WO2012009703A3 - Targeted nanoparticles for cancer and other disorders - Google Patents

Targeted nanoparticles for cancer and other disorders Download PDF

Info

Publication number
WO2012009703A3
WO2012009703A3 PCT/US2011/044288 US2011044288W WO2012009703A3 WO 2012009703 A3 WO2012009703 A3 WO 2012009703A3 US 2011044288 W US2011044288 W US 2011044288W WO 2012009703 A3 WO2012009703 A3 WO 2012009703A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
disorders
targeted nanoparticles
viral particles
engineered
Prior art date
Application number
PCT/US2011/044288
Other languages
French (fr)
Other versions
WO2012009703A2 (en
Inventor
Frederick L. Hall
Erlinda M. Gordon
Original Assignee
Epeius Biotechnologies Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epeius Biotechnologies Corporation filed Critical Epeius Biotechnologies Corporation
Priority to CA2805643A priority Critical patent/CA2805643A1/en
Priority to EP11807610.8A priority patent/EP2593118A2/en
Priority to AU2011278931A priority patent/AU2011278931A1/en
Priority to JP2013519868A priority patent/JP2013541497A/en
Publication of WO2012009703A2 publication Critical patent/WO2012009703A2/en
Publication of WO2012009703A3 publication Critical patent/WO2012009703A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13071—Demonstrated in vivo effect
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
    • C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
    • C12N2810/857—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from blood coagulation or fibrinolysis factors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Targeted gene therapeutic systems are provided for the treatment of cancer, including viral particles. The viral particles are engineered to specifically deliver therapeutic or diagnostic agents to a disease site, such as cancer metastatic sites. Localized dosing regimens are provided to treat diseases such as cancer.
PCT/US2011/044288 2010-07-16 2011-07-15 Targeted nanoparticles for cancer and other disorders WO2012009703A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA2805643A CA2805643A1 (en) 2010-07-16 2011-07-15 Targeted nanoparticles for cancer and other disorders
EP11807610.8A EP2593118A2 (en) 2010-07-16 2011-07-15 Targeted nanoparticles for cancer and other disorders
AU2011278931A AU2011278931A1 (en) 2010-07-16 2011-07-15 Targeted nanoparticles for cancer and other disorders
JP2013519868A JP2013541497A (en) 2010-07-16 2011-07-15 Targeted nanoparticles for cancer and other disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36524010P 2010-07-16 2010-07-16
US61/365,240 2010-07-16

Publications (2)

Publication Number Publication Date
WO2012009703A2 WO2012009703A2 (en) 2012-01-19
WO2012009703A3 true WO2012009703A3 (en) 2013-08-08

Family

ID=45470113

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/044288 WO2012009703A2 (en) 2010-07-16 2011-07-15 Targeted nanoparticles for cancer and other disorders

Country Status (6)

Country Link
US (1) US20120027727A1 (en)
EP (1) EP2593118A2 (en)
JP (1) JP2013541497A (en)
AU (1) AU2011278931A1 (en)
CA (1) CA2805643A1 (en)
WO (1) WO2012009703A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014039533A2 (en) * 2012-09-04 2014-03-13 Eleison Pharmaceuticals, Llc Preventing pulmonary recurrence of cancer with lipid-complexed cisplatin
EP2958993B1 (en) 2013-02-22 2020-04-08 Case Western Reserve University Non-covalent loading of plant picornavirus particles
US10035009B2 (en) 2013-04-15 2018-07-31 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for treating pancreatic cancer
US9861726B2 (en) 2014-09-15 2018-01-09 Covidien Lp Coupling a body conduit to tissue
KR101943989B1 (en) 2015-06-05 2019-01-30 삼성전자주식회사 Method, server and terminal for transmitting and receiving data
EP3371221A2 (en) 2015-11-07 2018-09-12 MultiVir Inc. Methods and compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer
JP2020510624A (en) 2016-12-12 2020-04-09 マルチビア インコーポレイテッド Methods and compositions comprising viral gene therapy and immune checkpoint inhibitors for the treatment and prevention of cancer and infectious diseases
EP3576766A4 (en) * 2017-02-04 2020-11-18 Delta Next-Gene, LLC Cyclin g1 inhibitors and related methods of treating cancer
WO2020036635A2 (en) 2018-03-19 2020-02-20 Multivir Inc. Methods and compositions comprising tumor suppressor gene therapy and cd122/cd132 agonists for the treatment of cancer
WO2019199803A1 (en) * 2018-04-09 2019-10-17 Board Of Regents, The University Of Texas System Therapeutic targeting of oncogenes using exosomes
WO2020131951A1 (en) * 2018-12-17 2020-06-25 Gordon Erlinda M Methods of using rexin-g: a tumor-targeted retrovector encoding a dominant-negative cyclin g1 inhibitor for advanced pancreatic cancer
WO2021113644A1 (en) 2019-12-05 2021-06-10 Multivir Inc. Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer
WO2021222818A2 (en) * 2020-04-30 2021-11-04 Gordon Erlinda M Damage-targeted treatments of disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100016413A1 (en) * 2006-11-03 2010-01-21 Hall Frederick L Pathotropic targeted gene delivery system for cancer and other disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6825033B2 (en) * 2000-03-02 2004-11-30 University Of Southern California Mutated cyclin G1 protein
EP1619951B1 (en) * 2003-04-21 2011-06-22 Epeius Biotechnologies Corporation Methods and compositions for treating disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100016413A1 (en) * 2006-11-03 2010-01-21 Hall Frederick L Pathotropic targeted gene delivery system for cancer and other disorders

Also Published As

Publication number Publication date
AU2011278931A1 (en) 2013-03-07
JP2013541497A (en) 2013-11-14
EP2593118A2 (en) 2013-05-22
US20120027727A1 (en) 2012-02-02
WO2012009703A2 (en) 2012-01-19
CA2805643A1 (en) 2012-01-19

Similar Documents

Publication Publication Date Title
WO2012009703A3 (en) Targeted nanoparticles for cancer and other disorders
PH12019502269A1 (en) Quinazoline derivatives for the treatment of viral infections and further diseases
PH12017500023A1 (en) Targeted conjugates and particles and formulations thereof
WO2011017534A3 (en) Treatment of prostate cancer
WO2013110058A3 (en) Use of substituted hexitols including dianhydrogalactitol and analogs to treat neoplastic disease and cancer stem cells including glioblastoma multforme and medulloblastoma
WO2012062925A3 (en) Compounds and methods for treating pain
MX2013006591A (en) Controlled release oral dosage forms of poorly soluble drugs and uses thereof.
WO2008054826A3 (en) Pathotropic targeted gene delivery system for cancer and other disorders
WO2012045090A3 (en) Therapeutic use of a tlr agonist and combination therapy
MX360098B (en) Targeted conjugates encapsulated in particles and formulations thereof.
TW201129382A (en) Antibody formulation and therapeutic regimens
WO2013169864A3 (en) TETRAHYDRO[1,8]NAPHTHYRIDINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORƴ AND THE TREATMENT OF DISEASE
WO2012018948A3 (en) Combination therapy for the treatment of prostate carcinoma
WO2014167126A3 (en) Platform for targeted delivery to stem cells and tumor cells and uses thereof
WO2011041584A3 (en) Methods for modulation of autophagy through the modulation of autophagy-enhancing gene products
WO2012002760A3 (en) Method for treating and diagnosing cancer by using cell-derived microvesicles
WO2010042471A3 (en) Medical devices for delivery of therapeutic agents to body lumens
IL217467A (en) Aminopyridine derivatives for the treatment of tumours and inflammatory diseases, use thereof and medicaments comprising them
WO2011106788A3 (en) Car peptide for homing, diagnosis, & targeted therapy for pulmonary and fibrotic disorders
WO2013028942A8 (en) Targeting microbubbles
WO2012142615A3 (en) Auranofin and auranofin analogs useful to treat proliferative disease and disorders
WO2014036556A3 (en) Drug delivery systems and methods for treatment of prostate disease comprising gemicitabine
WO2011133957A3 (en) Devices for delivering neuro-electro-adaptive therapy (neat)
WO2010088527A3 (en) Peptides and nanoparticles for therapeutic and diagnostic applications
MX336761B (en) Compounds for treatment of cancer.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11807610

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 12013500080

Country of ref document: PH

ENP Entry into the national phase

Ref document number: 2013519868

Country of ref document: JP

Kind code of ref document: A

Ref document number: 2805643

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2011807610

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2011278931

Country of ref document: AU

Date of ref document: 20110715

Kind code of ref document: A