WO2012099770A3 - Diazeniumdiolate derivatives - Google Patents

Diazeniumdiolate derivatives Download PDF

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Publication number
WO2012099770A3
WO2012099770A3 PCT/US2012/021048 US2012021048W WO2012099770A3 WO 2012099770 A3 WO2012099770 A3 WO 2012099770A3 US 2012021048 W US2012021048 W US 2012021048W WO 2012099770 A3 WO2012099770 A3 WO 2012099770A3
Authority
WO
WIPO (PCT)
Prior art keywords
diazeniumdiolate derivatives
diazeniumdiolate
derivatives
eclampsia
nephropathy
Prior art date
Application number
PCT/US2012/021048
Other languages
French (fr)
Other versions
WO2012099770A2 (en
Inventor
Amjad Ali
Michael Man-Chu Lo
Edward Metzger
Shrenik K. Shah
James Dellureficio
Original Assignee
Merck Sharp & Dohme Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.
Priority to JP2013550500A priority Critical patent/JP2014508742A/en
Priority to KR1020137018869A priority patent/KR20140003482A/en
Priority to AU2012207528A priority patent/AU2012207528A1/en
Priority to CA2824437A priority patent/CA2824437A1/en
Priority to US13/980,442 priority patent/US20130296278A1/en
Priority to MX2013008373A priority patent/MX2013008373A/en
Priority to CN2012800058730A priority patent/CN103476744A/en
Priority to EP12736335.6A priority patent/EP2665701A2/en
Priority to RU2013138391/04A priority patent/RU2013138391A/en
Priority to BR112013017517A priority patent/BR112013017517A2/en
Publication of WO2012099770A2 publication Critical patent/WO2012099770A2/en
Publication of WO2012099770A3 publication Critical patent/WO2012099770A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
    • C07C245/04—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/04—N-nitroso compounds
    • C07C243/06—N-nitroso-amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/08—Azoxy compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A compound having the structure (I) useful for treating hypertension, pulmonary arterial hypertension, congestive heart failure, conditions resulting from excessive water retention, cardiovascular disease, diabetes, oxidative stress, endothelial dysfunction, cirrhosis, pre-eclampsia, osteoporosis or nephropathy.
PCT/US2012/021048 2011-01-19 2012-01-12 Diazeniumdiolate derivatives WO2012099770A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP2013550500A JP2014508742A (en) 2011-01-19 2012-01-12 Diazeniumdiolate derivatives
KR1020137018869A KR20140003482A (en) 2011-01-19 2012-01-12 Diazeniumdiolate derivatives
AU2012207528A AU2012207528A1 (en) 2011-01-19 2012-01-12 Diazeniumdiolate derivatives
CA2824437A CA2824437A1 (en) 2011-01-19 2012-01-12 Diazeniumdiolate derivatives
US13/980,442 US20130296278A1 (en) 2011-01-19 2012-01-12 Diazeniumdiolate Derivatives
MX2013008373A MX2013008373A (en) 2011-01-19 2012-01-12 Diazeniumdiolate derivatives.
CN2012800058730A CN103476744A (en) 2011-01-19 2012-01-12 Diazeniumdiolate derivatives
EP12736335.6A EP2665701A2 (en) 2011-01-19 2012-01-12 Diazeniumdiolate derivatives
RU2013138391/04A RU2013138391A (en) 2011-01-19 2012-01-12 DIAZENIUM DIOLATE DERIVATIVES
BR112013017517A BR112013017517A2 (en) 2011-01-19 2012-01-12 diazeniodiolate derivative, use thereof, and pharmaceutical composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161434148P 2011-01-19 2011-01-19
US61/434,148 2011-01-19

Publications (2)

Publication Number Publication Date
WO2012099770A2 WO2012099770A2 (en) 2012-07-26
WO2012099770A3 true WO2012099770A3 (en) 2012-11-15

Family

ID=46516310

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/021048 WO2012099770A2 (en) 2011-01-19 2012-01-12 Diazeniumdiolate derivatives

Country Status (11)

Country Link
US (1) US20130296278A1 (en)
EP (1) EP2665701A2 (en)
JP (1) JP2014508742A (en)
KR (1) KR20140003482A (en)
CN (1) CN103476744A (en)
AU (1) AU2012207528A1 (en)
BR (1) BR112013017517A2 (en)
CA (1) CA2824437A1 (en)
MX (1) MX2013008373A (en)
RU (1) RU2013138391A (en)
WO (1) WO2012099770A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9272987B2 (en) 2011-05-02 2016-03-01 Merck Sharp & Dohme Corp. Diazeniumdiolate cyclohexyl derivatives

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009004164A2 (en) * 2007-05-30 2009-01-08 Les Laboratoires Servier Diazeniumdiolate derivatives, method for preparing same and pharmaceutical compositions containing same
WO2009094242A1 (en) * 2008-01-24 2009-07-30 Merck & Co., Inc. Angiotensin ii receptor antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050137191A1 (en) * 1996-06-04 2005-06-23 Thatcher Gregory R. Nitrate esters and their use for mitigating cellular damage
WO2005074598A2 (en) * 2004-01-30 2005-08-18 Johns Hopkins University Nitroxyl progenitor compounds and methods of use
FR2902428B1 (en) * 2006-06-15 2008-08-15 Servier Lab NOVEL DIAZENIUMDIOLATE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009004164A2 (en) * 2007-05-30 2009-01-08 Les Laboratoires Servier Diazeniumdiolate derivatives, method for preparing same and pharmaceutical compositions containing same
WO2009094242A1 (en) * 2008-01-24 2009-07-30 Merck & Co., Inc. Angiotensin ii receptor antagonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOSEPH A. HIRABIE ET AL.: "Chemistry of the Nitric Oxide-Releasing Diazeniumdiolate (''Nitrosohydroxylamine'') Functional Group and Its Oxygen-Substituted Derivatives", CHEMICAL REVIEWS, vol. 102, no. 4, 2002, pages 1135 - 1154, XP002512904 *

Also Published As

Publication number Publication date
EP2665701A2 (en) 2013-11-27
AU2012207528A1 (en) 2013-07-04
BR112013017517A2 (en) 2016-09-27
CA2824437A1 (en) 2012-07-26
CN103476744A (en) 2013-12-25
RU2013138391A (en) 2015-02-27
KR20140003482A (en) 2014-01-09
JP2014508742A (en) 2014-04-10
MX2013008373A (en) 2013-08-12
WO2012099770A2 (en) 2012-07-26
US20130296278A1 (en) 2013-11-07

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