WO2012054365A2 - Novel low molecular weight cationic lipids for oligonucleotide delivery - Google Patents
Novel low molecular weight cationic lipids for oligonucleotide delivery Download PDFInfo
- Publication number
- WO2012054365A2 WO2012054365A2 PCT/US2011/056502 US2011056502W WO2012054365A2 WO 2012054365 A2 WO2012054365 A2 WO 2012054365A2 US 2011056502 W US2011056502 W US 2011056502W WO 2012054365 A2 WO2012054365 A2 WO 2012054365A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- lipid
- sirna
- cationic lipids
- alkenyl
- Prior art date
Links
- 0 CC*CCCCCCC(CCC1)C1O Chemical compound CC*CCCCCCC(CCC1)C1O 0.000 description 1
- ZFEQGWFIIBBXKJ-UHFFFAOYSA-N CN(C)CCCC(C=C)=O Chemical compound CN(C)CCCC(C=C)=O ZFEQGWFIIBBXKJ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020137009957A KR20130124308A (en) | 2010-10-21 | 2011-10-17 | Novel low molecular weight cationic lipids for oligonucleotide delivery |
AU2011318289A AU2011318289A1 (en) | 2010-10-21 | 2011-10-17 | Novel low molecular weight cationic lipids for oligonucleotide delivery |
CA2813024A CA2813024A1 (en) | 2010-10-21 | 2011-10-17 | Novel low molecular weight cationic lipids for oligonucleotide delivery |
EP11834914.1A EP2629802B1 (en) | 2010-10-21 | 2011-10-17 | Low molecular weight cationic lipids for oligonucleotide delivery |
US13/880,254 US9029590B2 (en) | 2010-10-21 | 2011-10-17 | Low molecular weight cationic lipids for oligonucleotide delivery |
EP18204838.9A EP3485913A1 (en) | 2010-10-21 | 2011-10-17 | Low molecular weight cationic lipids for oligonucleotide delivery |
JP2013534981A JP2013545727A (en) | 2010-10-21 | 2011-10-17 | Novel low molecular weight cationic lipids for oligonucleotide delivery |
CN2011800500153A CN103153347A (en) | 2010-10-21 | 2011-10-17 | Novel low molecular weight cationic lipids for oligonucleotide delivery |
US14/682,494 US9458090B2 (en) | 2010-10-21 | 2015-04-09 | Low molecular weight cationic lipids for oligonucleotide delivery |
US15/282,294 US9981907B2 (en) | 2010-10-21 | 2016-09-30 | Low molecular weight cationic lipids for oligonucleotide delivery |
US15/926,936 US20180208545A1 (en) | 2010-10-21 | 2018-03-20 | Novel low molecular weight cationic lipids for oligonucleotide delivery |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40541310P | 2010-10-21 | 2010-10-21 | |
US61/405,413 | 2010-10-21 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/880,254 A-371-Of-International US9029590B2 (en) | 2010-10-21 | 2011-10-17 | Low molecular weight cationic lipids for oligonucleotide delivery |
US14/682,494 Continuation US9458090B2 (en) | 2010-10-21 | 2015-04-09 | Low molecular weight cationic lipids for oligonucleotide delivery |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012054365A2 true WO2012054365A2 (en) | 2012-04-26 |
WO2012054365A3 WO2012054365A3 (en) | 2012-08-02 |
Family
ID=45975815
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2011/056502 WO2012054365A2 (en) | 2010-10-21 | 2011-10-17 | Novel low molecular weight cationic lipids for oligonucleotide delivery |
Country Status (8)
Country | Link |
---|---|
US (4) | US9029590B2 (en) |
EP (2) | EP3485913A1 (en) |
JP (1) | JP2013545727A (en) |
KR (1) | KR20130124308A (en) |
CN (1) | CN103153347A (en) |
AU (1) | AU2011318289A1 (en) |
CA (1) | CA2813024A1 (en) |
WO (1) | WO2012054365A2 (en) |
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WO2013151666A2 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of biologics and proteins associated with human disease |
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WO2013158579A1 (en) * | 2012-04-19 | 2013-10-24 | Merck Sharp & Dohme Corp. | Novel diester and triester based low molecular weight, biodegradable cationic lipids for oligonucleotide delivery |
WO2014152540A1 (en) | 2013-03-15 | 2014-09-25 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
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WO2015005253A1 (en) | 2013-07-08 | 2015-01-15 | 第一三共株式会社 | Novel lipid |
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WO2012054365A3 (en) | 2012-08-02 |
JP2013545727A (en) | 2013-12-26 |
US9981907B2 (en) | 2018-05-29 |
US20130274504A1 (en) | 2013-10-17 |
EP3485913A1 (en) | 2019-05-22 |
CN103153347A (en) | 2013-06-12 |
US20180208545A1 (en) | 2018-07-26 |
US20150284317A1 (en) | 2015-10-08 |
AU2011318289A1 (en) | 2013-03-07 |
CA2813024A1 (en) | 2012-04-26 |
EP2629802B1 (en) | 2019-12-04 |
US20170022146A1 (en) | 2017-01-26 |
EP2629802A4 (en) | 2014-06-25 |
US9458090B2 (en) | 2016-10-04 |
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KR20130124308A (en) | 2013-11-13 |
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