WO2014035798A8 - Silk lyogels for sustained release of protein therapeutics and methods of making and uses - Google Patents

Silk lyogels for sustained release of protein therapeutics and methods of making and uses Download PDF

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Publication number
WO2014035798A8
WO2014035798A8 PCT/US2013/056232 US2013056232W WO2014035798A8 WO 2014035798 A8 WO2014035798 A8 WO 2014035798A8 US 2013056232 W US2013056232 W US 2013056232W WO 2014035798 A8 WO2014035798 A8 WO 2014035798A8
Authority
WO
WIPO (PCT)
Prior art keywords
lyogels
silk
sustained release
making
methods
Prior art date
Application number
PCT/US2013/056232
Other languages
French (fr)
Other versions
WO2014035798A1 (en
Inventor
Nicholas GUZIEWICZ
Andrew MASSETTI
Benardo PEREZ-RAMIREZ
David Kaplan
Original Assignee
Sanofi
Trustees Of Tufts College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi, Trustees Of Tufts College filed Critical Sanofi
Publication of WO2014035798A1 publication Critical patent/WO2014035798A1/en
Publication of WO2014035798A8 publication Critical patent/WO2014035798A8/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts

Abstract

The present disclosure provides silk lyogels made with a hydrophobicity, ionic, or stability modification for use in sustained release of antibodies and other protein therapeutics. The disclosure also provides methods of making silk lyogels.
PCT/US2013/056232 2012-08-30 2013-08-22 Silk lyogels for sustained release of protein therapeutics and methods of making and uses WO2014035798A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261695112P 2012-08-30 2012-08-30
US61/695,112 2012-08-30
FR1356305 2013-06-28
FR1356305 2013-06-28

Publications (2)

Publication Number Publication Date
WO2014035798A1 WO2014035798A1 (en) 2014-03-06
WO2014035798A8 true WO2014035798A8 (en) 2015-01-15

Family

ID=50184180

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/056232 WO2014035798A1 (en) 2012-08-30 2013-08-22 Silk lyogels for sustained release of protein therapeutics and methods of making and uses

Country Status (1)

Country Link
WO (1) WO2014035798A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5245012A (en) 1990-04-19 1993-09-14 The United States Of America As Represented By The Secretary Of The Army Method to achieve solubilization of spider silk proteins
ES2153418T3 (en) 1993-02-23 2001-03-01 Genentech Inc STABILIZATION OF POLYPEPTIDES TREATED WITH ORGANIC SOLVENTS THROUGH EXCIPIENTS.
WO1997008315A1 (en) 1995-08-22 1997-03-06 Basel Richard M Cloning methods for high strength spider silk proteins
JP4638735B2 (en) 2002-06-24 2011-02-23 タフツ ユニバーシティー Silk biomaterial and method of using the same

Also Published As

Publication number Publication date
WO2014035798A1 (en) 2014-03-06

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