WO2012167051A3 - Microencapsulation device having microfluidic channels and related methods - Google Patents

Microencapsulation device having microfluidic channels and related methods Download PDF

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Publication number
WO2012167051A3
WO2012167051A3 PCT/US2012/040423 US2012040423W WO2012167051A3 WO 2012167051 A3 WO2012167051 A3 WO 2012167051A3 US 2012040423 W US2012040423 W US 2012040423W WO 2012167051 A3 WO2012167051 A3 WO 2012167051A3
Authority
WO
WIPO (PCT)
Prior art keywords
plurality
compressed gas
conduits
encapsulation
biological units
Prior art date
Application number
PCT/US2012/040423
Other languages
French (fr)
Other versions
WO2012167051A2 (en
Inventor
Melur K. Ramasubramanian
Sameer TENDULKAR
Original Assignee
North Carolina State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201161493011P priority Critical
Priority to US61/493,011 priority
Application filed by North Carolina State University filed Critical North Carolina State University
Publication of WO2012167051A2 publication Critical patent/WO2012167051A2/en
Publication of WO2012167051A3 publication Critical patent/WO2012167051A3/en

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • B01J13/04Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5036Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089Processes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M45/00Means for pre-treatment of biological substances
    • C12M45/22Means for packing or storing viable microorganisms

Abstract

Devices for the microencapsulation of biological units include a chamber for containing a plurality of biological units suspended in a liquid, and a plurality of liquid conduits in fluid communication with the chamber. Each of the plurality of liquid conduits has an encapsulation outlet. The device includes a compressed gas inlet, and a plurality of compressed gas conduits in fluid communication with the compressed gas inlet. Each of the plurality of compressed gas conduits has a compressed gas outlet that at least partially surrounds a respective encapsulation outlet. The encapsulation outlets and the compressed gas outlets are sized and configured to encapsulate the biological units from the solution when the biological units pass from the chamber through the plurality of fluid conduits and exit the encapsulation outlets.
PCT/US2012/040423 2011-06-03 2012-06-01 Microencapsulation device having microfluidic channels and related methods WO2012167051A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US201161493011P true 2011-06-03 2011-06-03
US61/493,011 2011-06-03

Publications (2)

Publication Number Publication Date
WO2012167051A2 WO2012167051A2 (en) 2012-12-06
WO2012167051A3 true WO2012167051A3 (en) 2013-04-18

Family

ID=47260371

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/040423 WO2012167051A2 (en) 2011-06-03 2012-06-01 Microencapsulation device having microfluidic channels and related methods

Country Status (1)

Country Link
WO (1) WO2012167051A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10179896B2 (en) 2015-05-12 2019-01-15 Baker Group, LLP Method and system for a bioartificial organ
CN105457100B (en) * 2015-12-21 2018-09-25 上海赛立维生物科技有限公司 Artificial liver cell microfluidic body microcapsule preparation method and its microfluid microcapsule generating apparatus

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050175978A1 (en) * 2004-01-08 2005-08-11 M.K. Ramasubramanian Methods and devices for mecroencapsulation of cells
US20060071357A1 (en) * 2004-09-27 2006-04-06 Pilon Laurent G Method and apparatus for liquid microencapsulation with polymers using ultrasonic atomization
US20070009668A1 (en) * 2004-11-18 2007-01-11 Wyman Jason L Microencapsulation of particles in a polymer solution by selective withdrawal through a high viscosity low density fluid and subsequent crosslinking
WO2011017524A1 (en) * 2009-08-05 2011-02-10 The Trustees Of The University Of Pennsylvania Microfluidic-based generation of functionalized microbubbles for ultrasound imaging and therapy

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050175978A1 (en) * 2004-01-08 2005-08-11 M.K. Ramasubramanian Methods and devices for mecroencapsulation of cells
US20060071357A1 (en) * 2004-09-27 2006-04-06 Pilon Laurent G Method and apparatus for liquid microencapsulation with polymers using ultrasonic atomization
US20070009668A1 (en) * 2004-11-18 2007-01-11 Wyman Jason L Microencapsulation of particles in a polymer solution by selective withdrawal through a high viscosity low density fluid and subsequent crosslinking
WO2011017524A1 (en) * 2009-08-05 2011-02-10 The Trustees Of The University Of Pennsylvania Microfluidic-based generation of functionalized microbubbles for ultrasound imaging and therapy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MAZZITELLI, STEFANIA ET AL.: 'Encapsulation of eukaryotic cells in alginate microparticles: cell signaling by TNF-alpha through capsular structure of cystic fibrosis cells' JOURNAL OF CELL COMMUNICATION AND SIGNALING vol. 5, no. 2, 25 November 2010, ISSN 1873-9601 pages 157 - 165 *
TENDULKAR, SAMEER ET AL.: 'A three-dimensional microfluidic approach to scaling up microencapsulation of cells' BIOMEDICAL MICRODEVICES vol. 14, no. ISSUE, 14 January 2012, ISSN 1387-2176 pages 461 - 469 *

Also Published As

Publication number Publication date
WO2012167051A2 (en) 2012-12-06

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