WO2012070890A2 - Pharmaceutical composition comprising extract of lonicera japonica for prevention and treatment of gastroesophageal reflux disease - Google Patents
Pharmaceutical composition comprising extract of lonicera japonica for prevention and treatment of gastroesophageal reflux disease Download PDFInfo
- Publication number
- WO2012070890A2 WO2012070890A2 PCT/KR2011/009027 KR2011009027W WO2012070890A2 WO 2012070890 A2 WO2012070890 A2 WO 2012070890A2 KR 2011009027 W KR2011009027 W KR 2011009027W WO 2012070890 A2 WO2012070890 A2 WO 2012070890A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- extract
- reflux disease
- gastroesophageal reflux
- fraction
- lonicerae flos
- Prior art date
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- 230000000144 pharmacologic effect Effects 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- 238000009160 phytotherapy Methods 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 235000013550 pizza Nutrition 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000010318 polygalacturonic acid Substances 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000004804 polysaccharides Chemical class 0.000 description 1
- 229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
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- 230000003449 preventive effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 210000001187 pylorus Anatomy 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 1
- 239000011764 pyridoxine hydrochloride Substances 0.000 description 1
- 229960004172 pyridoxine hydrochloride Drugs 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
- 239000012925 reference material Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229960000342 retinol acetate Drugs 0.000 description 1
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 description 1
- 235000019173 retinyl acetate Nutrition 0.000 description 1
- 239000011770 retinyl acetate Substances 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- YXJHJCDOUFKMBG-BMZHGHOISA-M riboflavin sodium Chemical compound [Na+].OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)[N-]C2=O YXJHJCDOUFKMBG-BMZHGHOISA-M 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 235000013580 sausages Nutrition 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000001542 size-exclusion chromatography Methods 0.000 description 1
- 235000011888 snacks Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 238000000194 supercritical-fluid extraction Methods 0.000 description 1
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- 235000018553 tannin Nutrition 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000000892 thaumatin Substances 0.000 description 1
- 235000010436 thaumatin Nutrition 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- CWVRJTMFETXNAD-NXLLHMKUSA-N trans-5-O-caffeoyl-D-quinic acid Chemical compound O[C@H]1[C@H](O)C[C@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-NXLLHMKUSA-N 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 239000004563 wettable powder Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Images
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the pharmaceutical composition for treatment or prevention of gastroesophageal reflux disease which includes, as an active ingredient, the Lonicerae Flos fraction or the compound represented by Formula 1 or 2
- the composition includes, as the active ingredient, the Lonicerae Flos fraction or the compound represented by Formula 1 or 2, in a unit dose of about 0.1 to 1500 mg.
- the dosage is based on a doctor s prescription according to a patient's weight, age, disease particularity, and disease severity.
- a drink is prepared by the compositions and contents above according to a conventional method.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Botany (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
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- Food Science & Technology (AREA)
- Alternative & Traditional Medicine (AREA)
- Nutrition Science (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
index | administraton amount (㎎/㎏) | esophagus lesion inhibition ratio with respect to control group (%) |
control group | - | - |
Comparative Example 1 (water extract) | 50 ㎎/㎏ | 30 |
Example 1 (70% ethanol extract) | 50 ㎎/㎏ | 70 |
Example 2 (ethanol extract) | 50 ㎎/㎏ | 70 |
Example 3 (methanol extract) | 50 ㎎/㎏ | 68 |
Example 4 (ethyle acetate fracton) | 50 ㎎/㎏ | 85 |
Example 5 (butanol fraction) | 50 ㎎/㎏ | 75 |
3,5-di- | 10 ㎎/㎏ | 90 |
4,5-di- | 10 ㎎/㎏ | 81 |
| 10 ㎎/㎏ | 83 |
index | amount(㎎/㎏) | TNF-alpha (pg/㎎ Tissue weight) | inflammation inhibition ratio (%) |
Normal group | - | 120.3 | - |
Control group | - | 325.2 | - |
Comparative Example 1 (water extract) | 50 | 270.3 | 26.8 |
Example 1 (70% ethanol extract) | 50 | 220.3 | 51.2 |
Example 4 (ethyle acetate fracton) | 50 | 132.5 | 94.0 |
Example 5 (butanol fraction) | 50 | 178.3 | 71.7 |
3,5-di- | 10 | 145.3 | 87.8 |
4,5-di- | 10 | 150.1 | 85.5 |
| 10 | 160.2 | 80.5 |
Group | Administration amount(㎎/㎏) | unit: ㎍/100㎎ dry tissue | |
Sialic acid | Hexosamine | ||
Normal group | - | 125.2 | 1101.3 |
Control group | - | 95.2 | 925.3 |
Comparative Example1 (Water extract) | 50 | 123.3 | 1130.5 |
Example 1 (70% ethanol extract) | 50 | 138.0 | 1220.5 |
Example 4 (ethyle acetate fraction) | 50 | 163.3 | 1512.5 |
Example 5 (butanol fraction) | 50 | 147.8 | 1278.3 |
3,5-di- | 10 | 155.3 | 1445.2 |
4,5-di- | 10 | 148.1 | 1380.2 |
| 10 | 132.2 | 1176.3 |
Instrument | Shiseido Nonospace SI-2 | ||
Column | Capcell Pak C18 UG80 4.6×150㎜ (5μm) | ||
UV wavelength | 254㎚ | ||
Flow rate | 1.00 mL/mim | ||
Injection volume | 5μL | ||
Temperature | 40℃ | ||
Mobile phase | A) 5% Acetonitrile B) 80% Acetonitrile | ||
Gradient program | Min | A (%) | B (%) |
0 | 100 | 0 | |
10 | 95 | 5 | |
20 | 80 | 20 | |
25 | 75 | 25 | |
35 | 50 | 50 | |
40 | 100 | 0 | |
50 | 100 | 0 |
Index | Content of 3,5-di-CQA(%) | Content of 4,5-di-CQA(%) |
Comparative Example1 (Water extract) | 0.8 | 0.08 |
Example 1 (70% ethanol extract) | 2.1 | 1.0 |
Example 2 (ethanol extract) | 2.4 | 1.1 |
Example 3 (methanol extract) | 2.2 | 1.2 |
Example 4 (ethyle acetate fraction) | 13.0 | 2.5 |
Example 5 (butanol fraction) | 6.7 | 1.1 |
Claims (6)
- A pharmaceutical composition for treating or preventing gastroesophageal reflux disease, the composition comprising, as an active ingredient, at least one compound selected from the group including 3,5-di-O-caffeoylquinic acid (Formula 1) and 4,5-di-O-caffeoylquinic acid (Formula 2) as a C1~C4 alcohol or 50~100% C1~C4 alcohol aqueous solution extract of Lonicerae Flos.
- The pharmaceutical composition as claimed in claim 1, wherein in the pharmaceutical composition, a content of 3,5-di-O-caffeoylquinic acid is 2% or more, or a content of 4,5-di-O-caffeoylquinic acid is 1% or more.
- The pharmaceutical composition as claimed in any one of claims 1 to 3, further comprising at least one therapeutic agent of gastroesophageal reflux disease selected from the group including proton-pump inhibitors and histamine-2 receptor antagonists.
- A health care food composition for improving or preventing gastroesophageal reflux disease, the composition comprising, as an active ingredient, at least one compound selected from the group including 3,5-di-O-caffeoylquinic acid (Formula 1) and 4,5-di-O-caffeoylquinic acid (Formula 2) as a C1~C4 alcohol or 50~100% C1~C4 alcohol aqueous solution extract of Lonicerae Flos.
- The health care food composition as claimed in claim 5, wherein in the health care food composition, a content of 3,5-di-O-caffeoylquinic acid is 2% or more, or a content of 4,5-di-O-caffeoylquinic acid is 1% or more.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011800548241A CN103327993A (en) | 2010-11-25 | 2011-11-24 | Pharmaceutical composition comprising extract of lonicera japonica for prevention and treatment of gastroesophageal reflux disease |
EP11842716.0A EP2643007B1 (en) | 2010-11-25 | 2011-11-24 | Pharmaceutical composition comprising extract of lonicera japonica for prevention and treatment of gastroesophageal reflux disease |
JP2013539780A JP5793739B2 (en) | 2010-11-25 | 2011-11-24 | Pharmaceutical composition for treatment or prevention of reflux esophagitis comprising gold and silver flower extract |
US13/988,999 US20130310454A1 (en) | 2010-11-25 | 2011-11-24 | Pharmaceutical composition comprising extract of lonicera japonica for prevention and treatment of gastroesophageal reflux disease |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2010-0117984 | 2010-11-25 | ||
KR1020100117984A KR101074839B1 (en) | 2010-11-25 | 2010-11-25 | Pharmaceutical composition comprising extract of lonicera japonica for prevention and treatment of gastroesophageal reflux disease |
Publications (2)
Publication Number | Publication Date |
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WO2012070890A2 true WO2012070890A2 (en) | 2012-05-31 |
WO2012070890A3 WO2012070890A3 (en) | 2012-10-04 |
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Application Number | Title | Priority Date | Filing Date |
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PCT/KR2011/009027 WO2012070890A2 (en) | 2010-11-25 | 2011-11-24 | Pharmaceutical composition comprising extract of lonicera japonica for prevention and treatment of gastroesophageal reflux disease |
Country Status (6)
Country | Link |
---|---|
US (1) | US20130310454A1 (en) |
EP (1) | EP2643007B1 (en) |
JP (1) | JP5793739B2 (en) |
KR (1) | KR101074839B1 (en) |
CN (1) | CN103327993A (en) |
WO (1) | WO2012070890A2 (en) |
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KR101420347B1 (en) * | 2011-01-31 | 2014-07-16 | 성균관대학교산학협력단 | Composition for preventing or treating gastroesophageal reflux disease comprising chlorogenic acid |
KR101182582B1 (en) | 2012-04-27 | 2012-09-18 | 주식회사 휴온스 | A method for preparing a purified extract of lonicera japonica thunberg and the composition comprising the same for treating and preventing sepsis and septic shock |
KR101964054B1 (en) | 2012-09-13 | 2019-04-01 | (주)녹십자웰빙 | Pharmaceutical composition comprising extract of Lonicera japonica for prevention and treatment of Crohn's disease |
KR101432939B1 (en) | 2013-06-05 | 2014-08-22 | 대구한의대학교산학협력단 | Pharmaceutical composition having extract of curculigo orchioides for prevention or treatment of reflux esophagitis |
US20200260767A1 (en) | 2017-10-06 | 2020-08-20 | Cargill, Incorporated | Readily dissolvable steviol glycoside compositions |
KR102082860B1 (en) * | 2018-07-17 | 2020-02-28 | 주식회사한국야쿠르트 | Food composition for prevention and improvment of reflux esophagitis containing Cudrania tricuspidata extract as an effective factor |
CN108752208B (en) * | 2018-07-17 | 2021-03-16 | 深圳市人民医院 | Extraction method of caffeoylquinic acid compounds, and product and application thereof |
KR102364978B1 (en) * | 2018-11-14 | 2022-02-18 | 경희대학교 산학협력단 | Method of processing lonicera japonica thunb to increase anti-oxidant and anti-obesity |
KR102364977B1 (en) * | 2018-11-14 | 2022-02-18 | 경희대학교 산학협력단 | Method of processing lonicera japonica thunb to increase anti-oxidant and anti-obesity |
KR102157795B1 (en) * | 2018-12-06 | 2020-09-18 | (주)녹십자웰빙 | A pharmaceutical composition comprising water extract of Lonicerae Flos for preventing or treating of Helicobacter pylori infectious diseases |
WO2020210161A1 (en) | 2019-04-06 | 2020-10-15 | Cargill, Incorporated | Methods for making botanical extract composition |
WO2020210118A1 (en) | 2019-04-06 | 2020-10-15 | Cargill, Incorporated | Sensory modifiers |
KR20210023243A (en) * | 2019-08-22 | 2021-03-04 | (주)녹십자웰빙 | Functional food composition for suppressing of irritable bowel syndrome |
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WO2004024172A1 (en) * | 2002-09-11 | 2004-03-25 | Sk Chemicals, Co., Ltd. | Extraction and purification method of active constituents from stem of lonicera japonica thunb., its usage for anti-inflammatory and analgesic drug |
JP2007077117A (en) * | 2005-09-16 | 2007-03-29 | Ucc Ueshima Coffee Co Ltd | alpha-AMYLASE INHIBITOR |
JP2007197386A (en) * | 2006-01-27 | 2007-08-09 | Maruzen Pharmaceut Co Ltd | Cyclic amp phosphodiesterase inhibitor |
WO2007146983A2 (en) * | 2006-06-15 | 2007-12-21 | Novartis Ag | Compositions comprising tegaserod alone or in combination with a proton pump inhibitor for treating or preventing gastric injury |
BRPI0911496A2 (en) * | 2008-04-30 | 2015-07-28 | Nestec Sa | Coffee extract |
KR100878436B1 (en) * | 2008-08-18 | 2009-01-13 | 주식회사 지씨에이치앤피 | Pharmaceutical composition comprising extract of lonicera japonica for prevention and treatment of digestive ulcer |
EP2379092B1 (en) * | 2009-01-20 | 2013-12-25 | Indena S.p.A. | Compositions comprising a lipophilic extract of zingiber officinale and an extract of cynara scolymus |
KR101158835B1 (en) * | 2009-12-07 | 2012-06-27 | 강원대학교산학협력단 | Anti-inflammatory pharmaceutical composition comprising the extracts from Broussonetia papyrifera and Lonicera japonica |
KR101420347B1 (en) * | 2011-01-31 | 2014-07-16 | 성균관대학교산학협력단 | Composition for preventing or treating gastroesophageal reflux disease comprising chlorogenic acid |
-
2010
- 2010-11-25 KR KR1020100117984A patent/KR101074839B1/en active IP Right Grant
-
2011
- 2011-11-24 CN CN2011800548241A patent/CN103327993A/en active Pending
- 2011-11-24 US US13/988,999 patent/US20130310454A1/en not_active Abandoned
- 2011-11-24 JP JP2013539780A patent/JP5793739B2/en active Active
- 2011-11-24 EP EP11842716.0A patent/EP2643007B1/en active Active
- 2011-11-24 WO PCT/KR2011/009027 patent/WO2012070890A2/en active Application Filing
Non-Patent Citations (4)
Title |
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J. SEP. SCI., vol. 31, 2008, pages 3519 - 3526 |
NAKAMURA K ET AL., JPN. J PHARMACOL., vol. 32, no. 3, 1982, pages 445 - 456 |
OKABE S ET AL., JPN. J PHARMACOL., vol. 69, no. 4, 1995, pages 317 - 323 |
See also references of EP2643007A4 |
Also Published As
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WO2012070890A3 (en) | 2012-10-04 |
EP2643007B1 (en) | 2016-08-10 |
KR101074839B1 (en) | 2011-10-19 |
JP5793739B2 (en) | 2015-10-14 |
US20130310454A1 (en) | 2013-11-21 |
EP2643007A4 (en) | 2014-04-02 |
CN103327993A (en) | 2013-09-25 |
JP2014507374A (en) | 2014-03-27 |
EP2643007A2 (en) | 2013-10-02 |
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