WO2013038242A1 - Procédé de mesure spatiale de structures tissulaires - Google Patents

Procédé de mesure spatiale de structures tissulaires Download PDF

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Publication number
WO2013038242A1
WO2013038242A1 PCT/IB2012/001670 IB2012001670W WO2013038242A1 WO 2013038242 A1 WO2013038242 A1 WO 2013038242A1 IB 2012001670 W IB2012001670 W IB 2012001670W WO 2013038242 A1 WO2013038242 A1 WO 2013038242A1
Authority
WO
WIPO (PCT)
Prior art keywords
organ
probe
tissue structures
reference probe
measuring
Prior art date
Application number
PCT/IB2012/001670
Other languages
German (de)
English (en)
Inventor
Zoran Djinovic
Milos Tomic
Marljana STOJKOVIC
Original Assignee
Ima Integrated Microsystems Austria Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ima Integrated Microsystems Austria Gmbh filed Critical Ima Integrated Microsystems Austria Gmbh
Publication of WO2013038242A1 publication Critical patent/WO2013038242A1/fr

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802Sensor mounted on worn items
    • A61B5/6803Head-worn items, e.g. helmets, masks, headphones or goggles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/1005Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring distances inside the eye, e.g. thickness of the cornea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/102Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062Arrangements for scanning
    • A61B5/0066Optical coherence imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/103Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107Measuring physical dimensions, e.g. size of the entire body or parts thereof
    • A61B5/1072Measuring physical dimensions, e.g. size of the entire body or parts thereof measuring distances on the body, e.g. measuring length, height or thickness
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/103Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107Measuring physical dimensions, e.g. size of the entire body or parts thereof
    • A61B5/1075Measuring physical dimensions, e.g. size of the entire body or parts thereof for measuring dimensions by non-invasive methods, e.g. for determining thickness of tissue layer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00Measuring instruments characterised by the use of optical techniques
    • G01B9/02Interferometers
    • G01B9/02015Interferometers characterised by the beam path configuration
    • G01B9/02017Interferometers characterised by the beam path configuration with multiple interactions between the target object and light beams, e.g. beam reflections occurring from different locations
    • G01B9/02021Interferometers characterised by the beam path configuration with multiple interactions between the target object and light beams, e.g. beam reflections occurring from different locations contacting different faces of object, e.g. opposite faces
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00Measuring instruments characterised by the use of optical techniques
    • G01B9/02Interferometers
    • G01B9/02015Interferometers characterised by the beam path configuration
    • G01B9/02025Interference between three or more discrete surfaces
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00Measuring instruments characterised by the use of optical techniques
    • G01B9/02Interferometers
    • G01B9/02015Interferometers characterised by the beam path configuration
    • G01B9/02027Two or more interferometric channels or interferometers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00Measuring instruments characterised by the use of optical techniques
    • G01B9/02Interferometers
    • G01B9/0209Low-coherence interferometers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00Measuring instruments characterised by the use of optical techniques
    • G01B9/02Interferometers
    • G01B9/0209Low-coherence interferometers
    • G01B9/02091Tomographic interferometers, e.g. based on optical coherence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/16Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers
    • A61B3/165Non-contacting tonometers

Definitions

  • the invention relates to a method for spatially measuring a plurality of successive biological tissue structures in an organ, in particular in an eye obtained by evaluating interferograms, from reflected, low-coherent light from a reference probe directed to a reference probe and at least one measuring probe ,
  • the invention further relates to a device for carrying out this method.
  • IOP intraocular pressure
  • interferometric methods in which the spatial extent or thicknesses and spacings of reflective surfaces, e.g. the cornea and the lens are measured by means of an interferometer.
  • the eye to be examined is positioned at a defined distance from a measuring probe, generally a measuring light guide, and coherent light is transmitted through this measuring probe and through a reference probe or a reference light guide directed to a reference reflector in the interferometer. directed.
  • the coherent light from the measuring probe or measuring light guide is reflected at the different structures and the superimposition of the reflected light leads to interference patterns due to the different path lengths which the coherently emerging light from the probes or light guides has to travel back to the respective reflecting structures. which can be evaluated with conventional mathematical algorithms to determine the distances of the reflective structures to each other.
  • the reference probe was directed to a reflector in the interferometer and the superimposition of the reflected light from the probe was via relatively complicated and large-scale devices with lenses and semi-transparent mirrors, which is why the corresponding devices in the practice were used stationary.
  • the intraocular pressure and thus the spatial extent of the tissue structures to be examined which allow a conclusion on the intraocular pressure vary so much in one and the same patient depending on the time of day and the physical activity that a single measurement of spatial Extension or the relative position of the relevant structures does not allow a satisfactory conclusion about the actual physiological conditions.
  • the invention is therefore based on the object of specifying a method with which a spatial measurement of a plurality of biological tissue structures in an organ by means of interferometry can be carried out continuously and over a longer period by means of mobile devices.
  • the method of the type mentioned above is characterized in that, when the spatial extent of a first tissue structure of the organ is known, both the reference probe and the at least one measuring probe are directed onto the organ, the path difference between the two both probes is kept constant.
  • a first tissue structure of the organ is therefore measured and determined with respect to its spatial extent before the actual measurement. For example, the thickness of the cornea, which remains practically constant even with fluctuating intraocular pressure, is suitable for this purpose.
  • both the reference probe and the probe are directed to the organ and the path difference between the two probes is kept constant.
  • the path difference between see the two probes or optical fibers is always meant as a distance in the axial direction, ie in the direction of the path of the light or the electromagnetic reference and measurement signal.
  • one of the biological tissue structures to be measured itself serves as a quasi reference reflector, so that a complex arrangement of lenses and semi-transparent mirrors in the interferometer is no longer necessary. Even a varying distance between the two probes and the tissue structures to be measured does not hinder a precise measurement of the respective spatial extent, so that no apparatus precautions must be taken to keep the eye at a suitable distance.
  • the expenditure on equipment of an interferometer can be considerably reduced so that apart from the reference and measuring probes, only one arithmetic unit with a corresponding program logic is necessary in order to be able to process and store the measured data.
  • the method is developed such that the path difference between the reference probe and the at least one measuring probe is adjusted and fixed to the organ to be measured such that the interference bands corresponding to the first tissue structure in a coupling curve, the known spatial extent of this structure specify, preferably in the interferogram associated with the other tissue structures to be measured interference bands and the actual distances of the other tissue structures are determined relative to the distance of the first tissue structure corresponding interference bands.
  • a coupling curve is understood in the art of fiber optics that signal of a photodiode, in which the interference patterns are reflected in the AC component of the signal. This signal is obtained by varying the optical wavelength in a fiberoptic component Michelson interferometer (Fiber Optics Essentials, K.
  • the distances of the respective biological tissue structures from each other can be directly determined and recorded in order to subsequently be used for diagnosis.
  • the interferograms obtained can have interference bands for different tissue structures.
  • the method according to the invention has been used to measure, for example, the mean corneal thickness (CCT), the anterior chamber depth (ACD) and the length of the eyeball (axial length, AL). All of these values can be correlated with intraocular pressure and thus taken into account in the medical diagnosis.
  • the interference bands have the basic shape of a Gaussian bell curve and have a certain width, referred to as the "dynamic rank", depending on the coherence length of the light used.
  • the invention is therefore preferred further developed that the exact positions of the interference bands are determined by distance determination of the maxima of the Gaussian envelopes of the interference bands.
  • the measured data determined over a certain period of time are used to calculate the relative movements of the plurality of tissue structures of the organ relative to one another. The treating physician can then determine the course of intraocular pressure over the period in question and receive appropriate information for the indicated treatment.
  • the reference light guide and the measuring light guide only one-dimensional length information can be obtained.
  • the invention is developed to advantage in that a plurality of arranged in the form of an array probes are used and activated by an electronic circuit sequentially for the determination of measurement data. Due to the extremely short time required for a spatial measurement or length determination, a corresponding number of measurements can be made in a very short time, with appropriate wiring of the light guides or probes arranged next to each other on the array, so that practically a snapshot of the relevant Organ in the sense of a spatial, three-dimensional survey at a given time can be created.
  • the device for carrying out the method according to the invention is characterized in that reference and measuring probes of an interferometer are fixed to a holder that is portable by a patient and are connected to a portable computing unit.
  • the patient thus carries the arithmetic unit and the holder with him, wherein the holder may be formed, for example in the form of glasses.
  • the holder preferably has means for setting and fixing the path difference between the reference probe and the at least one measuring probe to the organ to be measured.
  • FIG. 1 shows the basic arrangement of the reference and measuring probes
  • FIG. 2 shows a coupling curve as obtained in the method according to the invention
  • FIG. 3 shows a curve indicating the changes of a measured value over time
  • FIG. 4 shows a representation of an application example the invention.
  • 1 denotes an eye as an organ to be measured, the anterior chamber 4 being delimited by the lens 2 and the cornea 3.
  • the distance between the lens 2 and the cornea 3 is subject to measurable fluctuations with changing intraocular pressure and can thus be used to determine the intraocular pressure, which is an important diagnostic indicator in connection with glaucoma.
  • two light guides 6 and 7 are now fixed to a holder 8 (not shown) at a distance D to the organ to be examined which is adjustable and fixable.
  • 9 with an unspecified light guide is referred to, which directs the reflected light from the optical fibers 6 and 7 to a computing unit, also not shown.
  • interference bands 14 result, with a suitable setting of ⁇ L the distance X between the third and the fourth band regardless of the distance D corresponds to the average thickness of the cornea 3 and the Cornea representing glass plate 11.
  • the distance Y between the fourth and the sixth interference band corresponds to the spatial extent 5 of the anterior chamber 4. If there are other structures which reflect light, such as a retina (not shown) in an eye, then further interference bands would be displayed which represent the distance specify the retina to the other structures.
  • FIG. 3 now shows a graph of the values for the spatial extent 5 of the anterior chamber 4 and it can be seen that it is subject to fluctuations over time.
  • Fig. 4 it can be seen that the method according to the present invention can be applied to an interferometer in which a holder 8 carries the optical fibers 6 and 7, wherein the optical fibers 6 and 7 are fed to a computing unit 15 in which the evaluation the interference pattern takes place.
  • a portable measuring device has been provided which allows continuous measurement of the spatial extent of biological tissue structures.

Abstract

L'invention concerne un procédé de mesure spatiale d'une pluralité de structures tissulaires biologiques, situées les unes à la suite des autres dans un organe, en particulier dans un oeil (1), par évaluation d'interférogrammes obtenus par lumière cohérente, réfléchie, à partir d'une sonde de référence (6) dirigée sur un réflecteur de référence (3), et d'au moins une sonde de mesure (7), procédé selon lequel, pour une extension spatiale connue d'une première structure tissulaire de l'organe, la sonde de référence, ainsi que ladite au moins une sonde de mesure, est dirigée sur l'organe, la différence de trajet (ƒ¢L) entre les deux sondes étant maintenue constante.
PCT/IB2012/001670 2011-09-12 2012-08-30 Procédé de mesure spatiale de structures tissulaires WO2013038242A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ATA1306/2011 2011-09-12
ATA1306/2011A AT511935B1 (de) 2011-09-12 2011-09-12 Verfahren und vorrichtung zum räumlichen vermessen von gewebestrukturen

Publications (1)

Publication Number Publication Date
WO2013038242A1 true WO2013038242A1 (fr) 2013-03-21

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PCT/IB2012/001670 WO2013038242A1 (fr) 2011-09-12 2012-08-30 Procédé de mesure spatiale de structures tissulaires

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AT (1) AT511935B1 (fr)
WO (1) WO2013038242A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102014007106A1 (de) * 2014-05-12 2015-11-12 Friedrich-Schiller-Universität Jena Verfahren und Vorrichtung zur Bestimmung der ein- oder mehrdimensionalen Struktur von Objekten mittels Strahlung kurzer Wellenlänge

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102021200773A1 (de) 2021-01-28 2022-07-28 Robert Bosch Gesellschaft mit beschränkter Haftung Verfahren und Vorrichtung zum Überprüfen von Vitalparametern

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WO1999049780A1 (fr) * 1998-03-30 1999-10-07 The Regents Of The University Of California Guide-fil de reflectometrie a domaine de coherence optique
WO2006054975A1 (fr) * 2004-11-12 2006-05-26 Medeikon Corporation Detecteur interferometrique a faible coherence, a canaux multiples et a trace unique
US20070081166A1 (en) * 2005-09-29 2007-04-12 Bioptigen, Inc. Portable Optical Coherence Tomography (OCT) Devices and Related Systems
WO2007059206A2 (fr) * 2005-11-15 2007-05-24 Bioptigen, Inc. Systemes d'imagerie sdpm a deux modes et procedes et programmes informatiques associes
US20070278389A1 (en) * 2006-06-02 2007-12-06 Mahesh Ajgaonkar Multi-channel low coherence interferometer
US7821643B2 (en) * 2006-09-06 2010-10-26 Imalux Corporation Common path systems and methods for frequency domain and time domain optical coherence tomography using non-specular reference reflection and a delivering device for optical radiation with a partially optically transparent non-specular reference reflector
US20120013909A1 (en) * 2010-07-13 2012-01-19 University Of Kent At Canterbury Apparatus and method of monitoring and measurement using spectral low coherence interferometry

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US8348429B2 (en) * 2008-03-27 2013-01-08 Doheny Eye Institute Optical coherence tomography device, method, and system
US8783866B2 (en) * 2008-04-24 2014-07-22 Bioptigen, Inc. Optical coherence tomography (OCT) imaging systems having adaptable lens systems and related methods and computer program products
JP5324839B2 (ja) * 2008-06-19 2013-10-23 株式会社トプコン 光画像計測装置
US7708408B1 (en) * 2008-10-10 2010-05-04 Amo Development Llc. Single-arm optical coherence tomography pachymetry system and method

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999049780A1 (fr) * 1998-03-30 1999-10-07 The Regents Of The University Of California Guide-fil de reflectometrie a domaine de coherence optique
WO2006054975A1 (fr) * 2004-11-12 2006-05-26 Medeikon Corporation Detecteur interferometrique a faible coherence, a canaux multiples et a trace unique
US20070081166A1 (en) * 2005-09-29 2007-04-12 Bioptigen, Inc. Portable Optical Coherence Tomography (OCT) Devices and Related Systems
WO2007059206A2 (fr) * 2005-11-15 2007-05-24 Bioptigen, Inc. Systemes d'imagerie sdpm a deux modes et procedes et programmes informatiques associes
US20070278389A1 (en) * 2006-06-02 2007-12-06 Mahesh Ajgaonkar Multi-channel low coherence interferometer
US7821643B2 (en) * 2006-09-06 2010-10-26 Imalux Corporation Common path systems and methods for frequency domain and time domain optical coherence tomography using non-specular reference reflection and a delivering device for optical radiation with a partially optically transparent non-specular reference reflector
US20120013909A1 (en) * 2010-07-13 2012-01-19 University Of Kent At Canterbury Apparatus and method of monitoring and measurement using spectral low coherence interferometry

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102014007106A1 (de) * 2014-05-12 2015-11-12 Friedrich-Schiller-Universität Jena Verfahren und Vorrichtung zur Bestimmung der ein- oder mehrdimensionalen Struktur von Objekten mittels Strahlung kurzer Wellenlänge

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Publication number Publication date
AT511935A2 (de) 2013-03-15
AT511935A3 (de) 2014-02-15
AT511935B1 (de) 2015-09-15

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