WO2013160780A4 - Short-wave infrared imaging and spectroscopy technique for inflammation classification and tumor and inflammation differentiation in human tissues inside the body - Google Patents

Short-wave infrared imaging and spectroscopy technique for inflammation classification and tumor and inflammation differentiation in human tissues inside the body Download PDF

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Publication number
WO2013160780A4
WO2013160780A4 PCT/IB2013/052790 IB2013052790W WO2013160780A4 WO 2013160780 A4 WO2013160780 A4 WO 2013160780A4 IB 2013052790 W IB2013052790 W IB 2013052790W WO 2013160780 A4 WO2013160780 A4 WO 2013160780A4
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WO
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Patent type
Prior art keywords
region
interest
bands
tissue
swir
Prior art date
Application number
PCT/IB2013/052790
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French (fr)
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WO2013160780A1 (en )
Inventor
Ronnie Klein
Dekel BEN-ZION
Yaniv Cohen
Arkadi ZILBERMAN
Nathan Blaunstein
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I.R.Med Ltd.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163Optical arrangements
    • A61B1/00186Optical arrangements with imaging filters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0638Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements providing two or more wavelengths
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0661Endoscope light sources
    • A61B1/0684Endoscope light sources using light emitting diodes [LED]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/0059Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/0059Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086Detecting, measuring or recording for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infra-red radiation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02Details
    • G01J3/0205Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0218Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using optical fibers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02Details
    • G01J3/0294Multi-channel spectroscopy
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28Investigating the spectrum
    • G01J3/42Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry
    • G01J3/427Dual wavelengths spectrometry
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813Specially adapted to be attached to a specific body part
    • A61B5/6814Head
    • A61B5/6815Ear
    • A61B5/6817Ear canal
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infra-red light
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infra-red light
    • G01N21/359Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infra-red light using near infra-red light

Abstract

A method for detection, classification and differentiation of inflammation and tumor in animal body tissue, the method comprising: illuminating a region of interest with incident light beams of at least two different wave-bands each of which is in a range in which at least one of the scattering and the absorbing properties of tissue of said region of interest are sensitive to light radiation; (b) sensing, with a sensor unit, reflected light of said least two different wave-bands that is reflected from said region of interest; and (c) determining a presence of irregular tissue in said region of interest based upon identification of at least one local absorbance data in at least one of said least two different wave-bands that is indicative of the present state of tissue inside in body.

Claims

AMENDED CLAIMS received by the International Bureau on 17 October 2013 (17.10.2013)
1. A method for detection, classification and differentiation of the present state of tissue inside an animal body, the method comprising:
(a) illuminating a region of interest with incident light beams of at least two different wave-bands each of which is in a range in which at least one of the scattering and the absorbing properties of tissue of said region of interest are sensitive to light radiation, said at least two different wave-bands being implemented in VIS and SWIR ranges;
(b) sensing, with a sensor unit, reflected or transmitted light of said least two different wave-bands that is reflected or transmitted from said region of interest;
(c) determining a presence of irregular tissue in said region of interest based upon identification of at least one local absorbance data in at least one of said at least two different wave-bands that is indicative of the present state of tissue inside in body; and
(d) determining the existence of inflammation with liquid behind at least a portion of the tissue of said region of interest.
2. The method of claim 1, wherein said at least two different wavebands are implemented in VIS and SWIR ranges.
3. The method of claim 2, wherein said VIS wave-band is implemented at 350-700 nm for color imaging (RGB) and said SWIR wave-band is implemented at 1200-2500 nm for SWIR spectroscopy and SWIR imaging.
4. The method of claim 2, wherein said SWIR wave-band is implemented as at least three discrete SWIR wavelengths, 1200-1350 nm, 1400 -1500 nm and 1500-2500 nm.
5. The method of claim 1, wherein said illuminating, said sensing and said determining are implemented as providing substantially continuous illumination, sensing and determining over a predetermined period of time.
6. The method of claim 1, further including providing an optical fibers arrangement suitable for insertion into a cavity of an animal body.
7. A device for detection, classification and differentiation of the present state of tissue inside an animal body tissue, the device comprising:
(a) an illumination unit configured to generate illumination of at least two different wave-bands each of which is in a range in which at least one of the scattering and the absorbing properties of tissue of said region of interest are sensitive to light radiation;
(b) transmission/receiving unit configured to transmit said illumination so as to illuminate a region of interest with incident light beams of said at least two different wave-bands and to receive reflected light of said least two different wave-bands that is reflected from said region of interest;
(c) a detection unit configured to sense said reflected light of said least two different wave-bands that is reflected from said region of interest; and
(d) a processing unit programmed to determine a presence of irregular tissue in said region of interest based upon identification of at least one local absorbance data in at least one of said at least two different wave-bands that is indicative of the present state of tissue inside in body;
wherein said determining a presence of irregular tissue in said region of interest includes determining the existence of inflammation with liquid behind at least a portion of the tissue of said region of interest.
8. The device of claim 7, wherein said least two different wave-bands are in VIS and SWIR ranges.
9. The device of claim 8, wherein said VIS wave-band is in a range of 350-700 nm for color imaging (RGB) and said SWIR wave-band is in a range of 1200-2500 nm for SWIR spectroscopy and SWIR imaging.
10. The device of claim 8, wherein said SWIR wave-band is configured as at least three discrete SWIR wavelengths, in a range of 1200-1350 nm, in a range of 1400 -1500 nm and in a range of 1500-2500 nm.
1 1. The device of claim 7, wherein said illuminating, said sensing and said determining are substantially continuous illumination, sensing and determining over a predetermined period of time.
12. The device of claim 7, wherein said transmission/receiving unit includes an optical fibers arrangement suitable for insertion into a cavity of an animal body.
13. A method for detection, classification and differentiation of the present state of tissue inside an animal body, the method comprising:
(a) illuminating a region of interest with incident light beams of at least two different wave-bands each of which is in a range in which at least one of the scattering and the absorbing properties of tissue of said region of interest are sensitive to light radiation;
(b) sensing, with a sensor unit, reflected light of said at least two different wave-bands that is reflected from said region of interest using a combination of imaging and spectroscopy; and
(c) determining a presence of irregular tissue in said region of interest based upon identification of at least one local absorbance data in at least one of said least two different wave-bands that is indicative of the present state of tissue inside in body.
14. The method of claim 14, further including determining the existence of inflammation with liquid behind at least a portion of the tissue of said region of interest, wherein said at least two different wave-bands are implemented in VIS and SWIR ranges.
PCT/IB2013/052790 2012-04-23 2013-04-08 Short-wave infrared imaging and spectroscopy technique for inflammation classification and tumor and inflammation differentiation in human tissues inside the body WO2013160780A4 (en)

Priority Applications (2)

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US201261687260 true 2012-04-23 2012-04-23
US61/687,260 2012-04-23

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WO2013160780A4 true true WO2013160780A4 (en) 2014-01-03

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WO2014173558A1 (en) 2013-04-24 2014-10-30 Fresenius Kabi Deutschland Gmbh Method of operating a control device for controlling an infusion device
US20160051147A1 (en) * 2014-08-21 2016-02-25 Irmed System and method for noninvasive analysis of subcutaneous tissue
WO2017019805A1 (en) 2015-07-30 2017-02-02 Massachusetts Institute Of Technology Systems and methods for a short wave infrared device
US10007971B2 (en) 2016-03-14 2018-06-26 Sensors Unlimited, Inc. Systems and methods for user machine interaction for image-based metrology
US9928592B2 (en) 2016-03-14 2018-03-27 Sensors Unlimited, Inc. Image-based signal detection for object metrology
WO2018072807A1 (en) * 2016-09-27 2018-04-26 Siemens Aktiengesellschaft Apparatus and method for ascertaining pathological implications

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CA2401234A1 (en) * 2000-04-13 2001-10-25 Mark D. Hewko Tissue viability/health monitor utilizing near infrared spectroscopy
US8175666B2 (en) * 2002-04-26 2012-05-08 Grove Instruments, Inc. Three diode optical bridge system
US7920908B2 (en) * 2003-10-16 2011-04-05 David Hattery Multispectral imaging for quantitative contrast of functional and structural features of layers inside optically dense media such as tissue
CN101285764B (en) * 2008-04-25 2010-07-28 华东师范大学 Molecular spectrum imager

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