WO2013054137A1 - Compositions comprising salbutamol sulphate - Google Patents
Compositions comprising salbutamol sulphate Download PDFInfo
- Publication number
- WO2013054137A1 WO2013054137A1 PCT/GB2012/052544 GB2012052544W WO2013054137A1 WO 2013054137 A1 WO2013054137 A1 WO 2013054137A1 GB 2012052544 W GB2012052544 W GB 2012052544W WO 2013054137 A1 WO2013054137 A1 WO 2013054137A1
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- WO
- WIPO (PCT)
- Prior art keywords
- pharmaceutical composition
- propellant
- component
- container
- drug
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B31/00—Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
- B65B31/003—Adding propellants in fluid form to aerosol containers
Definitions
- the present invention relates to a pharmaceutical composition
- a pharmaceutical composition comprising salbutamol sulphate, a propellant and a surfactant.
- the composition is suitable for delivering the salbutamol sulphate from a pressurised aerosol container using a metered dose inhaler (MDI).
- MDI metered dose inhaler
- MDIs are the most significant type of inhalation drug delivery system and are well known to those skilled in the art. They are designed to deliver, on demand, a discrete and accurate amount of a drug to the respiratory tract of a patient using a liquefied propellant in which the drug is dissolved, suspended or dispersed.
- the design and operation of MDIs is described in many standard textbooks and in the patent literature. They all comprise a pressurised container that holds the drug formulation, a nozzle and a valve assembly that is capable of dispensing a controlled quantity of the drug through the nozzle when it is activated. All of these components are typically located in a housing that is equipped with a mouth piece.
- the drug formulation will comprise a propellant, in which the drug is dissolved, suspended or dispersed, and may contain other materials such as polar excipients, surfactants and preservatives.
- a propellant In order for a propellant to function satisfactorily in MDIs, it needs to have a number of properties. These include an appropriate boiling point and vapour pressure so that it can be liquefied in a closed container at room temperature but develop a high enough pressure when the MDI is activated to deliver the drug as an atomised formulation even at low ambient temperatures. Further, the propellant should be of low acute and chronic toxicity and have a high cardiac sensitisation threshold. It should have a high degree of chemical stability in contact with the drug, the container and the metallic and non-metallic components of the MDI device, and have a low propensity to extract low molecular weight substances from any elastomeric materials in the MDI device.
- the propellant should also be capable of maintaining the drug in a homogeneous solution, in a stable suspension or in a stable dispersion for a sufficient time to permit reproducible delivery of the drug in use.
- the density of the liquid propellant is desirably similar to that of the solid drug in order to avoid rapid sinking or floating of the drug particles in the liquid.
- the propellant should not present a significant flammability risk to the patient in use. In particular, it should form a non-flammable or low flammability mixture when mixed with air in the respiratory tract.
- Dichlorodifluoromethane (R-12) possesses a suitable combination of properties and was for many years the most widely used MDI propellant, often blended with trichlorofluoromethane (R-11). Due to international concern that fully and partially halogenated chlorofluorocarbons (CFCs), such as dichlorodifluoromethane and trichlorofluoromethane, were damaging the earth's protective ozone layer, many countries entered into an agreement, the Montreal Protocol, stipulating that their manufacture and use should be severely restricted and eventually phased out completely.
- CFCs fully and partially halogenated chlorofluorocarbons
- Dichlorodifluoromethane and trichlorofluoromethane were phased out for refrigeration use in the 1990's, but are still used in small quantities in the MDI sector as a result of an essential use exemption in the Montreal Protocol.
- 1 ,1 ,1 ,2-tetrafluoroethane (R-134a) was introduced as a replacement refrigerant and MDI propellant for R-12.
- 1 ,1 ,1 , 2,3, 3,3-heptafluoropropane (R-227ea) was also introduced as a replacement for dichlorotetrafluoroethane (R-114) in the MDI sector and is sometimes blended with R-134a for this application.
- R-134a and R-227ea have low ozone depletion potentials (ODPs), they have global warming potentials (GWPs), 1430 and 3220 respectively, that are now considered to be too high by some regulatory bodies, especially for dispersive uses when they are released into the atmosphere.
- ODPs ozone depletion potentials
- GWPs global warming potentials
- 1430 and 3220 are now considered to be too high by some regulatory bodies, especially for dispersive uses when they are released into the atmosphere.
- One industrial area that has received particular attention recently has been the automotive air-conditioning sector where the use of R-134a has come under regulatory control as a result of the European F-Gas Regulations. Industry is developing a number of possible alternatives to R-134a in automotive air conditioning and other applications that have a low greenhouse warming potential (GWP) as well as a low ozone depletion potential (ODP).
- GWP greenhouse warming potential
- ODP low ozone depletion potential
- hydrofluoropropenes especially the tetrafluoropropenes, such as 2,3,3,3-tetrafluoropropene (R-1234yf) and 1 ,3,3,3-tetrafluoropropene (R- 1234ze).
- R-1234yf 2,3,3,3-tetrafluoropropene
- R- 1234ze 1 ,3,3,3-tetrafluoropropene
- R-134a and R-227ea There are also other problems with R-134a and R-227ea.
- Drug suspensions give rise to a number of problems, such as nozzle blockage, agglomeration and sedimentation, the latter problem making it essential to shake the MDI thoroughly before use to ensure that the drug is evenly distributed in the propellant.
- the pharmaceutical active settles quickly following re-suspension in the propellant, as is often the case, then the propellant/drug composition must be delivered from the MDI shortly after shaking in order to ensure that the dose that is delivered contains an effective concentration of the pharmaceutical active.
- a polar excipient in the composition which either helps to dissolve the drug to form a solution or else enhances wetting of suspended drug particles to yield a better dispersed and more stable suspension.
- a preferred polar excipient is ethanol.
- ethanol is ethanol.
- the use of large amounts of ethanol can tend to result in a coarse spray having droplet sizes that are too large for acceptable penetration into the deep bronchiole passages of the lung.
- high levels of ethanol can have unacceptable irritancy to the mouth and throat, especially with younger users.
- Surfactants have also been included in some formulations that include drugs that are either insoluble or only sparingly soluble in the propellant, as these can also help to produce a more stable suspension.
- many of the toxicologically acceptable surfactants have sufficient solubility in either R-134a or R-227ea.
- ethanol has been added to the composition, where it functions not only as a wetter but also as a solvent for the surfactant. It would be beneficial to find a propellant/surfactant combination that allows for sufficient surfactant to be dissolved in the propellant without the inclusion of a polar excipient such as ethanol or with reduced levels of such an excipient.
- a polar excipient such as ethanol or with reduced levels of such an excipient.
- composition that is free of polar excipients, said composition comprising:
- a propellant component consisting essentially of 1 ,1-difluoroethane (R-
- a surfactant component comprising oleic acid
- a drug component consisting of salbutamol sulphate.
- a pharmaceutical composition consisting essentially of:
- a propellant component consisting essentially of 1 ,1-difluoroethane (R-
- a surfactant component comprising oleic acid
- a drug component consisting of salbutamol sulphate.
- compositions of the first and second aspects of the present invention are suitable for delivery from a pressured container, e.g. using a metered dose inhaler (MDI).
- MDI metered dose inhaler
- compositions of the first and second aspects of the present invention typically comprise from 0.01 to 1.0 weight % of the drug component, from 96.5 to 99.94 weight % of the propellant component and from 0.05 to 2.5 weight % of the surfactant component.
- Preferred compositions comprise from 0.05 to 0.5 weight % of the drug component, from 97.5 to 99.85 weight % of the propellant component and from 0.1 to 2.0 weight % of the surfactant component.
- Particularly preferred pharmaceutical compositions comprise from 0.07 to 0.2 weight % of the drug component, from 98.8 to 99.73 weight % of the propellant component and from 0.2 to 1.0 weight % of the surfactant component. All percentages are based on the total weight of the pharmaceutical compositions.
- the propellant component in the pharmaceutical compositions of the first and second aspects of the present invention consists essentially of 1 ,1-difluoroethane (R-152a).
- the propellant component may include small amounts of propellant compounds in addition to the R-152a.
- the propellant component may additionally comprise one or more additional hydrofluorocarbon or hydrocarbon propellant compounds, e.g. selected from R-227ea, R-134a, difluoromethane (R-32), propane, butane, isobutane and dimethyl ether. If an additional propellant compound is included, the R-152a will constitute at least 90 weight %, e.g. from 90 to 99 weight % of the propellant component.
- the R-152a will constitute at least 95 weight %, e.g. from 95 to 99 weight %, and more preferably at least 99 weight % of the propellant component.
- the propellant component is entirely R-152a, so that the pharmaceutical compositions of the invention comprise R-152a as the sole propellant.
- the surfactant component in the pharmaceutical compositions of the first and second aspects of the present invention may also comprise one or more additional surfactants to aid in the dispersion of solid drug particles in the propellant.
- additional surfactants include ethyl oleate, sorbitan trioleate, isopropyl myristate, polyethylene glycol 300, polyoxyethylene 20 sorbitan monooleate and monolaurate, and propoxylated polyethyleneglycol.
- the surfactant component consists entirely of oleic acid. Accordingly, in a preferred embodiment of the present invention, the percentages listed above for the typical and preferred amounts of the surfactant component in the pharmaceutical compositions of the present invention define the typical and preferred amounts of oleic acid in those compositions.
- the drug component in the pharmaceutical compositions of the present invention consists entirely of salbutamol sulphate, so that the only drug in the pharmaceutical compositions is salbutamol sulphate.
- the salbutamol sulphate does not dissolve or dissolve significantly in the propellant component but forms a dispersion or suspension in the propellant/surfactant mixture.
- the suspended drug particles preferably have a diameter of less than 100 microns.
- the pharmaceutical composition of the first aspect of the present invention is free of polar excipients. Polar excipients, such as ethanol, are used routinely in pharmaceutical compositions for treating respiratory disorders that are delivered using metered dose inhalers (MDIs).
- MDIs metered dose inhalers
- solvents are also referred to as solvents, co- solvents, carrier solvents and adjuvants. Their inclusion can serve to solubilise the surfactant or the drug in the propellant and/or inhibit deposition of drug particles on the surfaces of the metered dose inhaler that are contacted by the pharmaceutical composition as it passes from the container in which it is stored to the nozzle outlet. They are also used as bulking agents in two-stage filling processes where the drug is mixed with a suitable polar excipient. The most commonly used polar excipient is ethanol.
- R- 152a as the propellant and oleic acid as the surfactant mitigates the need for polar excipients and allows compositions that are free of polar excipients, and especially ethanol, to be prepared that still deliver good performance when delivered from a medication delivery device, such as a metered dose inhaler (MDI).
- MDI metered dose inhaler
- the pharmaceutical composition of the first aspect of the present invention preferably consists essentially of and more preferably consists entirely of the three listed components.
- consists essentially of we mean that at least 95 weight %, more preferably at least 98 weight % and especially at least 99 weight % of the pharmaceutical composition consists of the three listed components.
- the pharmaceutical composition of the second aspect of the present invention consists essentially of and preferably consists entirely of the three listed components.
- consists essentially of we mean that at least 95 weight %, more preferably at least 98 weight % and especially at least 99 weight % of the pharmaceutical composition consists of the three listed components.
- the pharmaceutical composition of the second aspect of the present invention optionally contains at least one polar excipient.
- any polar material that is pharmaceutically acceptable may be employed as a polar excipient.
- suitable polar excipients include alcohols, such as ethyl alcohol (ethanol) and glycerol, and glycols, such as propylene glycol, polyethylene glycols and polypropylene glycols.
- the most preferred polar excipient is ethanol, which may be used together with other polar excipients but is preferably used alone.
- the pharmaceutical composition of the second aspect of the present invention is free of any polar excipients such as ethanol.
- the mandatory and preferred amounts of R- 152a in the propellant component are as discussed above.
- the propellant component will consist entirely of R-152a and the surfactant component will consist entirely of oleic acid even when a polar excipient is present.
- compositions of the first and second aspects of the present invention find particular utility in the delivery of salbutamol sulphate from a pressurised aerosol container using a metered dose inhaler (MDI).
- MDI metered dose inhaler
- the propellant component functions to deliver the drug as a fine aerosol spray.
- the present invention provides a pharmaceutical composition for delivery from a pressurized container that is free of polar excipients comprising:
- a propellant component consisting of 1 ,1-difluoroethane (R-152a);
- a surfactant component consisting of oleic acid
- a drug component consisting of salbutamol sulphate.
- the pharmaceutical composition preferably consists essentially of and more preferably consists entirely of the three listed components.
- the pharmaceutical compositions of the invention may also comprise one or more other additives of the type that are conventionally used in drug formulations for pressurised MDIs, such as valve lubricants. Where other additives are included in the pharmaceutical compositions, they are normally used in amounts that are conventional in the art.
- the pharmaceutical compositions of the invention are normally stored in pressurised containers or canisters which are to be used in association with a medication delivery device. When so stored, the pharmaceutical compositions are normally in the liquid state.
- the pressurised container is designed for use in a metered dose inhaler (MDI).
- a third aspect of the present invention provides pressurised containers holding respectively the pharmaceutical compositions of the first and second aspects of the present invention.
- the present invention provides medication delivery devices, especially metered dose inhalers, having pressurised containers respectively holding the pharmaceutical compositions of the first and second aspects of the present invention.
- the present invention provides a pressurised container holding a pharmaceutical composition that is free of polar excipients comprising:
- a propellant component consisting of 1 ,1-difluoroethane (R-152a);
- a surfactant component consisting of oleic acid
- a drug component consisting of salbutamol sulphate.
- the present invention provides a medication delivery device, especially a metered dose inhaler, having a pressurised container holding a pharmaceutical composition that is free of polar excipients comprising:
- a propellant component consisting of 1 ,1-difluoroethane (R-152a);
- a surfactant component consisting of oleic acid
- a drug component consisting of salbutamol sulphate.
- the pharmaceutical composition preferably consists essentially of and more preferably consists entirely of the three listed components.
- the typical and preferred proportions of the drug component, propellant component and surfactant component in the pharmaceutical composition of these especially preferred embodiments are as discussed above.
- the pharmaceutical compositions of the present invention are for use in medicine for treating a patient suffering or likely to suffer from a respiratory disorder and especially asthma. Accordingly, the present invention also provides a method for treating a patient suffering or likely to suffer from a respiratory disorder, especially asthma, which comprises administering to the patient a therapeutically or prophylactically effective amount of a pharmaceutical composition as discussed above.
- the pharmaceutical composition is preferably delivered to the patient using a MDI.
- the pharmaceutical compositions of the invention can be prepared by a simple blending operation in which the R-152a-containing propellant component, the oleic acid-containing surfactant component, and the salbutamol sulphate are mixed together in the required proportions in a suitable mixing vessel. Mixing can be promoted by stirring as is common in the art. Conveniently, the R-152a- containing propellant component is liquefied to aid mixing. If the pharmaceutical composition is made in a separate mixing vessel, it can then be transferred to pressurised containers for storage, such as pressurised containers that are used as part of medication delivery devices and especially MDIs.
- compositions of the invention can also be prepared within the confines of a pressurised container, such as an aerosol canister or vial, from which the compositions are ultimately released as an aerosol spray using a medication delivery device, such as a MDI.
- a weighed amount of the salbutamol sulphate is introduced into the open container.
- a valve is then crimped onto the container and the 152a-containing propellant component, in liquid form, introduced through the valve into the container under pressure, optionally after first evacuating the container through the valve.
- the oleic acid- containing surfactant component can be mixed with the salbutamol sulphate or, alternatively, introduced into the container after the valve has been fitted, either alone or as a premix with the propellant component.
- Suitable canisters may be made of plastics, metal or glass.
- the canister may be filled with enough of the pharmaceutical composition to provide for a plurality of dosages.
- the pressurized aerosol canisters that are used in MDIs typically contain 50 to 150 individual dosages.
- the problem can arise that the suspended drug particles deposit on the interior surfaces of the canister and the valve of the drug delivery device.
- the pharmaceutical compositions of the invention are capable of forming a stable dispersion of the drug, thereby avoiding the problem of drug deposition, and yet deliver the drug as a sufficiently fine aerosol mist that is able to deliver the drug deep into the lung.
- the present invention is now illustrated but not limited by the following examples.
- a formulation containing salbutamol sulphate, oleic acid and R-152a was prepared.
- the drug and oleic acid were weighed directly into standard aluminium 19mL cans (C128, Presspart, Blackburn, UK).
- the can was crimped with a 50 ⁇ _ valve and the R-152a was then filled into the cans through the valve using a manual Pamasol crimper/filler (Pamasol, Switzerland).
- the can was then sonicated for 90 mins to ensure dissolution of the surfactant in the propellant and dispersion of drug in the medium.
- the final concentration of oleic acid in the formulation was 0.05w/w.
- a comparative formulation containing salbutamol sulphate, ethanol, oleic acid and R-134a was prepared. Intense mixing and sonication for 60 mins was employed to dissolve the oleic acid in the ethanol. The drug was weighed directly into standard aluminium 19mL cans (C128, Presspart, Blackburn, UK), to which an appropriate amount of the oleic acid/ethanol solution was added such that the final concentrations of oleic acid and ethanol were 0.05 and 15%w/w respectively. This slurry was further sonicated for 60 mins in order to disperse the drug in the ethanol. The can was then crimped with a 50 ⁇ _ valve (Bespak, Kings Lynn, UK). Finally, the R-134a was then filled into the cans through the valve using a manual Pamasol crimper/filler (Pamasol, Switzerland).
- HPLC High performance liquid chromatography
- the in vitro aerosolization performance of the formulation was studied using a Next Generation Impactor (NGI, Copley Scientific, Nottingham UK), which was connected to a vacuum pump (GE Motors, NJ, USA). Prior to testing, the cups of the NGI system were coated with 1 % v/v silicone oil in hexane to eliminate particle bounce. For each experiment, three actuations of the can were discharged into the NGI at 30 L.min "1 as per pharmacopeia guidelines. Following aerosolization, the NGI apparatus was dismantled and the actuator and each part of the NGI was washed down into known volumes of the HPLC mobile phase. The mass of drug deposited on each part of the NGI was determined by HPLC.
- MMAD mass median aerodynamic diameter
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Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2012322455A AU2012322455B2 (en) | 2011-10-12 | 2012-10-12 | Compositions comprising salbutamol sulphate |
BR112014008602-8A BR112014008602B1 (en) | 2011-10-12 | 2012-10-12 | Pharmaceutical composition, sealed container, metered dose inhaler, and method for making a pharmaceutical composition |
US14/351,075 US9517216B2 (en) | 2011-10-12 | 2012-10-12 | Compositions comprising salbutamol sulphate |
CA2851026A CA2851026C (en) | 2011-10-12 | 2012-10-12 | Compositions comprising salbutamol sulphate |
CN201280049866.0A CN103874489B (en) | 2011-10-12 | 2012-10-12 | Comprise the compositions of salbutamol sulfate |
EP12787054.1A EP2766006B1 (en) | 2011-10-12 | 2012-10-12 | Compositions comprising salbutamol sulphate |
MX2014004279A MX335944B (en) | 2011-10-12 | 2012-10-12 | Compositions comprising salbutamol sulphate. |
ES12787054.1T ES2556586T3 (en) | 2011-10-12 | 2012-10-12 | Compositions comprising salbutamol sulfate |
JP2014535167A JP5894283B2 (en) | 2011-10-12 | 2012-10-12 | Composition containing salbutamol sulfate |
ZA2014/02321A ZA201402321B (en) | 2011-10-12 | 2014-03-28 | Compositions comprising salbutamol sulphate |
US15/357,279 US10039828B2 (en) | 2011-10-12 | 2016-11-21 | Compositions comprising salbutamol sulphate |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1117619.5A GB201117619D0 (en) | 2011-10-12 | 2011-10-12 | Compositions |
GB1117619.5 | 2011-10-12 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/351,075 A-371-Of-International US9517216B2 (en) | 2011-10-12 | 2012-10-12 | Compositions comprising salbutamol sulphate |
US15/357,279 Continuation US10039828B2 (en) | 2011-10-12 | 2016-11-21 | Compositions comprising salbutamol sulphate |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2013054137A1 true WO2013054137A1 (en) | 2013-04-18 |
Family
ID=45091931
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2012/052544 WO2013054137A1 (en) | 2011-10-12 | 2012-10-12 | Compositions comprising salbutamol sulphate |
Country Status (12)
Country | Link |
---|---|
US (2) | US9517216B2 (en) |
EP (1) | EP2766006B1 (en) |
JP (1) | JP5894283B2 (en) |
CN (1) | CN103874489B (en) |
AU (1) | AU2012322455B2 (en) |
BR (1) | BR112014008602B1 (en) |
CA (1) | CA2851026C (en) |
ES (1) | ES2556586T3 (en) |
GB (1) | GB201117619D0 (en) |
MX (1) | MX335944B (en) |
WO (1) | WO2013054137A1 (en) |
ZA (1) | ZA201402321B (en) |
Cited By (6)
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---|---|---|---|---|
WO2014170689A1 (en) * | 2013-04-17 | 2014-10-23 | Mexichem Amanco Holding S.A. De C.V. | Composition comprising salbutamol sulphate |
WO2018051128A1 (en) * | 2016-09-19 | 2018-03-22 | Mexichem Fluor S.A. De C.V. | Pharmaceutical composition |
US10792256B2 (en) | 2016-09-19 | 2020-10-06 | Mexichem Fluor S.A. De C.V. | Pharmaceutical composition |
US10888546B2 (en) | 2016-09-19 | 2021-01-12 | Mexichem Fluor S.A. De C.V. | Pharmaceutical composition |
FR3130554A1 (en) | 2021-12-20 | 2023-06-23 | Aptar France Sas | Pharmaceutical composition comprising salbutamol |
WO2024013455A1 (en) | 2022-07-13 | 2024-01-18 | Aptar France Sas | Pharmaceutical composition comprising salbutamol |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2545025A (en) * | 2015-12-04 | 2017-06-07 | Mexichem Fluor Sa De Cv | Pharmaceutical composition |
EP3701940A1 (en) * | 2015-12-04 | 2020-09-02 | Mexichem Fluor S.A. de C.V. | Pharmaceutical composition |
WO2018051131A1 (en) * | 2016-09-19 | 2018-03-22 | Mexichem Fluor S.A. De C.V. | Pharmaceutical composition |
CN114712337A (en) * | 2016-09-19 | 2022-07-08 | 墨西哥氟石股份公司 | Pharmaceutical composition |
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US10959965B2 (en) | 2013-04-17 | 2021-03-30 | Mexichem Amanco Holding S.A. De C.V. | Composition comprising salbutamol sulphate |
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Also Published As
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GB201117619D0 (en) | 2011-11-23 |
CA2851026A1 (en) | 2013-04-18 |
AU2012322455A1 (en) | 2014-04-17 |
BR112014008602B1 (en) | 2022-05-24 |
JP2014528470A (en) | 2014-10-27 |
US20140230812A1 (en) | 2014-08-21 |
AU2012322455B2 (en) | 2015-07-02 |
CA2851026C (en) | 2016-01-05 |
MX2014004279A (en) | 2014-05-28 |
JP5894283B2 (en) | 2016-03-23 |
ES2556586T3 (en) | 2016-01-19 |
CN103874489A (en) | 2014-06-18 |
US20170165367A1 (en) | 2017-06-15 |
CN103874489B (en) | 2016-01-20 |
BR112014008602A2 (en) | 2017-04-18 |
US10039828B2 (en) | 2018-08-07 |
US9517216B2 (en) | 2016-12-13 |
EP2766006A1 (en) | 2014-08-20 |
ZA201402321B (en) | 2015-03-25 |
MX335944B (en) | 2016-01-04 |
EP2766006B1 (en) | 2015-11-25 |
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