WO2012150487A1 - Low-cost diagnostic devices - Google Patents
Low-cost diagnostic devices Download PDFInfo
- Publication number
- WO2012150487A1 WO2012150487A1 PCT/IB2011/052753 IB2011052753W WO2012150487A1 WO 2012150487 A1 WO2012150487 A1 WO 2012150487A1 IB 2011052753 W IB2011052753 W IB 2011052753W WO 2012150487 A1 WO2012150487 A1 WO 2012150487A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hydrophilic
- matrix
- diagnostic device
- hydrophobic
- silk
- Prior art date
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
- B01L2300/0845—Filaments, strings, fibres, i.e. not hollow
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/087—Multiple sequential chambers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
Definitions
- FIG. 2 shows an alternate embodiment of a configuration of the hydrophilic matrix
- the hydrophilic matrix is characterized by having at least one thread derived from degummed silk and at least one thread made of a hydrophilic material.
- Degummed silk is known in the art. Briefly, silk is a fiber obtained from silkworms, more specifically from the larvae of mulberry silkworms. The silk most useful in the invention are those that can be woven into textiles, such as that obtained from the silkworm Bombyx Mori, however, other forms of silk that may be synthetically made or produced from other sources may also be used for this invention. Chemically, silk fiber comprises a chain of amino acids, which possesses functional groups that may be further used for binding useful moieties.
- hydrophilic material is a material that is capable of being wet with water. Hydrophilicity of a material is generally understood by the physical phenomena of wicking, as measured by wicking rate. Hydrophilicity may also be understood by the contact angle made by the water droplet on the surface of the material.
- the hydrophilic materials useful in the invention must also have the ability to form fibers. Useful hydrophilic materials for the diagnostic device include, but not limited to, poly(vinyl alcohol), cotton, rayon, cellulosic fibers, derivatives thereof, and blends therefrom.
- Fig. 2 shows an alternate embodiment of a configuration of a section of the hydrophilic matrix 22.
- the weft 24 is shown to be made of cotton 26 while the warp 28 is predominantly silk 30 with two strands of hydrophilic material 32.
- the thread is made using at least one strand of degummed silk, at least one strand of polyester fiber, at least one strand of cotton, at least one strand of nylon and at least one strand of nylon fiber.
- the exact properties desired for the hydrophilic matrix in terms of a defined flow path, stiffness, tensile properties, and other factors, will determine the number and the exact composition of the strands used to form the thread.
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1562/CHE/2011 | 2011-05-05 | ||
IN1562CH2011 | 2011-05-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2012150487A1 true WO2012150487A1 (en) | 2012-11-08 |
Family
ID=44509490
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2011/052753 WO2012150487A1 (en) | 2011-05-05 | 2011-06-23 | Low-cost diagnostic devices |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2012150487A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3120927A1 (en) | 2015-07-24 | 2017-01-25 | Centre National De La Recherche Scientifique | Entangled fluidic device |
WO2018167261A1 (en) | 2017-03-17 | 2018-09-20 | Porcher Industries | Device and method for rapid testing of a liquid sample |
EP3385708A1 (en) * | 2017-04-03 | 2018-10-10 | HFT Smart Sensors, Incorporated | Wearable technology with electrochemical sensors integrated into clothing fibers |
US11344230B2 (en) | 2017-04-03 | 2022-05-31 | HFT Smart Sensors, Incorporated | Wearable technology with sensors integrated into clothing fibers |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040224406A1 (en) | 2001-11-16 | 2004-11-11 | Tissue Regeneration, Inc. | Immunoneutral silk-fiber-based medical devices |
WO2009121043A2 (en) | 2008-03-27 | 2009-10-01 | President And Fellows Of Harvard College | Cotton thread as a low-cost multi-assay diagnostic platform |
-
2011
- 2011-06-23 WO PCT/IB2011/052753 patent/WO2012150487A1/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040224406A1 (en) | 2001-11-16 | 2004-11-11 | Tissue Regeneration, Inc. | Immunoneutral silk-fiber-based medical devices |
WO2009121043A2 (en) | 2008-03-27 | 2009-10-01 | President And Fellows Of Harvard College | Cotton thread as a low-cost multi-assay diagnostic platform |
Non-Patent Citations (9)
Title |
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DAVARPANAH: "Environmentally friendly surface modification of silk fiber: Chitosan grafting and dyeing", APPLIED SURFACE SCIENCE, vol. 255, no. 7, 15 January 2009 (2009-01-15), pages 4171 - 4176, XP025860623, DOI: doi:10.1016/j.apsusc.2008.11.001 |
LI, X., TIAN, J., SHEN, W.: "Thread as a Versatile Material for Low-Cost Microfluidic Diagnostics", ACS APPLIED MATERIALS & INTERFACES, vol. 2, no. 1, 2009, pages 1 - 6, XP009145513, DOI: doi:10.1021/am9006148 |
MARTINEZ, A. W., PHILLIPS, S. T., BUTTE, M. J., WHITESIDES, G. M.: "Patterned paper as a platform for inexpensive, low-volume, portable bioassays", ANGEW CHEM INT ED ENGL, vol. 46, no. 8, 2007, pages 1318 - 20, XP008142366, DOI: doi:10.1002/anie.200603817 |
MEITAL RECHES ET AL: "Thread as a Matrix for Biomedical Assays", A C S APPLIED MATERIALS AND INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 2, no. 6, 1 January 2010 (2010-01-01), pages 1722 - 1728, XP009145514, ISSN: 1944-8244, [retrieved on 20100524], DOI: 10.1021/AM1002266 * |
R.SAFAVIEH, M. MIRZAEI, M.A. QASAIMEH, D. JUNCKER: "Yarn based microfluidics: from basic elements to complex circuits", 13TH INTERNATIONAL CONFERENCE ON MINIATURIZED SYSTEMS FOR CHEMISTRY AND LIFE SCIENCES, MICROTAS 2009, JEJU, SOUTH KOREA, 1 November 2009 (2009-11-01) - 5 November 2009 (2009-11-05), pages 685 - 687, XP002668867, ISSN: 1556-5904, ISBN: 978-0-9798064-2-1 * |
RECHES ET AL.: "ACS APPLIED MATERIALS AND INTERFACES", vol. 2, 1 January 2010, AMERICAN CHEMICAL SOCIETY, article "Thread as a Matrix for Biomedical Assays", pages: 1722 - 1728 |
ROOZBEH SAFAVIEH, MARYAM MIRZAEI, MOHAMMAD A. QASAIMEH, DAVID JUNCKER, YAM BASED MICROFLUIDICS: FROM BASIC ELEMENTS TO COMPLEX CIRCUITS, 1 November 2009 (2009-11-01) |
XU LI ET AL: "Thread as a Versatile Material for Low-Cost Microfluidic Diagnostics", A C S APPLIED MATERIALS AND INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 2, no. 1, 1 January 2010 (2010-01-01), pages 1 - 6, XP009145513, ISSN: 1944-8244, [retrieved on 20091209], DOI: 10.1021/AM9006148 * |
YAGER, P., DOMINGO, G. J., GERDES, J.: "Point-of-care diagnostics for global health", ANNU REV BIOMED ENG, vol. 10, 2008, pages 107 - 44 |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3120927A1 (en) | 2015-07-24 | 2017-01-25 | Centre National De La Recherche Scientifique | Entangled fluidic device |
WO2017017002A1 (en) * | 2015-07-24 | 2017-02-02 | Centre National De La Recherche Scientifique | Composite woven fluidic device |
US10661274B2 (en) | 2015-07-24 | 2020-05-26 | Centre National De La Recherche Scientifique | Composite woven fluidic device |
WO2018167261A1 (en) | 2017-03-17 | 2018-09-20 | Porcher Industries | Device and method for rapid testing of a liquid sample |
FR3063918A1 (en) * | 2017-03-17 | 2018-09-21 | Porcher Industries | DEVICE AND METHOD FOR QUICKLY TESTING A LIQUID SAMPLE |
EP3385708A1 (en) * | 2017-04-03 | 2018-10-10 | HFT Smart Sensors, Incorporated | Wearable technology with electrochemical sensors integrated into clothing fibers |
US11344230B2 (en) | 2017-04-03 | 2022-05-31 | HFT Smart Sensors, Incorporated | Wearable technology with sensors integrated into clothing fibers |
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