WO2014035798A8 - Silk lyogels for sustained release of protein therapeutics and methods of making and uses - Google Patents
Silk lyogels for sustained release of protein therapeutics and methods of making and uses Download PDFInfo
- Publication number
- WO2014035798A8 WO2014035798A8 PCT/US2013/056232 US2013056232W WO2014035798A8 WO 2014035798 A8 WO2014035798 A8 WO 2014035798A8 US 2013056232 W US2013056232 W US 2013056232W WO 2014035798 A8 WO2014035798 A8 WO 2014035798A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- lyogels
- silk
- sustained release
- making
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
Abstract
The present disclosure provides silk lyogels made with a hydrophobicity, ionic, or stability modification for use in sustained release of antibodies and other protein therapeutics. The disclosure also provides methods of making silk lyogels.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261695112P | 2012-08-30 | 2012-08-30 | |
US61/695,112 | 2012-08-30 | ||
FR1356305 | 2013-06-28 | ||
FR1356305 | 2013-06-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2014035798A1 WO2014035798A1 (en) | 2014-03-06 |
WO2014035798A8 true WO2014035798A8 (en) | 2015-01-15 |
Family
ID=50184180
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2013/056232 WO2014035798A1 (en) | 2012-08-30 | 2013-08-22 | Silk lyogels for sustained release of protein therapeutics and methods of making and uses |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2014035798A1 (en) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5245012A (en) | 1990-04-19 | 1993-09-14 | The United States Of America As Represented By The Secretary Of The Army | Method to achieve solubilization of spider silk proteins |
ES2153418T3 (en) | 1993-02-23 | 2001-03-01 | Genentech Inc | STABILIZATION OF POLYPEPTIDES TREATED WITH ORGANIC SOLVENTS THROUGH EXCIPIENTS. |
WO1997008315A1 (en) | 1995-08-22 | 1997-03-06 | Basel Richard M | Cloning methods for high strength spider silk proteins |
JP4638735B2 (en) | 2002-06-24 | 2011-02-23 | タフツ ユニバーシティー | Silk biomaterial and method of using the same |
-
2013
- 2013-08-22 WO PCT/US2013/056232 patent/WO2014035798A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2014035798A1 (en) | 2014-03-06 |
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