WO2011076840A2 - Aerosol formulation for copd - Google Patents
Aerosol formulation for copd Download PDFInfo
- Publication number
- WO2011076840A2 WO2011076840A2 PCT/EP2010/070476 EP2010070476W WO2011076840A2 WO 2011076840 A2 WO2011076840 A2 WO 2011076840A2 EP 2010070476 W EP2010070476 W EP 2010070476W WO 2011076840 A2 WO2011076840 A2 WO 2011076840A2
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- WO
- WIPO (PCT)
- Prior art keywords
- composition according
- pharmaceutical composition
- solvent
- canister
- copd
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B7/00—Closing containers or receptacles after filling
- B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
Definitions
- the present invention relates to pharmaceutical aerosol solution formulations comprising glycopyrronium chloride, intended for use in pressurized metered dose inhalers.
- the invention further relates to use of such formulations in the prevention and therapy of respiratory disorders, including COPD.
- Glycopyrronium bromide also known as glycopyrrolate
- glycopyrrolate is a muscarinic M3 anticholinergic agent used to reduce salivation associated with administration of certain anaesthetics, and as adjunctive therapy for peptic ulcers. It has also been reported to be effective in the treatment of asthmatic symptoms (Hansel et al., Chest 2005; 128: 1974- 1979).
- WO 2005/107873 relates to the use of glycopyrrolate for the treatment of childhood asthma.
- WO 01/76575 discloses a controlled release formulation for pulmonary delivery of glycopyrrolate.
- the formulation is intended for use in treatment of respiratory disease, in particular chronic obstructive pulmonary disease (COPD).
- COPD chronic obstructive pulmonary disease
- the application focuses on dry powder formulations suitable for delivery by means of a dry powder inhaler (DPI).
- DPI dry powder inhaler
- glycopyrronium chloride is either clinically effective or capable of being formulated in a manner suitable for administration to patients with respiratory disease.
- the present inventors have observed that glycopyrronium chloride has several advantages over glycopyrronium bromide with respect to pharmaceutical formulations.
- glycopyrronium chloride has better solubility properties than glycopyrronium bromide, and it has also been found to have better compatibility with other active ingredients, especially with formoterol.
- the present invention provides a pharmaceutical composition
- a pharmaceutical composition comprising glycopyrronium chloride dissolved in an HFA propellant, an optional co-solvent, and an amount of acid sufficient to stabilize the glycopyrronium chloride. Additional pharmaceutically active ingredients may also be included.
- the invention provides a pressurized metered dose inhaler or other container suitable for aerosol delivery, comprising the pharmaceutical composition of the invention.
- the invention provides the use of pharmaceutical compositions as described herein for the therapeutic or palliative treatment or prevention of respiratory disease conditions, such as COPD.
- a solution formulation of glycopyrronium chloride in HFA propellant with ethanol as co-solvent was prepared and checked for stability after 3 months following storage under different conditions of temperature and humidity.
- One batch was stored under optimal conditions (refrigeration); the other batches were stored under accelerated degradation conditions of high temperature and humidity. Although the refrigerated batch remained stable over the 3 month period, the other batches degraded significantly over that time-span.
- glycopyrronmm chloride This is the first time that it has been attempted to formulate glycopyrronmm chloride in an aerosol solution.
- This simple aerosol solution formulation of glycopyrronmm chloride dissolved in propellant and co-solvent fails to meet the requirements for practical use, namely that it should be capable of being carried on the person without refrigeration and yet deliver consistent dosages of active ingredient.
- the present inventors were able to overcome these stability issues by inclusion of a specific amount of inorganic acid in the formulation.
- inclusion of an amount of 1M hydrochloric acid (HC1) in the range of 0.05-0.4 g/ ⁇ , preferably 0.1 -0.3 g/ ⁇ , more preferably 0.19-0.25 g/ ⁇ , optionally 0.21-0.23 ⁇ g/ ⁇ of the solution is sufficient to eliminate degradation of glycopyrronmm chloride over an extended period of non-optimal storage, thereby ensuring a consistent dose of glycopyrronmm chloride per actuation of the pMDI containing the solution formulation.
- Glycopyrronmm chloride chemically defined as 3- [(cyclopentylhydroxyphenylacetyl)oxy]-l , l-dimethylpyrrolidinium chloride, has two chiral centres corresponding to four potential different stereoisomers with configuration (3 ,2' )-, (3S,2'R)-, (3R,2'S)- and (3S,2'S)-.
- Glycopyrronmm chloride in the form of any of these pure enantiomers or diastereomers or any combination thereof may be used in practicing the present invention.
- the (3S,2'R),(3R,2'S)-3- [(cyclopentylhydroxyphenylacetyl)oxy]- 1 , 1 -dimethylpyrrolidinium chloride racemic mixture is preferred.
- Glycopyrronium chloride is present in the formulation in an amount in the range from 0.005 to 0.83% (w/w), preferably from 0.010 to 0.13% (w/w), more preferably from 0.015 to 0.04% (w/w), wherein% (w/w) means the amount by weight of the component, expressed as percent with respect to the total weight of the composition.
- Glycopyrronium chloride can be prepared using any suitable synthesis technique, such as that described in a co-pending application filed by Chiesi Farmaceutici SpA.
- the propellant component of the composition may be any pressure- liquefied propellant but is preferably a hydro fluoroalkane (HFA) or a mixture of different HFAs, more preferably selected from the group consisting of HFA 134a (1 ,1 , 1 ,2-tetrafluoroethane), HFA 227 (1 , 1 , 1 ,2,3,3,3- heptafluoropropane), and mixtures thereof.
- HFA 134a hydro fluoroalkane
- HFAs may be present in the formulation in an amount in the range from 75 to 95% (w/w), preferably from 85 to 90% (w/w).
- the co-solvent incorporated into formulations of the invention has a higher polarity than that of the propellant and may include one or more substances such as a pharmaceutically acceptable alcohol, in particular ethanol, or a polyol such as propylene glycol or polyethylene glycol.
- a pharmaceutically acceptable alcohol in particular ethanol
- a polyol such as propylene glycol or polyethylene glycol.
- the co-solvent is selected from the group of lower branched or linear alkyl (Ci-C 4 ) alcohols such as ethanol and isopropyl alcohol.
- the co-solvent is ethanol.
- the concentration of the co-solvent will vary depending on the final concentration of the active ingredient in the formulation and on the type of propellant.
- ethanol may be used in a concentration comprised in the range from 5 to 25% (w/w), preferably from 8 to 20% (w/w), more preferably from 10 to 15% (w/w). In one of the preferred embodiments the concentration of ethanol is 12% (w/w).
- the ratio of propellant to co-solvent in the formulation is in the range 50:50 to 95 :5 (w/w).
- HC1 of different molarity or alternative inorganic acids could substitute for 1M HC1 in the formulations of the invention.
- alternative acids could be any pharmaceutically acceptable monoprotic or polyprotic acid, such as (but not limited to): hydrogen halides (hydrochloric acid hydrobromic acid, hydroiodic acid etc.) phosphoric acid, nitric acid, sulphuric acid, and halogen oxoacids.
- composition is preferably a solution formulation.
- solution formulation compositions may comprise other known pharmaceutical excipients or additives, such as one or more low- volatility components in order to either increase the mass median aerodynamic diameter (MMAD) of the aerosol particles upon actuation of the inhaler and/or to improve the solubility of the active ingredient in the propellant/co-solvent mixture.
- MMAD mass median aerodynamic diameter
- the low volatility component when present, has a vapour pressure at 25°C lower than 0.1 kPa, preferably lower than 0.05 kPa.
- low-volatility components may be esters such as isopropyl myristate, ascorbyl myristate, tocopherol esters; glycols such as propylene glycol, polyethylene glycol, glycerol; or surface active agents such as a saturated organic carboxylic acid (i.e. lauric, myristic, stearic acid) or an unsaturated carboxylic acid (i.e. oleic or ascorbic acid).
- esters such as isopropyl myristate, ascorbyl myristate, tocopherol esters
- glycols such as propylene glycol, polyethylene glycol, glycerol
- surface active agents such as a saturated organic carboxylic acid (i.e. lauric, myristic, stearic acid) or an unsaturated carboxylic acid (i.e. oleic or ascorbic acid).
- the amount of low volatility component may vary from 0.1 to 10% w/w, preferably from 0.5 to 5% (w/w), more preferably between 1 and 2% (w/w).
- an amount of water comprised between 0.005 and 0.5% (w/w), and preferably up to 0.2% (w/w) may optionally be added to the formulations in order to favourably affect the solubility of the active ingredient without increasing the MMAD of the aerosol droplets upon actuation.
- the formulations of the invention are free of other excipients such as surfactants besides the co-solvent, the propellant and a stabilizing amount of an acid.
- the invention also relates to a method for preparing a pharmaceutical composition, comprising adding 1M HC1 to a solution of glycopyrronium chloride in HFA propellant and co-solvent, wherein the amount of 1M HC1 added is in the range of 0.05-0.4 ⁇ g per ⁇ of the final solution.
- compositions of the invention may further comprise other, additional pharmaceutically active agents for separate, sequential or simultaneous use.
- additional pharmaceutically active components of the composition include any known compound for the prophylaxis or treatment of respiratory diseases and their symptoms.
- these active components are: beta-2-agonists such as formoterol, salbutamol, fenoterol, carmoterol (TA2005), indacaterol, milveterol, vilanterol (GSK 642444), terbutaline, salmeterol, bitolterol, and metaproterenol all in form of single stereoisomers or mixtures thereof and salts thereof; corticosteroids such as beclometasone dipropionate, fluticasone propionate, butixocort, mometasone furoate, triamcinolone acetonide, budesonide and its 22R-epimer, ciclesonide, fhmisolide, loteprednol, and rofleponide
- compositions of the invention can be inhaled from any suitable known MDI device. Desired doses of the individual pharmaceutically active components of the formulation are dependent on the identity of the component and the type and severity of the disease condition, but are preferably such that a therapeutic amount of the active ingredient is delivered in one or two actuations. Generally speaking, doses of active ingredient are in the range of about 0.5 ⁇ g-lmg per actuation, e.g. about 1-100 ⁇ g/actuation, and sometimes about 5-50 ⁇ g/actuation. The skilled person in the field is familiar with how to determine the appropriate dosage for each individual pharmaceutically active ingredient.
- the preferred dosage is about 0.5- 100 ⁇ g per actuation, preferably about 1-40 ⁇ g per actuation, and more preferably about 5-26 ⁇ g per actuation, even more preferably 25 ⁇ g per actuation.
- the pharmaceutical formulation of the invention is filled into known pMDI devices.
- Said devices comprise a canister fitted with a metering valve. Actuation of the metering valve allows a small portion of the spray product to be released.
- Part or all of the canister may be made of a metal, for example aluminium, aluminium alloy, stainless steel or anodized aluminium.
- the canister may be a plastic cans or a plastic-coated glass bottle.
- the metal canisters may have part or all of the internal surfaces lined with an inert organic coating.
- preferred coatings are epoxy- phenol resins, perfluorinated polymers such as perfluoroalkoxyalkanes, perfluoroalkoxyalkylenes, perfluoroalkylenes such as poly-tetrafluoroethylene (Teflon), fluorinated-ethylene-propylene (FEP), polyether sulfone (PES) or fluorinated-ethylene-propylene polyether sulfone (FEP-PES) mixtures or combination thereof.
- Other suitable coatings could be polyamide, polyimide, polyamideimide, polyphenylene sulfide or their combinations.
- canisters having the internal surface lined with FEP-PES or Teflon may preferably be used.
- canisters made of stainless steel may be used.
- the container is closed with a metering valve for delivering a daily therapeutically effective dose of the active ingredient.
- the metering valve assembly comprises a ferrule having an aperture formed therein, a body moulding attached to the ferrule which houses the metering chamber, a stem consisting of a core and a core extension, an inner- and an outer- seal around the metering chamber, a spring around the core, and a gasket to prevent leakage of propellant through the valve.
- the gasket seal and the seals around the metering valve may comprise elastomeric material such as EPDM, chlorobutyl rubber, bromobutyl rubber, butyl rubber, or neoprene. EPDM rubbers are particularly preferred.
- the metering chamber, core and core extension are manufactured using suitable materials such as stainless steel, polyesters (e.g. polybutyleneterephthalate (PBT)), or acetals.
- the spring is manufactured in stainless steel eventually including titanium.
- the ferrule may be made of a metal, for example aluminum, aluminum alloy, stainless steel or anodized aluminum. Suitable valves are available from manufacturers such as Valois, Bespak pic and 3M-Neotechnic Ltd.
- the pMDI is actuated by a metering valve capable of delivering a volume of between 25-100 ⁇ , preferably between 40-70 ⁇ , and optionally about 50 ⁇ , or about 63 ⁇ per actuation.
- Suitable channeling devices comprise, for example, a valve actuator and a cylindrical or cone-like passage through which medicament may be delivered from the filled canister via the metering valve to the mouth of a patient e.g. a mouthpiece actuator.
- valve stem is seated in a nozzle block which has an orifice leading to an expansion chamber.
- the expansion chamber has an exit orifice which extends into the mouthpiece.
- Actuator (exit) orifices having a diameter in the range 0.15 - 0.45 mm and a length from 0.30 to 1.7 mm are generally suitable.
- an orifice having a diameter from 0.2 to 0.44 mm is used, e.g. 0.22 0.25, 0.30, 0.33 or 0.42 mm.
- actuator orifices having a diameter ranging from 0.10 to 0.22 mm, in particular from 0.12 to 0.18 mm, such as those described in WO 03/053501.
- the use of said fine orifices may also increase the duration of the cloud generation and hence, may facilitate the coordination of the cloud generation with the slow inspiration of the patient.
- the MDI product in case the ingress of water into the formulation is to be avoided, it may be desired to overwrap the MDI product in a flexible package capable of resisting water ingress. It may also be desirable to incorporate a material within the packaging which is able to adsorb any propellant and co-solvent which may leak from the canister (e.g. a molecular sieve).
- a material within the packaging which is able to adsorb any propellant and co-solvent which may leak from the canister (e.g. a molecular sieve).
- the MDI device filled with the formulation of the invention may be utilized together with suitable auxiliary devices favoring the correct use of the inhaler.
- Said auxiliary devices are commercially available and, depending on their shape and size, are known as "spacers", “reservoirs” or “expansion chambers”. VolumaticTM is, for instance, one of the most widely known and used reservoirs, while AerochamberTM is one of the most widely used and known spacers.
- a suitable expansion chamber is reported, for example, in WO 01/49350.
- the formulation of the invention may also be used with common pressurized breath-activated inhalers such as those known with the registered names of Easi-BreatheTM and AutohalerTM.
- the efficacy of an MDI device is a function of the dose deposited at the appropriate site in the lungs. Deposition is affected by the aerodynamic particle size distribution of the formulation which may be characterised in vitro through several parameters.
- the aerodynamic particle size distribution of the formulation of the invention may be characterized using a Cascade Impactor according to the procedure described in the European Pharmacopoeia 6 th edition, 2009 (6.5), part 2.09.18.
- An Apparatus E operating at a flow rate range of 30 litres/min to 100 litres/min or an Apparatus D -Andersen Cascade Impactor (ACI)-, operating at a flow rate of 28.3 1/min, may be utilized.
- Deposition of the drug on each ACI plate is determined by high performance liquid chromatography (HPLC).
- the following parameters of the particles emitted by a pressurized MDI may be determined:
- MMAD mass median aerodynamic diameter
- ii) delivered dose is calculated from the cumulative deposition in the ACI, divided by the number of actuations per experiment;
- fine particle dose FPD
- the solutions of the invention are capable of providing, upon actuation of the pMDI device in which they are contained, a total FPF higher than 40%, preferably higher than 50%, more preferably higher than 60%.
- the formulations of the invention are capable of providing, on actuation, a fraction higher than or equal to 30% of emitted particles of diameter equal to or less than 1.1 microns as defined by the content stages S6-AF of an Andersen Cascade Impactor, relative to the total fine particle dose collected in the stages S3-AF of the impactor.
- the fraction of emitted particles of diameter equal to or less than 1.1 microns is higher than or equal to 40%, more preferably higher than 50%, even more preferably higher than 60%, most preferably higher than 70%.
- a method of filling an aerosol inhaler with a composition of the invention there is provided a method of filling an aerosol inhaler with a composition of the invention.
- Known conventional bulk manufacturing methods and machinery in the field of pharmaceutical aerosol manufacture may be employed for the preparation of large scale batches for the commercial production of filled canisters.
- the method comprises:
- a propellant comprising a HFA and optionally a low volatility component at a temperature from -50 to
- An alternative method comprises:
- a further alternative method comprises:
- the packaged formulations of the invention are stable for extended periods of time when stored under normal conditions of temperature and humidity.
- the packaged formulations are stable for at least 6 months at 25 °C and 60% H, more preferably for at least 1 year, most preferably for at least 2 years. Stability is assessed by measuring content of residual active ingredient.
- a "stable" formulation as defined herein means one retaining at least about 85%, preferably at least about 90%, and most preferably at least about 95% of residual content of each active ingredient at a given time point, as measured by HPLC-UV VIS.
- the optimized stable formulations meet the specifications required by the ICH Guideline Q1B relevant for drug product stability testing for the purposes of drug registration.
- the product of the invention may be used for prophylactic purposes or for symptomatic relief for a wide range of respiratory disorders, such as asthma of all types and chronic obstructive pulmonary disease (COPD).
- COPD chronic obstructive pulmonary disease
- compositions of the invention may be beneficial are those characterized by obstruction of the peripheral airways as a result of inflammation and presence of mucus, such as chronic obstructive bronchiolitis, chronic bronchitis, emphysema, acute lung injury (ALI), cystic fibrosis, rhinitis, and adult or acute respiratory distress syndrome (A DS).
- mucus such as chronic obstructive bronchiolitis, chronic bronchitis, emphysema, acute lung injury (ALI), cystic fibrosis, rhinitis, and adult or acute respiratory distress syndrome (A DS).
- the samples containing acid are formulated by the addition of 1M HCl in an amount corresponding to 0.222 ⁇ g/ ⁇ of the solution.
- the solution is filled into canisters which are stored inverted under different conditions: 5°; 25°C/60% RH; 30°C/75% RH.
- the samples are analyzed chromatographically for glycopyrronium chloride content after 1 , 2, and 3 months of storage.
- the formulation is found to maintain a constant content in the presence of 1 M HCl, but to be highly dependent on time and temperature of storage if the acid is omitted. See in the following Table 2 the data when the formulation was stored for 3 months at 25°C/60% relative humidity with or without the acid.
- the formulation containing GLY is found to maintain a constant content in the presence of 1M HC1, but to be highly dependent on time and temperature of storage if the acid is omitted. See in the following Table 3 the data for the total percent amount of impurities and/or degradation products expressed versus the initial amount of active ingredient when the single agent formulation was stored for 3 months at 40°C/75% relative humidity with or without the same amount of acid.
- the formulations were tested by a standard
- HPLC/UV VIS method for non-chiral impurities and degradation products of the active ingredient.
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Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201080058036.5A CN102695496B (en) | 2009-12-23 | 2010-12-22 | Aerosol formulation for COPD |
KR1020177013857A KR101795348B1 (en) | 2009-12-23 | 2010-12-22 | Aerosol formulation for copd |
RU2012125965/15A RU2567040C2 (en) | 2009-12-23 | 2010-12-22 | Aerosol formulation for treating chronic obstructive pulmonary disease |
CA2785347A CA2785347C (en) | 2009-12-23 | 2010-12-22 | Aerosol formulation for copd |
EP10800932.5A EP2515856B1 (en) | 2009-12-23 | 2010-12-22 | Aerosol Formulation for COPD |
ES10800932.5T ES2467928T3 (en) | 2009-12-23 | 2010-12-22 | Aerosol formulation for COPD |
BR112012015335-8A BR112012015335B1 (en) | 2009-12-23 | 2010-12-22 | aerosol formulation for chronic obstructive pulmonary disease |
HK13101925.3A HK1174562A1 (en) | 2009-12-23 | 2013-02-15 | Aerosol formulation for copd copd |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09180662.0 | 2009-12-23 | ||
EP09180662 | 2009-12-23 |
Publications (2)
Publication Number | Publication Date |
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WO2011076840A2 true WO2011076840A2 (en) | 2011-06-30 |
WO2011076840A3 WO2011076840A3 (en) | 2011-12-01 |
Family
ID=42102003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2010/070476 WO2011076840A2 (en) | 2009-12-23 | 2010-12-22 | Aerosol formulation for copd |
Country Status (10)
Country | Link |
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US (3) | US20110146677A1 (en) |
EP (1) | EP2515856B1 (en) |
KR (2) | KR101795348B1 (en) |
CN (1) | CN102695496B (en) |
BR (1) | BR112012015335B1 (en) |
CA (1) | CA2785347C (en) |
ES (1) | ES2467928T3 (en) |
HK (1) | HK1174562A1 (en) |
RU (1) | RU2567040C2 (en) |
WO (1) | WO2011076840A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011076842A2 (en) | 2009-12-23 | 2011-06-30 | Chiesi Farmaceutici S.P.A. | Aerosol formulation for copd |
CN102665679B (en) | 2009-12-23 | 2014-11-26 | 奇斯药制品公司 | Combination therapy for COPD |
RU2561052C2 (en) * | 2009-12-23 | 2015-08-20 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Combination treatment of chronic obstructive pulmonary disease |
SG11201605311UA (en) | 2013-12-30 | 2016-07-28 | Chiesi Farma Spa | Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination |
ME03076B (en) | 2013-12-30 | 2019-01-20 | Chiesi Farm Spa | Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination |
WO2019147154A1 (en) * | 2018-01-23 | 2019-08-01 | Александр Григорьевич ЧУЧАЛИН | Pharmaceutical formulation (embodiments) and use of a pharmaceutical formulation (embodiments) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001049350A1 (en) | 2000-01-07 | 2001-07-12 | Chiesi Farmaceutici S.P.A. | Aerosol inhaler |
WO2001076575A2 (en) | 2000-04-07 | 2001-10-18 | Arakis Ltd. | The treatment of respiratory diseases |
WO2003053501A1 (en) | 2001-12-21 | 2003-07-03 | Chiesi Farmaceutici S.P.A. | Metered dose inhaler |
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US20060257324A1 (en) * | 2000-05-22 | 2006-11-16 | Chiesi Farmaceutici S.P.A. | Pharmaceutical solution formulations for pressurised metered dose inhalers |
PL207377B1 (en) * | 2001-03-30 | 2010-12-31 | Jagotec Ag | Medical aerosol formulations |
DE602005007708D1 (en) * | 2004-02-06 | 2008-08-07 | Meda Pharma Gmbh & Co Kg | NEW COMBINATION OF ANTICHOLINERGEN AND BETA MIMETIKA FOR THE CONTROL OF RESPIRATORY DISEASES |
GB0613161D0 (en) * | 2006-06-30 | 2006-08-09 | Novartis Ag | Organic Compounds |
EP2200550B1 (en) * | 2007-10-18 | 2018-04-18 | Rose U, LLC | Topical glycopyrrolate formulations |
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2010
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- 2010-12-22 WO PCT/EP2010/070476 patent/WO2011076840A2/en active Application Filing
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RU2567040C2 (en) | 2015-10-27 |
WO2011076840A3 (en) | 2011-12-01 |
KR20170060618A (en) | 2017-06-01 |
HK1174562A1 (en) | 2013-06-14 |
CA2785347A1 (en) | 2011-06-30 |
EP2515856A2 (en) | 2012-10-31 |
US20180021301A1 (en) | 2018-01-25 |
CN102695496A (en) | 2012-09-26 |
EP2515856B1 (en) | 2014-04-02 |
KR101795348B1 (en) | 2017-12-01 |
KR20120106753A (en) | 2012-09-26 |
BR112012015335B1 (en) | 2021-05-18 |
BR112012015335A2 (en) | 2016-03-15 |
ES2467928T3 (en) | 2014-06-13 |
RU2012125965A (en) | 2013-12-27 |
US20140363383A1 (en) | 2014-12-11 |
CA2785347C (en) | 2018-02-27 |
US20110146677A1 (en) | 2011-06-23 |
CN102695496B (en) | 2014-10-01 |
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