WO2013104687A3 - Collagène modifié - Google Patents

Collagène modifié Download PDF

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Publication number
WO2013104687A3
WO2013104687A3 PCT/EP2013/050333 EP2013050333W WO2013104687A3 WO 2013104687 A3 WO2013104687 A3 WO 2013104687A3 EP 2013050333 W EP2013050333 W EP 2013050333W WO 2013104687 A3 WO2013104687 A3 WO 2013104687A3
Authority
WO
WIPO (PCT)
Prior art keywords
collagen
modified collagen
modified
isolated
maturing
Prior art date
Application number
PCT/EP2013/050333
Other languages
English (en)
Other versions
WO2013104687A2 (fr
Inventor
Alexandra DIETRICH
Michael Myers
Original Assignee
Innocoll Technologies Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP20120150527 external-priority patent/EP2612888A1/fr
Priority claimed from GBGB1220868.2A external-priority patent/GB201220868D0/en
Priority to EA201491278A priority Critical patent/EA027745B1/ru
Priority to PL17181156T priority patent/PL3255106T3/pl
Priority to EP17181156.5A priority patent/EP3255106B1/fr
Priority to JP2014550739A priority patent/JP6494285B2/ja
Priority to EP13700286.1A priority patent/EP2802624B1/fr
Priority to SI201330815T priority patent/SI2802624T1/en
Priority to MX2014008327A priority patent/MX368037B/es
Priority to US14/371,161 priority patent/US10487134B2/en
Priority to EP21157555.0A priority patent/EP3901218A1/fr
Priority to RS20171104A priority patent/RS56564B1/sr
Priority to CA2860552A priority patent/CA2860552C/fr
Priority to PL19165538T priority patent/PL3536748T3/pl
Application filed by Innocoll Technologies Limited filed Critical Innocoll Technologies Limited
Priority to EP19165538.0A priority patent/EP3536748B1/fr
Priority to ES13700286.1T priority patent/ES2645445T3/es
Priority to PL13700286T priority patent/PL2802624T3/pl
Priority to AU2013208952A priority patent/AU2013208952B2/en
Priority to DK13700286.1T priority patent/DK2802624T3/da
Priority to LTEP13700286.1T priority patent/LT2802624T/lt
Priority to NO13700286A priority patent/NO2802624T3/no
Publication of WO2013104687A2 publication Critical patent/WO2013104687A2/fr
Publication of WO2013104687A3 publication Critical patent/WO2013104687A3/fr
Priority to US15/285,082 priority patent/US20170022266A1/en
Priority to HRP20171635TT priority patent/HRP20171635T1/hr
Priority to CY20171101134T priority patent/CY1119524T1/el
Priority to CY20191100545T priority patent/CY1121643T1/el
Priority to US16/537,339 priority patent/US11746141B2/en
Priority to CY20211100346T priority patent/CY1124160T1/el
Priority to US17/700,120 priority patent/US20220213173A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/28—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
    • C08L89/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne un collagène modifié pouvant être obtenu par un procédé consistant à se procurer du collagène isolé ; congeler le collagène isolé ; déshydrater le collagène congelé ; et faire maturer le collagène déshydraté. L'invention concerne également des procédés de préparation du collagène modifié et des utilisations de celui-ci.
PCT/EP2013/050333 2012-01-09 2013-01-09 Collagène modifié WO2013104687A2 (fr)

Priority Applications (26)

Application Number Priority Date Filing Date Title
LTEP13700286.1T LT2802624T (lt) 2012-01-09 2013-01-09 Modifikuotas kolagenas
NO13700286A NO2802624T3 (fr) 2012-01-09 2013-01-09
PL13700286T PL2802624T3 (pl) 2012-01-09 2013-01-09 Zmodyfikowany kolagen
ES13700286.1T ES2645445T3 (es) 2012-01-09 2013-01-09 Colágeno modificado
JP2014550739A JP6494285B2 (ja) 2012-01-09 2013-01-09 変性コラーゲン
PL17181156T PL3255106T3 (pl) 2012-01-09 2013-01-09 Zmodyfikowany kolagen
SI201330815T SI2802624T1 (en) 2012-01-09 2013-01-09 Modified collagen
MX2014008327A MX368037B (es) 2012-01-09 2013-01-09 Colágeno modificado.
US14/371,161 US10487134B2 (en) 2012-01-09 2013-01-09 Modified collagen
EP21157555.0A EP3901218A1 (fr) 2012-01-09 2013-01-09 Collagène modifié
RS20171104A RS56564B1 (sr) 2012-01-09 2013-01-09 Modifikovan kolagen
CA2860552A CA2860552C (fr) 2012-01-09 2013-01-09 Collagene modifie
AU2013208952A AU2013208952B2 (en) 2012-01-09 2013-01-09 A modified collagen
EA201491278A EA027745B1 (ru) 2012-01-09 2013-01-09 Модифицированный коллаген
EP19165538.0A EP3536748B1 (fr) 2012-01-09 2013-01-09 Collagène modifié
EP17181156.5A EP3255106B1 (fr) 2012-01-09 2013-01-09 Collagène modifié
EP13700286.1A EP2802624B1 (fr) 2012-01-09 2013-01-09 Collagène modifié
PL19165538T PL3536748T3 (pl) 2012-01-09 2013-01-09 Zmodyfikowany kolagen
DK13700286.1T DK2802624T3 (da) 2012-01-09 2013-01-09 Et modificeret kollagen
US15/285,082 US20170022266A1 (en) 2012-01-09 2016-10-04 Modified collagen
HRP20171635TT HRP20171635T1 (hr) 2012-01-09 2017-10-25 Modificirani kolagen
CY20171101134T CY1119524T1 (el) 2012-01-09 2017-10-31 Ena τροποποιημενο κολλαγονο
CY20191100545T CY1121643T1 (el) 2012-01-09 2019-05-22 Ενα τροποποιημενο κολλαγονο
US16/537,339 US11746141B2 (en) 2012-01-09 2019-08-09 Modified collagen
CY20211100346T CY1124160T1 (el) 2012-01-09 2021-04-21 Ενα τροποποιημενο κολλαγονο
US17/700,120 US20220213173A1 (en) 2012-01-09 2022-03-21 Modified collagen

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP20120150527 EP2612888A1 (fr) 2012-01-09 2012-01-09 Collagène modifié
EP12150527.5 2012-01-09
GBGB1220868.2A GB201220868D0 (en) 2012-11-20 2012-11-20 A modified collagen
GB1220868.2 2012-11-20

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US14/371,161 A-371-Of-International US10487134B2 (en) 2012-01-09 2013-01-09 Modified collagen
US15/285,082 Continuation US20170022266A1 (en) 2012-01-09 2016-10-04 Modified collagen
US16/537,339 Division US11746141B2 (en) 2012-01-09 2019-08-09 Modified collagen

Publications (2)

Publication Number Publication Date
WO2013104687A2 WO2013104687A2 (fr) 2013-07-18
WO2013104687A3 true WO2013104687A3 (fr) 2013-12-05

Family

ID=47559477

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2013/050333 WO2013104687A2 (fr) 2012-01-09 2013-01-09 Collagène modifié

Country Status (21)

Country Link
US (4) US10487134B2 (fr)
EP (4) EP3901218A1 (fr)
JP (3) JP6494285B2 (fr)
AU (1) AU2013208952B2 (fr)
CA (1) CA2860552C (fr)
CY (3) CY1119524T1 (fr)
DK (3) DK2802624T3 (fr)
EA (2) EA037396B1 (fr)
ES (3) ES2728205T3 (fr)
HK (1) HK1244296B (fr)
HR (3) HRP20171635T1 (fr)
HU (3) HUE037043T2 (fr)
LT (3) LT2802624T (fr)
MX (1) MX368037B (fr)
NO (1) NO2802624T3 (fr)
PL (3) PL2802624T3 (fr)
PT (2) PT3255106T (fr)
RS (3) RS61726B1 (fr)
SI (3) SI3536748T1 (fr)
TR (1) TR201907156T4 (fr)
WO (1) WO2013104687A2 (fr)

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Publication number Priority date Publication date Assignee Title
ES2728205T3 (es) * 2012-01-09 2019-10-22 Innocoll Pharm Ltd Colágeno modificado
US20180237259A1 (en) * 2017-02-22 2018-08-23 Otis Elevator Company Method for detecting trapped passengers in elevator car
RU2704248C1 (ru) * 2018-10-02 2019-10-25 Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет инженерных технологий" (ФГБОУ ВО "ВГУИТ") Способ получения пористого коллагенового материала
RU2760326C1 (ru) * 2021-03-04 2021-11-24 Общество с ограниченной ответственностью научно-производственное объединение «Велис» Способ получения пористого влагоемкого материала на коллагеновой основе
US20240226382A1 (en) 2021-04-12 2024-07-11 Innocoll Pharmaceuticals Limited Drug-release implant for laparoscopic surgery
CN113201569B (zh) * 2021-06-21 2022-08-30 江南大学 一种牛ⅰ型胶原蛋白的纯化方法
WO2023006922A2 (fr) * 2021-07-28 2023-02-02 Innocoll Pharmaceuticals Limited Implant d'administration de médicament à base de bupivacaïne-collagène et ses procédés de fabrication et d'utilisation
WO2023084005A1 (fr) * 2021-11-12 2023-05-19 Innocoll Pharmaceuticals Limited Échafaudage de collagène résorbable pour réparation durale
WO2024079289A1 (fr) 2022-10-12 2024-04-18 Innocoll Pharmaceuticals Limited Nécessaire d'implantation d'un implant à libération de médicament pour chirurgie laparoscopique

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