WO2013004590A1 - Corneal implant - Google Patents

Corneal implant Download PDF

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Publication number
WO2013004590A1
WO2013004590A1 PCT/EP2012/062591 EP2012062591W WO2013004590A1 WO 2013004590 A1 WO2013004590 A1 WO 2013004590A1 EP 2012062591 W EP2012062591 W EP 2012062591W WO 2013004590 A1 WO2013004590 A1 WO 2013004590A1
Authority
WO
WIPO (PCT)
Prior art keywords
implant
characterized
marking
corneal
corneal implant
Prior art date
Application number
PCT/EP2012/062591
Other languages
German (de)
French (fr)
Inventor
Gregor Stobrawa
Michael Bergt
Original Assignee
Carl Zeiss Meditec Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE102011106289.4 priority Critical
Priority to DE102011106289A priority patent/DE102011106289A1/en
Application filed by Carl Zeiss Meditec Ag filed Critical Carl Zeiss Meditec Ag
Publication of WO2013004590A1 publication Critical patent/WO2013004590A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/142Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/147Implants to be inserted in the stroma for refractive correction, e.g. ring-like implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/148Implantation instruments specially adapted therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0096Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
    • A61F2250/0098Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers

Abstract

The invention relates to a corneal implant, in particular for placing in a corneal pocket, and to a device for fitting such an implant in place. To this end, the corneal implant for correcting defective vision, in particular of higher order, has at least one marking which permits a clear orientation of the implant in the cornea and is designed such that the visual impression is not impaired. The device has an observation arrangement and at least one illumination system for illuminating and exciting at least one marking of the corneal implant arranged in an eye.

Description

Corneal implant

The invention relates to a corneal implant, in particular for placing in a corneal pocket as well as a device for placement of such an implant.

It is known, refractive errors of the eye, ie to treat refractive errors by means of laser, to make use of a spectacle superfluous.

In this case, on the one hand by means of an excimer laser corneal material selectively vaporized and removed with it, and so the refractive effect of the cornea be altered so that the refractive error is compensated.

Another method is based on separate by means of a femtosecond laser, a substantially lens-shaped piece of tissue within the cornea and a

remove opening cut. This process is known as FLEx (femtosecond lenticule extraction) known. The dimensions of this woven fabric piece are chosen so that after removal of the separated piece of fabric, the resulting shape of the cornea also corrects the refractive error. In this case, asymmetrical error (coma, astigmatism, ...) can be compensated for by suitable control of the laser, which are also known as higher order aberrations. The removed corneal material is destroyed in general.

Since the cornea has only a small thickness (about 400-650 μιη), not all

correct refractive errors by material removal, in particular, relates to the

Nearsightedness (myopia). Therefore, it is also known, in the corneal material to bring in the form of intrastromal corneal rings or ring segments (ICR - intracorneal ring ICRS - intracorneal ring segment). These consist of a

biocompatible plastic material and in z. "Pockets" made as femtosecond laser used in the cornea (see US Pat. 6,875,232). With these, however, only lower order refractive errors can be corrected.

There is therefore a need to be able to also use corneal implants to correct refractive errors of higher order. These beats the US 7,776,086, incorporated herein by reference the entire contents, the right to use an aspherical lens as an implant. but that this solution is limited to addressing radially symmetrical errors of the eye.

In the US 6,855,163, the entire contents incorporated herein by reference, discloses placing multiple implants at various points in the cornea. Although the inventor does not execute, in this way, a non-symmetrical refractive errors could be treated. However, this solution by the need for multiple pockets in the cornea and the exact placement of the various implants is very expensive.

EP 1871298 discloses a method for the treatment of presbyopia by introducing corneal inlay in the cornea, which have the effect of a diaphragm, and in addition means for detecting the depth of insertion are provided.

The invention is therefore based on the object to overcome the disadvantages of the prior art and to provide a corneal implant with the not radially symmetric higher order aberrations can be treated.

It is a further object of the present invention to provide a device for the placement of such a corneal implant, that to ensure a reliable and safe detection of the location and position of the ophthalmologic implant.

These objects are achieved by an implant cornea and a device for the placement of such an implant according to the independent claims.

Advantageous embodiments of the invention are given in the respective subclaims.

According to the invention, the corneal implant for correction of a visual defect, in particular higher order, at least one marking, through which is possible an unambiguous orientation of the implant in the cornea.

the marking is advantageously carried out so that the visual impression is not disturbed.

For this purpose they may be designed so that it is visible only outside the visible light spectrum to the human eye, which lies between about 380 nm and 780 nm, or a portion of the visual spectral range between about 450 nm and 750 nm. Thereby, it is possible to provide permanent indicia on the implant, on the one hand does not affect the light transmission of the implant in the visual spectral range and the other fluorescent outside the visible to the human light spectrum or absorb, so that with a corresponding illumination of the implant a reliable and safe detection of the location and position and / or identification of the implant on the basis of the marker without affecting or compromising the visual perception point of view of the implant wearer is made possible. For identification, the

Mark have a corresponding encoding, eg for right / left,

Patient number or similar .. In advantageous embodiments of the cornea implant according to the invention a fluorescent dye can be used for marking of one of the structural classes the cyanines,

includes Mercocyanine, phthalocyanines, Pvhodamine, porphyrins, chlorophylls, triarylmethanes, xanthenes, oxazines, thiazines, Safranine, heterocyclic pyrilium and Thiapyriliumsalze, Perrylene, Terrylene, quaterrylene, Quaternele, azo dyes, metal complexes or quinones, be selected. However, it is also possible that as a light absorbing dye, a UV absorber of one of the structural classes, the benzophenones, benzotriazoles,

is salicylic acid, Resorcinmonobenzonate, oxanilides, cinnamic ester derivatives, p-hydroxy-benzoic acid ester and / or an IR absorber of one of these structural classes, used .. Other fluorescent or absorbing dyes are useful for making the marks.

Alternatively, the at least one marking can be temporary and disappear in particular solely by timing or external influences. Then it could also be designed so that they can be seen in the visible spectral range. Such a dye may be, for example, water soluble and are removed, for example by the tear fluid. Alternatively, the marker for example, with a "Removeable Ink Skin Marker" from the company Viscot Medical LLC (www.viscot.com/PSRpMarkers.html) are made.

Further alternatively, the label may also be a special, generally

asymmetrical shaping of the implant can be realized.

According to the invention, the corneal implant of a biocompatible synthetic or natural material (e.g., corneal material from a donor or its own cornea). This corneal material is advantageously obtained by means of a femtosecond laser.

The inventive corneal implants it is possible to display the location and position, for example, during or after a surgical procedure using a suitable observation system safe and reliable.

The invention also includes an apparatus for placement of a corneal implant which is part of an arrangement for monitoring and at least one illumination system for illumination and excitation of at least one marking disposed of in an eye

Corneal implant has.

, When this apparatus further comprises at least one camera for recording the emitting, fluorescent or absorbent outside the visible light spectrum for humans marking and at least one evaluation unit or display unit for at least one image captured by the camera image of the mark of advantage.

The observation system according to the invention allows a reliable and secure

Detection of the location and position and / or identification of the implant.

A preferred embodiment of the invention is obtained when the evaluation unit at least one coupler lungsy stem for coupling the captured images of the marker in the

An arrangement for observation.

It is advantageous if the illumination system comprises at least one light source, the light source, white light or excitation light for the dye of the marker in a predetermined wavelength range radiated.

A likewise inventive optical detection method for detecting the location and position and / or identification of an implant as described above comprising the steps of: a) illuminating the implant with at least one light source of a lighting system, wherein the light source, white light or excitation light for a dye of radiates marking the implant in a predetermined wavelength range; b) receiving the emitting outside the visible light spectrum for humans fluorescent or absorbing marking means of a camera; c) evaluation of at least one recorded by the camera of the marking by means of at least one evaluation unit. The inventive detection method is a reliable and safe detection of the location and position and / or identification of the implant is guaranteed. In addition, it is ensured that the application of the method does not cause deterioration of the visual sensation view of an implant carrier, since the light emitted by white light or excitation light in a predetermined wavelength range irradiated mark outside the light spectrum visible to humans or absorbed.

A preferred embodiment of the invention is explained below with reference to the schematic drawings.

Show it:

Fig. 1 shows a section through the cornea

Fig. 2 is a plan view of the cornea with correctly incorporated of the inventive implant

FIG. 3 is a first variant of the introduction of the inventive implant

Fig. 4 shows a second variant of the introduction of the implant Fig. 5 according to the invention, a top view of the cornea with false incorporated of inventive implant

Fig. 6 shows a second embodiment of the implant according to the invention

Fig. 7 shows a third embodiment of the implant according to the invention

Fig. 8 shows an embodiment of the device for placement of a corneal implant according to the invention.

Fig. 1 shows schematically a cross-section of a cornea 1. This has a generated with a femtosecond laser pocket 2 in which an implant was placed 3 by the implant was introduced 3 through the access 4 in the bag 2. A method for producing the bag 2 in the cornea 1 by means of a femtosecond laser is

for example, described in DE 10 2006 053120, reference is hereby made to the entire contents. With the same procedure, the implant 3 can be obtained from the donor cornea of ​​an eye. In this case, the implant 3 just such a shape that the locally modified by the introduction of the implant 3 in the cornea 1 refractive power of the cornea 1 corrects the imaging properties of the eye in a desired manner, wherein the implant 3, a thin (less 200μιη), in has generally flexible structure has to be transparent and is adapted in its refractive index of the refractive index of the cornea 1, so it is by conventional means difficult to recognize. Therefore not radially symmetrical aberrations of the eye can be corrected and the implant must have a different from the radial symmetry shape. So that the orientation of the implant in the pocket 2 is to correct an important variable which must be adhered to the imaging properties of the eye. In order to determine this orientation during insertion of the implant in the cornea, the implant has one or more labels 3 5 which enables an accurate insertion of the implant 3 through the access 4 (see Figure 2). The implant 3 must be so placed to in the bag 2, that the marking 5 on a

predetermined location is located. Around the implant 3 through access 4, which

is usually smaller than the diameter of the implant 3 to introduce into the bag 2, it can be partially folded over (Fig. 3) or folded (Fig. 4) and only after the

be folded or unfolded insertion. By the marks 5 is easy to check whether the implant 3 has been folded or unfolded correctly addition in these cases. Here, 3 and 4 show the characters each have the wrong insertion state of the implant, which is clearly seen in the incorrect position of the mark. 5 Fig. 5 shows the case of example that the placement of the implant was not correct, the label 5 is not in place, the implant is rotated. So that the imaging properties of the eye can not be corrected as desired, it may even come to generate additional errors. The label 5 is attached at a defined site in the previous preparation, or provision of the implant. 3

Fig. 6 shows a variant of the invention in which the marking of the correct orientation by the shape of the periphery of the implant 3 is made here as an elliptical shape.

Fig. 7 shows a further variant of the marker by molding the extent here by a bulge 6 of the implant. 3

Fig. 8 shows a schematic representation of an apparatus for placement of a

Corneal implant as has been described in the embodiments of FIG. 2. The device 7 in this case comprises a microscope with an optical microscope 8, a

The illumination system 9 for illuminating the one or more dyes existing mark 5 of the arrayed in the eye 10 the implant 3 over a part of the beam path 17. In addition, 7, the device comprises a camera 11 for receiving the emissive outside the visible to the human light spectrum fluorescent or absorbing markings 5 and at least one evaluation unit 12 for at least an image taken by the camera 11 or image of the mark of the marks 5 on. In the illustrated embodiment, the marks 5 consist of a fluorescent dye in the near infrared region, for example, the dye indocyanine green. From Fig. 8 it is clear that the illumination system emits light of a certain wavelength and 9 also white light via a beam splitter 13 to the eye 10 with the implant. 3 The radiation emitted by the implant 3 and the marks 5 is again radiation via the beam splitter 13 and a second beam splitter 14 sent over a part of the beam path 15 to the camera. 11 that of the eye 10 and the implant 3 captured image is provided 18 of an observer via the microscope 8 with the optical microscope available to the eye via a further partial beam path sixteenth For this purpose, the beam splitter 13 as

partially transparent mirror formed. The images recorded by the camera 11 images are transmitted as image data via a data line 19 to the evaluation unit 12th The

Evaluation unit 12 comprises in the microscope optics of the microscope 8, a coupling system 19 for coupling of the recorded images of the mark. 5 The coupling system 19 encompasses a beam splitter or deflecting mirror 20 is formed as a partially transparent mirror, and sends the captured by the camera 11 and evaluated by the evaluation unit 12 image to the eye 18 of the observer. This makes it possible, an overlay image consisting of the image taken by the camera 11 of the image

provide mark 5 and the imaging of the object region, namely the observed implant 3 and the vicinity thereof to a viewer. Furthermore, the

Evaluation unit 12 having an automatic tracking system for detecting movement and / or the orientation and position changes of the mark 5 and the implant. 3 Furthermore, it is possible that the evaluation unit includes an auto-focus system, the focus of the microscope optics on the implant 3 by means of images recorded by the camera 11 images of the mark 5 and its evaluation is carried out.

The illumination system comprises a light source 9, wherein the light source, white light or excitation light for the dye of the mark 5 in a predetermined

Wavelength range radiated. As light sources such as halogen lamps or laser light sources can be used. Furthermore, it is possible that the

The illumination system 9 is formed as a slit illumination system (not shown).

The device 7 as well as the implants 3 described in the embodiments shown in FIGS. 2 to 7 can be used in surgical procedures that have the correction of aberrations of the eye by inserting a corneal implant 3 in the cornea 1 of the patient for the object. In particular, during the insertion of the implant 3 in the cornea 1 is an attitude and position control can already

Implant made 3 or the surgeon make appropriate corrections. A secure and precise positioning of the implant 3 is guaranteed.

Claims

claims
1) corneal implant for correcting a visual defect, in particular higher order, characterized in that the implant has at least one marking.
2) corneal implant according to claim 1, characterized in that the at least one marking is carried out so that the visual impression is not disturbed.
3) corneal implant according to claim 1 or 2, characterized in that
at least one marking is visible in a non-visible to the human eye the light spectrum.
4) corneal implant according to claim 1, characterized in that the at least one marking is temporary.
5) corneal implant according to claim 4, characterized in that the at least one marking disappears by timing or external influences.
6) corneal implant according to any one of claims 1 to 5, characterized in that it consists of a biocompatible synthetic or natural material.
7) A device for placement of a cornea implant according to one of claims 1 to 6, characterized in that the device comprises an arrangement for observation and at least one illumination system for illumination and excitation of at least one mark of the placed in an eye cornea implant.
8) Device according to claim 7 :, characterized in that the illumination excites the marker for emission in the visible spectrum.
9) Device according to claim 7, characterized in that the device
at least one camera for recording the visible outside the visible light spectrum for humans and at least one marking
Evaluation unit or display unit for at least one of the camera
having picked-up image of the mark.
10) Device according to claim 8, characterized in that the evaluation unit or display unit, at least one coupling system for coupling the
has captured images of the mark in the arrangement for observation.
11) Device according to one of claims 7 to 10, characterized in that the illumination system comprises at least one light source, wherein the light source, white light or excitation light for the dye of the marker in a predetermined wavelength range radiated.
PCT/EP2012/062591 2011-07-01 2012-06-28 Corneal implant WO2013004590A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE102011106289.4 2011-07-01
DE102011106289A DE102011106289A1 (en) 2011-07-01 2011-07-01 Corneal implant

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201280032938.0A CN103687573A (en) 2011-07-01 2012-06-28 Corneal implant

Publications (1)

Publication Number Publication Date
WO2013004590A1 true WO2013004590A1 (en) 2013-01-10

Family

ID=46397271

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/062591 WO2013004590A1 (en) 2011-07-01 2012-06-28 Corneal implant

Country Status (3)

Country Link
CN (2) CN108992205A (en)
DE (1) DE102011106289A1 (en)
WO (1) WO2013004590A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106466203A (en) * 2015-08-14 2017-03-01 爱博诺德(苏州)医疗器械有限公司 Intraocular implant with texture structure for stress deformation

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WO2001015779A1 (en) * 1999-08-27 2001-03-08 Anamed, Inc. Corneal implant and method of manufacture
US6650357B1 (en) * 1997-04-09 2003-11-18 Richardson Technologies, Inc. Color translating UV microscope
US6855163B2 (en) 2002-07-19 2005-02-15 Minu, Llc Gradual correction of corneal refractive error using multiple inlays
US20060235428A1 (en) * 2005-04-14 2006-10-19 Silvestrini Thomas A Ocular inlay with locator
DE102006053120A1 (en) 2006-11-10 2008-05-15 Carl Zeiss Meditec Ag Treatment device for correcting e.g. myopia, has controller selecting pattern such that volume is isolated in cornea by anterior cutting area, where cornea depleted around volume has preset radius of curvature
DE102008017592A1 (en) * 2008-04-07 2009-10-08 Carl Zeiss Meditec Ag Ophthalmological implant, microscopy system and optical detection methods for the detection and / or identification of an ophthalmologic implant
US7776086B2 (en) 2004-04-30 2010-08-17 Revision Optics, Inc. Aspherical corneal implant

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US6102946A (en) * 1998-12-23 2000-08-15 Anamed, Inc. Corneal implant and method of manufacture
DE10333794A1 (en) * 2003-07-24 2005-03-03 Technovision Gmbh Method and apparatus for contact lens online review
US20060287721A1 (en) * 2004-10-05 2006-12-21 David Myung Artificial cornea
MX2010006475A (en) * 2007-12-12 2010-09-28 Neoptics Ag Intracorneal lenses having a central hole.
CN201160919Y (en) * 2008-03-05 2008-12-10 黄一飞 Novel split type artificial cornea
WO2009158723A2 (en) * 2008-06-27 2009-12-30 Amo Development, Llc. Intracorneal inlay, system, and method

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6650357B1 (en) * 1997-04-09 2003-11-18 Richardson Technologies, Inc. Color translating UV microscope
US6875232B2 (en) 1998-12-23 2005-04-05 Anamed, Inc. Corneal implant and method of manufacture
WO2001015779A1 (en) * 1999-08-27 2001-03-08 Anamed, Inc. Corneal implant and method of manufacture
US6855163B2 (en) 2002-07-19 2005-02-15 Minu, Llc Gradual correction of corneal refractive error using multiple inlays
US7776086B2 (en) 2004-04-30 2010-08-17 Revision Optics, Inc. Aspherical corneal implant
US20060235428A1 (en) * 2005-04-14 2006-10-19 Silvestrini Thomas A Ocular inlay with locator
EP1871298A1 (en) 2005-04-14 2008-01-02 Acufocus, Inc. Ocular inlay with locator
DE102006053120A1 (en) 2006-11-10 2008-05-15 Carl Zeiss Meditec Ag Treatment device for correcting e.g. myopia, has controller selecting pattern such that volume is isolated in cornea by anterior cutting area, where cornea depleted around volume has preset radius of curvature
DE102008017592A1 (en) * 2008-04-07 2009-10-08 Carl Zeiss Meditec Ag Ophthalmological implant, microscopy system and optical detection methods for the detection and / or identification of an ophthalmologic implant

Also Published As

Publication number Publication date
CN108992205A (en) 2018-12-14
CN103687573A (en) 2014-03-26
DE102011106289A1 (en) 2013-01-03

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