WO2011132941A3 - Tf-bpb specifically binding to transcription factor - Google Patents

Tf-bpb specifically binding to transcription factor Download PDF

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Publication number
WO2011132941A3
WO2011132941A3 PCT/KR2011/002841 KR2011002841W WO2011132941A3 WO 2011132941 A3 WO2011132941 A3 WO 2011132941A3 KR 2011002841 W KR2011002841 W KR 2011002841W WO 2011132941 A3 WO2011132941 A3 WO 2011132941A3
Authority
WO
WIPO (PCT)
Prior art keywords
present
specifically binding
peptide binder
bipodal peptide
region
Prior art date
Application number
PCT/KR2011/002841
Other languages
French (fr)
Korean (ko)
Other versions
WO2011132941A2 (en
Inventor
전상용
김성현
박세호
김대진
이상헌
Original Assignee
광주과학기술원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 광주과학기술원 filed Critical 광주과학기술원
Priority to KR1020127023552A priority Critical patent/KR20130103301A/en
Publication of WO2011132941A2 publication Critical patent/WO2011132941A2/en
Publication of WO2011132941A3 publication Critical patent/WO2011132941A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to a TF-bipodal peptide binder specifically binding to TF, comprising: (a) a structure stabilizing region comprising parallel, antiparallel, or parallel and antiparallel amino acid strands in which an interstrand noncovalent bond is formed; and (b) a TF-target binding region I and a TF-target binding region II which bind respectively to both ends of the structure stabilizing region and comprise randomly selected n and m amino acids, respectively. The TF-bipodal peptide binder of the present invention shows a very low level (for example, nM level) of KD value (dissociation constant) to TF, thereby showing very high affinity to a TF target. The TF-bipodal peptide binder of the present invention has a medical use, can be used for in vivo molecular imaging and targeting for drug delivery, and also can be very usefully used as an escort molecule.
PCT/KR2011/002841 2010-04-20 2011-04-20 Tf-bpb specifically binding to transcription factor WO2011132941A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020127023552A KR20130103301A (en) 2010-04-20 2011-04-20 Tf-bpb specifically binding to transcription fator

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2010-0036601 2010-04-20
KR20100036601 2010-04-20

Publications (2)

Publication Number Publication Date
WO2011132941A2 WO2011132941A2 (en) 2011-10-27
WO2011132941A3 true WO2011132941A3 (en) 2012-05-10

Family

ID=44834647

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/002841 WO2011132941A2 (en) 2010-04-20 2011-04-20 Tf-bpb specifically binding to transcription factor

Country Status (2)

Country Link
KR (1) KR20130103301A (en)
WO (1) WO2011132941A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2909226A4 (en) * 2012-10-19 2016-04-13 Nat Res Council Canada Derivatives of collagen-binding hairpin peptides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5427908A (en) * 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US6914123B2 (en) * 2001-04-17 2005-07-05 Genentech, Inc. Hairpin peptides with a novel structural motif and methods relating thereto
KR20100044128A (en) * 2008-10-20 2010-04-29 광주과학기술원 Bipodal peptide binder

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5427908A (en) * 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US6914123B2 (en) * 2001-04-17 2005-07-05 Genentech, Inc. Hairpin peptides with a novel structural motif and methods relating thereto
KR20100044128A (en) * 2008-10-20 2010-04-29 광주과학기술원 Bipodal peptide binder

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
2010 KOREAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY ANNUAL INTERNATIONAL CONFERENCE POSTER SESSTION A-18-85, 17 May 2010 (2010-05-17), pages 153 *
BAGALKOT, V. ET AL.: "An aptamer doxorubicin physical conjugate as a novel targeted drug-delivery platform.", ANGEW. CHEM. INT. ED., vol. 45, 2006, pages 8149 - 8152 *
CLACKSON, T. ET AL.: "Making antibody fragments using phage display libraries.", NATURE, vol. 352, 15 August 1991 (1991-08-15), pages 624 - 628 *

Also Published As

Publication number Publication date
WO2011132941A2 (en) 2011-10-27
KR20130103301A (en) 2013-09-23

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