WO2012000356A1 - Quinazoline compounds - Google Patents

Quinazoline compounds Download PDF

Info

Publication number
WO2012000356A1
WO2012000356A1 PCT/CN2011/074637 CN2011074637W WO2012000356A1 WO 2012000356 A1 WO2012000356 A1 WO 2012000356A1 CN 2011074637 W CN2011074637 W CN 2011074637W WO 2012000356 A1 WO2012000356 A1 WO 2012000356A1
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
pyrrole
yl
carboxamide
methylhexahydropyrrolo
Prior art date
Application number
PCT/CN2011/074637
Other languages
English (en)
French (fr)
Inventor
Weihan Zhang
Wei-Guo Su
Haibin Yang
Yumin Cui
Yongxin Ren
Xiaoqiang Yan
Original Assignee
Hutchison Medipharma Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CNPCT/CN2010/074792 priority Critical
Priority to PCT/CN2010/074792 priority patent/WO2012000182A1/en
Application filed by Hutchison Medipharma Limited filed Critical Hutchison Medipharma Limited
Priority claimed from CN 201180024971 external-priority patent/CN102906086B/zh
Priority claimed from TW100123269A external-priority patent/TWI466888B/zh
Publication of WO2012000356A1 publication Critical patent/WO2012000356A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
PCT/CN2011/074637 2010-06-30 2011-05-25 Quinazoline compounds WO2012000356A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CNPCT/CN2010/074792 2010-06-30
PCT/CN2010/074792 WO2012000182A1 (en) 2010-06-30 2010-06-30 Quinazoline compounds

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
AU2011274183A AU2011274183B2 (en) 2010-06-30 2011-05-25 Quinazoline compounds
BR112012033344A BR112012033344A2 (pt) 2010-06-30 2011-05-25 "compostos de quinazolina"
RS20160973A RS55470B1 (sr) 2010-06-30 2011-05-25 Hinazolinska jedinjenja
SG2012093779A SG186410A1 (en) 2010-06-30 2011-05-25 Quinazoline compounds
US13/807,460 US9168253B2 (en) 2010-06-30 2011-05-25 Quinazoline compounds
DK11800101.5T DK2590966T3 (en) 2010-06-30 2011-05-25 quinazoline
CN 201180024971 CN102906086B (zh) 2010-06-30 2011-05-25 喹唑啉化合物
LTEP11800101.5T LT2590966T (lt) 2010-06-30 2011-05-25 Chinazolino junginiai
ES11800101.5T ES2604929T3 (es) 2010-06-30 2011-05-25 Compuestos de quinazolina
MX2012015047A MX2012015047A (es) 2010-06-30 2011-05-25 Compuestos de quinazolina.
CA2801814A CA2801814C (en) 2010-06-30 2011-05-25 Quinazoline compounds
JP2013516973A JP5736452B2 (ja) 2010-06-30 2011-05-25 キナゾリン化合物
EP11800101.5A EP2590966B1 (en) 2010-06-30 2011-05-25 Quinazoline compounds
SI201131012A SI2590966T1 (sl) 2010-06-30 2011-05-25 Kinazolinske spojine
RU2012153174/04A RU2530887C2 (ru) 2010-06-30 2011-05-25 Соединения хиназолина
KR20137001865A KR101480481B1 (ko) 2010-06-30 2011-05-25 퀴나졸린 화합물
TW100123269A TWI466888B (en) 2011-05-25 2011-06-30 Quinazoline compounds
HK13107098.1A HK1179954A1 (en) 2010-06-30 2013-06-18 Quinazoline compounds
HRP20161490TT HRP20161490T1 (hr) 2010-06-30 2016-11-11 Spojevi kinazolina

Publications (1)

Publication Number Publication Date
WO2012000356A1 true WO2012000356A1 (en) 2012-01-05

Family

ID=45401313

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/CN2010/074792 WO2012000182A1 (en) 2010-06-30 2010-06-30 Quinazoline compounds
PCT/CN2011/074637 WO2012000356A1 (en) 2010-06-30 2011-05-25 Quinazoline compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/CN2010/074792 WO2012000182A1 (en) 2010-06-30 2010-06-30 Quinazoline compounds

Country Status (21)

Country Link
US (1) US9168253B2 (pt-PT)
EP (1) EP2590966B1 (pt-PT)
JP (1) JP5736452B2 (pt-PT)
KR (1) KR101480481B1 (pt-PT)
AU (1) AU2011274183B2 (pt-PT)
BR (1) BR112012033344A2 (pt-PT)
CA (1) CA2801814C (pt-PT)
DK (1) DK2590966T3 (pt-PT)
ES (1) ES2604929T3 (pt-PT)
HK (1) HK1179954A1 (pt-PT)
HR (1) HRP20161490T1 (pt-PT)
HU (1) HUE029801T2 (pt-PT)
LT (1) LT2590966T (pt-PT)
MX (1) MX2012015047A (pt-PT)
PL (1) PL2590966T3 (pt-PT)
PT (1) PT2590966T (pt-PT)
RS (1) RS55470B1 (pt-PT)
RU (1) RU2530887C2 (pt-PT)
SG (1) SG186410A1 (pt-PT)
SI (1) SI2590966T1 (pt-PT)
WO (2) WO2012000182A1 (pt-PT)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR092289A1 (es) 2011-11-14 2015-04-15 Sunshine Lake Pharma Co Ltd Derivados de aminoquinazolina y sus sales y metodos de uso
KR101957464B1 (ko) 2018-10-18 2019-03-12 대흥전력기술 주식회사 활선 상태에서 지상기기의 점검 및 누유 보수방법

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3989816A (en) 1975-06-19 1976-11-02 Nelson Research & Development Company Vehicle composition containing 1-substituted azacycloheptan-2-ones
US4444762A (en) 1980-04-04 1984-04-24 Nelson Research & Development Company Vehicle composition containing 1-substituted azacyclopentan-2-ones
CN101619043A (zh) * 2008-06-30 2010-01-06 和记黄埔医药(上海)有限公司 喹唑啉衍生物及其医药用途
WO2010002845A2 (en) 2008-06-30 2010-01-07 Hutchison Medipharma Enterprises Limited Quinazoline derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9718972D0 (en) * 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3989816A (en) 1975-06-19 1976-11-02 Nelson Research & Development Company Vehicle composition containing 1-substituted azacycloheptan-2-ones
US4444762A (en) 1980-04-04 1984-04-24 Nelson Research & Development Company Vehicle composition containing 1-substituted azacyclopentan-2-ones
CN101619043A (zh) * 2008-06-30 2010-01-06 和记黄埔医药(上海)有限公司 喹唑啉衍生物及其医药用途
WO2010002845A2 (en) 2008-06-30 2010-01-07 Hutchison Medipharma Enterprises Limited Quinazoline derivatives

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"Encyclopedia of Reagents for Organic Synthesis", 1995, JOHN WILEY AND SONS
L. FIESER; M. FIESER: "Fieser and Fieser 's Reagents for Organic Synthesis", 1994, JOHN WILEY AND SONS
R. LAROCK: "Comprehensive Organic Transformations", 1989, VCH PUBLISHERS
See also references of EP2590966A4 *
T.W. GREENE; P.G.M. WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY AND SONS

Also Published As

Publication number Publication date
US20130172373A1 (en) 2013-07-04
KR20130031358A (ko) 2013-03-28
HUE029801T2 (en) 2017-04-28
RU2012153174A (ru) 2014-08-10
EP2590966B1 (en) 2016-08-31
EP2590966A4 (en) 2014-01-15
SI2590966T1 (sl) 2016-12-30
PL2590966T3 (pl) 2017-05-31
KR101480481B1 (ko) 2015-01-09
WO2012000182A1 (en) 2012-01-05
HK1179954A1 (en) 2014-06-27
HRP20161490T1 (hr) 2016-12-16
RU2530887C2 (ru) 2014-10-20
LT2590966T (lt) 2016-11-25
EP2590966A1 (en) 2013-05-15
MX2012015047A (es) 2013-02-07
RS55470B1 (sr) 2017-04-28
SG186410A1 (en) 2013-01-30
ES2604929T3 (es) 2017-03-10
AU2011274183B2 (en) 2013-09-26
JP2013529653A (ja) 2013-07-22
CA2801814C (en) 2015-04-07
AU2011274183A1 (en) 2013-01-10
CA2801814A1 (en) 2012-01-05
BR112012033344A2 (pt) 2016-11-29
JP5736452B2 (ja) 2015-06-17
US9168253B2 (en) 2015-10-27
PT2590966T (pt) 2016-11-29
DK2590966T3 (en) 2016-12-19

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