WO2011073092A1 - 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment - Google Patents
3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment Download PDFInfo
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- WO2011073092A1 WO2011073092A1 PCT/EP2010/069352 EP2010069352W WO2011073092A1 WO 2011073092 A1 WO2011073092 A1 WO 2011073092A1 EP 2010069352 W EP2010069352 W EP 2010069352W WO 2011073092 A1 WO2011073092 A1 WO 2011073092A1
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- indole
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Definitions
- the present invention relates to 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide compounds, pharmaceutical compositions containing them and their use in tumor treatment.
- Angiogenesis is a morphogenetic process which relates to the formation of new blood vessels from the endothelial cells of already existing capillary vessels.
- Angiogenetic proc- esses are pathologically responsible inter alia in rheumatoid arthritis, psoriasis, ischemia and malignant diseases.
- Angiogenesis plays an important role in genesis, growth and progression of tumors. Once tumors have reached a size of about 3 mm 3 , their growth is completely dependent on this process. In general, tumors with a high expression of angiogenic factors, e.g.
- VEGF vascular endothelial growth factor
- bFGF matrix metalloproteinases and serine proteases
- inhibitors of angiogenesis e.g. thrombospondin and inhibitors of metalloproteinases
- thrombospondin and inhibitors of metalloproteinases have a higher mi- crovessel density, are locally more advanced, have a more aggressive behavior, and metastasize more frequently than tumors without this angiogenic phenotype.
- angiogenesis inhibitors are contemplated as potential therapeutic agents in the treatment of solid tumors for which no effective therapies are known so far, such as bronchial carcinoma, mamma carcinoma, prostate carcinoma, glioblastoma, Karposi sarcoma, melanoma, lymphoma and multiple myeloma.
- PK protein kinases
- WO 02/38561 discloses kinase inhibitors of the formula
- R is an aryl radical such as a hydroxy substituted phenyl group.
- WO 2006/061212 discloses compounds of formula I
- R 1 is H, Ci-C6-alkyl, phenyl-Ci-C/i-alkyl or phenyl;
- R 2 is a phenyl group which is substituted with 2 or 3 Cj-Ce-alkoxy groups
- R 3 is indolyl or azaindolyl which may carry one or two substituents independently selected from Ci-Ce-alkyl, Ci-C6-alkoxy, phenyl, OH, halogen, NH 2 , Ci-Ce-alkylamino, di-Ci- C6-alkylamino, heteroaryl with 5 or 6 ring atoms containing 1 or 2 heteroatoms which are independently selected from O, N, and S and heterocyclyl with 5 or 6 ring atoms containing 1 or 2 heteroatoms which are independently selected from O, N, and S and the physiologically acceptable salts thereof as well as the solvates of the compounds of formula I and of the salts thereof.
- the compounds are useful as angiogenesis inhibitors. J. Med. Chem. 2006, 49, 1271- 1281 and J. Med. Chem. 2006, 49, 7549-7553 are concerned with the design, synthesis and evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors.
- the present invention relates to compounds of formula I: wherein
- R 1 is H, Ci-C6-alkyl, phenyl-Ci-C i-alkyl or phenyl;
- R 2 is a phenyl group which is substituted with 3 Ci-C6-alkoxy groups
- R 3 is selected from:
- R 7 is H or Ci-C6-alkyl
- R 8 is is Ci-C6-alkyl-R 10 and R 10 is selected from a) amino,
- R 9 is H, Ci-C6-alkyl, Ci-C6-alkoxy, OH, or halogen;
- R n is Ci-C 6 -alkyl;
- R 12 is H or Ci-Ce-alk l; and the physiologically acceptable salts thereof as well as the solvates of the compounds of formula I and of the salts thereof.
- alkyl includes linear or branched alkyl or alkylene groups having 1 to 6 and preferably 1 to 4 carbon atoms.
- alkyl groups are methyl, ethyl, n-propyl, i-propyl, n-butyl, sec-butyl, iso-butyl, t-butyl, n-pentyl or n-hexyl.
- alkoxy groups are methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy.
- alkylene groups are methylene, ethylene, n-propylene, isopropylene, n-butylene, iso- butylene etc.
- Halogen means F, CI, Br and I, preferably F and CI.
- heterocyclyl examples are pyrrolidinyl, imidazolidinyl, piperidinyl, morpholinyl, thio- morpholinyl and piperazinyl.
- heterocyclyl is piperidinyl, mor- pholinyl and piperazinyl. If heterocyclyl is substituted, the substituent may be at a carbon atom or at the additional nitrogen heteroatom.
- substituted heterocyclyl are 4- methylpiperazinyl or 2,2,6,6-tetramethylpiperidine.
- Physiologically acceptable salts of the compounds of formula I include acid addition salts with inorganic acids, such as hydrochloric acid, sulfuric acid, or phosphoric acid, or with organic acids, in particular carboxylic acids, such as acetic acid, tartaric acid, lactic acid, citric acid, maleic acid, amygdalic acid, ascorbic acid, fumaric acid, gluconic acid or sulfonic acids, such as methane sulfonic acid, benzene sulfonic acid and toluene sulfonic acid.
- inorganic acids such as hydrochloric acid, sulfuric acid, or phosphoric acid
- organic acids in particular carboxylic acids, such as acetic acid, tartaric acid, lactic acid, citric acid, maleic acid, amygdalic acid, ascorbic acid, fumaric acid, gluconic acid or sulfonic acids, such as methane sulfonic acid, benzene sulfonic
- Physiologically acceptable salts of the compounds of formula I include also base addition salts with inorganic bases, such as alkali metal hydroxides, like sodium or potassium hydroxide, alkaline earth metal hydroxides, like magnesium or calcium hydroxide; ammonium salts, or salts with organic bases such as tetramethylammonium hydroxide, triethylamine, tri(hydroxyethyl)amine, lysine, arginine or glutamic acid.
- inorganic bases such as alkali metal hydroxides, like sodium or potassium hydroxide, alkaline earth metal hydroxides, like magnesium or calcium hydroxide
- ammonium salts, or salts with organic bases such as tetramethylammonium hydroxide, triethylamine, tri(hydroxyethyl)amine, lysine, arginine or glutamic acid.
- Physiologically acceptable solvates are in particular hydrates.
- An embodiment of the present invention includes compounds of formula (I) wherein R 2 is a group having the formula
- R 4 , R 5 and R 6 are Ci-C6-alkoxy.
- the indolyl or azaindolyl group for example groups (a) to (e) are preferably attached maleimide group via the 3-position of the indolyl or azaindolyl group.
- the present invention relates to the compounds of formula (la):
- R 1 , and R 4 to R 9 have the meanings given above.
- the present invention relates to the compounds of formula (lb):
- R , and R to R are as defined above.
- the present invention relates to the compounds of formula (Ic):
- R 1 , and R 4 to R 9 are as defined above.
- the present invention relates to the compounds of formula (Ie):
- R 1 , and R 4 to R 9 are as defined above.
- R 1 and R 7 are independently of each other H or Ci-Cg- alkyl, and, in particular H.
- R 9 is H, Ci-C6-alkyl or halogen and in particular H.
- R 10 is selected from
- Ci-C6-alkoxy e) Ci-C6-alkoxy, and f) saturated heterocyclyl with 5 or 6 ring atoms containing a nitrogen heteroatom and optionally 1 or 2 additional heteroatoms which are independently selected from O, N and S, wherein the heterocyclyl is attached to the Ci-Cg-alkyl group via the nitrogen atom and may carry an additional Cl-C6-alkyl substituent at a carbon atom or a nitro- gen atom.
- R 10 is selected from
- R 10 is selected from
- R 10 is selected from
- R 10 is
- R 10 is selected from
- R 10 is selected from
- R 10 is selected from
- R is selected from
- R 10 is selected from
- a compound of the invention is a compound of II, formula III or formula IV:
- the compounds of the present invention can be prepared according to known methods, for example according to the methods, which are disclosed in WO 02/38561, EP 328 026, WO 03/095452, WO 03/103663 and WO 2006/061212.
- WO 02/38561 European Patent Application Laidicide
- EP 328 026 WO 03/095452
- WO 03/103663 WO 2006/061212.
- WO 2006/061212 WO 2006/061212.
- a modified procedure reported in Tetrahedron Letters (1999) 40: 1109-1112 has been proven to be particularly efficient. This procedure can be illustrated by the following reaction sequence:
- An indole glyoxyl ester is reacted with a phenyl acetamide derivative in a one-pot reaction in an inert solvent in the presence of a strong base.
- a strong base Preferably an ether is used as an inert solvent, such as tetrahydrofurane or dioxane.
- potassium t-butoxide can for example be used.
- the water formed during the reaction is removed, for example by using a molecular sieve.
- the phenyl acetamides used as starting material are readily available from the corresponding acetic acids which are converted to the acid chloride and hydrolyzed with ammonia.
- the corresponding azaindole glyoxyl esters can be prepared according to the method reported in J. Org. Chem. 2002, 67, 6226-6227 or by Friedel- Crafts acylation in the presence of aluminum chloride, cf. Organic Letters (2000) vol. 2, no. 10, 1485-1487.
- the 4- and 6-azaindole starting compounds can be prepared by reacting 2- chloro-3-nitropyridine or 3-nitro-4-chloropyridine with vinyl magnesium bromide to give the 7-chloro-substituted 4- or 6-azaindole.
- the chloro substituent is then removed by catalytic hydro genation. Said reactions are carried out as described in J. Org. Chem. 67, 2345-2347 (2002) and J. Heterocycl. Chem. 29, 359-363 (1992).
- the 4-aza-indole starting compound can also be synthesized according to the procedures disclosed in Org.Biomol. Chem. 3, 20, 3701-3706 (2005).
- the 5- and 7-azaindole starting compounds can be prepared by reacting 2- or 4-aminopyridine with di-tert-butyldicarbonate to 2- or 4- t-butoxycarbonylaminopyridine which is then reacted with methyl iodide and dimethylformamide in the presence of t-butyl lithium. The obtained product is then treated with a strong acid to give 5- or 7-azaindole. Said reactions are de- scribed in Synthesis 7, 877-882 (1996).
- the compounds of the present invention have antineoplastic activity and can therefore be used for the treatment or prevention of tumors, in particular solid tumors, such as astrocytoma, bladder cancer, bone cancer, brain tumor, breast cancer, bronchial tumor, cervical cancer, colorectal cancer, endometrial cancer, esophageal cancer, gallbladder cancer, gastrointes- tinal stromal tumor, germ cell tumor, glioma, head and neck cancer, liver cancer, lymphoma, sarcoma, lung cancer, melanoma, ovarian cancer, pancreatic cancer, thyroid cancer, neuro- blastoma, prostate cancer, renal cancer, skin cancer, squamous neck cancer, stomach (gastric) cancer, testicular cancer.
- the compounds of the invention are especially useful for treatment or prevention of cervical cancer, colorectal cancer, gastrointestinal stromal tumor, liver cancer, lung cancer, ovarian cancer, prostate cancer, stomach cancer, andpancreatic carcinoma.
- the compounds of the present invention can be used for the treatment or prevention of leukemia.
- Leukemia according to the present invention comprises in particular acute lymphocytic leukemia (also known as acute lymphoblastic leukemia, or ALL), acute myelogenous leukemia (also known as acute myeloid leukemia, or AML); chronic lymphocytic leukemia (CLL), mixed- lineage leukemia and chronic myelogenous leukemia (CML).
- ALL acute lymphocytic leukemia
- ALL acute myelogenous leukemia
- AML acute myeloid leukemia
- CLL chronic lymphocytic leukemia
- CML chronic myelogenous leukemia
- CML chronic myelogenous leukemia
- CML chronic myelogenous leukemia
- the invention relates to the treatment of AML or ALL.
- the leukemia is characterized by leukemic cells which are positive for expression of FLT3.
- the leukemia is characterized by leukemic cells which show enhanced expression of FLT3, com- pared to non-malignant cells of the same cell type.
- a further embodiment of the invention is a combination of the compounds of the present invention with one or more than one chemotherapeutic agent including antineoplastic agents, multidrug resistance reversing agents; and biological response modifiers, and combinations thereof, examples being given below.
- chemotherapeutic agent including antineoplastic agents, multidrug resistance reversing agents; and biological response modifiers, and combinations thereof, examples being given below.
- Suitable antineoplastic agents may be selected from the group comprising compounds affecting integrity and synthesis of DNA, e.g. topoisomerase I inhibitors; alkylating agents: intercalating agents or DNA-binding antibiotics; antimitotic compounds such as taxanes: vinca alka- loids or colchicine derivatives; compounds for targeted cancer therapy such as protein kinase inhibitors, antibodies binding to cell membrane receptors and soluble decoy receptors; compounds affecting the cell metabolism, e.g. farnesyltransf erase inhibitors, purin or pyrimidin analogues.
- compounds affecting integrity and synthesis of DNA e.g. topoisomerase I inhibitors
- alkylating agents intercalating agents or DNA-binding antibiotics
- antimitotic compounds such as taxanes: vinca alka- loids or colchicine derivatives
- compounds for targeted cancer therapy such as protein kinase inhibitors, antibodies binding to cell membrane receptors and soluble decoy receptors
- antineoplastic agents examples include aflibercept, asparaginase, bleomycin, busulfan, car- mustine, chlorambucil, cladribine, cyclophosphamide, cytarabine, dacarbazine, daunorubicin, doxorubicin, etoposide, fludarabine, gemcitabine, hydroxyurea, idarubicin, ifosfamide, iri- notecan, lomustine, mechlorethamine, melphalan, mercaptopurine, methotrexate, mitomycin, mitoxantrone, pentostatin, procarbazine, 6-thioguanine, topotecan, vinblastine, vincristine, retinoic acid, oxaliplatin, cis-platin, carboplatin, 5-FU (5-fluorouracil), teniposide, ama- sacrine, docetaxel, paclitaxel,
- antineoplastic agents which are protein kinase inhibitors include imatinib, er- lotinib, sorafenib, sunitinib, dasatinib, nilotinib, lapatinib, gefitinib, temsirohmus, everolimus, rapamycine, bosutinib, pzopanib, axitinib, neratinib, vatalanib, pazopanib, midostaurin and enzastaurin.
- antineoplastic agents which are antibodies comprise trastuzumab, cetuximab, panitumumab, rituximab, bevacizumab, mapatumumab, conatumumab, lexatumumab and the like.
- PSC 833 a potent inhibitor of the efflux of antitumor drugs mediated by P-glycoprotein.
- Suitable biological response modifiers may be selected from the group consisting of monoclonal antibodies and cytokines, such as interferons, interleukins and colony- stimulating factors, e.g., rituxan, CMA-676, interferon-alpha recombinant, inter leukin-2, interleukin-3, erythropoetin, epoetin, G-CSF, GM-CSF, filgrastim, sargramostim and thrombopoietin.
- cytokines such as interferons, interleukins and colony- stimulating factors, e.g., rituxan, CMA-676, interferon-alpha recombinant, inter leukin-2, interleukin-3, erythropoetin, epoetin, G-CSF, GM-CSF, filgrastim, sargramostim and thrombopoietin.
- the further chemotherapeutic agent is a topoisomerase I inhibitor and especially camptothecin or a derivative thereof such as described by Pommier, Y. (2006), Nature Reviews Cancer 6: 789-802.
- topomerase I inhibitors comprise compounds such as irinotecan (in particular irinotecan hydrochloride), topotecan (in particular topotecan hydrochloride), rubitecan, exatecan (in particular exatecan mesylate), lurtotecan, gimatecan, prothecan, karenitecin, belotecan (in particular belotecan hydrochloride), silatecan or diflomotecan and the salts thereof.
- the weight ratio of the compounds of the invention to the chemotherapeutic agent is in gen- eral in the range from 5:1 to 1 :500, in particular 3 : 1 to 1 :200.
- the combination of the invention exhibits enhanced tumor activity.
- a further embodiment of the invention is a pharmaceutical composition
- a pharmaceutical composition comprising a compound of formula I, II, III or IV or a combination thereof with an additional chemotherapeutic agent as defined above.
- the pharmaceutical compositions comprise an amount therapeutically effective for tumor treatment of a compound of formula I, II, III or IV or a combination as above-defined.
- a further embodiment of the invention is a compound of formula I, II, III or IV for use in a method of treating tumors.
- said method comprises the use of an additional therapeutic agent (other than a compound of formula I, II, III or IV).
- the additional therapeutic agent may be as defined above.
- the compounds or combinations of the present invention can be incorporated into standard pharmaceutical dosage forms.
- the compounds or combinations are useful when administered in systemic or local, oral or parenteral applications and for this purpose are combined with the usual pharmaceutical excipients, diluents and adjuvants, e.g., organic and inorganic inert carrier materials such as water, gelatin, lactose, starch, magnesium stearate, talc, vegetable oils, gums, polyalkyleneglycols, etc.
- pharmaceutical excipients e.g., organic and inorganic inert carrier materials such as water, gelatin, lactose, starch, magnesium stearate, talc, vegetable oils, gums, polyalkyleneglycols, etc.
- These pharmaceutical preparations can be employed in a solid form, e.g., as tablets, capsules, and especially in combination with or for admixture with a palatable food item suitable for mammals; or they can be administered in liquid form, e.g., as solutions and elixirs.
- compositions for improving compressibility, or to create a delayed-, sustained-, or controlled-release of the active ingredient include various salts to change the osmotic pressure of the pharmaceutical preparation or to act as buffers.
- the therapeutically effective amount of a compound of Formula I, II, III or IV or combination as defined may be administered systemically to said mammal, wherein said systemic administration comprises: (1) injection or infusion into suitable body tissues or cavities of a pharmaceutical composition containing said compound or combination in suitable liquid form such as aqueous solutions, emulsions or suspensions for intraarterial, intra- or transdermal (including subcutaneous) and most commonly intramuscular or intravenous delivery thereof; or for serving as a depot for delivery thereof; (2) instillation into suitable body tissues or cavities of a pharmaceutical composition containing said compound or combination in suitable solid form, e.g., comprising a matrix of bio-compatible and bio-erodible materials in which particles of a compound of Formula I, II, III or IV or combination are dispersed for serving as a solid im- plant composition for delayed-, sustained-, and/or controlled-release delivery thereof; or (3) ingestion or administration of a pharmaceutical composition containing said compound or combination in suitable solid or liquid form for transdermal delivery thereof, for instance a
- Preferred peroral dosage forms for systemic administration are solids, e.g., palatable oral compositions such as fast dissolving palatable wafers, tablets, capsules, caplets, etc., and liq- uids, e.g., solutions, suspensions, emulsions, etc.
- compositions of special types suitable for oral administration to mammals may be used, and include, but are not limited to such items as an oral paste to be delivered to the back of the tongue of the mammal being treated, a granular form to be delivered through incorporation in the mammal's food, and a chewable form wherein the active ingredient is consumed along with the palatable chew, or a chewable form which may deliver the active ingredient by leaching from the body of the chew which is not consumed, during mastication by the mammal being treated. Tablets and capsules are preferred dosage forms.
- Said therapeutically effective amount of a compound of Formula I, II, III or IV or combina- tion as defined may also be administered locally to said mammal, wherein said local administration comprises: (1) injection or infusion into a local site affected with abnormal angio- genesis and/or vascular dysfunction of a pharmaceutical composition containing said compound of formula (I) or combination in suitable liquid form for delivery thereof, including components which provide delayed-release, controlled-release, and/or sustained-release of said compound or combination into said local site; or for serving as a depot for delivery thereof wherein said composition provides storage of said compound or combination and thereafter delayed-, sustained-, and/or controlled-release thereof; or (2) instillation of a pharmaceutical composition containing said compound or combination in suitable solid form for serving as a solid implant for delivery thereof, said composition optionally providing delayed- , sustained-, and/or controlled-release of said compound or combination to said local site.
- the therapeutically effective amount of the compound of Formula I, II, III or IV is administered to a mammal to be treated in an amount expressed as milligrams per m 2 of body surface of said mammal, per day: "mg/m 2 /day".
- the dose, i.e. , the therapeutically effective amount of a compound of Formula I, II, III or IV will usually range from about 0.2 mg/m 2 /day to about 2000 mg/m 2 /day, preferably from about 0.5 mg/m 2 /day to about 1500 mg/m 2 /day, more preferably from about 1.0 mg/m 2 /day to about 1000 mg/m 2 /day.
- a combination of a compound of formula I with a chemotherapeutic agent such as an anticancer agent
- administration may be simultaneously, for example given as coformulation or separately, or sequen- tially.
- the dose of a compound of formula I, II, III or IV will usually be as given above whereas the dose of the chemotherapeutic agent will range from about 0.2 mg/m 2 /day to about 2000 mg/m /day, preferably from about 0.5 mg/m 2 /day to about 1500 mg/m /day, more preferably from about 1.0 mg/m /day to about 1000 mg/m /day.
- the antineoplastic activity of the compounds or combinations of the present invention was determined by the following assays:
- Antiproliferative activity of test compounds was determined by the 3-(4,5-dimethylthiazol-2- yl)-2,5-diphenyltetrazolium bromide (MTT) assay as described previously (Mosmann, T. et al. (1983) J.Immunol.Methods 65, 55-63). Cells in the exponential growth phase were trans- ferred to 96-well flat-bottomed plates. Cell suspensions (200 ⁇ ) containing 10,000 viable cells were plated into each well and incubated over night before exposure with various concentrations of agents. Cells were then incubated with 100 ⁇ of different concentrations of compounds for 3 days at 37°C with 5% C0 2 .
- MTT 3-(4,5-dimethylthiazol-2- yl)-2,5-diphenyltetrazolium bromide
- Cancer cells were transferred to 12-well flat-bottomed plates.
- Cell suspensions (1ml) containing l,5xl0 5 viable cells were plated into each well and incubated over night before exposure with various concentrations of agents.
- Cells were then incubated in 1ml medium with various concentrations of single applied moguntinones, irinotecan alone, or with the combinations of moguntinones with irinotecan or topotecan at 37°C with 5% C0 2 .
- IC5 0 - values were carried out at Millipore UK Ltd; Gemini Crescent; Dundee Technology Park; Dundee DD2 1SW; UK (lC 50 Profiler).
- HCT-1 16, HT-29, Caco-2, SW480 and the stomach cancer cell line MK -45 were obtained from the DSMZ, Germany.
- HCT- 116, HT-29 and S W480 cells were routinely cultured in RPMI 1640 supplemented with 10% FCS, MKN-45 in RPMI 1640 supplemented with 20% FCS and Caco-2 cells in 80% MEM (with Earle's salts) + 20% FCS + non-essential amino acids. All cells were maintained at 37°C in an incubator under an atmosphere containing 5% CO2.
- PI buffer containing 0.1% sodium citrate, 0.1% triton X-100, 50 mg/ml propidium iodide (PI)
- PI propidium iodide
- the antitumor efficacy of the compounds of the invention was examined against HT-29 hu- man colon adenocarcinoma cells.
- the tested compounds showed initial dose dependent cytotoxicity when used in concentrations up to low micromolar range (Table 1).
- the compound of example 1 of WO 2006/061212 was used as comparative compound.
- Table 1 Decrease of HT-29 colon cancer cell viability (%) under treatment with compounds of the invention for 3 days detected in MTT-assay
- Elemental analyses were performed on a Haereus CHN rapid, Carlo Erba Strumentazione 1106. Combustion analyses agreed with the calculated data within ⁇ 0,4 unless otherwise stated. Melting points/decomposition temperatures were determined on a Buchi apparatus according to Dr. Tottloi and are uncorrected. Where appropriate, column chromatography was performed for crude precursors with Merck silica gel 60 (0.063-0.200 mm). Column chromatography for test compounds was performed using a MPLC-System B-680 (Buchi) with Merck silica gel (0.015-0.040 mm). The progress of the reactions was monitored by thin layer chromatography (TLC) performed with Merck silica gel 60 F-254 plates. Where necessary, reactions were car- ried out in a nitrogen atmosphere using 4 A molecular sieves. All reagents and solvents were obtained from commercial sources and used as received.
- Ethyl-2-[l-(ier/.-butoxycarbonyl)-5-bromo-lH-indol-3-yl]-2-oxoacetate was prepared using the same procedure as in Example 10. The following amounts were used: Ethyl 2-(5-bromo- lH-indol-3-yi)-2-oxoacetate (3.5 mmol; 1.05 g); Ai-tert. -butyldicarbonat (4 mmol; 0.8 g); DMAP; dichloromethan (30 ml).
- Aluminium chloride (3.1 g, 23 mmol) and 4-azaindole (0.38 g, 4.6 mmol) were stirred in 100 ml dry dichloromethane at room temperature under nitrogen atmosphere. After 30 min ethoxalylchloride (2.5 ml, 3.0 g, 23 mmol) was added dropwise. The reaction mixture was stirred over night and then carefully hydro lyzed with ethanol/ice. After addition of dichloromethane the organic layer was separated, washed with NaHC0 3 solution, dried over Na2SC>4, filtered and concentrated.
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Abstract
Description
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AU2010333083A AU2010333083B2 (en) | 2009-12-18 | 2010-12-10 | 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
US13/517,004 US9012659B2 (en) | 2009-12-18 | 2010-12-10 | 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
CA2782574A CA2782574C (en) | 2009-12-18 | 2010-12-10 | 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
JP2012543626A JP5980684B2 (en) | 2009-12-18 | 2010-12-10 | 3- (Indolyl)-or 3- (azaindolyl) -4-arylmaleimide compounds and their use in tumor treatment |
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JP2016504299A (en) * | 2012-12-10 | 2016-02-12 | セントジーン アーゲー | Use of maleimide derivatives to prevent and treat leukemia |
JP2016508962A (en) * | 2012-12-10 | 2016-03-24 | セントジーン アーゲー | Use of maleimide derivatives to prevent and treat cancer |
US9364459B2 (en) | 2009-12-18 | 2016-06-14 | Johannes Gutenberg-Universität Mainz | 3-(indolyl)- or 3-(azaindolyl)- 4-arylmaleimide derivatives for use in the treatment of colon and gastric adenocarcinoma |
EP3187495A1 (en) | 2015-12-30 | 2017-07-05 | Johannes Gutenberg-Universität Mainz | 3-(5-fluoroindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
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EP2474541A1 (en) * | 2010-12-23 | 2012-07-11 | Johannes- Gutenberg-Universität Mainz | Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
CN104370903A (en) * | 2013-08-14 | 2015-02-25 | 苏州科捷生物医药有限公司 | Practical synthesis method of 3-acetyl-4-azaindole |
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JP2016504299A (en) * | 2012-12-10 | 2016-02-12 | セントジーン アーゲー | Use of maleimide derivatives to prevent and treat leukemia |
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JP5980684B2 (en) | 2016-08-31 |
US20130131060A1 (en) | 2013-05-23 |
AU2010333083A1 (en) | 2012-06-21 |
CA2782574C (en) | 2017-05-16 |
EP2513089A1 (en) | 2012-10-24 |
US9012659B2 (en) | 2015-04-21 |
CA2782574A1 (en) | 2011-06-23 |
EP2343291A1 (en) | 2011-07-13 |
AU2010333083B2 (en) | 2016-02-25 |
EP2513089B1 (en) | 2015-09-09 |
JP2013514295A (en) | 2013-04-25 |
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