WO2012042484A1 - Dynamic filter for computed tomography (ct) - Google Patents
Dynamic filter for computed tomography (ct) Download PDFInfo
- Publication number
- WO2012042484A1 WO2012042484A1 PCT/IB2011/054268 IB2011054268W WO2012042484A1 WO 2012042484 A1 WO2012042484 A1 WO 2012042484A1 IB 2011054268 W IB2011054268 W IB 2011054268W WO 2012042484 A1 WO2012042484 A1 WO 2012042484A1
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- WO
- WIPO (PCT)
- Prior art keywords
- filter
- radiation
- filtered
- regions
- subject
- Prior art date
Links
- 238000002591 computed tomography Methods 0.000 title description 9
- 230000005855 radiation Effects 0.000 claims abstract description 66
- 230000002093 peripheral effect Effects 0.000 claims abstract description 15
- 238000003384 imaging method Methods 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims description 14
- 238000001914 filtration Methods 0.000 claims description 13
- 238000005259 measurement Methods 0.000 claims description 13
- 230000004907 flux Effects 0.000 claims description 7
- 238000013459 approach Methods 0.000 description 4
- 230000003068 static effect Effects 0.000 description 4
- 230000007704 transition Effects 0.000 description 3
- 230000004075 alteration Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000010606 normalization Methods 0.000 description 2
- 206010029412 Nightmare Diseases 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
- G21K1/00—Arrangements for handling particles or ionising radiation, e.g. focusing or moderating
- G21K1/10—Scattering devices; Absorbing devices; Ionising radiation filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computed tomography [CT]
- A61B6/032—Transmission computed tomography [CT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/40—Arrangements for generating radiation specially adapted for radiation diagnosis
- A61B6/4021—Arrangements for generating radiation specially adapted for radiation diagnosis involving movement of the focal spot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/40—Arrangements for generating radiation specially adapted for radiation diagnosis
- A61B6/4035—Arrangements for generating radiation specially adapted for radiation diagnosis the source being combined with a filter or grating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
- A61B6/5258—Devices using data or image processing specially adapted for radiation diagnosis involving detection or reduction of artifacts or noise
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
- G01N23/02—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material
- G01N23/04—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material and forming images of the material
- G01N23/046—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material and forming images of the material using tomography, e.g. computed tomography [CT]
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
- G21K1/00—Arrangements for handling particles or ionising radiation, e.g. focusing or moderating
- G21K1/02—Arrangements for handling particles or ionising radiation, e.g. focusing or moderating using diaphragms, collimators
- G21K1/04—Arrangements for handling particles or ionising radiation, e.g. focusing or moderating using diaphragms, collimators using variable diaphragms, shutters, choppers
Definitions
- the following generally relates to imaging and more particular to a filter utilized to reduce the radiation at the edges of the radiation beam in computer tomography (CT) scanners.
- CT computer tomography
- a conventional CT scanner includes an x-ray tube that emits radiation.
- a source collimator is disposed between the x-ray tube and an examination region and collimates the emitted radiation to produce a fan or cone shaped x-ray beam.
- the collimated beam traverses the examination region and an object or subject therein (which attenuates the beam as a function of the radiodensity of the object or subject) and illuminates a detector array disposed across the examination region from the x-ray tube.
- the detector produces projection data indicative of the detected radiation, and the projection data has been reconstructed to generate volumetric image data indicative of the object or subject.
- a so-called bowtie filter has been positioned between the source collimator and the examination region and attenuates the fan or cone shape x-ray beam to a greater degree at the outer regions or periphery rays of the beam, thereby reducing the flux at the outer regions of the fan or cone beam.
- the name filter reflects the typical shape of the filter.
- Such filtering is well- suited for photon counting detectors, which suffer from insufficient count rate capabilities. By way of example, in a typical CT scan, excessive count rates are only required for rays of the beam that do not cross the subject or that travels only short distances through the subject in peripheral regions.
- Such filtering is also well-suited to be employed with scanners with non- counting detectors, for example, to improve radiation efficiency, etc.
- FIGURES 1(A), 1(B) and 1(C) illustrate an example of a conventional static bowtie filter 102 in connection with an x-ray source 104, a source collimator 106, and an examination region 108, and a portion of a subject 110 being scanned.
- the filter 102 corresponds to the profile or shape of the subject being scanned, and heavily filters the regions of the beam that traverse only air, lightly filters the region of the beam that traverses the subject, and smoothly transitions the degree of filtering for transitions therebetween so that a correct x-ray profile can be achieved.
- An air scan is performed to measure the attenuation profile of the filter and generate a calibration based thereon for detector pixel normalization during reconstruction.
- the profile of every subject is not the same as the shape may be larger for some subject, smaller for other subjects, and may also be different such as more or less cylindrical as shown in FIGURES 1(A) and 1(C).
- the profile of the same subject may be quite different depending on the angle at which the subject is viewed as shown in FIGURES 1(A) and 1(B).
- the static filter may be better-suited for some subjects but not be well-suited for other subjects as the filter cannot match each subject.
- a subject may be positioned off-center such that a portion of the beam traversing air is lightly filtered, and a portion of the beam traversing the subject is heavily filtered. As a result, photon flux at the edges of the subject may decrease the fidelity of the detector output to a level that may be prohibitively low for diagnostically valuable images.
- FIGURES 2(A), 2(B) and 2(C) illustrate an example of a dynamic bowtie filter 202 formed from two sub-filters 202i and 202 2 , each having a higher attenuation region that smoothly transitions to a lower attenuation tail.
- the sub- filters With the illustrated dynamic filter, the sub- filters
- FIGURES 2(A) and 2(B) linearly translate towards or away from each other to dynamically change the profile of the filter as shown in FIGURES 2(A) and 2(B). Note in FIGURE 2(B) only the sub- filter 202i (and not sub-filter 202 2 ) is shown for clarity. In this example, the sub- filters 202i and
- a length of a ray from the focal spot to each position along a sub-filter changes with the location of the sub-filter and a thickness of the sub- filter for the ray also changes with the location of the sub- filter, rendering calibration of each pixel for the profile of the filter 202 a nightmare, and image quality is very sensitive to the precise knowledge of the bowtie influence in each single detector pixel.
- an imaging system including a source having a focal spot that emits a radiation beam that traverses an examination region, a radiation sensitive detector array having a plurality of pixels that detects radiation traversing the examination region and generates projection data indicative of the detected radiation, and a filter, disposed between the source and the examination region, that filters peripheral regions of the emitted radiation, wherein the filter includes two separate and moveable regions, each region having a substantially same thickness and constant homogeneity.
- a method includes filtering peripheral rays, of an emitted radiation beam traversing an examination region, which substantially do not traverse an object or subject in the examination region, with a dynamically adjustable filter having a substantially same thickness and homogeneity along the filter.
- a method for reducing a flux of peripheral rays of a radiation beam includes identifying a location of the peripheral rays while scanning an object or subject, dynamically positioning a filter having a uniform thickness and substantially same homogeneity in a path of the peripheral rays, thereby filtering the peripheral rays with the dynamically positioned filter, and detecting radiation filtered by the filter and radiation not filtered by the filter and generating projection data indicative of the detected radiation.
- the invention may take form in various components and arrangements of components, and in various steps and arrangements of steps.
- the drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention.
- FIGURE 1 illustrates a prior art static filter.
- FIGURE 2 illustrates a prior art dynamic filter.
- FIGURE 3 illustrates an example imaging system including a dynamic filter having a uniform thickness and substantially constant homogeneity.
- FIGURES 4, 5 and 6 illustrate an example of the dynamic filter in connection with symmetric filter region movement.
- FIGURE 7 illustrates an example of the dynamic filter in connection with asymmetric filter region movement.
- FIGURE 8 illustrates an example of differently filtering a ray detected in opposing direction using the dynamic filter.
- FIGURE 9 illustrates an example method.
- FIGURE 3 illustrates an imaging system 300 such as a computed tomography (CT) scanner.
- the imaging system 300 includes a stationary gantry 302 and a rotating gantry 304, which is rotatably supported by the stationary gantry 302.
- the rotating gantry 304 rotates around an examination region 306 about a longitudinal or z-axis.
- a radiation source 310 such as an x-ray tube, is supported by the rotating gantry 304 and rotates with the rotating gantry 304 about the examination region 306, and emits radiation that traverses the examination region 306.
- a source collimator 312 collimates the emitted radiation, forming a generally fan, cone, or other shaped beam that traverses the examination region 306.
- a radiation sensitive detector array 316 is located opposite the radiation source 310, across the examination region 306. The detector array 316 includes a plurality of detector pixels that detect radiation traversing the examination region 306 and generate or projection data indicative of the detected radiation.
- a dynamic filter 314 is arranged between the collimator 312 and the examination region 306 and filters the collimated beam.
- the dynamic filter 314 is configured to dynamically adjust its profile, through movement of one or more filter regions thereof, based on the shape of the object or subject being scanned, while mitigating impact on the filter attenuation normalization calibration.
- the movement of the one or more regions can be achieved through one or more motors 322 in mechanical communication with the one or more filter regions, and a controller 324 that controls the one or motors 322 to move, individually or concurrently, the one or more filter regions along predefined path such as a track, a rail, or the like.
- a reconstructor 318 reconstructs the processed projection data and generates volumetric image data indicative of the examination region 306.
- the reconstructor 318 includes a data calibrator 326 for calibrating the detector pixels based on the profile of the dynamic filter 314. As described in greater detail below, various calibration algorithms can be employed, depending on whether a pixel detects fully filtered radiation, unfiltered radiation, or partly filtered / partly unfiltered radiation.
- the resulting volumetric image data can be processed by an image processor or the like to generate one or more images.
- a general purpose computing system serves as an operator console 320, and includes an output device such as a display and an input device such as a keyboard, mouse, and/or the like. Software resident on the console 320 allows the operator to control the operation of the system 300, for example, allowing the operator to select a protocol that employs the dynamic filter, initiate scanning, etc.
- FIGURE 4 illustrates an example of the dynamic filter 314.
- the filter 314 includes at least a first region 402i and a second region 402 2 , collectively referred to as filter regions 402.
- the filter regions 402 are disposed on opposing sides 411 and 412 of an imaginary line 414 extending perpendicularly from the focal spot 406 to the a generally planar or flat imaging plane 415.
- Each of filter regions 402 is a cylindrical volume of substantially uniform (e.g., the same) thickness 400 having a same or constant homogeneity.
- each of the filter regions 402 has a concave side 404 facing the focal spot 406 and an opposing convex side 408 facing the detector array 316.
- a distance 416 from points along the side 404 to the focal spot 406 is substantially the same along the filter regions 402.
- the illustrated filter regions 402 are configured to move, independently or in combination, along arc shaped paths 410, with respect to the focal spot 406, towards and away from the imaginary line 414, thereby changing the distance therebetween and hence the attenuation profile.
- the attenuation profile is binary in that radiation is either filtered by the uniform thickness or not filtered by the filter 314.
- the filter 314 filters only the outer or peripheral regions of a radiation beam.
- FIGURES 4, 5 and 6 graphically show an example of dynamically adjusting the regions 402 of the filter 314 in accordance with an object 418.
- the object 418 is centered in the imaginary line 414.
- the beam 420 is collimated such that a width 422 of the beam 420 at the imaging plane 415 is wider than a width 424 of the object 418, and the regions 402 are positioned such that the filter 314 is not filtering any of the beam 420.
- This particular configuration is for explanatory purposes, and the regions 402 may be otherwise initially positioned.
- the focal spot 406 is moving through the twelve o'clock position, and the regions 402 are moved along the paths 410 towards the imaginary line 414.
- the regions 402 are moved until edges 502 and 504 respectively substantially align with rays 506 and 508 traversing paths within and near the edges of the perimeter of the object 418 at the width 424 of the object 418.
- the filtering of the rays traversing the object at the edges does not prevent imaging of these regions.
- the edges 502 and 504 may be otherwise aligned, and a margin may be added to ensure the object 418 is adequately scanned, such as margins that would move the regions 402 closer to imaginary line 414, for example, to avoid excessive count rates.
- the filter 314 uniformly filters regions 510 between outer rays 512 and 514 of the beam 420 the rays 506 and 508, and does not filter a region 516 between the rays 506 and 508.
- the focal spot 406 is moving through the three o'clock position.
- the regions 402 are moved along the paths 410 towards the imaginary line 414 until the edges 502 and 504 respectively align with rays 602 and 604 traversing paths within and near the edges of the perimeter of the object 418 at a depth 606 of the object 418.
- the filter 314 uniformly filters regions 608 between outer rays 512 and 514 of the beam 420 the rays 602 and 604, and does not filter any portion of a region 610 between rays 602 and 604 within and near the edges of.
- the edges 502 and 504 are always parallel to the rays (e.g., 506, 508, 512, 514, 602, and 604) of the beam 420.
- the filter regions 402 can be continuously or discretely (at predetermined uniform or non-uniform intervals) dynamically adjusted as the focal spot 406 rotates around the examination region 306 over three hundred and sixty degrees or less.
- Various approaches can be utilized to determine where the edges 502 and 504 should be during a given acquisition interval. For example, in one instance one or more 2D and/or 3D pre-scans (e.g., scout, pilot, etc.) are performed and the resulting data is used for planning the scan, including identifying the perimeter of the object 418. In another instance, the perimeter of the object 418 is estimated during scanning based on relative intensity values of the detected data.
- 2D and/or 3D pre-scans e.g., scout, pilot, etc.
- FIGURE 7 graphically shows an example in which the object 418 is positioned off-center with respect to the imaginary center line 414.
- the regions 402 are moved through different distances (asymmetrically) and independently in order to align the edges 502 and 504 respectively with rays 702 and 704 traversing paths that cross the perimeter of the object 418 at the width 424 of the object 418.
- the filter 314 uniformly filters regions 706 and 708 between outer rays 512 and 514 of the beam 420 the rays 702 and 704, and does not filter any portion of the region 516.
- each detector pixel of the detector array 316 may operate under three different conditions: 1) the pixel sees the full flux (no filtering by the filter 314), 2.) the pixel sees reduced flux (filtering by the filter 314), or 3) the pixel is at a position where the flux is partly reduced (partly filtered and partly unfiltered) by the filter 314.
- Conditions 1 and 2 are stable situations and can be corrected with two different calibration sets. Only a small number of detector pixels will operate in condition 3 within a projection, and, generally, the pixels operating under condition 3 will suffer from unreliable calibration.
- the relative position of the moving regions 402 of the filter 314 can be tracked (e.g., via an encoder or the like) and/or estimated.
- the three operating conditions can be identified for each pixel.
- the pixel readings are then either calibrated with a calibration set for condition 1 , a calibration set for condition 2, or a hybrid calibration for condition 3.
- suitable calibrations for condition 3 follow.
- One or more of the following approaches can be combined or otherwise concurrently employed, and/or one or more of approaches may additionally or alternatively be employed.
- the data calibrator 326 discards the measurements for condition 3 and replaces the measurements with interpolated (e.g., linear or higher order) values based on neighboring pixels falling under condition 1 and/or 2.
- the measurements for condition 3 may be calibrated with an estimated calibration set based on the calibration sets for conditions 1 and 2.
- the estimated set may be a simple average of the calibration sets for conditions 1 and 2 or a weighted average in which a higher weight is applied to the calibration set corresponding to the pixel closer to the pixel under condition 3.
- the calibration may be blended from calibration set 1 to calibration set 2 by moving from the calibration set for condition 1 and the calibration set for condition 2.
- the reconstructor 318 employs an iterative algorithm in which pixels under condition 3 are rejected or weighted down to limit their impact.
- each ray is measured twice, but in opposite directions.
- the filter regions 402 can be moved so that at least one of the two redundant measurements falls under condition 1 or condition 2. Where the other of the two redundant measurements falls under condition 3, that measurement can be discarded and replaced with the redundant measurement falling under condition 1 or condition 2.
- FIGURE 8 This is shown in FIGURE 8 where ray 802 is measured when the focal spot 406 is located at a first position 804 and the ray 802 is also measured when the focal spot 406 is located at a second position 806, after the focal spot has traveled to the opposite side of the scanned object 418.
- the ray 802 falls under condition 3 (the ray 802 traverses along the edge of the filter), and when measured with the focal spot 406 at the second position 806, the ray 802 fall under condition 2 (the ray 802 traverses through and is filtered by the filter).
- FIGURE 9 illustrates a method. It is to be appreciated that the ordering of the acts is not limiting. As such, in other embodiments, the ordering of the acts may be different. In addition, one or more of the acts can be omitted and/or one or more other acts can be added.
- a shape of a subject (or object) being scanned is determined.
- the shape can be determined via a pre-scan and/or during scanning.
- a dynamic filter is dynamically adjusted during scanning the object or subject based on the determined shape.
- the filter has a constant thickness and a constant homogeneity, and is moved along an arc shaped path relative to the focal spot of the radiation source to change the region of the radiation beam to filter.
- detected data is normalized based on whether a corresponding detector pixel received radiation fully filtered by the filter, radiation not filtered by the filter, or radiation partially filter and partially unfiltered by the filter. As described herein, various approaches can be utilized to normalize the data corresponding to the partially filter and partially unfiltered radiation.
- the normalized data is reconstructed to generate volumetric image data.
- the volumetric image data can be further processed to generate on or more images.
- the dynamic filter 314 described herein can be used as, in connection with, and/or in place of a conventional bowtie filter, such as the bowtie filters discussed in conjunction with FIGURES 1 and 2, as well as other bowtie filters.
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Abstract
Description
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Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201180046964.4A CN103124520B (en) | 2010-09-30 | 2011-09-28 | Kinetic filter for computer tomography (CT) |
EP11776544.6A EP2621342B1 (en) | 2010-09-30 | 2011-09-28 | Dynamic filter for computed tomography (ct) |
RU2013120004/07A RU2589723C2 (en) | 2010-09-30 | 2011-09-28 | Dynamic filter for computed tomography (ct) |
US13/825,410 US9177682B2 (en) | 2010-09-30 | 2011-09-28 | Dynamic filter for computed tomography (CT) |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38802110P | 2010-09-30 | 2010-09-30 | |
US61/388,021 | 2010-09-30 |
Publications (1)
Publication Number | Publication Date |
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WO2012042484A1 true WO2012042484A1 (en) | 2012-04-05 |
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ID=44898087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/IB2011/054268 WO2012042484A1 (en) | 2010-09-30 | 2011-09-28 | Dynamic filter for computed tomography (ct) |
Country Status (5)
Country | Link |
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US (1) | US9177682B2 (en) |
EP (1) | EP2621342B1 (en) |
CN (1) | CN103124520B (en) |
RU (1) | RU2589723C2 (en) |
WO (1) | WO2012042484A1 (en) |
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WO2014202720A1 (en) * | 2013-06-19 | 2014-12-24 | Koninklijke Philips N.V. | Calibration of imagers with dynamic beam shapers |
WO2015022599A1 (en) * | 2013-08-13 | 2015-02-19 | Koninklijke Philips N.V. | Adjustable bow-tie filter for achieving optimal snr in helical computed tomography |
EP2862517A1 (en) * | 2013-09-13 | 2015-04-22 | Samsung Electronics Co., Ltd | Computed tomography apparatus and method of controlling x-ray by using the same |
US9316601B2 (en) | 2011-01-31 | 2016-04-19 | Koninklijke Philips N.V. | Detection values processing apparatus |
US9775572B2 (en) | 2012-12-05 | 2017-10-03 | Koninklijke Philips N.V. | Radiation beam intensity profile shaper |
WO2019105775A1 (en) * | 2017-11-28 | 2019-06-06 | Koninklijke Philips N.V. | Spectral imaging using a rotating spectral filter |
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US10463322B2 (en) | 2014-08-29 | 2019-11-05 | Shenyang Neusoft Medical Systems Co., Ltd. | Method and apparatus for controlling shape filter in CT scanning device |
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RU2013136560A (en) * | 2011-01-06 | 2015-02-20 | Конинклейке Филипс Электроникс Н.В. | VISUALIZATION SYSTEM FOR VISUALIZING AN OBJECT |
US9575015B2 (en) * | 2014-03-31 | 2017-02-21 | The General Hospital Corporation | Systems and methods for x-ray phase contrast imaging using arrays of x-ray focusing elements |
US10667767B2 (en) | 2014-05-02 | 2020-06-02 | General Electric Company | Systems and methods for selecting bowtie filter configuration |
WO2015173750A1 (en) * | 2014-05-15 | 2015-11-19 | Koninklijke Philips N.V. | Multi-focal spot imaging system |
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JP2020533059A (en) * | 2017-09-08 | 2020-11-19 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | Dynamic bowtie filter and how to use it |
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Also Published As
Publication number | Publication date |
---|---|
US20130182820A1 (en) | 2013-07-18 |
RU2589723C2 (en) | 2016-07-10 |
EP2621342A1 (en) | 2013-08-07 |
CN103124520B (en) | 2016-07-13 |
US9177682B2 (en) | 2015-11-03 |
CN103124520A (en) | 2013-05-29 |
EP2621342B1 (en) | 2017-08-09 |
RU2013120004A (en) | 2014-11-10 |
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