WO2012016242A3 - Systems and methods for segmentation and processing of tissue images and feature extraction from same for treating, diagnosing, or predicting medical conditions - Google Patents

Systems and methods for segmentation and processing of tissue images and feature extraction from same for treating, diagnosing, or predicting medical conditions Download PDF

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Publication number
WO2012016242A3
WO2012016242A3 PCT/US2011/046149 US2011046149W WO2012016242A3 WO 2012016242 A3 WO2012016242 A3 WO 2012016242A3 US 2011046149 W US2011046149 W US 2011046149W WO 2012016242 A3 WO2012016242 A3 WO 2012016242A3
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WO
WIPO (PCT)
Prior art keywords
diagnosing
segmentation
treating
methods
processing
Prior art date
Application number
PCT/US2011/046149
Other languages
French (fr)
Other versions
WO2012016242A2 (en
Inventor
Peter Ajemba
Yousef Al-Kofahi
Michael Donovan
Gerardo Fernandez
Faisal Khan
Qiuhua Liu
Janakiramanan Ramachandran
Marina Sapir
Richard Scott
Jack Zeineh
Original Assignee
Aureon Biosciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority to US40064210P priority Critical
Priority to US40065710P priority
Priority to US61/400,642 priority
Priority to US61/400,657 priority
Priority to US45600910P priority
Priority to US45598810P priority
Priority to US61/456,009 priority
Priority to US61/455,988 priority
Application filed by Aureon Biosciences, Inc. filed Critical Aureon Biosciences, Inc.
Publication of WO2012016242A2 publication Critical patent/WO2012016242A2/en
Publication of WO2012016242A3 publication Critical patent/WO2012016242A3/en

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    • GPHYSICS
    • G06COMPUTING; CALCULATING; COUNTING
    • G06KRECOGNITION OF DATA; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K9/00Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
    • G06K9/00127Acquiring and recognising microscopic objects, e.g. biological cells and cellular parts
    • G06K9/00147Matching; Classification
    • GPHYSICS
    • G06COMPUTING; CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T5/00Image enhancement or restoration
    • G06T5/007Dynamic range modification
    • G06T5/008Local, e.g. shadow enhancement
    • GPHYSICS
    • G06COMPUTING; CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection
    • G06T7/0012Biomedical image inspection
    • GPHYSICS
    • G06COMPUTING; CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/10Segmentation; Edge detection
    • G06T7/11Region-based segmentation
    • GPHYSICS
    • G06COMPUTING; CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/10Segmentation; Edge detection
    • G06T7/155Segmentation; Edge detection involving morphological operators
    • GPHYSICS
    • G06COMPUTING; CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/40Analysis of texture
    • G06T7/41Analysis of texture based on statistical description of texture
    • G06T7/45Analysis of texture based on statistical description of texture using co-occurrence matrix computation
    • GPHYSICS
    • G06COMPUTING; CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10056Microscopic image
    • GPHYSICS
    • G06COMPUTING; CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/20Special algorithmic details
    • G06T2207/20036Morphological image processing
    • G06T2207/20041Distance transform
    • GPHYSICS
    • G06COMPUTING; CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/20Special algorithmic details
    • G06T2207/20212Image combination
    • GPHYSICS
    • G06COMPUTING; CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30024Cell structures in vitro; Tissue sections in vitro

Abstract

Apparatus, methods, and computer-readable media are provided for segmentation, processing (e.g., preprocessing and/or postprocessing), and/or feature extraction from tissue images such as, for example, images of nuclei and/or cytoplasm. Tissue images processed by various embodiments described herein may be generated by Hematoxylin and Eosin (H&E) staining, immunofluorescence (IF) detection, immunohistochemistry (IHC), similar and/or related staining processes, and/or other processes. Predictive features described herein may be provided for use in, for example, one or more predictive models for treating, diagnosing, and/or predicting the occurrence (e.g., recurrence) of one or more medical conditions such as, for example, cancer or other types of disease.
PCT/US2011/046149 2010-07-30 2011-08-01 Systems and methods for segmentation and processing of tissue images and feature extraction from same for treating, diagnosing, or predicting medical conditions WO2012016242A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US40064210P true 2010-07-30 2010-07-30
US40065710P true 2010-07-30 2010-07-30
US61/400,642 2010-07-30
US61/400,657 2010-07-30
US45598810P true 2010-10-28 2010-10-28
US45600910P true 2010-10-28 2010-10-28
US61/456,009 2010-10-28
US61/455,988 2010-10-28

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP14160371.2A EP2779089B1 (en) 2010-07-30 2011-08-01 Systems and methods for segmentation and processing of tissue images and feature extraction from same for treating, diagnosing, or predicting medical conditions
CA2807144A CA2807144C (en) 2010-07-30 2011-08-01 Systems and methods for segmentation and processing of tissue images and feature extraction from same for treating, diagnosing, or predicting medical conditions
EP11749618.2A EP2599055A2 (en) 2010-07-30 2011-08-01 Systems and methods for segmentation and processing of tissue images and feature extraction from same for treating, diagnosing, or predicting medical conditions
US13/754,097 US9286505B2 (en) 2010-07-30 2013-01-30 Systems and methods for segmentation and processing of tissue images and feature extraction from same for treating, diagnosing, or predicting medical conditions
US14/981,352 US9754152B2 (en) 2010-07-30 2015-12-28 Systems and methods for segmentation and processing of tissue images and feature extraction from same for treating, diagnosing, or predicting medical conditions
US15/660,727 US9971931B2 (en) 2010-07-30 2017-07-26 Systems and methods for segmentation and processing of tissue images and feature extraction from same for treating, diagnosing, or predicting medical conditions

Related Child Applications (1)

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US13/754,097 Continuation US9286505B2 (en) 2010-07-30 2013-01-30 Systems and methods for segmentation and processing of tissue images and feature extraction from same for treating, diagnosing, or predicting medical conditions

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WO2012016242A3 true WO2012016242A3 (en) 2012-05-18

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US (3) US9286505B2 (en)
EP (2) EP2779089B1 (en)
CA (3) CA3048769A1 (en)
ES (1) ES2711196T3 (en)
PT (1) PT2779089T (en)
WO (1) WO2012016242A2 (en)

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WO2012016242A2 (en) 2012-02-02
EP2779089A2 (en) 2014-09-17
EP2779089A3 (en) 2014-12-31
EP2599055A2 (en) 2013-06-05
ES2711196T3 (en) 2019-04-30
PT2779089T (en) 2019-02-19
CA2807144A1 (en) 2012-02-02
US9754152B2 (en) 2017-09-05
EP2779089B1 (en) 2018-11-14
US9971931B2 (en) 2018-05-15
US20160188954A1 (en) 2016-06-30
CA3010836C (en) 2020-09-08
CA3010836A1 (en) 2012-02-02
CA2807144C (en) 2019-05-28
US9286505B2 (en) 2016-03-15
US20130230230A1 (en) 2013-09-05
CA3048769A1 (en) 2012-02-02
US20180025212A1 (en) 2018-01-25

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