WO2011072275A3 - Agents and methods for treating ischemic and other diseases - Google Patents

Agents and methods for treating ischemic and other diseases Download PDF

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Publication number
WO2011072275A3
WO2011072275A3 PCT/US2010/059976 US2010059976W WO2011072275A3 WO 2011072275 A3 WO2011072275 A3 WO 2011072275A3 US 2010059976 W US2010059976 W US 2010059976W WO 2011072275 A3 WO2011072275 A3 WO 2011072275A3
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WIPO (PCT)
Prior art keywords
methods
diseases
agents
treating ischemic
protein activity
Prior art date
Application number
PCT/US2010/059976
Other languages
French (fr)
Other versions
WO2011072275A2 (en
Inventor
Xiujun Sun
Michael Tymianski
Jonathan David Garman
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Nono, Inc.
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Publication date
Application filed by Nono, Inc. filed Critical Nono, Inc.
Priority to EP10836790.5A priority Critical patent/EP2521724B1/en
Priority to CA2781888A priority patent/CA2781888C/en
Priority to JP2012543324A priority patent/JP5848712B2/en
Priority to AU2010327936A priority patent/AU2010327936B2/en
Publication of WO2011072275A2 publication Critical patent/WO2011072275A2/en
Publication of WO2011072275A3 publication Critical patent/WO2011072275A3/en

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

This invention relates to methods of screening for modulators of mammalian cell injury cause by TRPM7 gene and protein activity, compounds that modulate TRPM7 gene and protein activity and methods of treatment of mammalian cell injury using modulators of murine TRPM7 gene and protein activity.
PCT/US2010/059976 2009-12-11 2010-12-10 Agents and methods for treating ischemic and other diseases WO2011072275A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP10836790.5A EP2521724B1 (en) 2009-12-11 2010-12-10 Agents and methods for treating ischemic and other diseases
CA2781888A CA2781888C (en) 2009-12-11 2010-12-10 Agents and methods for treating ischemic and other diseases
JP2012543324A JP5848712B2 (en) 2009-12-11 2010-12-10 Agents and methods for treating ischemic diseases and other diseases
AU2010327936A AU2010327936B2 (en) 2009-12-11 2010-12-10 Agents and methods for treating ischemic and other diseases

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28595409P 2009-12-11 2009-12-11
US61/285,954 2009-12-11
US31215410P 2010-03-09 2010-03-09
US61/312,154 2010-03-09

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