WO2013099789A1 - Sterilization method and sterilization device - Google Patents

Sterilization method and sterilization device Download PDF

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Publication number
WO2013099789A1
WO2013099789A1 PCT/JP2012/083210 JP2012083210W WO2013099789A1 WO 2013099789 A1 WO2013099789 A1 WO 2013099789A1 JP 2012083210 W JP2012083210 W JP 2012083210W WO 2013099789 A1 WO2013099789 A1 WO 2013099789A1
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Prior art keywords
hydrogen peroxide
sterilization
solvent
liquid
sterilized
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PCT/JP2012/083210
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French (fr)
Japanese (ja)
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睦 早川
唯子 中村
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大日本印刷株式会社
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Priority to JP2011286820 priority
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Publication of WO2013099789A1 publication Critical patent/WO2013099789A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/22Phase substances, e.g. smokes, aerosols or sprayed or atomised substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18Liquid substances or solutions comprising solids or dissolved gases
    • A61L2/186Peroxide solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2202/00Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20Targets to be treated
    • A61L2202/23Containers, e.g. vials, bottles, syringes, mail
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02Sterilising, e.g. of complete packages
    • B65B55/04Sterilising wrappers or receptacles prior to, or during, packaging
    • B65B55/10Sterilising wrappers or receptacles prior to, or during, packaging by liquids or gases

Abstract

A sterilization method using a liquid sterilizer comprising hydrogen peroxide, said liquid sterilizer being prepared by dissolving hydrogen peroxide in a solvent, wherein a liquid having a boiling point lower than 100oC is used as the solvent. By sterilizing a molded plastic container typified by a polyethylene terephthalate bottle or a paper container by attaching a mist of the aforesaid liquid sterilizer comprising hydrogen peroxide thereto, sterilization effect and sterilization efficiency can be increased and the amount of the sterilizer remaining in the container can be reduced.

Description

Sterilization method and sterilization apparatus

The present invention relates to a hydrogen peroxide sterilizing solution. More specifically, when aseptically filling fruit juice beverages, coffee beverages, other soft drinks, etc. into polyethylene terephthalate bottles (hereinafter referred to as PET bottles) or paper containers, PET bottles, PET bottle preforms, or paper containers The present invention relates to a hydrogen peroxide sterilizing liquid used for sterilizing containers such as, a sterilizing method and a sterilizing apparatus using the same.

Conventionally, when aseptically filling fruit juice drinks, coffee drinks, or the like into a container, it is necessary to sterilize the container in advance before filling the contents. Here, in the case where the container used is a plastic molded container represented by a PET bottle, “supply the molded PET bottle to an aseptic filling machine, and spray the hydrogen peroxide sterilizing liquid on the PET bottle in the aseptic filling machine, After that, the PET bottle is sterilized by drying and the contents are aseptically filled. ”Or“ A small amount of hydrogen peroxide sterilizing solution is dropped on the inner surface of the bottle when molding the PET bottle, The hydrogen oxide sterilization liquid is vaporized, the inner surface of the bottle is sterilized by the vapor, the sterilized bottle is supplied to the aseptic filling machine, the outer surface of the bottle is sterilized in the aseptic filling machine, the mouth is opened, and the contents In many cases, a hydrogen peroxide sterilizing solution is used (for example, Patent Documents 1 to 4).

Also, PET bottles are manufactured by injection molding, and the preforms are produced by stretching and blowing with a blow molding machine, and sterilized at the stage of preforms before becoming PET bottles. In this case, a hydrogen peroxide sterilizing solution is used (for example, Patent Document 5).

Japanese Unexamined Patent Publication No. 63-281937 Japanese Unexamined Patent Publication No. 1-167031 JP-A-1-254523 JP-A-8-244729 JP-A-8-282789

However, in order to improve the sterilization effect and the sterilization efficiency regardless of whether the PET bottle is sterilized or in the preform stage which is the previous stage, the excess in the hydrogen peroxide sterilization solution is required. Although it is necessary to increase the hydrogen oxide concentration, simply increasing the amount of hydrogen peroxide reduces the cost performance, and the high concentration hydrogen peroxide sterilizing solution also deteriorates the handling. Furthermore, when the concentration of hydrogen peroxide is increased, a problem that hydrogen peroxide remains in the container or the preform is likely to occur.

The present invention has been made in such a situation, and can be suitably used for sterilizing plastic molded containers and paper containers typified by PET bottles. The main object is to provide a hydrogen peroxide sterilizing solution that does not remain in the water, and a sterilization method and sterilizer using the same.

In order to solve the above-mentioned problem, the invention according to claim 1 uses a hydrogen peroxide sterilizing solution obtained by dissolving hydrogen peroxide in a solvent having a boiling point of less than 100 ° C. A sterilization method including a step of adhering to an object and a step of drying the object to be sterilized with hot air is employed.

In the above invention, the solvent may be a mixed solution of water and an alcohol having a boiling point of less than 100 ° C.

Furthermore, in the above invention, the alcohol may be ethyl alcohol, and the mixing volume ratio of water and ethyl alcohol may be 1: 199 to 1: 0.5.

According to the present invention, since the boiling point of the solvent for dissolving hydrogen peroxide is less than 100 ° C., that is, the boiling point is lower than that of water, Compared to the solvent, it is easy to vaporize. Therefore, when the hydrogen peroxide sterilization liquid of the present invention is heated and used as a condensation mist, the vaporization of the solvent proceeds at a low temperature and in a short time compared to the conventional hydrogen peroxide sterilization liquid, and the hydrogen peroxide sterilization liquid correspondingly. It is possible to quickly increase the concentration of hydrogen peroxide therein, thereby obtaining a higher sterilization effect and sterilization efficiency than conventional ones. In other words, while setting the hydrogen peroxide concentration in the hydrogen peroxide sterilizing solution to be low, the concentration can be increased during use.

Further, according to the present invention, the hydrogen peroxide concentration in the hydrogen peroxide sterilizing solution can be designed to be low, and the alcohol as a hydrophobic component is added to the sterilizing agent, so that the hydrogen peroxide is added to the resin. It can also be prevented from adsorbing and penetrating and remaining in a container which is an object of sterilization.

Furthermore, according to the sterilization method and sterilization apparatus of the present invention, since it has a step (means) for drying with hot air, the hydrogen peroxide concentration can be quickly increased, and the above-mentioned effects can be exhibited smoothly. can do.

It is a figure which shows the sterilization method concerning this invention. It is a vertical sectional view of the vaporizer of the hydrogen peroxide sterilization liquid used with the sterilization method concerning the present invention.

The hydrogen peroxide sterilization liquid used in the present embodiment is composed of hydrogen peroxide (A) and a solvent (B) for dissolving the hydrogen peroxide (A), and the solvent (B) is a liquid having a boiling point of less than 100 ° C. It has characteristics. Each will be described below.

(A) Hydrogen peroxide As the hydrogen peroxide used in this embodiment, a commercially available aqueous hydrogen peroxide solution having a hydrogen peroxide concentration of 30 to 35% by weight can be usually mentioned. A 3% by weight aqueous hydrogen peroxide solution marketed as oxidol can also be used. There are 30 to 35% by weight aqueous hydrogen peroxide solution for industrial use and food additives, and both can be used in this embodiment, but industrial use is stable to prevent decomposition of hydrogen peroxide. Since an agent or the like is added, an aqueous hydrogen peroxide solution for food additives with few additives is preferable.

(B) Solvent The solvent used in this embodiment is not particularly limited as long as it has a boiling point of less than 100 ° C. and can dissolve the hydrogen peroxide. By using a solvent having a boiling point of less than 100 ° C., the solvent can be vaporized more smoothly than a conventional hydrogen peroxide sterilizing solution using water (boiling point is 100 ° C.) as a solvent. The concentration of hydrogen peroxide can be improved over time (the concentration of hydrogen peroxide increases as the solvent is evaporated). As a result, the sterilization effect and sterilization efficiency can be improved.

Such a solvent may be a single substance or a mixture.

When a single solvent is used, for example, methyl alcohol, ethyl alcohol, isopropyl alcohol, acetone and the like can be suitably used, and among these, ethyl alcohol is particularly preferable. Since ethyl alcohol is recognized as a food additive, it can be used as a sterilization target for food containers, and is easy to obtain and handle and relatively inexpensive.

On the other hand, when the solvent is a mixture, it is preferable to use a mixture of the above methyl alcohol, ethyl alcohol, isopropyl alcohol, acetone and the like and water. It is particularly preferred to use a mixture of alcohol and water.

In addition, when the solvent is a mixture, the mixing volume ratio can be appropriately selected in consideration of the boiling point of the whole solvent. For example, when a mixture of ethyl alcohol and water is used as the solvent, The mixing volume ratio is preferably 1: 199 to 1: 0.5. This is because, by various experiments, effective results could be obtained within this range.

The hydrogen peroxide sterilization liquid described above is used for sterilization of plastic containers represented by PET bottles, sterilization of preforms before molding PET bottles, and further sterilization of paper containers filled with dairy products, etc. It can be used for sterilization of various containers.

More specifically, the method includes a step of adhering the hydrogen peroxide sterilization liquid to an object to be sterilized, and a step of drying the object to be sterilized with hot air, and sterilizing the hydrogen peroxide sterilization liquid. It can be suitably used in a sterilization apparatus including means for adhering to an object and means for drying the object to be sterilized with hot air.

In order to attach the hydrogen peroxide sterilizing liquid to the object to be sterilized, the hydrogen peroxide sterilizing liquid is misted by the mist generator shown in FIG. Uniform adhesion is possible.

As shown in FIG. 2, the mist generator includes a hydrogen peroxide sterilizing liquid supply unit 1 that is a two-fluid spray that supplies hydrogen peroxide sterilizing liquid in a drop form, and the hydrogen peroxide sterilizing liquid supply unit 1. And a vaporizing section 2 for heating and atomizing the spray of the supplied hydrogen peroxide sterilizing liquid to a non-decomposition temperature equal to or higher than its boiling point. The hydrogen peroxide sterilizing liquid supply unit 1 introduces the hydrogen peroxide sterilizing liquid and compressed air from the hydrogen peroxide sterilizing liquid supply path 1a and the compressed air supply path 1b, respectively, and sprays the hydrogen peroxide sterilizing liquid into the vaporizing unit 9. It is supposed to be. The vaporizer 2 is a pipe having a heater 2a sandwiched between inner and outer walls, and heats and vaporizes the spray of the hydrogen peroxide sterilizing solution blown into the pipe. This vaporized mixture is a mixture of hydrogen peroxide gas and solvent gas, and is ejected as condensed mist from the discharge nozzle 2b to the outside of the vaporizing section 2.

As shown in FIG. 1, this mist is introduced into the PET bottle in the process of attaching the hydrogen peroxide sterilizing solution to the object to be sterilized.

In addition, after condensing mist which comes out of the vaporization part 2 from the discharge nozzle 2b, it is made to mix with hot air at the front-end | tip of the discharge nozzle 2b, and you may make it introduce | transduce into a PET bottle. This gas is condensed when entering the PET bottle and adhering to the inner wall of the bottle, and exhibits sterilizing power.

The step (means) for attaching the hydrogen peroxide sterilizing solution and the drying step (means) are not particularly limited, and conventionally known steps (means) can be used.

Example 1
A hydrogen peroxide sterilizing solution of Example 1 was produced with hydrogen peroxide: 27.1% by volume, water: 23.1% by volume, and ethanol: 49.8% by volume. The solvent of this sterilizing solution is a mixture of water and ethanol, and its boiling point is less than 100 ° C.

(Comparative Example 1)
Hydrogen peroxide: A hydrogen peroxide sterilizing solution of Comparative Example 1 having 27.1 vol% and water 72.9 vol% was produced. Since the solvent of this sterilizing liquid is only water, its boiling point is 100 ° C.

(Comparative test)
Using a 500 ml PET bottle, The bactericidal effect on subtilis spores and residual hydrogen peroxide concentration were tested.

Specifically, using the apparatus shown in FIG. 1 and FIG. 2, the hydrogen peroxide sterilization gas of Example 1 and the hydrogen peroxide sterilization gas of Comparative Example 1 at 115 ° C. are applied to each sterilized PET bottle. Each was introduced for 3 seconds, and after 1.3 seconds, it was air rinsed with hot air at 100 ° C. for 4.6 seconds. Thereafter, SCD broth medium was dispensed into the bottle, sealed with a sterilized cap, and cultured at 35 ° C. for 7 days. The number of viable bacteria was calculated from the positive and negative numbers of the cultured bottles by MPN, and the sterilization effect was calculated by the following formula.

Sterilization effect (Log Reduction) = Log (number of adherent bacteria / MPN)

Also, the residual hydrogen peroxide concentration in the bottle was measured by the oxygen electrode method.

The sterilization effect and residual hydrogen peroxide concentration of Example 1 and Comparative Example 1 are shown in Table 1 below.

Figure JPOXMLDOC01-appb-T000001

(result)
According to Table 1, the bactericidal solution of Example 1 in which the boiling point of the solvent is less than 100 ° C., that is, the solvent is a mixture of water and ethanol, although the hydrogen peroxide concentration is the same as 27.1% by volume. Compared with Comparative Example 1, the sterilization effect was improved by 1.6 LRV or more. In addition, the residual hydrogen peroxide concentration was reduced by 20%.

DESCRIPTION OF SYMBOLS 1 ... Hydrogen peroxide disinfection liquid supply part 1a ... Hydrogen peroxide disinfection liquid supply path 1b ... Compressed air supply path 2 ... Vaporization part 2a ... Heater 2b ... Discharge nozzle

Claims (4)

  1. Using a hydrogen peroxide sterilizing solution obtained by dissolving hydrogen peroxide in a solvent having a boiling point of less than 100 ° C.,
    Attaching the hydrogen peroxide sterilization liquid to the object to be sterilized;
    A step of drying the object to be sterilized with hot air;
    A sterilization method comprising:
  2. The sterilization method according to claim 1, wherein a mixed liquid of water and an alcohol having a boiling point of less than 100 ° C is used as the solvent.
  3. 3. The sterilization method according to claim 2, wherein the alcohol is ethyl alcohol, and the mixing volume ratio of water and ethyl alcohol in the mixed solution is 1: 199 to 1: 0.5.
  4. Means for adhering a hydrogen peroxide sterilizing solution obtained by dissolving hydrogen peroxide in a solvent having a boiling point of less than 100 ° C. to an object to be sterilized;
    Means for drying the object to be sterilized with hot air;
    A sterilizer comprising:
PCT/JP2012/083210 2011-12-27 2012-12-21 Sterilization method and sterilization device WO2013099789A1 (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015171812A (en) * 2014-02-19 2015-10-01 大日本印刷株式会社 Blow molding machine and method for sterilizing the same
WO2016143772A1 (en) * 2015-03-09 2016-09-15 大日本印刷株式会社 Blow molding machine and sterilization method therefor
JP2016190500A (en) * 2014-02-19 2016-11-10 大日本印刷株式会社 Blow molding machine and sterilization method therefor
WO2017221991A1 (en) 2016-06-24 2017-12-28 大日本印刷株式会社 Method and device for sterilizing preform
JP2018020529A (en) * 2016-08-05 2018-02-08 大日本印刷株式会社 Bactericidal method and device for preform

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07315345A (en) * 1994-05-27 1995-12-05 Toppan Printing Co Ltd Sterilization for beverage liquid container or beverage liquid filling device

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JPH0413215B2 (en) * 1986-10-15 1992-03-09 Ckd Corp
JP4334670B2 (en) * 1999-05-20 2009-09-30 大日本印刷株式会社 Container sterilization method
JP5401828B2 (en) * 2008-05-20 2014-01-29 大日本印刷株式会社 Container sterilization method and apparatus
JP5784275B2 (en) * 2009-02-06 2015-09-24 大日本印刷株式会社 beverage filling method and apparatus

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07315345A (en) * 1994-05-27 1995-12-05 Toppan Printing Co Ltd Sterilization for beverage liquid container or beverage liquid filling device

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015171812A (en) * 2014-02-19 2015-10-01 大日本印刷株式会社 Blow molding machine and method for sterilizing the same
CN105829065A (en) * 2014-02-19 2016-08-03 大日本印刷株式会社 Blow molding machine and method for sterilizing same
US10046506B2 (en) 2014-02-19 2018-08-14 Dai Nippon Printing Co., Ltd. Blow molding machine and method for sterilizing the same
JP2016190500A (en) * 2014-02-19 2016-11-10 大日本印刷株式会社 Blow molding machine and sterilization method therefor
EP3109030A4 (en) * 2014-02-19 2018-02-21 Dai Nippon Printing Co., Ltd. Blow molding machine and method for sterilizing same
CN107206663A (en) * 2015-03-09 2017-09-26 大日本印刷株式会社 Blow molding machine and its method for disinfection
WO2016143772A1 (en) * 2015-03-09 2016-09-15 大日本印刷株式会社 Blow molding machine and sterilization method therefor
EP3269529A4 (en) * 2015-03-09 2018-10-03 Dai Nippon Printing Co., Ltd. Blow molding machine and sterilization method therefor
WO2017221991A1 (en) 2016-06-24 2017-12-28 大日本印刷株式会社 Method and device for sterilizing preform
JP2018020529A (en) * 2016-08-05 2018-02-08 大日本印刷株式会社 Bactericidal method and device for preform

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