carbon
US18/208,658 US20240016753A1 (en) 2012-09-21 2023-06-12 Pharmaceutical compositions

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP12185339 2012-09-21
EP12185339.4 2012-09-21
EP13160799 2013-03-25
EP13160799.6 2013-03-25

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/429,806 A-371-Of-International US10449158B2 (en) 2012-09-21 2013-09-20 Pharmaceutical activated carbon composition
US201916657038A Continuation 2012-09-21 2019-10-18

Publications (2)

Publication Number Publication Date
WO2014044794A2 WO2014044794A2 (en) 2014-03-27
WO2014044794A3 true WO2014044794A3 (en) 2014-06-19

Family

ID=49293599

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2013/069570 WO2014044794A2 (en) 2012-09-21 2013-09-20 Pharmaceutical composition

Country Status (8)

Country Link
US (3) US10449158B2 (en)
EP (1) EP2897594B1 (en)
JP (1) JP6456830B2 (en)
CN (2) CN111053759A (en)
CA (1) CA2885278A1 (en)
DK (1) DK2897594T3 (en)
ES (1) ES2801801T3 (en)
WO (1) WO2014044794A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6456830B2 (en) * 2012-09-21 2019-01-23 フェリング ベスローテン フェンノートシャップ Pharmaceutical composition
US9682101B2 (en) 2013-03-25 2017-06-20 Ferring B.V. Composition for the treatment of disease
CN105362496A (en) * 2015-06-13 2016-03-02 国网山东省电力公司临沂供电公司 Protection product for treating electric ophthalmia of electric power staff
JPWO2017073531A1 (en) * 2015-10-26 2018-08-09 第一三共株式会社 Delivery preparation of porous material to large intestine or lower intestine
WO2018063216A1 (en) * 2016-09-29 2018-04-05 M Pharmaceutical Usa Inc. Dual compartment capsule for the administration of orlistat
GB2569119A (en) * 2017-12-05 2019-06-12 Rainbow Valley Nutrients Ltd An aqueous beverage containing microencapsulated food supplement
AU2019320483A1 (en) 2018-08-05 2021-02-18 Da Volterra Compositions for the treatment of graft versus host disease
AU2019317986A1 (en) 2018-08-05 2021-02-11 Da Volterra Method for improving anticancer agent efficacy
EP3610860A1 (en) 2018-08-15 2020-02-19 Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen Composition of carbon dioxide absorbent or adsorbent, whereby the said composition contains a polymeric coating selected from silicone rubber and cellulose
DE102021127957A1 (en) 2021-10-27 2023-04-27 Rheinisch-Westfälische Technische Hochschule Aachen, Körperschaft des öffentlichen Rechts Coated drug formulation for controlled in vivo uptake of CO2
CA3235110A1 (en) * 2021-10-27 2023-05-04 Stefan Jockenhovel Coated active ingredient formulation for controlled in-vivo uptake of co2

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998022096A1 (en) * 1996-11-15 1998-05-28 The Procter & Gamble Company Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery
US20010051150A1 (en) * 1999-04-30 2001-12-13 Natarajan Ranganathan Compositions and methods for alleviating symptoms of uremia in patients
WO2011104275A1 (en) * 2010-02-23 2011-09-01 Da Volterra Formulations for oral delivery of adsorbents in the gut

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5489010A (en) * 1977-12-27 1979-07-14 Kureha Chem Ind Co Ltd Spherical activated charcoal antidote
IT1230576B (en) * 1988-10-20 1991-10-28 Angeli Inst Spa ORAL PHARMACEUTICAL FORMULATIONS WITH SELECTIVE LIBERATION IN THE COLON
US5843479A (en) * 1993-02-26 1998-12-01 The Procter & Gamble Company Bisacodyl dosage form with multiple enteric polymer coatings for colonic delivery
US20040166248A1 (en) * 2000-12-15 2004-08-26 Sheng-Hsin Hu Coated activated carbon
US7163696B2 (en) * 2001-10-11 2007-01-16 Pfizer Inc. Pharmaceutical formulations
US8048413B2 (en) * 2006-05-17 2011-11-01 Helene Huguet Site-specific intestinal delivery of adsorbents, alone or in combination with degrading molecules
US8110186B2 (en) * 2006-09-18 2012-02-07 Chelatexx, LLC Method to maintain the efficacy of orlistat
US7955622B2 (en) * 2006-10-13 2011-06-07 Actavis Group Ptc Hf Controlled-release galantamine formulations
WO2009049239A1 (en) 2007-10-12 2009-04-16 Ocera Therapeutics, Inc. Use of adsorbent carbon microspheres to treat pouchitis
TWI643623B (en) 2011-10-03 2018-12-11 菲瑞茵公司 Composition for the treatment of fistula
JP6456830B2 (en) * 2012-09-21 2019-01-23 フェリング ベスローテン フェンノートシャップ Pharmaceutical composition
US9682101B2 (en) * 2013-03-25 2017-06-20 Ferring B.V. Composition for the treatment of disease

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998022096A1 (en) * 1996-11-15 1998-05-28 The Procter & Gamble Company Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery
US20010051150A1 (en) * 1999-04-30 2001-12-13 Natarajan Ranganathan Compositions and methods for alleviating symptoms of uremia in patients
WO2011104275A1 (en) * 2010-02-23 2011-09-01 Da Volterra Formulations for oral delivery of adsorbents in the gut

Also Published As

Publication number Publication date
US11712422B2 (en) 2023-08-01
JP6456830B2 (en) 2019-01-23
US10449158B2 (en) 2019-10-22
EP2897594B1 (en) 2020-04-08
CA2885278A1 (en) 2014-03-27
CN111053759A (en) 2020-04-24
WO2014044794A2 (en) 2014-03-27
DK2897594T3 (en) 2020-06-29
US20240016753A1 (en) 2024-01-18
US20210196647A1 (en) 2021-07-01
US20150245999A1 (en) 2015-09-03
ES2801801T3 (en) 2021-01-13
JP2015529233A (en) 2015-10-05
EP2897594A2 (en) 2015-07-29
CN104797243A (en) 2015-07-22

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