WO2012033865A2 - Non-stick medical tubing - Google Patents

Non-stick medical tubing Download PDF

Info

Publication number
WO2012033865A2
WO2012033865A2 PCT/US2011/050736 US2011050736W WO2012033865A2 WO 2012033865 A2 WO2012033865 A2 WO 2012033865A2 US 2011050736 W US2011050736 W US 2011050736W WO 2012033865 A2 WO2012033865 A2 WO 2012033865A2
Authority
WO
WIPO (PCT)
Prior art keywords
medical
tubing
amide compound
plastic resin
stick
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/050736
Other languages
French (fr)
Other versions
WO2012033865A3 (en
Inventor
Ludmila Victoria Nikitina
Kenneth Whitley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CareFusion 303 Inc
Original Assignee
CareFusion 303 Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CareFusion 303 Inc filed Critical CareFusion 303 Inc
Priority to AU2011299250A priority Critical patent/AU2011299250A1/en
Publication of WO2012033865A2 publication Critical patent/WO2012033865A2/en
Publication of WO2012033865A3 publication Critical patent/WO2012033865A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
    • B29C48/09—Articles with cross-sections having partially or fully enclosed cavities, e.g. pipes or channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/022—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the choice of material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
    • B29C48/09—Articles with cross-sections having partially or fully enclosed cavities, e.g. pipes or channels
    • B29C48/10—Articles with cross-sections having partially or fully enclosed cavities, e.g. pipes or channels flexible, e.g. blown foils
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
    • Y10T428/1334—Nonself-supporting tubular film or bag [e.g., pouch, envelope, packet, etc.]
    • Y10T428/1341—Contains vapor or gas barrier, polymer derived from vinyl chloride or vinylidene chloride, or polymer containing a vinyl alcohol unit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
    • Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
    • Y10T428/1397—Single layer [continuous layer]

Definitions

  • This technology relates generally to medical equipment. More particularly, the technology relates to medical tubing.
  • Embodiments here described include a method for manufacturing a non stick medical tube.
  • the method includes providing a first plastic resin to a tubing extrusion device and providing a second plastic resin to a tubing extrusion device, the second plastic resin comprising a medical grade amide compound.
  • the method further includes mixing the first plastic resin with the second plastic resin and extruding the resin mixture such that the medical grade amide compound is present on an inner surface of the medical tube after extrusion to promote release of contacting surfaces of the inner surface of the medical tubing after contact.
  • Embodiments here described also include a non-stick medical tubing.
  • the medical tubing includes a plastic resin mixture including a first plastic resin component and a second plastic resin component, the second plastic resin comprising a medical grade amide compound.
  • the plastic resin mixture is extruded by an extruding apparatus such that the medical grade amide compound is present on an inner surface of the medical tube after extrusion to promote release of contacting surfaces of the inner surface of the medical tubing after contact.
  • Figure 1 shows a prior art medical tube with occlusion after to a clamping force has been applied.
  • Figure 2 shows an exemplary non-stick medical tube comprising a medical grade amide compound for preventing occlusion after a clamping force has been applied to the tube in accordance with embodiments of the present invention.
  • Figure 3 shows an exemplary system for extruding a non-stick medical tube comprising a medical grade amide compound for preventing occlusion in accordance with embodiments of the present invention.
  • Figure 4 shows an exemplary peristaltic pump with a non-stick medical tube comprising a medical grade amide compound for preventing occlusion in accordance with embodiments of the present invention.
  • Figure 5 is a flow diagram of an exemplary method for manufacturing a nonstick medical tube comprising a medical grade amide compound in accordance with embodiments of the present invention.
  • Figure 1 shows a conventional prior art medical tube 100 having an outer surface 130 and an inner surface 110. After a clamping force 20 is applied to the tubing, the inner surfaces 110 of the tube 100 contact each other and become stuck together at occlusion 150.
  • the occlusion 150 can damage the tubing, requiring replacement and can also cause possible patient harm. Ultimately, time is lost, cost increase and patient safety is at risk with conventional medical tubing that can kink or stick together.
  • Embodiments of the present invention include a medical tube comprising a medical grade amide compound that is added to the material prior to or during extrusion to prevent lumen sticking and immediately opens up after a clamping force is applied to the tube.
  • Embodiments of the present invention are well suited for preventing lumen occlusion after both short term and long term clamping.
  • embodiments of the present invention can prevent line sticking after a clamping force has been applied to a line for as long as 14 days.
  • the non stick medical tubing of the present invention is also well suited to be used as the pumping section of a peristaltic pump.
  • the tubing of the present invention is made in part from an amide compound that prevents sticking of the inner surfaces of the tube after they contact each other from clamping or kinking.
  • Embodiments of the present invention are well suited to prevent line sticking after clamping for up to 14 days.
  • Figure 2 shows an exemplary non-stick medical tube 200 comprising a medical grade amide compound for preventing occlusion after a clamping force 250 has been applied to the tube in accordance with embodiments of the present invention.
  • the amide compound serves as a release agent that promotes release of contacting surfaces in the tube.
  • the opposing surfaces of the inner passageway contact each other and form an occlusion that blocks or reduces flow.
  • the contacting surfaces release and the occlusion frees and the tubing is restored to the original shape and function.
  • the tubing of the present invention 200 does not stick and form an occlusion in the tube after the clamping force 250 is removed from the outer surface 230 of the tube 200.
  • Figure 2 shows the inner surface 210 of the tube 200 does not stick and the inner diameter 280 of the tubing is restored after the clamping force 250 is removed from the tube.
  • a medical grade amide compound is described as the release agent, other medical agents could be used.
  • any medical grade compound that reduces sticking of the line lumens and that can be integrated into the extrusion process could be used.
  • One such compound is a medical grade wax.
  • An amide fatty acid is an unsaturated long chain carboxylic acid amide and can be found in both food and medical grade.
  • One chemical formulation of an amide fatty acid in accordance with the present invention is C22H43NO.
  • Embodiments of the present invention include adding plastic resin containing an amide compound to the plastic resin used in tube extrusion. By mixing the amide compound into the plastic prior to extrusion, the amide compound is present on the inner tube surface and prevents lumen sticking and lumen occlusions.
  • the base material for the tubing is thermoplastic elastomer (TPE) resin.
  • TPE thermoplastic elastomer
  • a secondary material comprising an amide compound is added to the TPE prior to the extrusion process to reduce lumen occlusion and kinking.
  • all materials of the tubing are formed into pellets prior to extrusion.
  • a single pellet comprises the mixture of primary (TPE) and secondary (amide fatty acid) materials.
  • Figure 3 shows an exemplary system 300 for extruding a non-stick medical tube comprising a medical grade amide compound for preventing occlusion in accordance with embodiments of the present invention.
  • Resin A 302 and resin B 304 enter a hopper/mixer 306.
  • resin A 302 is a thermoplastic elastomer (TPE) resin.
  • resin A is a polyvinylchloride (PVC), polyurethane or any other plastic resin.
  • the resin is delivered to hopper/mixer 306 in pellet form.
  • resin A and resin B are both part of a homogeneous pellet mixture where a single pellet comprises both resin A 302 and resin B 304.
  • Resin B 304 included an amide compound and in one embodiment, a carrier compound. Since the amide compound may have different physical properties from the resin A 302, a carrier compound can be mixed with the amide compound to prevent problems during extrusion. The carrier compound aids in mixing of the amide compound with the TPE or PVC. In one embodiment, the carrier compound includes polypropylene, polyethylene, or any other plastic resin. In one embodiment, a specific ratio of amide compound to carrier compound is used to achieve a predetermined amount of amide compound in the extruded tubing. In one embodiment, the percentage of weight of the amide compound can be between .3% and 5% of the tube material after extrusion. In one embodiment, the percentage of weight of the amide compound can be between 1 % and 25% of resin B 304.
  • Resin A 302 and resin B 304 are mixed in hopper 306.
  • the amount of resin A 302 and resin B 304 that enter the hopper/mixer 306 is determined based on the final desired concentration of the amide compound in the tubing. The final concentration depends on the starting concentration of the amide compound in resin B 304 as well as other factors.
  • a mixture of resin A and resin B is provided in a single pellet whereby the hopper 306 receives a homogeneous mixture of pellets that have both resin A and resin B in them.
  • the ratio of resin A to resin B can be modified to achieve different tube characteristics.
  • the mixture of resin A 302 and resin B 304 enters the extruder 310.
  • altering configuration of the extruder 310 can modify the final concentration of the amide compound in the tubing.
  • altering the extrusion process can modify the concentration of amide compound in the extruded tube.
  • Some processes may facilitate heavier concentration of the amide at different locations of the tube.
  • localized heating during the extrusion process can form higher concentrations of the amide compound on the inner walls of the tube compared to the outer surface of the tube.
  • the non-stick medical tubing 200 of the present invention exits the extruder.
  • subsequent operations may be performed on the tubing to facilitate blooming of amide compound to the inner tube walls. Sterilization may also be performed after extrusion.
  • the non-stick tubing of the present invention does not stick and immediately opens up for fluid flow after short term and long term clamping.
  • short term clamping is the action of a peristaltic pump.
  • a line segment (tube) is squeezed in a linear motion to create a pumping force.
  • the squeezing can cause lumen sticking.
  • the non-stick medical tubing 200 of the present invention is well suited to be used as the pump segment in a peristaltic pump.
  • Figure 4 shows an exemplary peristaltic pump 402 with a non-stick medical tube 200 comprising a medical grade amide compound for preventing occlusion in accordance with embodiments of the present invention.
  • a separate pump line segment is used to prevent line occlusion.
  • a separate line segment is not needed and the non-stick medical tube of the present invention can be used as the pumping segment.
  • Figure 5 is a flow diagram of an exemplary method 500 for manufacturing a non-stick medical tube comprising a medical grade amide compound in accordance with embodiments of the present invention.
  • method 500 includes providing a first plastic resin to a tubing extrusion device.
  • the first resin includes a TPE resin or a PVC resin.
  • method 500 includes providing a second plastic resin to the tubing extrusion device, the second plastic resin comprising a medical grade amide compound and in one embodiment, a carrier compound.
  • the carrier compound includes polypropylene, polyethylene, or any other plastic resin.
  • the percentage of weight of the amide compound can be between 1% and 25% of the second resin.
  • method 500 includes mixing the first plastic resin with the second plastic resin.
  • the percentage of weight of the amide compound can be between .1 % and 5% of the mixture.
  • the first and second plastic resins are mixed and formed into pellet form so that both the first and second plastics are in a single pellet.
  • method 500 includes extruding the resin mixture such that the medical grade amide compound is present on an inner surface of the medical tube after extrusion to promote release of contacting surfaces of the inner surface of the medical tubing after contact.
  • non-stick medical tube of the present invention reduces lumen occlusion, improves patient safety and reduces costs.
  • non-stick medical tubing may be adapted to carry out the objects and obtain the ends and advantages mentioned, as well as those inherent therein.
  • the methods, procedures, and devices described herein are presently representative of embodiments and are exemplary and are not intended as limitations on the scope of the invention. Changes therein and other uses will occur to those skilled in the art which are encompassed within the spirit of the invention and are defined by the scope of the disclosure.
  • a method for manufacturing a non stick medical tube comprising:
  • a non-stick medical tubing comprising:
  • a plastic resin mixture including a first plastic resin component and a second plastic resin component, said second plastic resin comprising a medical grade amide compound, said plastic resin mixture extruded by an extruding apparatus such that said medical grade amide compound is present on an inner surface of said medical tube after extrusion to promote release of contacting surfaces of said inner surface of said medical tubing after contact.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

A method for manufacturing a non stick medical tube is provided. The method includes providing a first plastic resin to a tubing extrusion device and providing a second plastic resin to a tubing extrusion device, the second plastic resin comprising a medical grade amide compound. The method further includes mixing the first plastic resin with the second plastic resin and extruding the resin mixture such that the medical grade amide compound is present on an inner surface of the medical tube after extrusion to promote release of contacting surfaces of the inner surface of the medical tubing after contact.

Description

NON-STICK MEDICAL TUBING
Field
This technology relates generally to medical equipment. More particularly, the technology relates to medical tubing.
Background
Many times, medical tubing is clamped long and short term with devices such as hemostats, roller clamps and pinch clamps. One problem with clamping is that after the clamp is removed from the tubing, the inner walls of the tubing become stuck together and the opening is partially or fully occluded. The occluded line restricts or stops flow of fluids to the patient.
The appearance of tube occlusion makes clinicians pinch tubing and massage the kink out and when tubing still looks occluded, clinicians discard the existing tubing and start a new one. If the restriction is not identified, line occlusion could lead to improper administration of fluids to a patient. The sticking of tubing after clamping ultimately results in lost time, increased costs and possible patient harm. Summary
Embodiments here described include a method for manufacturing a non stick medical tube. The method includes providing a first plastic resin to a tubing extrusion device and providing a second plastic resin to a tubing extrusion device, the second plastic resin comprising a medical grade amide compound. The method further includes mixing the first plastic resin with the second plastic resin and extruding the resin mixture such that the medical grade amide compound is present on an inner surface of the medical tube after extrusion to promote release of contacting surfaces of the inner surface of the medical tubing after contact.
Embodiments here described also include a non-stick medical tubing. The medical tubing includes a plastic resin mixture including a first plastic resin component and a second plastic resin component, the second plastic resin comprising a medical grade amide compound. The plastic resin mixture is extruded by an extruding apparatus such that the medical grade amide compound is present on an inner surface of the medical tube after extrusion to promote release of contacting surfaces of the inner surface of the medical tubing after contact.
Brief Description of the Drawings
Features will become more apparent from the detailed description set forth below when taken in conjunction with the drawings in which like references identify corresponding parts throughout, and wherein:
Figure 1 shows a prior art medical tube with occlusion after to a clamping force has been applied.
Figure 2 shows an exemplary non-stick medical tube comprising a medical grade amide compound for preventing occlusion after a clamping force has been applied to the tube in accordance with embodiments of the present invention.
Figure 3 shows an exemplary system for extruding a non-stick medical tube comprising a medical grade amide compound for preventing occlusion in accordance with embodiments of the present invention.
Figure 4 shows an exemplary peristaltic pump with a non-stick medical tube comprising a medical grade amide compound for preventing occlusion in accordance with embodiments of the present invention. Figure 5 is a flow diagram of an exemplary method for manufacturing a nonstick medical tube comprising a medical grade amide compound in accordance with embodiments of the present invention.
Detailed Description of Embodiments
Certain embodiments of the invention will now be described in detail with reference to the figures.
Figure 1 shows a conventional prior art medical tube 100 having an outer surface 130 and an inner surface 110. After a clamping force 20 is applied to the tubing, the inner surfaces 110 of the tube 100 contact each other and become stuck together at occlusion 150.
The occlusion 150 can damage the tubing, requiring replacement and can also cause possible patient harm. Ultimately, time is lost, cost increase and patient safety is at risk with conventional medical tubing that can kink or stick together.
Embodiments of the present invention include a medical tube comprising a medical grade amide compound that is added to the material prior to or during extrusion to prevent lumen sticking and immediately opens up after a clamping force is applied to the tube. Embodiments of the present invention are well suited for preventing lumen occlusion after both short term and long term clamping. For example, embodiments of the present invention can prevent line sticking after a clamping force has been applied to a line for as long as 14 days. The non stick medical tubing of the present invention is also well suited to be used as the pumping section of a peristaltic pump. The tubing of the present invention is made in part from an amide compound that prevents sticking of the inner surfaces of the tube after they contact each other from clamping or kinking. Embodiments of the present invention are well suited to prevent line sticking after clamping for up to 14 days.
Figure 2 shows an exemplary non-stick medical tube 200 comprising a medical grade amide compound for preventing occlusion after a clamping force 250 has been applied to the tube in accordance with embodiments of the present invention.
The amide compound serves as a release agent that promotes release of contacting surfaces in the tube. For example, when clamping a tube, the opposing surfaces of the inner passageway contact each other and form an occlusion that blocks or reduces flow. With the non-stick medical tubing of the present invention, after the clamp is released, the contacting surfaces release and the occlusion frees and the tubing is restored to the original shape and function.
As opposed to the prior art medical tubing 100 of Figure 1 , the tubing of the present invention 200 does not stick and form an occlusion in the tube after the clamping force 250 is removed from the outer surface 230 of the tube 200. Figure 2 shows the inner surface 210 of the tube 200 does not stick and the inner diameter 280 of the tubing is restored after the clamping force 250 is removed from the tube. It is appreciated that although a medical grade amide compound is described as the release agent, other medical agents could be used. For example, any medical grade compound that reduces sticking of the line lumens and that can be integrated into the extrusion process could be used. One such compound is a medical grade wax.
One example of a suitable amide compound that can be used in accordance with the present invention is an amide fatty acid. An amide fatty acid is an unsaturated long chain carboxylic acid amide and can be found in both food and medical grade. One chemical formulation of an amide fatty acid in accordance with the present invention is C22H43NO.
Embodiments of the present invention include adding plastic resin containing an amide compound to the plastic resin used in tube extrusion. By mixing the amide compound into the plastic prior to extrusion, the amide compound is present on the inner tube surface and prevents lumen sticking and lumen occlusions.
In one embodiment of the invention, the base material for the tubing is thermoplastic elastomer (TPE) resin. A secondary material comprising an amide compound is added to the TPE prior to the extrusion process to reduce lumen occlusion and kinking. In one embodiment, all materials of the tubing are formed into pellets prior to extrusion. In one embodiment, a single pellet comprises the mixture of primary (TPE) and secondary (amide fatty acid) materials.
Figure 3 shows an exemplary system 300 for extruding a non-stick medical tube comprising a medical grade amide compound for preventing occlusion in accordance with embodiments of the present invention.
Resin A 302 and resin B 304 enter a hopper/mixer 306. In one embodiment, resin A 302 is a thermoplastic elastomer (TPE) resin. In another embodiment, resin A is a polyvinylchloride (PVC), polyurethane or any other plastic resin. In one embodiment of the invention, the resin is delivered to hopper/mixer 306 in pellet form. In one embodiment, resin A and resin B are both part of a homogeneous pellet mixture where a single pellet comprises both resin A 302 and resin B 304.
Resin B 304 included an amide compound and in one embodiment, a carrier compound. Since the amide compound may have different physical properties from the resin A 302, a carrier compound can be mixed with the amide compound to prevent problems during extrusion. The carrier compound aids in mixing of the amide compound with the TPE or PVC. In one embodiment, the carrier compound includes polypropylene, polyethylene, or any other plastic resin. In one embodiment, a specific ratio of amide compound to carrier compound is used to achieve a predetermined amount of amide compound in the extruded tubing. In one embodiment, the percentage of weight of the amide compound can be between .3% and 5% of the tube material after extrusion. In one embodiment, the percentage of weight of the amide compound can be between 1 % and 25% of resin B 304.
Resin A 302 and resin B 304 are mixed in hopper 306. The amount of resin A 302 and resin B 304 that enter the hopper/mixer 306 is determined based on the final desired concentration of the amide compound in the tubing. The final concentration depends on the starting concentration of the amide compound in resin B 304 as well as other factors. In one embodiment, a mixture of resin A and resin B is provided in a single pellet whereby the hopper 306 receives a homogeneous mixture of pellets that have both resin A and resin B in them. The ratio of resin A to resin B can be modified to achieve different tube characteristics.
Once the desired mixture of resin A 302 and resin B 304 is determined and provided to hopper/mixer 306, the mixture of resin A 302 and resin B 304 enters the extruder 310. In one embodiment, altering configuration of the extruder 310 can modify the final concentration of the amide compound in the tubing.
For example, altering the extrusion process can modify the concentration of amide compound in the extruded tube. Some processes may facilitate heavier concentration of the amide at different locations of the tube. For example, localized heating during the extrusion process can form higher concentrations of the amide compound on the inner walls of the tube compared to the outer surface of the tube.
The non-stick medical tubing 200 of the present invention exits the extruder. In one embodiment, subsequent operations may be performed on the tubing to facilitate blooming of amide compound to the inner tube walls. Sterilization may also be performed after extrusion.
The non-stick tubing of the present invention does not stick and immediately opens up for fluid flow after short term and long term clamping. One example of short term clamping is the action of a peristaltic pump. In a peristaltic pump, a line segment (tube) is squeezed in a linear motion to create a pumping force. The squeezing can cause lumen sticking. The non-stick medical tubing 200 of the present invention is well suited to be used as the pump segment in a peristaltic pump.
Figure 4 shows an exemplary peristaltic pump 402 with a non-stick medical tube 200 comprising a medical grade amide compound for preventing occlusion in accordance with embodiments of the present invention. In conventional peristaltic pumps, a separate pump line segment is used to prevent line occlusion. With the non-stick medical tubing of the present invention, a separate line segment is not needed and the non-stick medical tube of the present invention can be used as the pumping segment. Figure 5 is a flow diagram of an exemplary method 500 for manufacturing a non-stick medical tube comprising a medical grade amide compound in accordance with embodiments of the present invention.
At 502, method 500 includes providing a first plastic resin to a tubing extrusion device. In one embodiment, the first resin includes a TPE resin or a PVC resin.
At 504, method 500 includes providing a second plastic resin to the tubing extrusion device, the second plastic resin comprising a medical grade amide compound and in one embodiment, a carrier compound. In one embodiment, the carrier compound includes polypropylene, polyethylene, or any other plastic resin. In one embodiment, the percentage of weight of the amide compound can be between 1% and 25% of the second resin.
At 530, method 500 includes mixing the first plastic resin with the second plastic resin. In one embodiment, the percentage of weight of the amide compound can be between .1 % and 5% of the mixture. In one embodiment, the first and second plastic resins are mixed and formed into pellet form so that both the first and second plastics are in a single pellet. At 540, method 500 includes extruding the resin mixture such that the medical grade amide compound is present on an inner surface of the medical tube after extrusion to promote release of contacting surfaces of the inner surface of the medical tubing after contact.
CONCLUSION
Thus, those of skill in the art will appreciate that the non-stick medical tube of the present invention reduces lumen occlusion, improves patient safety and reduces costs.
One skilled in the art will appreciate that the non-stick medical tubing may be adapted to carry out the objects and obtain the ends and advantages mentioned, as well as those inherent therein. The methods, procedures, and devices described herein are presently representative of embodiments and are exemplary and are not intended as limitations on the scope of the invention. Changes therein and other uses will occur to those skilled in the art which are encompassed within the spirit of the invention and are defined by the scope of the disclosure.
It will be apparent to one skilled in the art that varying substitutions and modifications may be made to the invention disclosed herein without departing from the scope and spirit of the invention. Those skilled in the art recognize that the aspects and embodiments of the invention set forth herein may be practiced separate from each other or in
conjunction with each other. Therefore, combinations of separate embodiments are within the scope of the invention as disclosed herein.
The invention illustratively described herein suitably may be practiced in the absence of any element or elements, limitation or limitations which are not specifically disclosed herein. Thus, for example, in each instance herein any of the terms "comprising", "consisting essentially of and "consisting of may be replaced with either of the other two terms. The terms and expressions which have been employed are used as terms of description and not of limitation, and there is no intention that in the use of such terms and expressions indicates the exclusion of equivalents of the features shown and described or portions thereof. It is recognized that various modifications are possible within the scope of the invention disclosed. Thus, it should be understood that although the present invention has been specifically disclosed by embodiments and optional features, modification and variation of the concepts herein disclosed may be resorted to by those skilled in the art, and that such modifications and variations are considered to be within the scope of this invention as defined by the disclosure.
All elements, parts and steps described herein are preferably included. It is to be understood that any of these elements, parts and steps may be replaced by other elements, parts and steps or deleted altogether as will be obvious to those skilled in the art.
CONCEPTS
This writing has disclosed at least the following concepts.
Concept 1. A method for manufacturing a non stick medical tube comprising:
providing a first plastic resin to a tubing extrusion device;
providing a second plastic resin to said tubing extrusion device, said second plastic resin comprising a medical grade amide compound;
mixing said first plastic resin with said second plastic resin;
extruding the resin mixture such that said medical grade amide compound is present on an inner surface of said medical tube after extrusion to promote release of contacting surfaces of said inner surface of said medical tubing after contact.
Concept 2. The method of Concept 1 wherein said mixing is configured such that said medical grade amide compound is between .3% and 5% of said medical tubing.
Concept 3. The method of Concept 1 wherein said first plastic resin is a thermoplastic elastomer resin.
Concept 4. The method of Concept 1 wherein said first plastic resin is a Poly Vinyl Chloride (PVC) resin.
Concept 5. The method of Concept 1 wherein said medical grade amide compound comprises an amide fatty acid. Concept 6. The method of Concept 1 wherein said medical grade amide compound comprises medical grade wax.
Concept 7. The method of Concept 1 wherein said carrier compound comprises polypropylene. .
Concept 8. The method of Concept 1 wherein said carrier compound comprises polyethylene. .
Concept 9. The method of Concept 1 wherein said medical grade amide compound comprises between 10% and 25% of said second plastic resin.
Concept 10. The method of Concept 1 wherein said extruding comprises:
heating a portion of said tubing to facilitate migration of said medical grade amide compound to an inner portion of said medical tubing such that more said medical grade amide compound is located on the inner surface of the tubing than an outer surface of the tubing.
Concept 11. A non-stick medical tubing comprising:
a plastic resin mixture including a first plastic resin component and a second plastic resin component, said second plastic resin comprising a medical grade amide compound, said plastic resin mixture extruded by an extruding apparatus such that said medical grade amide compound is present on an inner surface of said medical tube after extrusion to promote release of contacting surfaces of said inner surface of said medical tubing after contact.
Concept 12. The non-stick medical tubing of Concept 10 wherein said medical grade amide compound is between .3% and 5% of the medical tubing.
Concept 13. The non-stick medical tubing of Concept 10 wherein said first plastic resin is a thermoplastic elastomer resin.
Concept 14. The non-stick medical tubing of Concept 10 wherein said first plastic resin is a Poly Vinyl Chloride (PVC) resin.
Concept 15. The non-stick medical tubing of Concept 10 wherein said medical grade amide compound comprises erucamide.
Concept 6. The non-stick medical tubing of Concept 10 wherein said medical grade amide compound comprises medical grade wax.
Concept 17. The non-stick medical tubing of Concept 10 wherein said carrier compound comprises polypropylene. . Concept 18. The non-stick medical tubing of Concept 10 wherein said carrier compound comprises polyethylene.
Concept 19. The non-stick medical tubing of Concept 10 wherein said medical grade amide compound comprises between 10% and 25% of said second plastic resin.
Concept 20. The non-stick medical tubing of Concept 10 wherein said non-stick medical tubing is used in a peristaltic pump as a pumping segment.

Claims

WHAT IS CLAIMED IS:
1. A method for manufacturing a non stick medical tube comprising:
providing a first plastic resin to a tubing extrusion device;
providing a second plastic resin to said tubing extrusion device, said second plastic resin comprising a medical grade amide compound;
mixing said first plastic resin with said second plastic resin;
extruding the resin mixture such that said medical grade amide compound is present on an inner surface of said medical tube after extrusion to promote release of contacting surfaces of said inner surface of said medical tubing after contact.
2. The method of Claim 1 wherein said mixing is configured such that said medical grade amide compound is between .3% and 5% of said medical tubing.
3. The method of Claim 1 wherein said first plastic resin is a thermoplastic elastomer resin.
4. The method of Claim 1 wherein said first plastic resin is a Poly Vinyl Chloride (PVC) resin.
5. The method of Claim 1 wherein said medical grade amide compound comprises an amide fatty acid.
6. The method of Claim 1 wherein said medical grade amide compound comprises medical grade wax.
7. The method of Claim 1 wherein said carrier compound comprises
polypropylene. .
8. The method of Claim 1 wherein said carrier compound comprises
polyethylene. .
9. The method of Claim 1 wherein said medical grade amide compound comprises between 10% and 25% of said second plastic resin.
10. The method of Claim 1 wherein said extruding comprises:
heating a portion of said tubing to facilitate migration of said medical grade amide compound to an inner portion of said medical tubing such that more said medical grade amide compound is located on the inner surface of the tubing than an outer surface of the tubing.
11. A non-stick medical tubing comprising:
a plastic resin mixture including a first plastic resin component and a second plastic resin component, said second plastic resin comprising a medical grade amide compound, said plastic resin mixture extruded by an extruding apparatus such that said medical grade amide compound is present on an inner surface of said medical tube after extrusion to promote release of contacting surfaces of said inner surface of said medical tubing after contact.
12. The non-stick medical tubing of Claim 10 wherein said medical grade amide compound is between .3% and 5% of the medical tubing.
13. The non-stick medical tubing of Claim 10 wherein said first plastic resin is a thermoplastic elastomer resin.
14. The non-stick medical tubing of Claim 10 wherein said first plastic resin is a Poly Vinyl Chloride (PVC) resin.
15. The non-stick medical tubing of Claim 10 wherein said medical grade amide compound comprises erucamide.
16. The non-stick medical tubing of Claim 10 wherein said medical grade amide compound comprises medical grade wax.
17. The non-stick medical tubing of Claim 10 wherein said carrier compound comprises polypropylene. .
18. The non-stick medical tubing of Claim 10 wherein said carrier compound comprises polyethylene. .
19. The non-stick medical tubing of Claim 10 wherein said medical grade amide compound comprises between 10% and 25% of said second plastic resin.
20. The non-stick medical tubing of Claim 10 wherein said non-stick medical tubing is used in a peristaltic pump as a pumping segment.
PCT/US2011/050736 2010-09-10 2011-09-07 Non-stick medical tubing Ceased WO2012033865A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2011299250A AU2011299250A1 (en) 2010-09-10 2011-09-07 Non-stick medical tubing

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/880,036 2010-09-10
US12/880,036 US8337734B2 (en) 2010-09-10 2010-09-10 Non-stick medical tubing

Publications (2)

Publication Number Publication Date
WO2012033865A2 true WO2012033865A2 (en) 2012-03-15
WO2012033865A3 WO2012033865A3 (en) 2012-06-07

Family

ID=45806974

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/050736 Ceased WO2012033865A2 (en) 2010-09-10 2011-09-07 Non-stick medical tubing

Country Status (4)

Country Link
US (2) US8337734B2 (en)
AU (1) AU2011299250A1 (en)
TW (1) TW201217009A (en)
WO (1) WO2012033865A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD737429S1 (en) * 2012-06-13 2015-08-25 Vijay A. Doraiswamy Medical tube with radio-opaque double helix indicia
JP6681212B2 (en) * 2015-11-30 2020-04-15 株式会社潤工社 Poly-Urethane-Tube

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3645822A (en) * 1969-01-31 1972-02-29 Dow Chemical Co Method for providing multilayer films having improved slip properties
US3821179A (en) * 1972-09-06 1974-06-28 Du Pont Ionic ethylene copolymers containing slip/block additives
US4198983A (en) * 1978-04-28 1980-04-22 Baxter Travenol Laboratories, Inc. Catheter made of a thermoplastic material having improved softness and low friction
US4510281A (en) * 1981-05-26 1985-04-09 E. I. Du Pont De Nemours And Company Tack-free polymer pellets
CA1207489A (en) * 1982-03-16 1986-07-08 Kazuhiko Kanki Resin composition suitable for use in medical devices
US4707389A (en) * 1983-09-30 1987-11-17 Baxter Travenol Laboratories, Inc. Multilayer tube, assembly and method
JPS61266438A (en) * 1985-05-21 1986-11-26 Shin Etsu Chem Co Ltd Method for manufacturing vinyl chloride resin molded products with modified surface properties
US4751262A (en) * 1985-09-03 1988-06-14 The Dow Chemical Company Ethylene-acrylic acid type interpolymer compositions and films having increased slip and reduced block
US5533992A (en) 1990-12-31 1996-07-09 Patel; Indrajit Material for medical grade products and products made therefrom
EP0664716B1 (en) * 1992-10-19 1998-08-05 E.I. Du Pont De Nemours And Company Flexible non-pvc articles
US5614297A (en) * 1994-05-19 1997-03-25 Viskase Corporation Polyolefin stretch film
US5932307A (en) * 1996-05-03 1999-08-03 Baxter International Inc. Oriented medical tubing
US6524694B1 (en) * 1997-06-13 2003-02-25 Polyone Corporation Compositions for imparting a translucent optical effect to transparent thermoplastic polymers
US6497965B1 (en) * 1997-10-09 2002-12-24 Applied Extrusion Technologies, Inc. Slip agents and polypropylene films prepared therefrom
US6673053B2 (en) 1999-05-07 2004-01-06 Scimed Life Systems, Inc. Hydrophilic lubricity coating for medical devices comprising an antiblock agent
EP1123715B1 (en) 2000-01-07 2004-04-28 Nipro Corporation Non-sticky medical tubing
US6595950B1 (en) * 2000-05-11 2003-07-22 Zevex, Inc. Apparatus and method for preventing free flow in an infusion line
US20020104544A1 (en) * 2000-11-30 2002-08-08 Kuraray Co., Ltd. Endotracheal tube
US6652942B2 (en) * 2001-01-08 2003-11-25 Baxter International Inc. Assembly for a flowable material container
DE10220409B4 (en) * 2002-05-08 2006-03-02 Raumedic Ag Use of a catheter tube
US6825255B2 (en) * 2003-05-01 2004-11-30 Solutia Incorporated Polyvinyl butyral sheet having antiblocking characteristics
US7411129B2 (en) * 2004-07-13 2008-08-12 Southwire Company Electrical cable having a surface with reduced coefficient of friction
US7416767B2 (en) 2004-09-30 2008-08-26 Graphic Packaging International, Inc. Anti-blocking coatings for PVdc-coated substrates
SG156632A1 (en) 2004-11-26 2009-11-26 Mitsui Chemicals Inc Medical tube
US20060235118A1 (en) * 2005-04-18 2006-10-19 Selby Larry M Antiblock additives for monovinylarene-conjugated diene block copolymers
ATE376274T1 (en) * 2006-03-15 2007-11-15 Nexans ELECTRICAL LINE
US8286667B2 (en) * 2008-04-03 2012-10-16 A.I. Innovations, N.V. Prevention of bacterial adhesion irrigation conduits
US20100010175A1 (en) * 2008-07-08 2010-01-14 Fina Technology, Inc. Additives for Polyolefin Extruder Start-Up
US8101685B2 (en) * 2008-12-15 2012-01-24 Exxonmobil Chemical Patents Inc. Thermoplastic elastomer polyolefin in-reactor blends and molded articles therefrom
US20110026889A1 (en) * 2009-07-31 2011-02-03 Draka Comteq B.V. Tight-Buffered Optical Fiber Unit Having Improved Accessibility
US8661578B2 (en) * 2009-09-15 2014-03-04 Wy'east Medical Corporation Patient transfer tube and method for manufacturing the same

Also Published As

Publication number Publication date
AU2011299250A1 (en) 2013-03-14
TW201217009A (en) 2012-05-01
US20130072873A1 (en) 2013-03-21
US9072826B2 (en) 2015-07-07
US8337734B2 (en) 2012-12-25
US20120064267A1 (en) 2012-03-15
WO2012033865A3 (en) 2012-06-07

Similar Documents

Publication Publication Date Title
JP3259267B2 (en) Chemical injection device
JP6561064B2 (en) Antibacterial insert for medical devices
CN100510399C (en) Tube for peristaltic pump and method for manufacturing deformable tube by extrusion
US20200269011A1 (en) Catheters with bevelled drainage holes
CN105237906A (en) High-resilience antibacterial medical polyvinyl chloride (PVC) plastic and preparation method thereof
JP2009144167A (en) Medical tubing produced from polybutadiene
JPS6159146B2 (en)
KR20090005320A (en) Medical tube
US9072826B2 (en) Non-stick medical tubing
JP2025170169A (en) Continuous tube with alternating compositions for medical devices - Patent Application 20070122999
US20100327477A1 (en) Method for Manufacturing a Separated Tip Catheter
JPH0523398A (en) catheter
CN111655761A (en) Alcohol-resistant siliconized polycarbonate urethane and medical devices incorporating the same
JP2003190274A (en) Manufacturing method of medical tubing
JP7847699B2 (en) Needle-free access connector with antimicrobial-resistant valve
JPH05137778A (en) Medical appliance
EP4482555B1 (en) Securement device, kit comprising securement device, and method of securing securement device on skin of user
DE10139168B4 (en) Use of a material in a device for use in dialysis
JP2004187817A (en) Infusion tube
JP2003164517A (en) Medical tube
Jordan Conversion of polymers–properties and processing
JPS6255427B2 (en)

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11824090

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2011299250

Country of ref document: AU

Date of ref document: 20110907

Kind code of ref document: A

122 Ep: pct application non-entry in european phase

Ref document number: 11824090

Country of ref document: EP

Kind code of ref document: A2