WO2012005898A3 - Chinese hamster ovary (cho) cell transcriptome, corresponding sirnas and uses thereof - Google Patents

Chinese hamster ovary (cho) cell transcriptome, corresponding sirnas and uses thereof Download PDF

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Publication number
WO2012005898A3
WO2012005898A3 PCT/US2011/040427 US2011040427W WO2012005898A3 WO 2012005898 A3 WO2012005898 A3 WO 2012005898A3 US 2011040427 W US2011040427 W US 2011040427W WO 2012005898 A3 WO2012005898 A3 WO 2012005898A3
Authority
WO
WIPO (PCT)
Prior art keywords
chinese hamster
hamster ovary
cho
cell transcriptome
corresponding sirnas
Prior art date
Application number
PCT/US2011/040427
Other languages
French (fr)
Other versions
WO2012005898A2 (en
Inventor
Anthony Rossomando
Stuart Pollard
John M. Maraganore
Greg Hinkle
Brian Bettencourt
Original Assignee
Alnylam Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals, Inc. filed Critical Alnylam Pharmaceuticals, Inc.
Publication of WO2012005898A2 publication Critical patent/WO2012005898A2/en
Publication of WO2012005898A3 publication Critical patent/WO2012005898A3/en

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Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/50—Mutagenesis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks

Abstract

The present invention provides a transcriptome of a Chinese hamster ovary cell comprising the genes expressed by the CHO cells and a set of siRNAs targeting these transcripts.
PCT/US2011/040427 2010-06-15 2011-06-15 Chinese hamster ovary (cho) cell transcriptome, corresponding sirnas and uses thereof WO2012005898A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35493210P 2010-06-15 2010-06-15
US61/354,932 2010-06-15

Publications (2)

Publication Number Publication Date
WO2012005898A2 WO2012005898A2 (en) 2012-01-12
WO2012005898A3 true WO2012005898A3 (en) 2014-04-03

Family

ID=45441711

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/040427 WO2012005898A2 (en) 2010-06-15 2011-06-15 Chinese hamster ovary (cho) cell transcriptome, corresponding sirnas and uses thereof

Country Status (1)

Country Link
WO (1) WO2012005898A2 (en)

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US9175291B2 (en) 2012-10-11 2015-11-03 Isis Pharmaceuticals Inc. Modulation of androgen receptor expression

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EP2831232A4 (en) 2012-03-30 2015-11-04 Univ Washington Methods for modulating tau expression for reducing seizure and modifying a neurodegenerative syndrome
JP6570447B2 (en) 2012-10-15 2019-09-04 アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． Composition for modulating C9ORF72 expression
EP2906697A4 (en) 2012-10-15 2016-06-22 Ionis Pharmaceuticals Inc Methods for monitoring c9orf72 expression
ES2807379T3 (en) 2013-03-14 2021-02-22 Ionis Pharmaceuticals Inc Compositions and methods to regulate the expression of Tau
TWI772856B (en) 2013-07-19 2022-08-01 美商百健Ｍａ公司 Compositions for modulating tau expression
EP4166667A3 (en) 2013-10-11 2023-08-02 Ionis Pharmaceuticals, Inc. Compositions for modulating c9orf72 expression
RS60762B1 (en) * 2015-04-03 2020-10-30 Univ Massachusetts Oligonucleotide compounds for targeting huntingtin mrna
ES2901455T3 (en) 2015-04-03 2022-03-22 Univ Massachusetts Oligonucleotide compounds for the treatment of preeclampsia and other angiogenic disorders
KR102104163B1 (en) 2015-04-16 2020-04-23 아이오니스 파마수티컬즈, 인코포레이티드 Composition for modulating C9ORF72 expression
US10633653B2 (en) 2015-08-14 2020-04-28 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
US11260073B2 (en) 2015-11-02 2022-03-01 Ionis Pharmaceuticals, Inc. Compounds and methods for modulating C90RF72
US10478503B2 (en) 2016-01-31 2019-11-19 University Of Massachusetts Branched oligonucleotides
WO2018031933A2 (en) 2016-08-12 2018-02-15 University Of Massachusetts Conjugated oligonucleotides
JOP20190065A1 (en) 2016-09-29 2019-03-28 Ionis Pharmaceuticals Inc Compounds and methods for reducing tau expression
WO2019070704A1 (en) * 2017-10-02 2019-04-11 Georgia Tech Research Corporation Methods and compositions for engineering synthetic bioswitches for remote control of biological activity
MX2020005939A (en) * 2017-12-08 2020-08-24 Synthetic Genomics Inc Improving algal lipid productivity via genetic modification of a tpr domain containing protein.
EP3775211B1 (en) * 2018-04-12 2023-04-05 MiNA Therapeutics Limited Sirt1-sarna compositions and methods of use
EP3833763A4 (en) 2018-08-10 2023-07-19 University of Massachusetts Modified oligonucleotides targeting snps
KR20210090660A (en) * 2018-11-13 2021-07-20 리피곤 파마슈티컬스 에이비 ANGPTL4 oligonucleotides affecting the regulation of fatty acid metabolism
KR20220033472A (en) * 2019-06-03 2022-03-16 큐랄리스 코포레이션 Oligonucleotides and methods of use for treating neurological disorders
WO2022271786A1 (en) 2021-06-23 2022-12-29 University Of Massachusetts Optimized anti-flt1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders
TW202334418A (en) * 2021-10-29 2023-09-01 美商艾拉倫製藥股份有限公司 Huntingtin (htt) irna agent compositions and methods of use thereof

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9175291B2 (en) 2012-10-11 2015-11-03 Isis Pharmaceuticals Inc. Modulation of androgen receptor expression

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WO2012005898A2 (en) 2012-01-12

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