WO2013041419A1 - Oral care compositions - Google Patents
Oral care compositions Download PDFInfo
- Publication number
- WO2013041419A1 WO2013041419A1 PCT/EP2012/067785 EP2012067785W WO2013041419A1 WO 2013041419 A1 WO2013041419 A1 WO 2013041419A1 EP 2012067785 W EP2012067785 W EP 2012067785W WO 2013041419 A1 WO2013041419 A1 WO 2013041419A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- calcium carbonate
- microns
- oral care
- abrasive
- teeth
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 66
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 112
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 41
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000011164 primary particle Substances 0.000 claims abstract description 11
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 7
- 239000013078 crystal Substances 0.000 claims description 32
- 239000002245 particle Substances 0.000 claims description 29
- 239000000551 dentifrice Substances 0.000 claims description 21
- 239000004094 surface-active agent Substances 0.000 claims description 5
- 239000011230 binding agent Substances 0.000 claims description 3
- 239000002562 thickening agent Substances 0.000 claims description 3
- 239000003906 humectant Substances 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 abstract description 10
- 235000010216 calcium carbonate Nutrition 0.000 description 37
- 238000009472 formulation Methods 0.000 description 18
- -1 calcium hydrogenphosphate anhydride Chemical class 0.000 description 10
- 239000002002 slurry Substances 0.000 description 10
- 230000001680 brushing effect Effects 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 9
- 229910021532 Calcite Inorganic materials 0.000 description 8
- 239000003082 abrasive agent Substances 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 210000003298 dental enamel Anatomy 0.000 description 7
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 239000012153 distilled water Substances 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 229910052500 inorganic mineral Inorganic materials 0.000 description 6
- 235000010755 mineral Nutrition 0.000 description 6
- 239000011707 mineral Substances 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 4
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 4
- 238000004626 scanning electron microscopy Methods 0.000 description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 4
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- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
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- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 239000004141 Sodium laurylsulphate Substances 0.000 description 3
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 3
- 239000000920 calcium hydroxide Substances 0.000 description 3
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- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 2
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 239000005642 Oleic acid Substances 0.000 description 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical group CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 238000005299 abrasion Methods 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 210000004268 dentin Anatomy 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 2
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- 238000003384 imaging method Methods 0.000 description 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- 229960002216 methylparaben Drugs 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
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- 229920000642 polymer Polymers 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 2
- 229960003415 propylparaben Drugs 0.000 description 2
- 239000008262 pumice Substances 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 2
- 235000019801 trisodium phosphate Nutrition 0.000 description 2
- MCNJOIMMYWLFBA-UHFFFAOYSA-N 2-dodecoxy-2-oxoethanesulfonic acid;sodium Chemical compound [Na].CCCCCCCCCCCCOC(=O)CS(O)(=O)=O MCNJOIMMYWLFBA-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
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- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 244000180278 Copernicia prunifera Species 0.000 description 1
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- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 239000001836 Dioctyl sodium sulphosuccinate Substances 0.000 description 1
- 239000004150 EU approved colour Substances 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
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- 235000019738 Limestone Nutrition 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- OAICVXFJPJFONN-OUBTZVSYSA-N Phosphorus-32 Chemical compound [32P] OAICVXFJPJFONN-OUBTZVSYSA-N 0.000 description 1
- 229920001800 Shellac Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
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- 125000000217 alkyl group Chemical group 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
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- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
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- 239000012166 beeswax Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
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- 235000010418 carrageenan Nutrition 0.000 description 1
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- 230000008859 change Effects 0.000 description 1
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- 239000006071 cream Substances 0.000 description 1
- AZSFNUJOCKMOGB-UHFFFAOYSA-K cyclotriphosphate(3-) Chemical compound [O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 AZSFNUJOCKMOGB-UHFFFAOYSA-K 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
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- 239000003085 diluting agent Substances 0.000 description 1
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- FJQXCDYVZAHXNS-UHFFFAOYSA-N methadone hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 FJQXCDYVZAHXNS-UHFFFAOYSA-N 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229940006093 opthalmologic coloring agent diagnostic Drugs 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
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- OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
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- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
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- ADWNFGORSPBALY-UHFFFAOYSA-M sodium;2-[dodecyl(methyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCCN(C)CC([O-])=O ADWNFGORSPBALY-UHFFFAOYSA-M 0.000 description 1
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- 238000007910 systemic administration Methods 0.000 description 1
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- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical class [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
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- 229940078499 tricalcium phosphate Drugs 0.000 description 1
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- 239000001993 wax Substances 0.000 description 1
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- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/0245—Specific shapes or structures not provided for by any of the groups of A61K8/0241
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/027—Fibers; Fibrils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
Definitions
- the present invention is concerned with oral care compositions. More particularly, the present invention is concerned with oral care compositions containing calcium carbonate as an abrasive, and having low abrasivity whilst maintaining desirable cleaning properties. BACKGROUND OF THE INVENTION
- Abrasives for use in oral care compositions such as dentifrices are required to be effective in removing extrinsic stains, dental plaque and food debris which builds up on the pellicle on the surface of teeth.
- the present inventors have found that this problem can be solved by the use of a calcium carbonate abrasive having a particular particle size and shape.
- US 4,743,274 relates to the modification of crystal morphology to provide a high cleaning, low abrading abrasive for use in oral compositions. This describes how, in the case of an abrasive which consists of calcium hydrogenphosphate anhydride (secondary calcium phosphate anhydride), reducing the average crystallite size produces a material which meets both the requirements of high tooth cleanability and low tooth surface abrasiveness.
- an abrasive which consists of calcium hydrogenphosphate anhydride (secondary calcium phosphate anhydride)
- US2004/0161388 mentions how the dentifrice-relevant properties of a calcium carbonate material are correlated to its morphology and particle size, and describes how small scalenohedral-shaped calcium carbonate particles tend to have relatively insignificant cleaning effectiveness, whereas large rhombohedral- shaped (sometimes referred to as "cubic") calcium carbonate particles have increased cleaning and abrasive benefits, but often abrade too well: their abrasiveness leading to a concern for possible damage to teeth and gums.
- US2004/0161388 proposes an abrasive, precipitated calcium carbonate having a primary particle size of about 1 to 4 microns. These primary particles themselves may come together and, through covalent bonding to one another, form aggregates having a particle size of about 3 to 10 microns.
- the material has a calcite crystalline form and essentially a cubic crystal structure.
- the present invention provides an oral care composition comprising:
- a particulate calcium carbonate abrasive composed of primary particles which are acicular and which have a length of 2 microns or greater; in which the level of the particulate calcium carbonate abrasive ranges from 10 to 70%, preferably from 20 to 60%, more preferably from 30 to 40%, by total weight of the particulate calcium carbonate abrasive based on the total weight of the composition.
- composition of the invention comprises, inter alia, a particulate calcium carbonate abrasive composed of primary particles which have a specific shape and size, as defined above.
- primary particles is meant individual particles.
- the primary particles of the particulate calcium carbonate abrasive are acicular and have a length of 2 microns or greater.
- the primary particles may associate under certain conditions to form larger secondary structures such as aggregates or agglomerates.
- the primary particles may be surface-modified, for example by coating with hydrophobic materials such as ethylcellulose, hydroxypropylcellulose, waxes (such as shellac, carnauba or beeswax) and fat or fatty acids such as stearic and oleic acid. Coating can be done using colloidal precipitation using solvent or temperature change, for instance.
- hydrophobic materials such as ethylcellulose, hydroxypropylcellulose, waxes (such as shellac, carnauba or beeswax) and fat or fatty acids such as stearic and oleic acid.
- a suitable class of particulate calcium carbonate abrasive includes crystalline calcium carbonates in which the crystals are acicular and have a length of 2 microns or greater.
- crystal means an essentially fully dense solid composed of atoms arranged in an orderly repetitive array bounded by plane surfaces which are the external expression of internal structure.
- Calcium carbonate may occur naturally or may be synthetically produced in three particular crystalline morphologies, calcite, aragonite, and less commonly found, vaterite.
- the vaterite form of calcium carbonate is metastable and irreversibly transforms into calcite and aragonite.
- the calcite crystalline morphology is the most commonly used crystal form of calcium carbonate. Over 300 crystalline forms of calcite have been reported in the literature.
- acicular in this context refers to the shape of the crystals. Usually, crystals grow in three directions, length, width and height. Some crystals however, have one or two preferred growth directions. Acicular crystals have a preferred crystal growth in one direction. Examples are crystals in the form of needles, rods, fibres, whiskers or columns and the like. For the purposes of the present invention, preferred acicular crystals are rod-like or needle-like with a generally uniform, typically generally circular, cross-sectional shape.
- the ratio between the length and the width of a crystal is higher than 1 :1 for acicular crystals.
- the higher the aspect ratio the longer the crystal.
- the aspect ratio is preferably at least 2.5:1 , more preferably at least 10:1 .
- the aspect ratio may typically range from 2.5:1 to 200:1 , and preferably ranges from 10:1 to 60:1 , more preferably from 20:1 to 30:1 .
- acicular calcium carbonate crystals for use in the invention have a length ranging from 2 to 100 microns, more preferably from 10 to 30 microns and a width ranging from 0.1 to 4.0 microns, more preferably from 0.5 to 1 .0 microns. Crystal morphology and structure may be determined by standard techniques known to those skilled in the art such as scanning electron microscopy (SEM). SEM is an imaging and analysis technique based on the detection of electrons and
- Imaging allows the user to distinguish between primary particle and agglomerate sizes.
- Scanning electron microscopy is a particle counting technique and produces a number-weighted size distribution.
- a specific class of material suitable for use in the invention includes aragonite crystal form calcium carbonates such as those described for example in US 5,164,172.
- aragonite crystal form calcium carbonate with an acicular shape is prepared by premixing aragonite calcium carbonate and Ca(OH) 2 to prepare an aqueous slurry, adding a water-soluble phosphoric acid compound (such as phosphoric acid or a water-soluble salt thereof) into the aqueous slurry, and introducing CO2 gas into the aqueous slurry to cause a carbonation reaction to take place.
- a water-soluble phosphoric acid compound such as phosphoric acid or a water-soluble salt thereof
- the resulting aragonite calcium carbonate crystals have an acicular shape and have a particle size of 10 to 100 microns (length) by 0.5 to 4.0 microns (width).
- the exemplified crystals are shown by microscopy to be rod-like or needle-like with a length of 10 to 100 microns.
- the rods or needles are generally uniform and typically circular in cross-section, with a cross-sectional diameter of 0.5 to 4.0 microns.
- the most preferred aragonite calcium carbonate crystals are rod-like or needle-like as described above, with a length ranging from 10 to 30 microns, a width ranging from 0.5 to 1 .0 microns and an aspect ratio ranging from 20:1 to 30:1 .
- Suitable aragonite crystal form calcium carbonates for use in the invention are commercially available and include those marketed by Maruo Calcium Company Limited, Japan under the trade name WHISCAL®.
- the level of particulate calcium carbonate abrasive generally ranges from 10 to 70%, preferably from 20 to 60%, more preferably from 30 to 40%, by total weight particulate calcium carbonate abrasive (as defined above) based on the total weight of the composition.
- the oral care compositions of the invention demonstrate satisfactory levels of cleaning, yet are not unduly abrasive and damaging to the teeth.
- a further advantage of the oral care compositions of the invention is that they are gentle enough for use on bridgework, dentures and other forms of artificial teeth which are made from polymers much softer than natural tooth enamel, such as acrylic resin (PMMA) ..
- the level of cleaning ability of the composition of the invention may be measured by assessing its effect on accumulated pellicle, for example by using a method such as that described by Pickles et al. (International Dental Journal 55 (2005), pp. 197-202).
- This model uses enamel slabs cut from bovine central incisors, embedded in methacrylate resin.
- the enamel surfaces are smoothed by hand using an alumina paste on a glass block and lightly acid etched in order to facilitate stain accumulation and adherence.
- the enamel blocks are placed in an incubator set at a constant temperature of 50°C and slowly rotated to alternate between immersion in a staining broth (consisting of tea, coffee and mucin) and air drying.
- the broth is changed daily and after five days the slabs are removed and washed with distilled water to remove any loose debris.
- the stained slabs are then brushed in a mechanical brushing machine with distilled water to remove any loosely adhered stain. They are then dried and the L* values (L* st ained) from the CIE L * a * b * colour system are measured with a chroma meter in L * a * b * mode. To assess cleaning performance, the stained specimens are then mounted in the mechanical brushing machine and the required load applied to each brush.
- the test composition is dispersed in an aqueous diluent to form a slurry (typically 38.5g test composition and 61 .5g of distilled water) and the stained specimens brushed for a set number of brush strokes with 10ml of slurry.
- a slurry typically 38.5g test composition and 61 .5g of distilled water
- the enamel slabs are rinsed with distilled water, dried and the L* values (LVushed) are re-measured.
- all traces of stain are removed from the enamel slabs using flour of pumice, on a soft cloth using a grinder/polisher.
- the enamel slabs are then rinsed with distilled water, dried and the L* values (L*p Umi ced) are measured and recorded.
- the percentage of the stain removed by the test composition compared to full removal by pumice (hereinafter referred to as the pellicle cleaning ratio or PCR) may be calculated using the following equation:
- composition of the invention preferably has a PCR value of at least 30%, more preferably at least 40%, most preferably at least 45%.
- the level of abrasivity of the composition of the invention may be assessing its Radioactive Dentine Abrasion Test (RDA) value.
- RDA Radioactive Dentine Abrasion Test
- a standard test procedure for measuring these values follows the method for assessment of dentifrice abrasivity recommended by the American Dental Association (Journal of Dental Research 55(4) 563, 1976). In this procedure, extracted human teeth are irradiated with a neutron flux and subjected to a standard brushing regime. The radioactive phosphorus 32 removed from the dentin in the roots is used as the index of the abrasion of the composition tested.
- a reference slurry containing 10 g of calcium pyrophosphate in 50 cm 3 of 0.5% aqueous solution of sodium carboxymethyl cellulose is also measured and the RDA of this mixture is arbitrarily taken as 100.
- a slurry of 25g of the test composition in 40 cm 3 water is prepared and submitted to the same brushing regime.
- composition of the invention preferably has a RDA value of no more than 100, more preferably no more than 80, most preferably no more than 60.
- composition of the invention preferably has a PCR:RDA ratio of at least 0.5, more preferably at least 0.6, most preferably at least 0.8.
- a preferred type of product form in the context of the present invention is a dentifrice.
- the term "dentifrice” denotes a formulation which are used to clean the surfaces of the oral cavity.
- the dentifrice is an oral composition that is not intentionally swallowed for purposes of systemic administration of therapeutic agents, but is retained in the oral cavity for a sufficient time to contact substantially all of the dental surfaces and/or mucosal tissues for purposes of oral activity.
- the dentifrice is suitable for application with a toothbrush and is rinsed off after use.
- the dentifrice is in the form of an extrudable semi-solid such as a cream, paste or gel (or mixture thereof).
- a dentifrice composition according to the invention will usually contain a liquid continuous phase in an amount of from 40 to 99% by weight based on the total weight of the dentifrice.
- Such a liquid continuous phase will typically comprise a mixture of water and polyhydric alcohol in various relative amounts, with the amount of water generally ranging from 10 to 45% by weight (based on the total weight of the dentifrice) and the amount of polyhydric alcohol generally ranging from 30 to 70% by weight (based on the total weight of the dentifrice).
- Typical polyhydric alcohols include humectants such as glycerol, sorbitol, polyethylene glycol, polypropylene glycol, propylene glycol, xylitol (and other edible polyhydric alcohols), hydrogenated partially hydrolyzed polysaccharides and mixtures thereof.
- humectants such as glycerol, sorbitol, polyethylene glycol, polypropylene glycol, propylene glycol, xylitol (and other edible polyhydric alcohols), hydrogenated partially hydrolyzed polysaccharides and mixtures thereof.
- a dentifrice composition according to the invention will generally contain further ingredients to enhance performance and/or consumer acceptability.
- the dentifrice may comprise other abrasive materials (in addition to the particulate calcium carbonate abrasives described above).
- Such other abrasive materials will generally be present in an amount of from 3 to 75% by weight based on the total weight of the dentifrice.
- Suitable other abrasive materials include abrasive silicas , other calcium carbonates (which are different to the particulate calcium carbonate abrasives described above), dicalcium phosphate, tricalcium phosphate, calcined alumina, sodium and potassium metaphosphate, sodium and potassium pyrophosphates, sodium
- trimetaphosphate sodium hexametaphosphate, particulate hydroxyapatite and mixtures thereof.
- the dentifrice will usually contain a binder or thickening agent in an amount of from 0.5 to 10% by weight based on the total weight of the dentifrice.
- Suitable binders or thickening agents include carboxyvinyl polymers (such as polyacrylic acids cross-linked with polyallyl sucrose or polyallyl pentaerythritol), hydroxyethyl cellulose, hydroxypropyl cellulose, water soluble salts of cellulose ethers (such as sodium carboxymethyl cellulose and sodium carboxymethyl hydroxyethyl cellulose), natural gums (such as carrageenan, gum karaya, guar gum, xanthan gum, gum arabic, and gum tragacanth), finely divided silicas, hectorites, colloidal magnesium aluminium silicates and mixtures thereof.
- the dentifrice will usually contain a surfactant in an amount of from 0.2 to 5% by weight based on the total weight of the dentifrice.
- Suitable surfactants include anionic surfactants, such as the sodium, magnesium, ammonium or ethanolamine salts of Cs to Cis alkyl sulphates (for example sodium lauryl sulphate), Cs to Cis alkyl sulphosuccinates (for example dioctyl sodium sulphosuccinate), Cs to Cis alkyl sulphoacetates (such as sodium lauryl sulphoacetate), Cs to Cis alkyl sarcosinates (such as sodium lauryl sarcosinate), Cs to Cis alkyl phosphates (which can optionally comprise up to 10 ethylene oxide and/or propylene oxide units) and sulphated monoglycerides.
- anionic surfactants such as the sodium, magnesium, ammonium or ethanolamine salts of C
- Suitable surfactants include nonionic surfactants, such as optionally polyethoxylated fatty acid sorbitan esters, ethoxylated fatty acids, esters of polyethylene glycol, ethoxylates of fatty acid monoglycerides and diglycerides, and ethylene oxide/propylene oxide block polymers.
- suitable surfactants include amphoteric surfactants, such as betaines or sulphobetaines. Mixtures of any of the above described materials may also be used.
- compositions of the present invention may also contain further optional ingredients customary in the art such as fluoride ion sources, anticalculus agents, buffers, flavouring agents, sweetening agents, colouring agents, opacifying agents, preservatives, antisensitivity agents and antimicrobial agents.
- fluoride ion sources such as in particular dentifrices
- anticalculus agents such as in particular buffers, flavouring agents, sweetening agents, colouring agents, opacifying agents, preservatives, antisensitivity agents and antimicrobial agents.
- Example 1 represents a formulation according to the invention.
- the remaining formulations are comparative examples (not according to the invention).
- Titanium dioxide (anatase) 1 1 1 1 1
- VICRON® Food Grade 45-3 (4) - - - 40 ( ' Precipitated calcium carbonate ex Maruo Calcium Company Limited, consisting of aragonite rods/needles with length 10 to 30 microns and diameter 0.5 to 1 .0 micron.
- Precipitated calcium carbonate ex Speciality Minerals Inc. consisting of agglomerates of acicular aragonite crystals, crystal length about 1 micron or less.
- the agglomerates have an average particle size (d50) of about 2.5 micron (equivalent spherical diameter).
- Ground calcium carbonate ex Omya which is fine ground natural marble from Avenza, Italy, having an irregular rhombohedral particle shape and a median particle diameter of 5 ⁇ .
- Ground calcium carbonate ex Speciality Minerals Inc. which is fine ground natural limestone from Adams, MA, with an irregular rhombohedral particle shape and an average particle size of 10.0 microns.
- Precipitated calcium carbonate ex Speciality Minerals Inc. consisting of clustered cubic particles having a calcite crystal habit, a cubic particle shape and a median particle size of 4.5 microns.
- Precipitated calcium carbonate ex Speciality Minerals Inc. consisting of semi- regular prismatic particles having a calcite crystal habit, a semi-regular prismatic shape and a median particle size of 12.0 microns.
- PCR was measured using the method of Pickles et
- RDA was measured using the method for assessment of dentifrice abrasivity recommended by the American Dental Association (Journal of Dental Research 55(4) 563, 1976).
- Example 1 Compared to the Comparative Examples.
- the cleaning performance of Example 1 is not significantly inferior to any of the Comparative Examples, but abrasivity, as indicated by the RDA measurement, is greatly reduced.
- Example 2 and Comparative Example H
- Example 2 represents a formulation according to the invention.
- the other formulation is a comparative example (not according to the invention)
- Chalk 800M - 15 ( ' Calcium carbonate rods ( ', modified by dispersion of the rods into a solution of oleic acid in ethanol, followed by filtering and washing with distilled water to obtain a slurry (36% a.i.).
- False teeth (made from PMMA) were embedded in self-setting resins before being brushed by the test formulations, as follows:
- Group 1 brushed with clean water only
- the brushing medium is made up of the test formulation and water in a weight ratio of 1 :2.
- a brushing machine (Martindale M235), was set up with loading head of 275 g in total.
- the teeth of Groups 1 to 3 were brushed for 15 minutes at a speed of 150 rpm, and then removed for observation.
- the teeth of Group 4 were brushed for 15 minutes at a speed of 150 rpm with the formulation of Comparative Example H, then brushed for 15 minutes at a speed of 150 rpm with the formulation of Example 2, and then removed for observation.
- Image D (Group 3 teeth): Much fewer scratches observed
- Image E (Group 4 teeth): The number as well as the depth of scratches is less than that observed for the Group 2 teeth, which indicates that the rods have a reparative effect.
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Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
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CN201280057118.7A CN103930089B (en) | 2011-09-23 | 2012-09-12 | Oral care composition |
BR112014006689-2A BR112014006689B1 (en) | 2011-09-23 | 2012-09-12 | oral care composition |
US14/345,013 US9220665B2 (en) | 2011-09-23 | 2012-09-12 | Oral care compositions |
EP12756508.3A EP2758026B1 (en) | 2011-09-23 | 2012-09-12 | Oral care compositions |
MX2014003524A MX2014003524A (en) | 2011-09-23 | 2012-09-12 | Oral care compositions. |
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CNPCT/CN2011/001607 | 2011-09-23 | ||
CN2011001607 | 2011-09-23 |
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WO2013041419A1 true WO2013041419A1 (en) | 2013-03-28 |
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PCT/EP2012/067785 WO2013041419A1 (en) | 2011-09-23 | 2012-09-12 | Oral care compositions |
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US (1) | US9220665B2 (en) |
EP (1) | EP2758026B1 (en) |
CN (1) | CN103930089B (en) |
BR (1) | BR112014006689B1 (en) |
CL (1) | CL2014000697A1 (en) |
MX (1) | MX2014003524A (en) |
WO (1) | WO2013041419A1 (en) |
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WO2015067422A1 (en) * | 2013-11-07 | 2015-05-14 | Unilever Plc | Compositions and methods for treating tooth hypersensitivity |
WO2015094152A1 (en) * | 2013-12-16 | 2015-06-25 | Colgate-Palmolive Company | Oral care compositions comprisng calcium carbonate and silica |
EP2758026B1 (en) | 2011-09-23 | 2015-08-26 | Unilever Plc. | Oral care compositions |
WO2015172347A1 (en) * | 2014-05-15 | 2015-11-19 | The Procter & Gamble Company | Dentifrice compositions having dental plaque mitigation or improved fluoride uptake |
DE102014115518A1 (en) | 2014-10-24 | 2016-04-28 | orochemie GmbH + Co. KG | Dental polishing and cleaning paste |
WO2017079954A1 (en) * | 2015-11-13 | 2017-05-18 | The Procter & Gamble Company | Dentifrice compositions with improved fluoride stability |
EP2883573B1 (en) | 2013-12-13 | 2017-10-25 | Omya International AG | Abrasive cleaning composition |
WO2020212361A1 (en) * | 2019-04-17 | 2020-10-22 | Unilever Plc | Oral care compositions |
EP3888623A1 (en) * | 2020-04-02 | 2021-10-06 | Unilever Global IP Ltd | Oral care system |
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- 2012-09-12 WO PCT/EP2012/067785 patent/WO2013041419A1/en active Application Filing
- 2012-09-12 CN CN201280057118.7A patent/CN103930089B/en active Active
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EP2758026B1 (en) | 2011-09-23 | 2015-08-26 | Unilever Plc. | Oral care compositions |
WO2015067422A1 (en) * | 2013-11-07 | 2015-05-14 | Unilever Plc | Compositions and methods for treating tooth hypersensitivity |
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EP2883573B2 (en) † | 2013-12-13 | 2020-10-28 | Omya International AG | Abrasive cleaning composition |
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WO2015094152A1 (en) * | 2013-12-16 | 2015-06-25 | Colgate-Palmolive Company | Oral care compositions comprisng calcium carbonate and silica |
CN105813618A (en) * | 2013-12-16 | 2016-07-27 | 高露洁-棕榄公司 | Oral care compositions comprisng calcium carbonate and silica |
AU2013408425B2 (en) * | 2013-12-16 | 2017-02-02 | Colgate-Palmolive Company | Oral care compositions comprising calcium carbonate and silica |
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CN105813618B (en) * | 2013-12-16 | 2019-03-29 | 高露洁-棕榄公司 | Oral care composition comprising calcium carbonate and silica |
WO2015172347A1 (en) * | 2014-05-15 | 2015-11-19 | The Procter & Gamble Company | Dentifrice compositions having dental plaque mitigation or improved fluoride uptake |
DE102014115518A1 (en) | 2014-10-24 | 2016-04-28 | orochemie GmbH + Co. KG | Dental polishing and cleaning paste |
WO2017079954A1 (en) * | 2015-11-13 | 2017-05-18 | The Procter & Gamble Company | Dentifrice compositions with improved fluoride stability |
CN113645937A (en) * | 2019-03-28 | 2021-11-12 | 联合利华知识产权控股有限公司 | Solid oral care compositions |
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WO2020212361A1 (en) * | 2019-04-17 | 2020-10-22 | Unilever Plc | Oral care compositions |
EP3888623A1 (en) * | 2020-04-02 | 2021-10-06 | Unilever Global IP Ltd | Oral care system |
Also Published As
Publication number | Publication date |
---|---|
CN103930089B (en) | 2016-03-16 |
US9220665B2 (en) | 2015-12-29 |
EP2758026A1 (en) | 2014-07-30 |
BR112014006689B1 (en) | 2018-11-21 |
US20150050322A1 (en) | 2015-02-19 |
EP2758026B1 (en) | 2015-08-26 |
BR112014006689A2 (en) | 2017-04-04 |
CN103930089A (en) | 2014-07-16 |
CL2014000697A1 (en) | 2015-01-09 |
MX2014003524A (en) | 2014-07-14 |
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