WO2012099770A3 - Diazeniumdiolate derivatives - Google Patents
Diazeniumdiolate derivatives Download PDFInfo
- Publication number
- WO2012099770A3 WO2012099770A3 PCT/US2012/021048 US2012021048W WO2012099770A3 WO 2012099770 A3 WO2012099770 A3 WO 2012099770A3 US 2012021048 W US2012021048 W US 2012021048W WO 2012099770 A3 WO2012099770 A3 WO 2012099770A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- diazeniumdiolate derivatives
- diazeniumdiolate
- derivatives
- eclampsia
- nephropathy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
- C07C245/04—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/04—Nitro compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/04—N-nitroso compounds
- C07C243/06—N-nitroso-amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
- C07C291/08—Azoxy compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/980,442 US20130296278A1 (en) | 2011-01-19 | 2012-01-12 | Diazeniumdiolate Derivatives |
BR112013017517A BR112013017517A2 (en) | 2011-01-19 | 2012-01-12 | diazeniodiolate derivative, use thereof, and pharmaceutical composition |
CN2012800058730A CN103476744A (en) | 2011-01-19 | 2012-01-12 | Diazeniumdiolate derivatives |
KR1020137018869A KR20140003482A (en) | 2011-01-19 | 2012-01-12 | Diazeniumdiolate derivatives |
AU2012207528A AU2012207528A1 (en) | 2011-01-19 | 2012-01-12 | Diazeniumdiolate derivatives |
CA2824437A CA2824437A1 (en) | 2011-01-19 | 2012-01-12 | Diazeniumdiolate derivatives |
JP2013550500A JP2014508742A (en) | 2011-01-19 | 2012-01-12 | Diazeniumdiolate derivatives |
EP12736335.6A EP2665701A2 (en) | 2011-01-19 | 2012-01-12 | Diazeniumdiolate derivatives |
MX2013008373A MX2013008373A (en) | 2011-01-19 | 2012-01-12 | Diazeniumdiolate derivatives. |
RU2013138391/04A RU2013138391A (en) | 2011-01-19 | 2012-01-12 | DIAZENIUM DIOLATE DERIVATIVES |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161434148P | 2011-01-19 | 2011-01-19 | |
US61/434,148 | 2011-01-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012099770A2 WO2012099770A2 (en) | 2012-07-26 |
WO2012099770A3 true WO2012099770A3 (en) | 2012-11-15 |
Family
ID=46516310
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2012/021048 WO2012099770A2 (en) | 2011-01-19 | 2012-01-12 | Diazeniumdiolate derivatives |
Country Status (11)
Country | Link |
---|---|
US (1) | US20130296278A1 (en) |
EP (1) | EP2665701A2 (en) |
JP (1) | JP2014508742A (en) |
KR (1) | KR20140003482A (en) |
CN (1) | CN103476744A (en) |
AU (1) | AU2012207528A1 (en) |
BR (1) | BR112013017517A2 (en) |
CA (1) | CA2824437A1 (en) |
MX (1) | MX2013008373A (en) |
RU (1) | RU2013138391A (en) |
WO (1) | WO2012099770A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012151114A1 (en) | 2011-05-02 | 2012-11-08 | Merck Sharp & Dohme Corp. | Diazeniumdiolate cyclohexyl derivatives |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009004164A2 (en) * | 2007-05-30 | 2009-01-08 | Les Laboratoires Servier | Diazeniumdiolate derivatives, method for preparing same and pharmaceutical compositions containing same |
WO2009094242A1 (en) * | 2008-01-24 | 2009-07-30 | Merck & Co., Inc. | Angiotensin ii receptor antagonists |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050137191A1 (en) * | 1996-06-04 | 2005-06-23 | Thatcher Gregory R. | Nitrate esters and their use for mitigating cellular damage |
JP2007522135A (en) * | 2004-01-30 | 2007-08-09 | ザ ジョンズ ホプキンス ユニバーシティ | Nitroxyl precursor compounds and methods of use |
FR2902428B1 (en) * | 2006-06-15 | 2008-08-15 | Servier Lab | NOVEL DIAZENIUMDIOLATE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
-
2012
- 2012-01-12 BR BR112013017517A patent/BR112013017517A2/en not_active IP Right Cessation
- 2012-01-12 JP JP2013550500A patent/JP2014508742A/en not_active Withdrawn
- 2012-01-12 CN CN2012800058730A patent/CN103476744A/en active Pending
- 2012-01-12 CA CA2824437A patent/CA2824437A1/en not_active Abandoned
- 2012-01-12 US US13/980,442 patent/US20130296278A1/en not_active Abandoned
- 2012-01-12 RU RU2013138391/04A patent/RU2013138391A/en not_active Application Discontinuation
- 2012-01-12 MX MX2013008373A patent/MX2013008373A/en not_active Application Discontinuation
- 2012-01-12 KR KR1020137018869A patent/KR20140003482A/en not_active Application Discontinuation
- 2012-01-12 WO PCT/US2012/021048 patent/WO2012099770A2/en active Application Filing
- 2012-01-12 AU AU2012207528A patent/AU2012207528A1/en not_active Abandoned
- 2012-01-12 EP EP12736335.6A patent/EP2665701A2/en not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009004164A2 (en) * | 2007-05-30 | 2009-01-08 | Les Laboratoires Servier | Diazeniumdiolate derivatives, method for preparing same and pharmaceutical compositions containing same |
WO2009094242A1 (en) * | 2008-01-24 | 2009-07-30 | Merck & Co., Inc. | Angiotensin ii receptor antagonists |
Non-Patent Citations (1)
Title |
---|
JOSEPH A. HIRABIE ET AL.: "Chemistry of the Nitric Oxide-Releasing Diazeniumdiolate (''Nitrosohydroxylamine'') Functional Group and Its Oxygen-Substituted Derivatives", CHEMICAL REVIEWS, vol. 102, no. 4, 2002, pages 1135 - 1154, XP002512904 * |
Also Published As
Publication number | Publication date |
---|---|
JP2014508742A (en) | 2014-04-10 |
MX2013008373A (en) | 2013-08-12 |
RU2013138391A (en) | 2015-02-27 |
CN103476744A (en) | 2013-12-25 |
AU2012207528A1 (en) | 2013-07-04 |
BR112013017517A2 (en) | 2016-09-27 |
US20130296278A1 (en) | 2013-11-07 |
WO2012099770A2 (en) | 2012-07-26 |
EP2665701A2 (en) | 2013-11-27 |
KR20140003482A (en) | 2014-01-09 |
CA2824437A1 (en) | 2012-07-26 |
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