WO2012156498A1 - Quinazoline derivatives for the treatment of viral infections and further diseases - Google Patents
Quinazoline derivatives for the treatment of viral infections and further diseases Download PDFInfo
- Publication number
- WO2012156498A1 WO2012156498A1 PCT/EP2012/059234 EP2012059234W WO2012156498A1 WO 2012156498 A1 WO2012156498 A1 WO 2012156498A1 EP 2012059234 W EP2012059234 W EP 2012059234W WO 2012156498 A1 WO2012156498 A1 WO 2012156498A1
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- Prior art keywords
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- compound
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Links
- BDPCBRSHZVHPKX-UHFFFAOYSA-N Nc1nc(ccc(Br)c2)c2c(O)n1 Chemical compound Nc1nc(ccc(Br)c2)c2c(O)n1 BDPCBRSHZVHPKX-UHFFFAOYSA-N 0.000 description 2
- WMHXUSMJTMNJPS-UHFFFAOYSA-N COC(c(c(N)c1)c2OCCOc2c1Cl)=O Chemical compound COC(c(c(N)c1)c2OCCOc2c1Cl)=O WMHXUSMJTMNJPS-UHFFFAOYSA-N 0.000 description 1
- NDIWEEKVHKFZSB-UHFFFAOYSA-N COC(c(c([N+]([O-])=O)c1)c2OCCOc2c1Cl)=O Chemical compound COC(c(c([N+]([O-])=O)c1)c2OCCOc2c1Cl)=O NDIWEEKVHKFZSB-UHFFFAOYSA-N 0.000 description 1
- YQPCAZNPQRCKOR-UHFFFAOYSA-O COC(c(c1c(c(Cl)c2)OCCO1)c2[NH+]=O)=O Chemical compound COC(c(c1c(c(Cl)c2)OCCO1)c2[NH+]=O)=O YQPCAZNPQRCKOR-UHFFFAOYSA-O 0.000 description 1
- HENIVJLKPYBYJH-UHFFFAOYSA-N COC(c(c1c2OCCO1)cc([N+]([O-])=O)c2Cl)=O Chemical compound COC(c(c1c2OCCO1)cc([N+]([O-])=O)c2Cl)=O HENIVJLKPYBYJH-UHFFFAOYSA-N 0.000 description 1
- WDEDLWKPDMCWTD-UHFFFAOYSA-N COC(c(c1c2OCCO1)ccc2Cl)=O Chemical compound COC(c(c1c2OCCO1)ccc2Cl)=O WDEDLWKPDMCWTD-UHFFFAOYSA-N 0.000 description 1
- QDZOJOIJLSSJRF-UHFFFAOYSA-N COc(cc1)cc2c1c(O)nc(N)n2 Chemical compound COc(cc1)cc2c1c(O)nc(N)n2 QDZOJOIJLSSJRF-UHFFFAOYSA-N 0.000 description 1
- OAOJGBYGABVLCL-UHFFFAOYSA-N C[Si](C)(C)C#Cc(cc1)cc2c1nc(N)nc2O Chemical compound C[Si](C)(C)C#Cc(cc1)cc2c1nc(N)nc2O OAOJGBYGABVLCL-UHFFFAOYSA-N 0.000 description 1
- BBLYLHBKDJTOCY-UHFFFAOYSA-N Nc1nc(ccc(F)c2)c2c(O)n1 Chemical compound Nc1nc(ccc(F)c2)c2c(O)n1 BBLYLHBKDJTOCY-UHFFFAOYSA-N 0.000 description 1
- SDGYTPHKRYYEDT-UHFFFAOYSA-N Nc1nc(cccc2C#Cc3ccccn3)c2c(O)n1 Chemical compound Nc1nc(cccc2C#Cc3ccccn3)c2c(O)n1 SDGYTPHKRYYEDT-UHFFFAOYSA-N 0.000 description 1
- IAAKEIJBPLJOIM-UHFFFAOYSA-N Nc1nc(cccc2CCc3ccccn3)c2c(O)n1 Chemical compound Nc1nc(cccc2CCc3ccccn3)c2c(O)n1 IAAKEIJBPLJOIM-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims
Priority Applications (27)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014510818A JP6050329B2 (en) | 2011-05-18 | 2012-05-18 | Quinazoline derivatives for treating viral infections and other diseases |
NO12721852A NO2709989T3 (en) | 2011-05-18 | 2012-05-18 | |
KR1020137030262A KR102038895B1 (en) | 2011-05-18 | 2012-05-18 | Quinazoline derivatives for the treatment of viral infections and further diseases |
CN201280023969.XA CN103748081B (en) | 2011-05-18 | 2012-05-18 | Infect and the quinazoline derivant of other disease for treating virus |
SI201231260T SI2709989T1 (en) | 2011-05-18 | 2012-05-18 | Quinazoline derivatives for the treatment of viral infections and further diseases |
EA201391719A EA028254B1 (en) | 2011-05-18 | 2012-05-18 | Quinazoline derivatives for the treatment of viral infections and further diseases |
AU2012258220A AU2012258220B2 (en) | 2011-05-18 | 2012-05-18 | Quinazoline derivatives for the treatment of viral infections and further diseases |
MEP-2018-82A ME02986B (en) | 2011-05-18 | 2012-05-18 | Quinazoline derivatives for the treatment of viral infections and further diseases |
KR1020197031596A KR102119700B1 (en) | 2011-05-18 | 2012-05-18 | Quinazoline derivatives for the treatment of viral infections and further diseases |
DK12721852.7T DK2709989T3 (en) | 2011-05-18 | 2012-05-18 | QUINAZOLINE DERIVATIVES FOR TREATING VIRUS INFECTIONS AND ADDITIONAL DISEASES |
EP12721852.7A EP2709989B8 (en) | 2011-05-18 | 2012-05-18 | Quinazoline derivatives for the treatment of viral infections and further diseases |
ES12721852.7T ES2663601T3 (en) | 2011-05-18 | 2012-05-18 | Quinazoline derivatives for the treatment of viral infections and other diseases |
NZ616642A NZ616642B2 (en) | 2011-05-18 | 2012-05-18 | Quinazoline derivatives for the treatment of viral infections and further diseases |
PL12721852T PL2709989T3 (en) | 2011-05-18 | 2012-05-18 | Quinazoline derivatives for the treatment of viral infections and further diseases |
UAA201312081A UA114476C2 (en) | 2011-05-18 | 2012-05-18 | Quinazoline derivatives for the treatment of viral infections and further diseases |
RS20180329A RS57023B1 (en) | 2011-05-18 | 2012-05-18 | Quinazoline derivatives for the treatment of viral infections and further diseases |
BR112013029537-6A BR112013029537B1 (en) | 2011-05-18 | 2012-05-18 | quinazoline derivatives, their use in the treatment of viral infections and other diseases and the pharmaceutical composition that comprises them |
MX2013013448A MX347966B (en) | 2011-05-18 | 2012-05-18 | Quinazoline derivatives for the treatment of viral infections and further diseases. |
SG2013082821A SG194852A1 (en) | 2011-05-18 | 2012-05-18 | Quinazoline derivatives for the treatment of viral infections and further diseases |
US14/118,527 US8916575B2 (en) | 2011-05-18 | 2012-05-18 | Quinazoline derivatives for the treatment of viral infections and further diseases |
LTEP12721852.7T LT2709989T (en) | 2011-05-18 | 2012-05-18 | Quinazoline derivatives for the treatment of viral infections and further diseases |
CA2835229A CA2835229C (en) | 2011-05-18 | 2012-05-18 | Quinazoline derivatives for the treatment of viral infections and further diseases |
IL228906A IL228906A (en) | 2011-05-18 | 2013-10-16 | Quinazoline derivatives for the treatment of viral infections and further diseases |
ZA2013/08746A ZA201308746B (en) | 2011-05-18 | 2013-11-15 | Quinazoline derivatives for the treatment of viral infections and further diseases |
HRP20180447TT HRP20180447T1 (en) | 2011-05-18 | 2018-03-16 | Quinazoline derivatives for the treatment of viral infections and further diseases |
CY20181100320T CY1120429T1 (en) | 2011-05-18 | 2018-03-20 | KINAZOLIN DERIVATIVE FOR THE THERAPEUTIC TREATMENT OF VIRUS INFECTIONS AND OTHER DISEASES |
PH12019502269A PH12019502269A1 (en) | 2011-05-18 | 2019-10-01 | Quinazoline derivatives for the treatment of viral infections and further diseases |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11166538 | 2011-05-18 | ||
EP11166538.6 | 2011-05-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2012156498A1 true WO2012156498A1 (en) | 2012-11-22 |
Family
ID=44849923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2012/059234 WO2012156498A1 (en) | 2011-05-18 | 2012-05-18 | Quinazoline derivatives for the treatment of viral infections and further diseases |
Country Status (29)
Country | Link |
---|---|
US (1) | US8916575B2 (en) |
EP (1) | EP2709989B8 (en) |
JP (1) | JP6050329B2 (en) |
KR (2) | KR102038895B1 (en) |
AU (1) | AU2012258220B2 (en) |
BR (1) | BR112013029537B1 (en) |
CA (1) | CA2835229C (en) |
CL (1) | CL2013003313A1 (en) |
CY (1) | CY1120429T1 (en) |
DK (1) | DK2709989T3 (en) |
EA (1) | EA028254B1 (en) |
ES (1) | ES2663601T3 (en) |
HR (1) | HRP20180447T1 (en) |
HU (1) | HUE036220T2 (en) |
IL (1) | IL228906A (en) |
LT (1) | LT2709989T (en) |
ME (1) | ME02986B (en) |
MX (1) | MX347966B (en) |
MY (1) | MY166557A (en) |
NO (1) | NO2709989T3 (en) |
PH (1) | PH12019502269A1 (en) |
PL (1) | PL2709989T3 (en) |
PT (1) | PT2709989T (en) |
RS (1) | RS57023B1 (en) |
SG (1) | SG194852A1 (en) |
SI (1) | SI2709989T1 (en) |
UA (1) | UA114476C2 (en) |
WO (1) | WO2012156498A1 (en) |
ZA (1) | ZA201308746B (en) |
Cited By (30)
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WO2014076221A1 (en) * | 2012-11-16 | 2014-05-22 | Janssen R&D Ireland | Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections |
WO2015014815A1 (en) * | 2013-07-30 | 2015-02-05 | Janssen R&D Ireland | THIENO[3,2-d]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS |
WO2016141092A1 (en) * | 2015-03-04 | 2016-09-09 | Gilead Sciences, Inc. | Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds |
WO2017048727A1 (en) | 2015-09-15 | 2017-03-23 | Gilead Sciences, Inc. | Modulators of toll-like recptors for the treatment of hiv |
WO2018002319A1 (en) | 2016-07-01 | 2018-01-04 | Janssen Sciences Ireland Uc | Dihydropyranopyrimidines for the treatment of viral infections |
WO2018045144A1 (en) | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
WO2018045150A1 (en) * | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators |
WO2018181420A1 (en) | 2017-03-29 | 2018-10-04 | 大日本住友製薬株式会社 | Vaccine adjuvant formulation |
US10259793B2 (en) | 2013-02-21 | 2019-04-16 | Janssen Sciences Ireland Uc | 2-aminopyrimidine derivatives for the treatment of viral infections |
US10259814B2 (en) | 2012-10-10 | 2019-04-16 | Janssen Sciences Ireland Uc | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases |
US10266543B2 (en) | 2013-03-29 | 2019-04-23 | Janssen Sciences Ireland Uc | Macrocyclic deaza-purinones for the treatment of viral infections |
US10272085B2 (en) | 2011-04-08 | 2019-04-30 | Janssen Sciences Ireland Uc | Pyrimidine derivatives for the treatment of viral infections |
US10280167B2 (en) | 2011-11-09 | 2019-05-07 | Janssen Sciences Ireland Uc | Purine derivatives for the treatment of viral infections |
US10280180B2 (en) | 2012-07-13 | 2019-05-07 | Janssen Sciences Ireland Uc | Macrocyclic purines for the treatment of viral infections |
US10377738B2 (en) | 2013-05-24 | 2019-08-13 | Janssen Sciences Ireland Unlimited Company | Pyridone derivatives for the treatment of viral infections and further diseases |
US10385054B2 (en) | 2013-06-27 | 2019-08-20 | Janssen Sciences Ireland Unlimited Company | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases |
WO2019166532A1 (en) | 2018-03-01 | 2019-09-06 | Janssen Sciences Ireland Unlimited Company | 2,4-diaminoquinazoline derivatives and medical uses thereof |
WO2020022272A1 (en) | 2018-07-23 | 2020-01-30 | 公益財団法人ヒューマンサイエンス振興財団 | Composition containing influenza vaccine |
WO2020162705A1 (en) | 2019-02-08 | 2020-08-13 | 성균관대학교산학협력단 | Toll-like receptor 7 or 8 agonist-cholesterol complex, and use of same |
WO2020254473A1 (en) * | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Quinazoline prodrugs for the treatment of viral infections and further diseases |
WO2020255039A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and quinazoline derivatives |
US10968184B2 (en) | 2016-09-29 | 2021-04-06 | Janssen Sciences Ireland Unlimited Company | Pyrimidine prodrugs for the treatment of viral infections and further diseases |
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