WO2014031583A1 - Systems and methods for detection of carotenoid-related compounds in biological tissue - Google Patents
Systems and methods for detection of carotenoid-related compounds in biological tissue Download PDFInfo
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- WO2014031583A1 WO2014031583A1 PCT/US2013/055690 US2013055690W WO2014031583A1 WO 2014031583 A1 WO2014031583 A1 WO 2014031583A1 US 2013055690 W US2013055690 W US 2013055690W WO 2014031583 A1 WO2014031583 A1 WO 2014031583A1
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- 238000004441 surface measurement Methods 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 238000012418 validation experiment Methods 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 230000005186 women's health Effects 0.000 description 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
- A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
- A61B5/443—Evaluating skin constituents, e.g. elastin, melanin, water
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3563—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0091—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for mammography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14535—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring haematocrit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6814—Head
- A61B5/6815—Ear
- A61B5/6816—Ear lobe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6814—Head
- A61B5/6819—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6825—Hand
- A61B5/6826—Finger
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N2021/1789—Time resolved
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/02—Food
- G01N33/025—Fruits or vegetables
Definitions
- Figure 3 is a block diagram illustrating one example of an absorption spectroscopy based apparatus for measuring and quantifying biological compounds in tissue
- Figure 10 illustrates the transmission-derived absorption spectra of different fingers (thumb, index and small finger) of a subject
- the sample 322 may be a thin piece of excised skin tissue only a few mm thick or it may be a tissue fold such as the fold between thumb and index finger, or an ear lobe. Conversely, the sample 322 may be an animal bone that is several cm thick.
- the sample 422 should be thin enough to allow light 316 from the light source 312 pass through the sample 322 with sufficiently high transmitted light levels for rapid processing and calculation of absorption levels. In some configurations, a stronger light source 312 may be used to quantify and measure biological compounds from thicker samples 322.
- SRM estimates a baseline using a smoothing routine or low-order polynomial fit to the entire measured spectrum. After the initial estimation of the baseline, those points in the spectrum that have higher intensities than the baseline will be stripped from the spectrum by replacing them with the value of the estimated baseline. After stripping, a new baseline estimate is generated, and this procedure is iterated until the new baseline estimate does no longer change or changes just a little between two consecutive iterations. Usually, this procedure is fast and ideal for automation.
- Figure 9A illustrates the transmission spectrum measured for a living human finger as sample 322.
- the light 316 is from a white light source 312 and is measured with a spectrograph/CCD array instrument configuration. Because light 316 passes through a sample 322, only light 316 that is not absorbed or internally reflected exits the sample as transmitted light 330.
- the sample absorption at any wavelength can be estimate from the measured transmission at the corresponding wavelength by taking the logarithmic ratio between excitation light intensity and transmitted intensity. Additionally, because a strong signal may be emitted from the sample 322, a low-cost light source 312 may be used in obtaining transmission measurements.
- the processor 1803 may also be in electronic communication with a communication interface 1811.
- the communication interface 1811 may be used for communications with other devices 1846.
- the communication interface 1811 may be used to communicate with the light source 312 and/or the optical detectors 336.
- the communication interfaces 1811 of the various devices 1846 may be designed to communicate with each other to send signals or messages between computing devices 1846.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020157007070A KR20150081251A (en) | 2012-08-21 | 2013-08-20 | Systems and methods for detection of carotenoid-related compounds in biological tissue |
JP2015528566A JP2015526734A (en) | 2012-08-21 | 2013-08-20 | System and method for detection of compounds related to carotenoids in biological tissue |
AU2013306014A AU2013306014A1 (en) | 2012-08-21 | 2013-08-20 | Systems and methods for detection of carotenoid-related compounds in biological tissue |
EP13830330.0A EP2887872A4 (en) | 2012-08-21 | 2013-08-20 | Systems and methods for detection of carotenoid-related compounds in biological tissue |
CA2881031A CA2881031A1 (en) | 2012-08-21 | 2013-08-20 | Systems and methods for detection of carotenoid-related compounds in biological tissue |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/590,961 | 2012-08-21 | ||
US13/590,961 US20140058224A1 (en) | 2012-08-21 | 2012-08-21 | Systems and methods for detection of carotenoid-related compounds in biological tissue |
Publications (1)
Publication Number | Publication Date |
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WO2014031583A1 true WO2014031583A1 (en) | 2014-02-27 |
Family
ID=50148623
Family Applications (1)
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PCT/US2013/055690 WO2014031583A1 (en) | 2012-08-21 | 2013-08-20 | Systems and methods for detection of carotenoid-related compounds in biological tissue |
Country Status (7)
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US (1) | US20140058224A1 (en) |
EP (1) | EP2887872A4 (en) |
JP (1) | JP2015526734A (en) |
KR (1) | KR20150081251A (en) |
AU (1) | AU2013306014A1 (en) |
CA (1) | CA2881031A1 (en) |
WO (1) | WO2014031583A1 (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2901954C (en) * | 2012-02-21 | 2021-05-04 | Natalja EIKJE | Analytical method for common and specific characterization of skin carcinogenesis by ftir microspectroscopy |
EP4197431A1 (en) * | 2012-03-23 | 2023-06-21 | MC Professional Ltd. | Skin cancer biomarker detection by infrared spectroscopy |
US10416079B2 (en) * | 2014-01-07 | 2019-09-17 | Opsolution Gmbh | Device and method for determining a concentration in a sample |
JP6826802B2 (en) * | 2016-06-06 | 2021-02-10 | 一般財団法人雑賀技術研究所 | Measurement method and equipment for functional pigment components of edible parts of fruits and vegetables |
KR102544670B1 (en) * | 2018-07-27 | 2023-06-16 | 삼성전자주식회사 | Antioxidant sensor, Antioxidant signal measurement method and Antioxidant level measurement method |
JP7148210B2 (en) * | 2018-11-14 | 2022-10-05 | カゴメ株式会社 | Vegetable intake improvement system, vegetable diet database, and vegetable intake improvement program |
JP6902816B2 (en) * | 2018-11-14 | 2021-07-14 | カゴメ株式会社 | Vegetable intake improvement system, vegetable intake database, and vegetable intake improvement program |
JP7299726B2 (en) * | 2019-03-20 | 2023-06-28 | キヤノン株式会社 | Skin color measuring device and program |
KR20200129409A (en) | 2019-05-08 | 2020-11-18 | 삼성전자주식회사 | Optical sensor, Apparatus and Method for estimating bio-information |
JP7398887B2 (en) * | 2019-06-12 | 2023-12-15 | カゴメ株式会社 | Vegetable intake awareness method and vegetable intake awareness system |
KR20210069945A (en) | 2019-12-04 | 2021-06-14 | 삼성전자주식회사 | Apparatus and method for estimating bio-information |
CN111307976B (en) * | 2020-03-12 | 2022-06-28 | 宁波大学 | High-throughput detection method for carotenoid in aquatic product |
KR20210151525A (en) * | 2020-06-05 | 2021-12-14 | 삼성전자주식회사 | Apparatus and method for estimating bio-information |
JP6846084B2 (en) * | 2020-06-12 | 2021-03-24 | カゴメ株式会社 | Vegetable intake improvement system, vegetable intake database, and vegetable intake improvement program |
JP6841557B2 (en) * | 2020-06-12 | 2021-03-10 | カゴメ株式会社 | Vegetable intake improvement system, vegetable intake database, and vegetable intake improvement program |
JP6804797B2 (en) * | 2020-06-12 | 2020-12-23 | カゴメ株式会社 | Vegetable intake improvement system, vegetable intake database, and vegetable intake improvement program |
JP7106196B2 (en) * | 2020-12-21 | 2022-07-26 | カゴメ株式会社 | Vegetable intake improvement system, vegetable diet database, and vegetable intake improvement program |
JP7256910B2 (en) * | 2020-12-21 | 2023-04-12 | カゴメ株式会社 | Vegetable intake improvement system, vegetable diet database, and vegetable intake improvement program |
JP7030381B2 (en) * | 2020-12-21 | 2022-03-07 | カゴメ株式会社 | Vegetable intake improvement system, vegetable intake database, and vegetable intake improvement program |
CN113447450B (en) * | 2021-05-11 | 2022-11-15 | 中国农业科学院农产品加工研究所 | Optical nondestructive testing device for determining nutrient content of dishes based on spectrum |
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- 2013-08-20 EP EP13830330.0A patent/EP2887872A4/en not_active Withdrawn
- 2013-08-20 CA CA2881031A patent/CA2881031A1/en not_active Abandoned
- 2013-08-20 AU AU2013306014A patent/AU2013306014A1/en not_active Abandoned
- 2013-08-20 JP JP2015528566A patent/JP2015526734A/en active Pending
- 2013-08-20 KR KR1020157007070A patent/KR20150081251A/en not_active Application Discontinuation
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Also Published As
Publication number | Publication date |
---|---|
CA2881031A1 (en) | 2014-02-27 |
KR20150081251A (en) | 2015-07-13 |
EP2887872A1 (en) | 2015-07-01 |
AU2013306014A1 (en) | 2015-03-26 |
EP2887872A4 (en) | 2016-05-25 |
US20140058224A1 (en) | 2014-02-27 |
JP2015526734A (en) | 2015-09-10 |
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