WO2011102645A3 - An improved process for preparing telmisartan - Google Patents

An improved process for preparing telmisartan Download PDF

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Publication number
WO2011102645A3
WO2011102645A3 PCT/KR2011/001041 KR2011001041W WO2011102645A3 WO 2011102645 A3 WO2011102645 A3 WO 2011102645A3 KR 2011001041 W KR2011001041 W KR 2011001041W WO 2011102645 A3 WO2011102645 A3 WO 2011102645A3
Authority
WO
WIPO (PCT)
Prior art keywords
reaction
benzimidazole
methyl
preparing
improved
Prior art date
Application number
PCT/KR2011/001041
Other languages
French (fr)
Other versions
WO2011102645A2 (en
Inventor
Jung-Uk Choi
O-Jin Kwon
Jun-Sang Lee
Jae-Kyung Lim
Yoon-Seok Oh
Original Assignee
Dong Wha Pharm. Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR10-2010-0014346 priority Critical
Priority to KR1020100014346A priority patent/KR20110094751A/en
Application filed by Dong Wha Pharm. Co., Ltd. filed Critical Dong Wha Pharm. Co., Ltd.
Publication of WO2011102645A2 publication Critical patent/WO2011102645A2/en
Publication of WO2011102645A3 publication Critical patent/WO2011102645A3/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

The present invention relates to an improved process for preparing telmisartan from 4-methyl-6-(1-methyl-1H-benzimidazole-2-yl)-2-propyl-1H-benzimidazole and 2-[4-(bromomethyl)phenyl] benzoate by using condensation reaction and hydrolysis reaction wherein the condensation reaction is performed to prepare an intermediate by using mixed solvent of dimethyl sulfoxide and isopropanol as reaction solvent using dimethyl sulfoxide of 0.5~1.5 times and isopropanol of 1.5~4.5 times on the basis of the usage of 4-methyl-6-(1-methyl-1H-benzimidazole-2-yl)-2-prophyl-1H-benzimidazole and the hydrolysis reaction is performed to cause the reaction in mixed solvent of methanol of 7~9 times and purified water of 5~7 times on the basis of the intermediate. The process for preparing telmisartan according to the present invention provides a simple preparing process for mass production and improves a manufacturing yield with high purity by eliminating an additional process for removing an inorganic salt as a byproduct due to a base used in the condensation reaction and the hydrolysis reaction.
PCT/KR2011/001041 2010-02-17 2011-02-17 An improved process for preparing telmisartan WO2011102645A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR10-2010-0014346 2010-02-17
KR1020100014346A KR20110094751A (en) 2010-02-17 2010-02-17 An improved process for preparing telmisartan

Publications (2)

Publication Number Publication Date
WO2011102645A2 WO2011102645A2 (en) 2011-08-25
WO2011102645A3 true WO2011102645A3 (en) 2012-01-19

Family

ID=44483463

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/001041 WO2011102645A2 (en) 2010-02-17 2011-02-17 An improved process for preparing telmisartan

Country Status (2)

Country Link
KR (1) KR20110094751A (en)
WO (1) WO2011102645A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101607661B1 (en) * 2013-12-24 2016-03-31 주식회사 파마코스텍 A Novel Method for Preparing of Telmisartan

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005108375A1 (en) * 2004-05-11 2005-11-17 Cipla Limited Process for the preparation of telmisartan
WO2006044754A2 (en) * 2004-10-18 2006-04-27 Dr. Reddy's Laboratories Ltd. Process for preparing telmisartan
US20060276525A1 (en) * 2005-05-18 2006-12-07 Itai Adin Processes of preparing highly pure telmisartan form A, suitable for pharmaceutical compositions
US7501448B2 (en) * 2004-10-15 2009-03-10 Teva Pharmaceutical Industries, Ltd. Process for preparing telmisartan

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005108375A1 (en) * 2004-05-11 2005-11-17 Cipla Limited Process for the preparation of telmisartan
US7501448B2 (en) * 2004-10-15 2009-03-10 Teva Pharmaceutical Industries, Ltd. Process for preparing telmisartan
WO2006044754A2 (en) * 2004-10-18 2006-04-27 Dr. Reddy's Laboratories Ltd. Process for preparing telmisartan
US20060276525A1 (en) * 2005-05-18 2006-12-07 Itai Adin Processes of preparing highly pure telmisartan form A, suitable for pharmaceutical compositions

Also Published As

Publication number Publication date
KR20110094751A (en) 2011-08-24
WO2011102645A2 (en) 2011-08-25

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