WO2012059798A3 - NOVEL METHOD FOR RACEMIZATION OF OPTICALLY PURE β-CYANO ESTER TO CORRESPONDING RACEMIC β-CYANO ACID - Google Patents

NOVEL METHOD FOR RACEMIZATION OF OPTICALLY PURE β-CYANO ESTER TO CORRESPONDING RACEMIC β-CYANO ACID Download PDF

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Publication number
WO2012059798A3
WO2012059798A3 PCT/IB2011/000485 IB2011000485W WO2012059798A3 WO 2012059798 A3 WO2012059798 A3 WO 2012059798A3 IB 2011000485 W IB2011000485 W IB 2011000485W WO 2012059798 A3 WO2012059798 A3 WO 2012059798A3
Authority
WO
WIPO (PCT)
Prior art keywords
cyano
racemization
novel method
optically pure
corresponding racemic
Prior art date
Application number
PCT/IB2011/000485
Other languages
French (fr)
Other versions
WO2012059798A2 (en
Inventor
Bhairab Nath Roy
Girij Pal Singh
Piyush Suresh Lathi
Manoj Kunjabihari Agrawal
Rangan Mitra
Manoj Dattatraya Rupnawar
Original Assignee
Lupin Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Limited filed Critical Lupin Limited
Publication of WO2012059798A2 publication Critical patent/WO2012059798A2/en
Publication of WO2012059798A3 publication Critical patent/WO2012059798A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups

Abstract

A novel process for racemization of (R)-3-cyano-5 -methyl hexanoic acid ethyl ester directly to (RS)-3-cyano-5 -methyl hexanoic acid has been developed through a base catalyzed mechanism in a specific solvent system.
PCT/IB2011/000485 2010-11-04 2011-03-07 NOVEL METHOD FOR RACEMIZATION OF OPTICALLY PURE β-CYANO ESTER TO CORRESPONDING RACEMIC β-CYANO ACID WO2012059798A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1234/KOL/2010 2010-11-04
IN1234KO2010 2010-11-04

Publications (2)

Publication Number Publication Date
WO2012059798A2 WO2012059798A2 (en) 2012-05-10
WO2012059798A3 true WO2012059798A3 (en) 2012-07-19

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ID=44627251

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/000485 WO2012059798A2 (en) 2010-11-04 2011-03-07 NOVEL METHOD FOR RACEMIZATION OF OPTICALLY PURE β-CYANO ESTER TO CORRESPONDING RACEMIC β-CYANO ACID

Country Status (1)

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WO (1) WO2012059798A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007143152A2 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. Preparation of (s)-pregabalin-nitrile

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007143152A2 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. Preparation of (s)-pregabalin-nitrile

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MARTINEZ C A ET AL: "Development of a Chemoenzymatic Manufacturing Process for Pregabalin", ORGANIC PROCESS RESEARCH AND DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 12, no. 3, 16 May 2008 (2008-05-16), pages 392 - 398, XP002556922, ISSN: 1083-6160, [retrieved on 20080318], DOI: 10.1021/OP7002248 *

Also Published As

Publication number Publication date
WO2012059798A2 (en) 2012-05-10

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