WO2012087040A3 - 광역학 진단 또는 치료를 위한 결합체 및 이의 제조방법 - Google Patents
광역학 진단 또는 치료를 위한 결합체 및 이의 제조방법 Download PDFInfo
- Publication number
- WO2012087040A3 WO2012087040A3 PCT/KR2011/009967 KR2011009967W WO2012087040A3 WO 2012087040 A3 WO2012087040 A3 WO 2012087040A3 KR 2011009967 W KR2011009967 W KR 2011009967W WO 2012087040 A3 WO2012087040 A3 WO 2012087040A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- conjugate
- therapy
- acetylated
- polysaccharide
- photodynamic diagnosis
- Prior art date
Links
- 238000003745 diagnosis Methods 0.000 title abstract 5
- 238000002560 therapeutic procedure Methods 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 210000004027 cell Anatomy 0.000 abstract 4
- 150000004676 glycans Chemical class 0.000 abstract 4
- 229920001282 polysaccharide Polymers 0.000 abstract 4
- 239000005017 polysaccharide Substances 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 3
- -1 phthalocyanine compound Chemical class 0.000 abstract 2
- 238000007385 chemical modification Methods 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0036—Porphyrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013543111A JP5721853B2 (ja) | 2010-12-21 | 2011-12-21 | 光力学診断または治療のための結合体およびその製造方法 |
RU2013119911/15A RU2537228C1 (ru) | 2010-12-21 | 2011-12-21 | Конъюгат для фотодинамической диагностики или терапии, а также способ его получения |
EP11851627.7A EP2656847A4 (en) | 2010-12-21 | 2011-12-21 | CONJUGATE FOR PHOTODYNAMIC DIAGNOSIS OR THERAPY AND PREPARATION METHOD THEREOF |
US13/877,162 US8946394B2 (en) | 2010-12-21 | 2011-12-21 | Conjugate for photodynamic diagnosis or therapy and method for preparing same |
KR1020137021979A KR101847187B1 (ko) | 2010-12-21 | 2011-12-21 | 광역학 진단 또는 치료를 위한 결합체 및 이의 제조방법 |
CN201180051894.1A CN103260626B (zh) | 2010-12-21 | 2011-12-21 | 用于光动力学诊断或治疗的轭合物及其制备方法 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KRPCT/KR2010/009173 | 2010-12-21 | ||
PCT/KR2010/009173 WO2012086857A1 (ko) | 2010-12-21 | 2010-12-21 | 광역학 진단 또는 치료를 위한 결합체 및 이의 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012087040A2 WO2012087040A2 (ko) | 2012-06-28 |
WO2012087040A3 true WO2012087040A3 (ko) | 2012-10-04 |
Family
ID=46314113
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2010/009173 WO2012086857A1 (ko) | 2010-12-21 | 2010-12-21 | 광역학 진단 또는 치료를 위한 결합체 및 이의 제조방법 |
PCT/KR2011/009967 WO2012087040A2 (ko) | 2010-12-21 | 2011-12-21 | 광역학 진단 또는 치료를 위한 결합체 및 이의 제조방법 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2010/009173 WO2012086857A1 (ko) | 2010-12-21 | 2010-12-21 | 광역학 진단 또는 치료를 위한 결합체 및 이의 제조방법 |
Country Status (7)
Country | Link |
---|---|
US (1) | US8946394B2 (ko) |
EP (1) | EP2656847A4 (ko) |
JP (1) | JP5721853B2 (ko) |
KR (1) | KR101847187B1 (ko) |
CN (1) | CN103260626B (ko) |
RU (1) | RU2537228C1 (ko) |
WO (2) | WO2012086857A1 (ko) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9765220B2 (en) | 2013-08-22 | 2017-09-19 | Sony Corporation | Water soluble fluorescent or colored dyes and methods for their use |
CN104069492B (zh) * | 2014-01-24 | 2019-05-28 | 中国科学院福建物质结构研究所 | 靶向表达尿激酶受体的肿瘤的光敏剂及其制备方法和用途 |
CN105412924B (zh) * | 2014-08-22 | 2018-10-16 | 苏州大学 | 具有血液稳定性及靶向性的含糖光动力学疗法纳米粒子及其制备方法 |
KR101781598B1 (ko) * | 2014-09-25 | 2017-09-25 | 한양대학교 산학협력단 | 광역학 치료용 테트라피라지노폴피라진 유도체 및 이의 제조방법 |
CA3231845A1 (en) | 2016-04-01 | 2017-10-05 | Sony Group Corporation | Ultra bright dimeric or polymeric fluorescent and colored dyes |
AU2017264861B2 (en) | 2016-05-11 | 2021-09-23 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes |
WO2018022925A1 (en) | 2016-07-29 | 2018-02-01 | Sony Corporation | Ultra bright dimeric or polymeric dyes and methods for preparation of the same |
KR102081666B1 (ko) * | 2017-04-07 | 2020-02-27 | 서울대학교산학협력단 | 암 치료용 약학 조성물 |
EP3691689A1 (en) * | 2017-10-05 | 2020-08-12 | Sony Corporation | Programmable dendritic drugs |
WO2019099789A1 (en) | 2017-11-16 | 2019-05-23 | Sony Corporation | Programmable polymeric drugs |
EP3769085B1 (en) | 2018-03-19 | 2022-08-24 | Sony Group Corporation | Use of divalent metals for enhancement of fluorescent signals |
EP3801643A4 (en) | 2018-05-09 | 2022-04-20 | Virginia Commonwealth University | SMALL NEAR-IR ACTIVABLE FLUORESCENT MOLECULES WITH A DUAL MODE OF CYTOTOXICITY |
JP2021529194A (ja) | 2018-06-27 | 2021-10-28 | ソニーグループ株式会社 | デオキシリボースを含むリンカー基を有するポリマー色素 |
WO2020189641A1 (ja) * | 2019-03-18 | 2020-09-24 | 株式会社日本触媒 | フタロシアニン化合物ならびにこれを用いるリポソーム製剤および癌/腫瘍治療剤 |
US20220218834A1 (en) * | 2019-05-20 | 2022-07-14 | Ohio State Innovation Foundation | Apohemoglobin-haptoglobin complexes and methods of using thereof |
JP7239904B2 (ja) | 2019-09-26 | 2023-03-15 | ソニーグループ株式会社 | リンカー基を有するポリマータンデム色素 |
CN111529715B (zh) * | 2020-04-22 | 2021-10-01 | 山东大学 | 一种右旋糖酐-二十二碳六烯酸偶联聚合物及其合成方法和应用 |
CN113484386B (zh) * | 2021-05-21 | 2024-02-13 | 郑州轻工业大学 | 一种金属聚酞菁纳米材料的制备方法及其应用,适配体传感器及其制备方法 |
CN114409663B (zh) * | 2022-01-28 | 2023-05-30 | 福州大学 | 靶向Mcl-1酶的锌酞菁3-氯-6甲基苯并[b]噻吩-2-羧酸轭合物及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20030046394A (ko) * | 2000-07-27 | 2003-06-12 | 포토큐레 에이에스에이 | 조성물 |
WO2005110388A1 (en) * | 2004-05-10 | 2005-11-24 | Hofmann Robert F | Use of targeted oxidative therapeutic formulation in treatment of cancer |
US7153841B2 (en) * | 2001-03-21 | 2006-12-26 | L. Molteni & C. Dei Fratelli Alitti Societa Di Esercizio S.P.A. | Metal substituted non-centrosimmetrical phthalocyanine analogues, their preparation and use in photodynamic therapy and in vivo diagnostic |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITPD20020271A1 (it) * | 2002-10-18 | 2004-04-19 | Fidia Farmaceutici | Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati. |
JP2004262777A (ja) * | 2003-02-27 | 2004-09-24 | Shiseido Co Ltd | アセチル化ヒアルロン酸含有眼用医薬組成物 |
CN101234203B (zh) * | 2007-01-30 | 2012-07-18 | 中国科学院福建物质结构研究所 | 用于抗肿瘤治疗的医用光敏剂及其制备方法 |
IN2012DN02780A (ko) | 2009-10-06 | 2015-09-18 | Immunogen Inc |
-
2010
- 2010-12-21 WO PCT/KR2010/009173 patent/WO2012086857A1/ko active Application Filing
-
2011
- 2011-12-21 JP JP2013543111A patent/JP5721853B2/ja not_active Expired - Fee Related
- 2011-12-21 US US13/877,162 patent/US8946394B2/en not_active Expired - Fee Related
- 2011-12-21 CN CN201180051894.1A patent/CN103260626B/zh not_active Expired - Fee Related
- 2011-12-21 EP EP11851627.7A patent/EP2656847A4/en not_active Withdrawn
- 2011-12-21 WO PCT/KR2011/009967 patent/WO2012087040A2/ko active Application Filing
- 2011-12-21 KR KR1020137021979A patent/KR101847187B1/ko active IP Right Grant
- 2011-12-21 RU RU2013119911/15A patent/RU2537228C1/ru not_active IP Right Cessation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20030046394A (ko) * | 2000-07-27 | 2003-06-12 | 포토큐레 에이에스에이 | 조성물 |
US7153841B2 (en) * | 2001-03-21 | 2006-12-26 | L. Molteni & C. Dei Fratelli Alitti Societa Di Esercizio S.P.A. | Metal substituted non-centrosimmetrical phthalocyanine analogues, their preparation and use in photodynamic therapy and in vivo diagnostic |
WO2005110388A1 (en) * | 2004-05-10 | 2005-11-24 | Hofmann Robert F | Use of targeted oxidative therapeutic formulation in treatment of cancer |
Non-Patent Citations (2)
Title |
---|
FANGYUAN LI ET AL.: "Acetylated hyaluronic acid/photosensitizer conjugate for the preparation of nanogels with controllable phototoxicity: synthesis, characterization, autophotoquenching properties, and in vitro phototoxicity against HeLa cells", BIOCONJUGATE CHEM., vol. 21, no. 7, 21 July 2010 (2010-07-21), pages 1312 - 1320, XP055116199 * |
See also references of EP2656847A4 * |
Also Published As
Publication number | Publication date |
---|---|
WO2012086857A1 (ko) | 2012-06-28 |
CN103260626B (zh) | 2015-04-01 |
RU2537228C1 (ru) | 2014-12-27 |
US8946394B2 (en) | 2015-02-03 |
KR101847187B1 (ko) | 2018-04-10 |
KR20140027096A (ko) | 2014-03-06 |
CN103260626A (zh) | 2013-08-21 |
JP2014500273A (ja) | 2014-01-09 |
US20130281679A1 (en) | 2013-10-24 |
RU2013119911A (ru) | 2014-12-10 |
EP2656847A2 (en) | 2013-10-30 |
EP2656847A4 (en) | 2016-06-29 |
WO2012087040A2 (ko) | 2012-06-28 |
JP5721853B2 (ja) | 2015-05-20 |
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