WO2012058666A3 - Novel formulations of water-insoluble chemical compounds and methods of using a formulation of compound fl118 for cancer therapy - Google Patents

Novel formulations of water-insoluble chemical compounds and methods of using a formulation of compound fl118 for cancer therapy Download PDF

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Publication number
WO2012058666A3
WO2012058666A3 PCT/US2011/058558 US2011058558W WO2012058666A3 WO 2012058666 A3 WO2012058666 A3 WO 2012058666A3 US 2011058558 W US2011058558 W US 2011058558W WO 2012058666 A3 WO2012058666 A3 WO 2012058666A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compositions
water
cancer therapy
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/058558
Other languages
French (fr)
Other versions
WO2012058666A2 (en
Inventor
Fengzhi Li
Xiang Ling
Shousong Cao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Health Research Inc
Original Assignee
Health Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Health Research Inc filed Critical Health Research Inc
Priority to CA2816418A priority Critical patent/CA2816418C/en
Priority to US13/881,785 priority patent/US9422303B2/en
Priority to CN201180063530.5A priority patent/CN103442565B/en
Priority to EP11837250.7A priority patent/EP2632264B1/en
Publication of WO2012058666A2 publication Critical patent/WO2012058666A2/en
Publication of WO2012058666A3 publication Critical patent/WO2012058666A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Provided are compositions, methods of making the compositions, and methods of using the compositions. The compositions can be provided as pharmaceutical preparations for use in disease treatment, such as cancer therapy. The compositions include novel pharmaceutical preparations which contain effective concentrations of a chemical compound. One compound used is 10H-1,3-Dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b] quinoline-8,11(7H,12H)-dione, 7-ethyl-7- hydroxy-, (S)-. The invention also provides methodologies for preparing pharmaceutical preparations for use in intravenous and oral pharmaceutical preparations that contain drug compounds that are difficult to dissolve in water.
PCT/US2011/058558 2010-10-29 2011-10-31 Novel formulations of water-insoluble chemical compounds and methods of using a formulation of compound fl118 for cancer therapy Ceased WO2012058666A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA2816418A CA2816418C (en) 2010-10-29 2011-10-31 Novel formulations of water-insoluble chemical compounds and methods of using a formulation of compound fl118 for cancer therapy
US13/881,785 US9422303B2 (en) 2010-10-29 2011-10-31 Formulations of water-insoluble chemical compounds and methods of using a formulation of compound FL118 for cancer therapy
CN201180063530.5A CN103442565B (en) 2010-10-29 2011-10-31 Use non-water soluble compounds new formulation and the method for the compound FL118 preparation for treatment of cancer
EP11837250.7A EP2632264B1 (en) 2010-10-29 2011-10-31 Novel formulations of water-insoluble chemical compounds and methods of using a formulation of compound fl118 for cancer therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40799610P 2010-10-29 2010-10-29
US61/407,996 2010-10-29

Publications (2)

Publication Number Publication Date
WO2012058666A2 WO2012058666A2 (en) 2012-05-03
WO2012058666A3 true WO2012058666A3 (en) 2013-01-10

Family

ID=45994848

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/058558 Ceased WO2012058666A2 (en) 2010-10-29 2011-10-31 Novel formulations of water-insoluble chemical compounds and methods of using a formulation of compound fl118 for cancer therapy

Country Status (5)

Country Link
US (1) US9422303B2 (en)
EP (1) EP2632264B1 (en)
CN (1) CN103442565B (en)
CA (1) CA2816418C (en)
WO (1) WO2012058666A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10344037B2 (en) * 2014-03-26 2019-07-09 Canget BioTek Pharma LLC Use of the FL-one hundred eighteen core chemical structure platform to generate FL-one hundred eighteen derivatives for treatment of human disease
CA3111403A1 (en) * 2018-09-17 2020-03-26 Canget Biotekpharma Matter of composition, synthesis, formulation and application of fl118 platform positions 7 and 9-derived analogues for treatment of human disease
CA3146165A1 (en) * 2019-07-22 2021-01-28 Tuna MUTIS Novel anticancer drug fl118 formulation in combination with immunotherapy for treatment of human cancer
KR102349925B1 (en) * 2020-07-16 2022-01-12 주식회사 피노바이오 A compound containing FL118 drug and immunoconjugates using the same
WO2025170834A1 (en) * 2024-02-06 2025-08-14 Canget Biotekpharma, Llc Fl118 complexes for targeting ddx5, ube2t or usp2a

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0556585A2 (en) * 1992-01-24 1993-08-25 Takeda Chemical Industries, Ltd. Condensed camptothecin derivatives their production and use as antitumor agents
US6653319B1 (en) * 2001-08-10 2003-11-25 University Of Kentucky Research Foundation Pharmaceutical formulation for poorly water soluble camptothecin analogues

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340817A (en) * 1987-04-14 1994-08-23 Research Triangle Institute Method of treating tumors with anti-tumor effective camptothecin compounds
WO2001074401A2 (en) * 2000-03-31 2001-10-11 Supergen, Inc. Camptothecin complexes
EP1299085B1 (en) * 2000-06-30 2005-11-16 Inex Pharmaceuticals Corp. Improved liposomal camptothecins and uses thereof
US6509027B2 (en) * 2001-02-12 2003-01-21 Supergen, Inc. Injectable pharmaceutical composition comprising coated particles of camptothecin
US7569221B2 (en) 2006-11-10 2009-08-04 Health Research, Inc. Compositions and methods for identifying agents that alter expression of survivin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0556585A2 (en) * 1992-01-24 1993-08-25 Takeda Chemical Industries, Ltd. Condensed camptothecin derivatives their production and use as antitumor agents
US6653319B1 (en) * 2001-08-10 2003-11-25 University Of Kentucky Research Foundation Pharmaceutical formulation for poorly water soluble camptothecin analogues

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE PUBCHEM [online] 27 March 2005 (2005-03-27), XP003031894, retrieved from NCBI Database accession no. CID 437971 *

Also Published As

Publication number Publication date
WO2012058666A2 (en) 2012-05-03
CN103442565B (en) 2016-08-10
CA2816418A1 (en) 2012-05-03
CA2816418C (en) 2020-05-26
CN103442565A (en) 2013-12-11
EP2632264A4 (en) 2014-04-23
EP2632264B1 (en) 2019-10-02
US9422303B2 (en) 2016-08-23
US20140066470A1 (en) 2014-03-06
EP2632264A2 (en) 2013-09-04

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