WO2013090986A1 - Treatment of seborrhoea - Google Patents
Treatment of seborrhoea Download PDFInfo
- Publication number
- WO2013090986A1 WO2013090986A1 PCT/AU2012/001543 AU2012001543W WO2013090986A1 WO 2013090986 A1 WO2013090986 A1 WO 2013090986A1 AU 2012001543 W AU2012001543 W AU 2012001543W WO 2013090986 A1 WO2013090986 A1 WO 2013090986A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- scymnol
- ester
- treatment
- pharmaceutically acceptable
- seborrhoea
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
Definitions
- the present invention also extends to a composition for use in the treatment of seborrhoea in a patient, which comprises an effective amount of (24RS) or (24S) scymnol, an ester thereof or a pharmaceutically acceptable salt of a said ester, or of (24R) scymnol, together with a pharmaceutically acceptable carrier or diluent.
- Enzymes and receptors in cells commonly select for one enantiomer of a chiral binding molecule (substrate or ligand) over the other enantiomer, because of the chirally- selective pockets inside their active sites. This is why most natural biological molecules (e.g. amino acids and sugars) are present in cells in only one chiral form.
- beneficial bioactivity from the overall dose (if it is inactive compared to the beneficial enantiomer), or even less than half of the beneficial bioactivity (if it antagonises the beneficial enantiomer), or unwanted and/or adverse side effects (if it has a different bioactivity and/or toxicity profile to the beneficial enantiomer).
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12859788.7A EP2793897B1 (en) | 2011-12-20 | 2012-12-14 | Treatment of seborrhoea |
JP2014547630A JP2015500841A (en) | 2011-12-20 | 2012-12-14 | Treatment of seborrhea |
AU2012321108A AU2012321108B2 (en) | 2011-12-20 | 2012-12-14 | Treatment of seborrhoea |
DK12859788.7T DK2793897T3 (en) | 2011-12-20 | 2012-12-14 | TREATMENT OF SEBORIE |
IN4693CHN2014 IN2014CN04693A (en) | 2011-12-20 | 2012-12-14 | |
ES12859788.7T ES2632591T3 (en) | 2011-12-20 | 2012-12-14 | Seborrhea treatment |
US14/366,261 US20140364405A1 (en) | 2011-12-20 | 2012-12-14 | Treatment of seborrhoea |
KR1020147020089A KR20140120890A (en) | 2011-12-20 | 2012-12-14 | treatment of seborrhoea |
MX2014007659A MX2014007659A (en) | 2011-12-20 | 2012-12-14 | Treatment of seborrhoea. |
NZ625852A NZ625852B2 (en) | 2011-12-20 | 2012-12-14 | Treatment of seborrhoea |
RU2014126635A RU2624238C2 (en) | 2011-12-20 | 2012-12-14 | Seborrhea treatment |
CA2859826A CA2859826A1 (en) | 2011-12-20 | 2012-12-14 | Treatment of seborrhoea |
PL12859788T PL2793897T3 (en) | 2011-12-20 | 2012-12-14 | Treatment of seborrhoea |
CN201280063798.3A CN104144689A (en) | 2011-12-20 | 2012-12-14 | Treatment of seborrhoea |
SG11201403078RA SG11201403078RA (en) | 2011-12-20 | 2012-12-14 | Treatment of seborrhoea |
BR112014014968A BR112014014968A2 (en) | 2011-12-20 | 2012-12-14 | seborrhea treatment |
ZA2014/04348A ZA201404348B (en) | 2011-12-20 | 2014-06-12 | Treatment of seborrhoea |
HK15100268.8A HK1199818A1 (en) | 2011-12-20 | 2015-01-12 | Treatment of seborrhoea |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2011905331A AU2011905331A0 (en) | 2011-12-20 | Treatment of seborrhoea | |
AU2011905331 | 2011-12-20 | ||
AU2012900670 | 2012-02-22 | ||
AU2012900670A AU2012900670A0 (en) | 2012-02-22 | Treatment of seborrhoea |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2013090986A1 true WO2013090986A1 (en) | 2013-06-27 |
Family
ID=48667492
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/AU2012/001543 WO2013090986A1 (en) | 2011-12-20 | 2012-12-14 | Treatment of seborrhoea |
Country Status (21)
Country | Link |
---|---|
US (1) | US20140364405A1 (en) |
EP (1) | EP2793897B1 (en) |
JP (1) | JP2015500841A (en) |
KR (1) | KR20140120890A (en) |
CN (1) | CN104144689A (en) |
AU (1) | AU2012321108B2 (en) |
BR (1) | BR112014014968A2 (en) |
CA (1) | CA2859826A1 (en) |
DK (1) | DK2793897T3 (en) |
ES (1) | ES2632591T3 (en) |
HK (1) | HK1199818A1 (en) |
HU (1) | HUE033800T2 (en) |
IN (1) | IN2014CN04693A (en) |
MX (1) | MX2014007659A (en) |
MY (1) | MY165030A (en) |
PL (1) | PL2793897T3 (en) |
PT (1) | PT2793897T (en) |
RU (1) | RU2624238C2 (en) |
SG (1) | SG11201403078RA (en) |
WO (1) | WO2013090986A1 (en) |
ZA (1) | ZA201404348B (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5026883A (en) * | 1986-08-21 | 1991-06-25 | Yoshiki Kosuge | Derivatives of scymol sulfate |
WO1995010283A1 (en) * | 1993-10-12 | 1995-04-20 | J.W. Broadbent Nominees Pty. Ltd. | Treatment of medical disorders associated with free radical formation |
JP2007063139A (en) * | 2005-08-29 | 2007-03-15 | Daicho Kikaku:Kk | Preparation for skin |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007244325A (en) * | 2006-03-17 | 2007-09-27 | Daicho Kikaku:Kk | New health food |
-
2012
- 2012-12-14 JP JP2014547630A patent/JP2015500841A/en active Pending
- 2012-12-14 BR BR112014014968A patent/BR112014014968A2/en not_active Application Discontinuation
- 2012-12-14 US US14/366,261 patent/US20140364405A1/en not_active Abandoned
- 2012-12-14 CA CA2859826A patent/CA2859826A1/en not_active Abandoned
- 2012-12-14 KR KR1020147020089A patent/KR20140120890A/en not_active Application Discontinuation
- 2012-12-14 AU AU2012321108A patent/AU2012321108B2/en active Active
- 2012-12-14 WO PCT/AU2012/001543 patent/WO2013090986A1/en active Application Filing
- 2012-12-14 RU RU2014126635A patent/RU2624238C2/en active
- 2012-12-14 PT PT128597887T patent/PT2793897T/en unknown
- 2012-12-14 SG SG11201403078RA patent/SG11201403078RA/en unknown
- 2012-12-14 EP EP12859788.7A patent/EP2793897B1/en active Active
- 2012-12-14 MX MX2014007659A patent/MX2014007659A/en unknown
- 2012-12-14 MY MYPI2014001674A patent/MY165030A/en unknown
- 2012-12-14 CN CN201280063798.3A patent/CN104144689A/en active Pending
- 2012-12-14 DK DK12859788.7T patent/DK2793897T3/en active
- 2012-12-14 HU HUE12859788A patent/HUE033800T2/en unknown
- 2012-12-14 ES ES12859788.7T patent/ES2632591T3/en active Active
- 2012-12-14 IN IN4693CHN2014 patent/IN2014CN04693A/en unknown
- 2012-12-14 PL PL12859788T patent/PL2793897T3/en unknown
-
2014
- 2014-06-12 ZA ZA2014/04348A patent/ZA201404348B/en unknown
-
2015
- 2015-01-12 HK HK15100268.8A patent/HK1199818A1/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5026883A (en) * | 1986-08-21 | 1991-06-25 | Yoshiki Kosuge | Derivatives of scymol sulfate |
WO1995010283A1 (en) * | 1993-10-12 | 1995-04-20 | J.W. Broadbent Nominees Pty. Ltd. | Treatment of medical disorders associated with free radical formation |
JP2007063139A (en) * | 2005-08-29 | 2007-03-15 | Daicho Kikaku:Kk | Preparation for skin |
Also Published As
Publication number | Publication date |
---|---|
RU2624238C2 (en) | 2017-07-03 |
SG11201403078RA (en) | 2014-07-30 |
PL2793897T3 (en) | 2017-10-31 |
EP2793897A1 (en) | 2014-10-29 |
MX2014007659A (en) | 2014-11-14 |
EP2793897A4 (en) | 2015-04-08 |
CA2859826A1 (en) | 2013-06-27 |
HK1199818A1 (en) | 2015-07-24 |
BR112014014968A2 (en) | 2017-06-13 |
JP2015500841A (en) | 2015-01-08 |
AU2012321108A1 (en) | 2013-07-04 |
EP2793897B1 (en) | 2017-04-12 |
KR20140120890A (en) | 2014-10-14 |
ES2632591T3 (en) | 2017-09-14 |
MY165030A (en) | 2018-02-28 |
PT2793897T (en) | 2017-07-17 |
AU2012321108B2 (en) | 2015-07-09 |
IN2014CN04693A (en) | 2015-09-18 |
US20140364405A1 (en) | 2014-12-11 |
NZ625852A (en) | 2015-07-31 |
RU2014126635A (en) | 2016-02-10 |
DK2793897T3 (en) | 2017-07-31 |
ZA201404348B (en) | 2016-10-26 |
HUE033800T2 (en) | 2018-01-29 |
CN104144689A (en) | 2014-11-12 |
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