WO2012071566A3 - Systems and methods for automated voxelation of regions of interest for magnetic resonance spectroscopy - Google Patents

Systems and methods for automated voxelation of regions of interest for magnetic resonance spectroscopy Download PDF

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Publication number
WO2012071566A3
WO2012071566A3 PCT/US2011/062137 US2011062137W WO2012071566A3 WO 2012071566 A3 WO2012071566 A3 WO 2012071566A3 US 2011062137 W US2011062137 W US 2011062137W WO 2012071566 A3 WO2012071566 A3 WO 2012071566A3
Authority
WO
WIPO (PCT)
Prior art keywords
roi
interest
population
voxel
magnetic resonance
Prior art date
Application number
PCT/US2011/062137
Other languages
French (fr)
Other versions
WO2012071566A2 (en
Inventor
John P. Claude
James C. Peacock
Paul H. Kane
Original Assignee
Nocimed, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nocimed, Llc filed Critical Nocimed, Llc
Priority to EP11842542.0A priority Critical patent/EP2642918A4/en
Publication of WO2012071566A2 publication Critical patent/WO2012071566A2/en
Publication of WO2012071566A3 publication Critical patent/WO2012071566A3/en
Priority to US13/830,632 priority patent/US9280718B2/en
Priority to US15/061,798 priority patent/US9808177B2/en
Priority to US15/802,293 priority patent/US10517504B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/483—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy
    • G01R33/485—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy based on chemical shift information [CSI] or spectroscopic imaging, e.g. to acquire the spatial distributions of metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/543—Control of the operation of the MR system, e.g. setting of acquisition parameters prior to or during MR data acquisition, dynamic shimming, use of one or more scout images for scan plane prescription
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/10—Segmentation; Edge detection
    • G06T7/11—Region-based segmentation
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/70—Determining position or orientation of objects or cameras
    • G06T7/73—Determining position or orientation of objects or cameras using feature-based methods
    • G06T7/75—Determining position or orientation of objects or cameras using feature-based methods involving models
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10072—Tomographic images
    • G06T2207/10088—Magnetic resonance imaging [MRI]
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30008—Bone
    • G06T2207/30012—Spine; Backbone

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Radiology & Medical Imaging (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Theoretical Computer Science (AREA)
  • Signal Processing (AREA)
  • Optics & Photonics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

A system and method for automating an appropriate voxel prescription in a uniquely definable region of interest (ROI) in a tissue of a patient is provided, such as for purpose of conducting magnetic resonance spectroscopy (MRS) in the ROI. The dimensions and coordinates of a single three dimensional rectilinear volume (voxel) within a single region of interest (ROI) are automatically identified. This is done, in some embodiments by: (1) applying statistically identified ROI search areas within a field of view (FOV); (2) image processing an MRI image to smooth the background and enhance a particular structure useful to define the ROI; (3) identifying a population of pixels that define the particular structure; (4) performing a statistical analysis of the pixel population to fit a 2D model such as an ellipsoid to the population and subsequently fit a rectilinear shape within the model; (5) repetiting elements (1) through (4) using multiple images that encompass the 3D ROI to create a 3D rectilinear shape; (6) a repetition of elements (1) through (5) for multiple ROIs with a common FOV. A manual interface may also be provided, allowing for override to replace by manual prescription, assistance to identify structures (e.g. clicking on disc levels), or modifying the automated voxel (e.g. modify location, shape, or one or more dimensions).
PCT/US2011/062137 2010-11-24 2011-11-23 Systems and methods for automated voxelation of regions of interest for magnetic resonance spectroscopy WO2012071566A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP11842542.0A EP2642918A4 (en) 2010-11-24 2011-11-23 Systems and methods for automated voxelation of regions of interest for magnetic resonance spectroscopy
US13/830,632 US9280718B2 (en) 2010-11-24 2013-03-14 Systems and methods for automated voxelation of regions of interest for magnetic resonance spectroscopy
US15/061,798 US9808177B2 (en) 2010-11-24 2016-03-04 Systems and methods for automated voxelation of regions of interest for magnetic resonance spectroscopy
US15/802,293 US10517504B2 (en) 2010-11-24 2017-11-02 Systems and methods for automated voxelation of regions of interest for magnetic resonance spectroscopy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41718210P 2010-11-24 2010-11-24
US61/417,182 2010-11-24

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/830,632 Continuation-In-Part US9280718B2 (en) 2010-11-24 2013-03-14 Systems and methods for automated voxelation of regions of interest for magnetic resonance spectroscopy

Publications (2)

Publication Number Publication Date
WO2012071566A2 WO2012071566A2 (en) 2012-05-31
WO2012071566A3 true WO2012071566A3 (en) 2012-10-11

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/062137 WO2012071566A2 (en) 2010-11-24 2011-11-23 Systems and methods for automated voxelation of regions of interest for magnetic resonance spectroscopy

Country Status (2)

Country Link
EP (1) EP2642918A4 (en)
WO (1) WO2012071566A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8761860B2 (en) 2009-10-14 2014-06-24 Nocimed, Llc MR spectroscopy system and method for diagnosing painful and non-painful intervertebral discs
US8825131B2 (en) 2009-10-14 2014-09-02 Nocimed, Llc MR spectroscopy system and method for diagnosing painful and non-painful intervertebral discs
US9280718B2 (en) 2010-11-24 2016-03-08 Nocimed, Llc Systems and methods for automated voxelation of regions of interest for magnetic resonance spectroscopy
US8965094B2 (en) 2012-04-14 2015-02-24 Nocimed, Llc Magnetic resonance spectroscopy pulse sequence, acquisition, and processing system and method
WO2014081023A1 (en) * 2012-11-22 2014-05-30 株式会社東芝 Magnetic resonance imaging device
WO2017158592A2 (en) 2016-03-13 2017-09-21 David Tolkowsky Apparatus and methods for use with skeletal procedures
EP4289347A3 (en) 2016-06-19 2024-03-06 Aclarion, Inc. Magnetic resonance spectroscopy system and method for diagnosing pain or infection associated with propionic acid
WO2019012520A1 (en) 2017-07-08 2019-01-17 Vuze Medical Ltd. Apparatus and methods for use with image-guided skeletal procedures
JP2020534536A (en) * 2017-09-20 2020-11-26 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． Real-time reconstruction native image element resampling for high-resolution image generation and processing

Citations (3)

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US20050240104A1 (en) * 2004-04-01 2005-10-27 Medison Co., Ltd. Apparatus and method for forming 3D ultrasound image
US20100086185A1 (en) * 2004-03-11 2010-04-08 Weiss Kenneth L Image creation, analysis, presentation and localization technology
US20100268225A1 (en) * 2009-04-15 2010-10-21 Tyco Healthcare Group Lp Methods for Image Analysis and Visualization of Medical Image Data Suitable for Use in Assessing Tissue Ablation and Systems and Methods for Controlling Tissue Ablation Using Same

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US8090178B2 (en) * 2006-04-06 2012-01-03 Siemens Medical Solutions Usa, Inc. System and method for automatic detection of internal structures in medical images
US20070249928A1 (en) * 2006-04-19 2007-10-25 General Electric Company Method and system for precise repositioning of regions of interest in longitudinal magnetic resonance imaging and spectroscopy exams
US7704072B2 (en) 2006-04-19 2010-04-27 Ormco Corporation Orthodontic bracket
US7804989B2 (en) * 2006-10-30 2010-09-28 Eigen, Inc. Object recognition system for medical imaging
EP2194486A1 (en) 2008-12-04 2010-06-09 Koninklijke Philips Electronics N.V. A method, apparatus, and computer program product for acquiring medical image data

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US20100086185A1 (en) * 2004-03-11 2010-04-08 Weiss Kenneth L Image creation, analysis, presentation and localization technology
US20050240104A1 (en) * 2004-04-01 2005-10-27 Medison Co., Ltd. Apparatus and method for forming 3D ultrasound image
US20100268225A1 (en) * 2009-04-15 2010-10-21 Tyco Healthcare Group Lp Methods for Image Analysis and Visualization of Medical Image Data Suitable for Use in Assessing Tissue Ablation and Systems and Methods for Controlling Tissue Ablation Using Same

Also Published As

Publication number Publication date
EP2642918A2 (en) 2013-10-02
EP2642918A4 (en) 2017-11-22
WO2012071566A2 (en) 2012-05-31

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