WO2011112983A3 - Psrp is a protective antigen against pneumococcal infection - Google Patents

Psrp is a protective antigen against pneumococcal infection Download PDF

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Publication number
WO2011112983A3
WO2011112983A3 PCT/US2011/028177 US2011028177W WO2011112983A3 WO 2011112983 A3 WO2011112983 A3 WO 2011112983A3 US 2011028177 W US2011028177 W US 2011028177W WO 2011112983 A3 WO2011112983 A3 WO 2011112983A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
amino acid
acid sequence
psrp
identity
seq id
Prior art date
Application number
PCT/US2011/028177
Other languages
French (fr)
Other versions
WO2011112983A2 (en )
Inventor
Carlos Orihuela
Original Assignee
The Board Of Regents Of The University Of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1275Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies

Abstract

Disclosed are method of inhibiting or preventing bacterial aggregation or biofilm formation that involve use of (a) an antibody or fragment thereof that binds to an epitope within an amino acid sequence selected from the group consisting of (i) an amino acid sequence that has at least 90% identity to SEQ ID NO: 1 (BR domain of PsrP), (ii) an amino acid sequence that has at least 90% identity to SEQ ID NO:2 (NR domain of SraP), and (iii) an amino acid sequence that has at least 90% identity to SEQ ID NO:3. These methods find particular application in the treatment or prevention of bacterial disease associated with bacterial aggregation, such as empyema and pneumococcal disease. Related kits, vaccines, and compositions are disclosed.
PCT/US2011/028177 2010-03-12 2011-03-11 Psrp is a protective antigen against pneumococcal infection WO2011112983A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US31350610 true 2010-03-12 2010-03-12
US61/313,506 2010-03-12

Publications (2)

Publication Number Publication Date
WO2011112983A2 true WO2011112983A2 (en) 2011-09-15
WO2011112983A3 true true WO2011112983A3 (en) 2012-01-19

Family

ID=44564157

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/028177 WO2011112983A3 (en) 2010-03-12 2011-03-11 Psrp is a protective antigen against pneumococcal infection

Country Status (1)

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WO (1) WO2011112983A3 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652448A (en) * 1982-10-07 1987-03-24 Molecular Genetics, Inc. Use of monoclonal antibodies against bacterial adhesins
WO2009143483A2 (en) * 2008-05-22 2009-11-26 The Board Of Regents Of The University Of Texas System PsrP IS A PROTECTIVE ANTIGEN AGAINST PNEUMOCOCCAL INFECTION

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652448A (en) * 1982-10-07 1987-03-24 Molecular Genetics, Inc. Use of monoclonal antibodies against bacterial adhesins
WO2009143483A2 (en) * 2008-05-22 2009-11-26 The Board Of Regents Of The University Of Texas System PsrP IS A PROTECTIVE ANTIGEN AGAINST PNEUMOCOCCAL INFECTION

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LLOYD ROSE ET AL.: 'Antibodies against PsrP, a novel Streptococcus pneumoniae adhesin, block adhesion and protect mice against Pneumococcal challenge.' THE JOURNAL OF INFECTIOUS DISEASES vol. 198, no. 3, 2008, ISSN 0022-1899 pages 375 - 383 *
POOJA SHIVSHANKAR ET AL.: 'The Streptococcus pneumoniae adhesin PsrP binds to Keratin 10 on lung cells.' MOLECULAR MICROBIOLOGY vol. 73, no. 4, 2009, ISSN 0950-382X pages 663 - 679 *

Also Published As

Publication number Publication date Type
WO2011112983A2 (en) 2011-09-15 application

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