WO2011072212A2 - Procédé de fabrication d'implants antimicrobiens en polyétheréthercétone - Google Patents

Procédé de fabrication d'implants antimicrobiens en polyétheréthercétone Download PDF

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Publication number
WO2011072212A2
WO2011072212A2 PCT/US2010/059868 US2010059868W WO2011072212A2 WO 2011072212 A2 WO2011072212 A2 WO 2011072212A2 US 2010059868 W US2010059868 W US 2010059868W WO 2011072212 A2 WO2011072212 A2 WO 2011072212A2
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WO
WIPO (PCT)
Prior art keywords
peek
zeolite
antimicrobial
silver
polyetheretherketone
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PCT/US2010/059868
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English (en)
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WO2011072212A3 (fr
Inventor
Joseph J. Crudden
Jami Hafiz
James E. Deaton
John R. Pepper
Derrick Johns
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Difusion Technologies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Difusion Technologies, Inc. filed Critical Difusion Technologies, Inc.
Priority to BR112012016027-3A priority Critical patent/BR112012016027B1/pt
Priority to US13/512,702 priority patent/US8821912B2/en
Priority to EP10836743.4A priority patent/EP2512538B1/fr
Priority to RU2012129171/15A priority patent/RU2526168C2/ru
Priority to CN201080063584.7A priority patent/CN102834122B/zh
Publication of WO2011072212A2 publication Critical patent/WO2011072212A2/fr
Publication of WO2011072212A3 publication Critical patent/WO2011072212A3/fr
Priority to US13/653,896 priority patent/US8840914B2/en
Priority to US14/471,329 priority patent/US9132576B2/en

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/0013—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor using fillers dispersed in the moulding material, e.g. metal particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B13/00—Conditioning or physical treatment of the material to be shaped
    • B29B13/02—Conditioning or physical treatment of the material to be shaped by heating
    • B29B13/022—Melting the material to be shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B13/00—Conditioning or physical treatment of the material to be shaped
    • B29B13/06—Conditioning or physical treatment of the material to be shaped by drying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
    • B29C43/003—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor characterised by the choice of material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
    • B29C43/22—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of indefinite length
    • B29C43/26—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of indefinite length in several steps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
    • B29C43/32—Component parts, details or accessories; Auxiliary operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
    • B29C43/32—Component parts, details or accessories; Auxiliary operations
    • B29C43/52—Heating or cooling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/0001—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor characterised by the choice of material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/0005—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor using fibre reinforcements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/0053—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor combined with a final operation, e.g. shaping
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2071/00—Use of polyethers, e.g. PEEK, i.e. polyether-etherketone or PEK, i.e. polyetherketone or derivatives thereof, as moulding material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
    • B29K2105/0011—Biocides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/04—Condition, form or state of moulded material or of the material to be shaped cellular or porous
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/06—Condition, form or state of moulded material or of the material to be shaped containing reinforcements, fillers or inserts
    • B29K2105/12—Condition, form or state of moulded material or of the material to be shaped containing reinforcements, fillers or inserts of short lengths, e.g. chopped filaments, staple fibres or bristles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/06—Condition, form or state of moulded material or of the material to be shaped containing reinforcements, fillers or inserts
    • B29K2105/16—Fillers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29K2307/00—Use of elements other than metals as reinforcement
    • B29K2307/04—Carbon
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29K2505/00—Use of metals, their alloys or their compounds, as filler
    • B29K2505/08—Transition metals
    • B29K2505/14—Noble metals, e.g. silver, gold or platinum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2709/00—Use of inorganic materials not provided for in groups B29K2703/00 - B29K2707/00, for preformed parts, e.g. for inserts
    • B29K2709/02—Ceramics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
    • B29K2995/0037—Other properties
    • B29K2995/0056—Biocompatible, e.g. biopolymers or bioelastomers
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Definitions

  • Implantable medical devices are implanted into the body for various reasons, including orthopedics (e.g., hip replacement, spinal procedures, knee replacement, bone fracture repair, etc.) .
  • orthopedics e.g., hip replacement, spinal procedures, knee replacement, bone fracture repair, etc.
  • materials of fabrication are limited, and conventionally include metal, plastic and composites .
  • MRSA Methicillin- resistant Staphylococcus aureus
  • Biofilms can facilitate the proliferation and transmission of microorganisms by providing a stable protective environment. These biofilms, when well developed, can disseminate bacterial planktonic showers which can result in broad systemic infection.
  • Bioengineered materials act as excellent hosts for the formation of bacterial biofilms. Occasionally, the implant itself carries the infecting organism, and the implants develop very tenacious biofilms seeded by infecting organisms. When this occurs, usually the implant must be removed, the patient must be treated with a prolonged course of one or more antibiotics in an effort to cure the infection, and a new implant is then re-implanted. This obviously subjects the patient to additional trauma and pain, and is extremely expensive.
  • Ceramics such as zeolite function as a cation cage, being able to be loaded with silver and other cations having antimicrobial properties.
  • Metal zeolites can be used as an antimicrobial agent, such as by being mixed with the resins used as thermoplastic materials to make the implantable devices, or as coatings to be applied to the devices; see, for example, U.S. Patent No. 6,582,715, the disclosure of which is hereby incorporated by reference.
  • the antimicrobial metal zeolites can be prepared by replacing all or part of the ion-exchangeable ions in zeolite with ammonium ions and antimicrobial metal ions. Preferably, not all of the ion-exchangeable ions are replaced.
  • thermoplastic resin that has been found to be useful in an implant is polyetheretherketone (PEEK) .
  • PEEK polyetheretherketone
  • This thermoplastic polymer has an aromatic backbone, interconnected by ketone and ether functionality.
  • PEEK is suitable for implants because its modulus closely matches that of bone, and is resistant to chemical and radiation damage.
  • Grades of PEEK approved for implantation are very pure and inert and need to pass stringent cytotoxicity testing before being allowed to be implanted into mammals.
  • the ISO 10993 set entails a series of standards for evaluating the biocompatibility of a medical device prior to a clinical study. These documents were preceded by the Tripartite agreement and are a part of the harmonization of the safe use evaluation of medical devices. Those standards include :
  • metal zeolite can release moisture if it is not extremely dry. This moisture can cause the formation of voids in the polymer melt and can contribute to the decomposition of the PEEK polymer and to oxidation of metals, such as silver, copper and/or zinc, incorporated into the zeolite antimicrobial. Although the presence of voids may not be critical for certain non-load bearing applications, the absence of voids is critical for load-bearing applications such as spinal repair.
  • metal zeolites If the process of incorporating metal zeolites is carried out in air, severe oxidation can occur as the temperature is raised, and moisture and oxygen come into contact with the metal ions. Silver will rapidly darken to a dark brown or black color. Also, the incorporation of significant quantities of metal zeolites into the PEEK polymer can affect the viscosity and rheology of the composition .
  • the present disclosure is based on the finding that it is possible, under conditions of high temperature and high shear, to incorporate antimicrobial zeolite, such as silver zeolite, into PEEK, such as by mixing doped metal zeolites into molten PEEK (melting point between 300 and 400°C, depending on purity) , followed by molding and processing of the composite blend.
  • antimicrobial zeolite such as silver zeolite
  • PEEK such as by mixing doped metal zeolites into molten PEEK (melting point between 300 and 400°C, depending on purity)
  • the result is the provision of medical devices such as implants with effective antimicrobial activity in order to reduce the growth of bacteria and risk of infection.
  • the shortcomings of the prior art have been overcome by the present disclosure, which relates to methods of fabricating implantable medical devices, preferably with PEEK, having antimicrobial properties.
  • the antimicrobial effect is produced by incorporating ceramic particles containing antimicrobial metal cations into molten PEEK resin, which is subsequently allowed to cool and set in its final shape achieved by injection molding, cutting and machining or other techniques.
  • the rate of release of metallic ions is governed by the extent of loading of the plastic with ceramic particles containing metal ions and the loading of metal in the ceramic material.
  • the electrolyte concentration in blood and body fluids is relatively constant and will cause ion exchange with ions such as silver, copper and zinc, and others from the surface of the implant, which deactivate or kill gram positive and gram negative organisms, including E. coli and Staphylococcus aureus.
  • Effective antimicrobial control of a six-log reduction of microorganisms is achieved, for example, at metal zeolite concentrations of 4% or greater.
  • the devices are implantable into animals, particularly humans. Spinal implants are particularly contemplated .
  • Fig. 1 is a perspective view of a cervical spacer in accordance with certain embodiments.
  • Embodiments disclosed herein relate to the processing of ceramics, preferably zeolites, as a cation cage in combination with medical implants to deliver and dose one or more antimicrobial cations.
  • ceramics preferably zeolites
  • other suitable ceramic antimicrobial materials include hydroxy apatite, zirconium phosphates and other ion-exchange ceramics .
  • Suitable cations include silver, copper, zinc, mercury, tin, lead, gold, bismuth, cadmium, chromium and thallium ions, and combinations thereof, with silver, zinc and/or copper being preferred.
  • Either natural zeolites or synthetic zeolites can be used to make the zeolites used in the embodiments disclosed herein.
  • Zerolite is an aluminosilicate having a three dimensional skeletal structure that is represented by the formula: ⁇ 2 / ⁇ ⁇ AI 2 O 3 ⁇ YS1O 2 ⁇ Z3 ⁇ 40 wherein M represents an ion- exchangeable ion, generally a monovalent or divalent metal ion, n represents the atomic valency of the (metal) ion, X and Y represent coefficients of metal oxide and silica respectively, and Z represents the number of water of crystallization.
  • Examples of such zeolites include A-type zeolites, X-type zeolites, Y-type zeolites, T-type zeolites, high-silica zeolites, sodalite, and others.
  • silicate materials such as metal doped phosphate glass, bioactive glass such as 45S5 and BG can be processed to deliver a suitable dose of antimicrobial cations .
  • PEEK is a high melting point material that has a melting point of approximately 340°C and must be processed at 360°C to 400°C to enable incorporation of metal zeolite powders and extruding or molding of the composite blend. At these high temperatures, release of any entrapped moisture can cause the formation of voids in the polymer melt. This can contribute to decomposition of the PEEK polymer and to oxidation of metals incorporated into the zeolite antimicrobial, reducing antimicrobial efficacy. Additionally, presence of voids can significantly degrade the properties of the final product. For material produced for load-bearing spinal implants, the minimization of the size and number of any voids is critical in maintaining the mechanical properties of the final product.
  • the silver zeolite powder should be heated to about 400°C at atmospheric pressure, and held there for sufficient time for the bound water to be released. If the powder is spread thinly, moisture release will be more efficient, and a holding time of 30 to 60 minutes is suitable.
  • the silver zeolite can also be dried at lower temperatures under reduced pressure. It is preferable that the composite blend components be dried in a clean environment to less than 0.1% moisture by weight prior to processing. Moreover, it is imperative to maintain the material in an anhydrous environment prior to and during processing.
  • the antimicrobial powder is extremely hygroscopic, requiring the material to be sealed in its original packaging prior to any usage. Exposure to ambient air has to be minimal during pre-blending operations. As an added precaution, the feeder powder hopper needs to be purged with dry nitrogen immediately before and after loading.
  • the PEEK material should be dried between 120°C-130°C for 12 hours (or at a time/temperature equivalent) before running any compounding operation. This ensures that the residual moisture of the PEEK pellets is less than 0.1% moisture by weight prior to processing.
  • Post-Processed Packaging The materials need to be packaged in moisture barrier bags immediately after compounding.
  • twin-screw extruder can be utilized for blending PEEK with required additives.
  • the additive is gravimetrically metered into molten PEEK just prior to entering the extruder screws to obtain the desire additive loading.
  • twin-screw extrusion improves filler distribution and wet-out, and results in a more reproducible rheological behavior.
  • One suitable extruder is a Leistritz ZSE twin screw extruder .
  • Near-net shaped compounded PEEK blanks suitable for secondary machining operations can be produced using the compression molding process.
  • Compression molding is a method of molding preheated compounded PEEK polymer pellets or pre-forms into predefined shapes in pressurized, heated mold cavities.
  • Compression molding is a high-volume, high- pressure method suitable for molding complex shapes. This process wastes relatively little material when compared to machining devices from extruded rods.
  • PEEK implants can be manufactured to final shape by removing material with machining process such as turning, boring, drilling, milling, broaching, sawing, shaping, planing and/or reaming. These machining processes can be manual or automated through the use of computer controlled machining centers .
  • the thermal conductivity of all polymeric materials is lower than that of metals, so heat build-up during machining is rapid. A cleaner cut and more open surface can be achieved if the bit is cooled and run at a slower rate.
  • Machined PEEK surfaces can smear and "skin" if the PEEK surface temperature significantly rises while the material is being machined into implants, possibly affecting the release of cations.
  • a clean cut and "open" surface structure is desired.
  • One method to achieve the desired surface finish is to cool the cutting tool with cold, clean compressed air in conjunction with optimized tool cutting speed and feed rates.
  • cooling rates can have a profound effect on the crystallinity of PEEK, which may be critical to optimize the rate of release of metallic ions. By adjusting the cooling rate during fabrication, the percent crystallinity of the implant material was carefully controlled .
  • Finished or significantly finished compounded PEEK devices can be manufactured using the injection molding process.
  • the injection molding process produces parts from compounded PEEK polymers by feeding compounded PEEK pellets into a heated barrel (400°C) where the molten compounded PEEK is mixed and forced into a heated mold cavity that is maintained at temperatures between about 175°C and 205°C. Once injected into to the mold, the molten compounded PEEK cools to a temperature below 343°C and hardens to the shape of the mold cavity.
  • the desired temperature between about 175°C to 205°C set- point of the molds, significant increases in part feature and tolerance control and minimization of surface skinning can be achieved.
  • the amount of metal zeolite incorporated into the resin should also be an amount effective for promoting antimicrobial activity; e.g., a sufficient amount so as to prevent or inhibit the growth and eradicate bacterial and fungal organisms.
  • incorporation of significant quantities of metal zeolites into the peek polymer melt can affect the viscosity and rheology of the composition. Therefore, a processing window was established that allowed for sufficient zeolite to be loaded without adversely affecting the bulk properties of the final product .
  • Suitable amounts of zeolite in the resin range from about 0.01 to 20.0 wt . % .
  • Optimal loading was found to range from 0.1 to about 10.0 wt . % .
  • the tightly controlled and monitored dimensions of the pellets produced from the optimal loading conditions are shown below in Table I .
  • the finished pellet color is an important indicator if severe oxidation occurred or moisture came into contact with the metal ions during the high temperature process. Pure PEEK is light tan in color while properly processed zeolite containing PEEK is brown in color. In cases where oxidation has occurred, the silver will rapidly darken to a dark brown or black color.
  • SEM Scanning electron micrographs
  • Pyrolysis was utilized for quantitative determination of the loading of silver metal zeolite.
  • a small accurately weighed sample of the PEEK/silver zeolite composite was placed in a ceramic crucible and burned with a propane torch. While plain PEEK burns away completely leaving no residue using this method, PEEK loaded with metal zeolites will burn off and leave behind a powdery residue.
  • the amount of silver zeolite loading can then be determined gravimetrically . The amount of silver present can be confirmed by extracting the silver from the residue and determining the amount of silver in the extraction solution by graphite furnace AA or ICP.
  • the elutable ionic silver content from samples with different loading rates was determined by chemical analysis using graphite furnace atomic absorption spectroscopy. l"xl" sample coupons were immersed into 40 ml of 0.8% sodium nitrate solution for a duration of 24 hours. The amount of silver eluted from different loadings is listed in Table II.
  • Elution of other antimicrobial metals can be determined similarly .
  • PEEK implants Because of PEEK' s radiolucent properties implanted devices made from PEEK do not show up well in X-ray images. Thus, identification of the precise location and integrity of the implant and observation of other important characteristics from X-rays can be difficult.
  • One method that has been used to overcome this drawback is the addition of barium sulfate to the compounding mix. Although devices can be radiopaque due to the addition of barium sulfate to PEEK, the addition of the required amounts of barium sulfate for the desired radiopacity tends to weaken the strength of the resulting device.
  • an implant made from a composition of barium sulfate and PEEK provides an undesirable tradeoff between the desired mechanical properties of the device and its radiopacity.
  • the materials disclosed herein display radiopaque properties even at low loading levels of silver zeolite when viewed under x-ray. This is an important additional benefit that can be derived without sacrificing antimicrobial effectiveness or mechanical integrity of the material .
  • Zeolite at the surface of the implant can significantly increase osteoblast cell attachment due to the presence of negatively charged silicates present in the zeolites.
  • a significant drawback of PEEK products oftentimes is the lack of cell adhesion at the implant site due to the inherent inertness of PEEK. This problem can be suitably alleviated through the availability of by negatively charged silicates at the implant surface.
  • the zeolite structure is inherently negatively charged. These silicates attract proteins containing the RGD peptide sequence with the correct confirmation, leading to the attachment and proliferation of bone forming osteoblast cells. This starts a cascading process that eventually results in significant bone growth.
  • PEEK is very impermeable to moisture so only material in the surface layer no deeper than the diameter of a zeolite particle will be accessible for silver elution. If the silver in this region were deactivated or otherwise converted into insoluble complexes the materials might well be ineffective as antimicrobial materials. So process conditions need to be carefully monitored and followed to maintain silver effectiveness on the implant surface. Effectiveness can be monitored quantitatively by measuring the elutable silver using an ICP and ensuring that the level is well above the reported minimum biofilm growth inhibitory concentration of 0.1 ppm of silver. 20 ppb silver has been shown to be active in the lab and formulations show antimicrobial activity below 5 ppb. Moreover, while the bulk solution concentration may be 5 ppb, the activity of cations close to the surface must necessarily be better.
  • Surface color can also be used as a qualitative measure for monitoring process conditions. Deactivated or otherwise converted silver will change color from brown to black or a mixture of black-brown.
  • surface roughness can be optimized to improve osteogenic properties of the implant.
  • In-vitro studies have shown that all parameters (adhesion, proliferation, alkaline phosphatase activity, synthesis of bone matrix proteins and mineralization) effecting bone growth appear to be influenced by the surface finish of the material.
  • Common manufacturing techniques such as abrasive blasting (bead blasting, sandblasting, sodablasting, cryogenic CO 2 blasting etc.), scraping or sanding with inert materials can be utilized to control the surface roughness to optimize both silver elution and cell growth.
  • Atomic force microscopy (AFM) or Profilometry can be utilized to calculate the average surface roughness in nanometers and this value can be correlated to bone growth parameters from vitro cell testing results to get the optimum range of surface roughness.
  • AFM Atomic force microscopy
  • Profilometry can be utilized to calculate the average surface roughness in nanometers and this value can be correlated to bone growth parameters from vitro cell testing results to get the
  • Figure 1 A specific example of the design is shown in Figure 1. As can be seen from the figure, the columnar design allows for a significant increase in surface area compared to a monolithic construction. This leads to a significantly enhanced silver elution profile as well as increasing the pathways for vascularization.
  • the PEEK can be made porous with suitable porosities including porosities between 50% and 85% by volume.
  • Porosity can be imparted using a pore forming agent such as sodium chloride, to create a porous polymer comprising a plurality of interconnected pores, by processes known in the art.
  • Average pore size is generally greater than 180 microns in diameter, suitably between about 300 and about 700 microns.
  • the PEEK can be reinforced with a reinforcing material such as ceramic or carbon fiber.
  • a reinforcing material such as ceramic or carbon fiber.
  • This can be produced by dispersing the reinforcing material in the PEEK polymer matrix, such as by twin screw compounding of implantable PEEK polymer with carbon fibers.
  • the resulting carbon fiber-reinforced product can be used to direct injection mold final devices and near net shapes, or it can be extruded into stock shapes for machining.
  • the incorporation of fibers or other suitable reinforcing material (s) provides high wear resistance, a Young's modulus of 12 GPa (matching the modulus of cortical bone) and providing sufficient strength to permit its use in very thin implant designs which distribute the stress more efficiently to the bone.
  • the amount of reinforcing material such as carbon fiber incorporated into the PEEK can be varied, such as to modify the Young' s modulus and flexural strength. One suitable amount is 30 wt . % carbon fiber.

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Abstract

La présente invention concerne des procédés permettant de fabriquer des dispositifs médicaux implantables, de préférence avec du polyétheréthercétone (en anglais PolyEtherEtherKetone ou PEEK), dotés de propriétés antimicrobiennes. On produit cet effet antimicrobien en ajoutant des particules de céramique contenant des ions métalliques antimicrobiens dans la résine de PEEK fondue, qu'on laisse ensuite refroidir et prendre dans sa forme définitive obtenue par moulage par injection, découpage et usinage ou par d'autres techniques.
PCT/US2010/059868 2009-12-11 2010-12-10 Procédé de fabrication d'implants antimicrobiens en polyétheréthercétone WO2011072212A2 (fr)

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BR112012016027-3A BR112012016027B1 (pt) 2009-12-11 2010-12-10 método de produção de implantes antimicrobianos de polieteretercetona
US13/512,702 US8821912B2 (en) 2009-12-11 2010-12-10 Method of manufacturing antimicrobial implants of polyetheretherketone
EP10836743.4A EP2512538B1 (fr) 2009-12-11 2010-12-10 Procédé de fabrication d'implants antimicrobiens en polyétheréthercétone
RU2012129171/15A RU2526168C2 (ru) 2009-12-11 2010-12-10 Способ получения противомикробных имплантатов из полиэфирэфиркетона
CN201080063584.7A CN102834122B (zh) 2009-12-11 2010-12-10 制备聚醚醚酮抗微生物植入物的方法
US13/653,896 US8840914B2 (en) 2009-12-11 2012-10-17 Method of manufacturing antimicrobial implants of polyetheretherketone
US14/471,329 US9132576B2 (en) 2009-12-11 2014-08-28 Method of manufacturing antimicrobial implants of polyetheretherketone

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US14/471,329 Continuation US9132576B2 (en) 2009-12-11 2014-08-28 Method of manufacturing antimicrobial implants of polyetheretherketone

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8778378B2 (en) 2009-12-21 2014-07-15 Orthovita, Inc. Bioactive antibacterial bone graft materials
EP2786854A4 (fr) * 2011-11-29 2015-10-07 Wuhan Constant Science And Technology Ltd Procédé utilisant de la matière peek pour fabriquer un os crânio-cérébral, équipement spécial et utilisation
WO2017025364A1 (fr) 2015-08-13 2017-02-16 Raumedic Ag Composant de fixation pour maintenir un moyen de travail médical
CN116021707A (zh) * 2023-03-27 2023-04-28 四川爱思达航天科技有限公司 一种peek材料的注塑加工成型方法

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104941004B (zh) * 2009-11-25 2018-09-14 扩散技术公司 用抗微生物金属离子对掺杂沸石的塑料的后加载方法
RU2526168C2 (ru) * 2009-12-11 2014-08-20 Дифьюжн Текнолоджиз, Инк. Способ получения противомикробных имплантатов из полиэфирэфиркетона
CA2795836C (fr) 2010-05-07 2015-11-17 Difusion Technologies, Inc. Implant medical comprenant une resine thermoplastique pourvue de particules d'aluminosilicate
CN102490350B (zh) * 2011-10-10 2014-12-17 黄登峰 利用peek材料制成脑颅骨的工艺及专用设备及应用
CA2882591C (fr) 2012-08-21 2021-01-12 Avery Dennison Corporation Systemes et procedes pour realiser des films, des fibres, des spheres et d'autres articles poreux
US9802844B2 (en) 2012-11-08 2017-10-31 Silver Aqua, Inc. Portable pathogen deactivation method and apparatus
US9277978B2 (en) 2012-11-15 2016-03-08 Stoma Ventures, LLC Disposable dental valve device
US9333061B2 (en) 2012-11-15 2016-05-10 Stoma Ventures, LLC Disposable dental valve device
DE102013100529A1 (de) * 2013-01-18 2014-07-24 Bredent Gmbh & Co. Kg Verankerungselement und Verfahren zur Herstellung
US9586381B1 (en) 2013-10-25 2017-03-07 Steriplate, LLC Metal plated object with biocidal properties
TWI607736B (zh) * 2013-11-29 2017-12-11 財團法人金屬工業研究發展中心 Intervertebral implant and its manufacturing method
US9504550B2 (en) 2014-06-26 2016-11-29 Vertera, Inc. Porous devices and processes for producing same
US9498922B2 (en) 2014-06-26 2016-11-22 Vertera, Inc. Apparatus and process for producing porous devices
US10786332B2 (en) 2014-07-17 2020-09-29 Stoma Ventures, LLC Dental valve tailpiece
TWI645842B (zh) * 2015-04-15 2019-01-01 施魯孫 Stress-distributed artificial intervertebral disc
USD815281S1 (en) 2015-06-23 2018-04-10 Vertera, Inc. Cervical interbody fusion device
EP3325079B1 (fr) 2015-07-23 2023-09-06 Novaflux, Inc. Implants et constructions comprenant des fibres creuses
US9765899B2 (en) 2015-11-03 2017-09-19 Stoma Ventures, LLC Disposable dental valve device
CN105559948B (zh) * 2015-12-14 2018-12-18 北京大学第一医院 一种人工关节假体
WO2017223162A1 (fr) * 2016-06-21 2017-12-28 Sabic Global Technologies B.V. Cage vertébrale et procédés de fabrication
US11766339B1 (en) 2017-10-24 2023-09-26 Omnia Medical, LLC Multi-material multi-component spinal implant
US10751196B1 (en) 2017-10-24 2020-08-25 Omnia Medical, LLC Multi-material multi-component spinal implant
CN110935069B (zh) * 2018-09-25 2021-03-05 华东理工大学 一种复合材料、原料组合物、骨修复体、制备方法和应用
US11439726B2 (en) 2018-12-03 2022-09-13 Osseomimetic, LLC Surgical implants
CN113288385A (zh) * 2021-05-17 2021-08-24 济南大学 连续碳纤维制备仿生腰椎弓根钉的方法
CN114533963B (zh) * 2021-11-17 2022-09-30 吉林大学 一种负载锌离子的聚醚醚酮复合材料及其制备方法和应用
MX2023000928A (es) 2022-06-29 2024-01-01 Arcosystem Spa Implante craneofacial de polieter eter cetona (peek) con depositos para almacenar y liberar sustancias activas.
CN118105538B (zh) * 2024-03-07 2024-07-26 常州集硕医疗器械有限公司 一种改性纤维增强peek骨支架材料及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0116865A1 (fr) 1983-01-21 1984-08-29 Kanebo, Ltd. Article polymère possédant des propriétés antibactériennes contenant des particules de zéolites et procédé pour sa fabrication
US6582715B1 (en) 1999-04-27 2003-06-24 Agion Technologies, Inc. Antimicrobial orthopedic implants
EP1813292A1 (fr) 2006-01-25 2007-08-01 Inion Oy Implant chirurgical et procédé de fabrication

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4088737A (en) 1976-11-02 1978-05-09 The United States Of America As Represented By The United States Department Of Energy Dry method for recycling iodine-loaded silver zeolite
JPS57500588A (fr) 1980-03-27 1982-04-08
DE3228849C2 (de) 1982-08-02 1989-06-08 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 8000 München In den Körper einzuführendes medizinisches Gerät
EP0124536A4 (fr) 1982-11-05 1985-06-06 Baxter Travenol Lab Compositions antimicrobiennes.
US4596574A (en) 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
US4612337A (en) 1985-05-30 1986-09-16 The Trustees Of Columbia University In The City Of New York Method for preparing infection-resistant materials
GB2190383B (en) 1986-04-08 1990-03-28 Dentsply Ltd Glass/poly (carboxylic acid)cement compositions
JPS6323960A (ja) * 1986-07-16 1988-02-01 Zenji Hagiwara 非晶質アルミノ珪酸塩粒子を含有する高分子体及びその製造方法
US4938958A (en) 1986-12-05 1990-07-03 Shinagawa Fuel Co., Ltd. Antibiotic zeolite
US4775586A (en) * 1987-02-17 1988-10-04 Armstrong World Industries, Inc. Paper, paper products, films composites and other silicate-polymer, construction materials
JPS63265958A (ja) 1987-04-22 1988-11-02 Shinagawa Nenryo Kk 抗菌性樹脂組成物
JPH0618899B2 (ja) 1987-06-30 1994-03-16 品川燃料株式会社 抗菌性ゼオライト含有フィルム
JPH0741061B2 (ja) 1987-07-09 1995-05-10 華郎 前田 医療用被覆材
JPS6415056A (en) 1987-07-09 1989-01-19 Hanarou Maeda Body indwelling tube
JPH0688885B2 (ja) 1987-12-26 1994-11-09 品川燃料株式会社 抗菌性粉体を含有する分散体の製造方法
US4957817A (en) 1988-11-25 1990-09-18 The Dow Chemical Film, fiber, and microporous membranes of poly(etheretherketone)dissolved in high boiling point polar organic solvents
US5649951A (en) 1989-07-25 1997-07-22 Smith & Nephew Richards, Inc. Zirconium oxide and zirconium nitride coated stents
JP2811331B2 (ja) 1989-10-02 1998-10-15 ゼリア新薬工業株式会社 骨形成促進剤
US5192590A (en) 1989-11-03 1993-03-09 Raychem Corporation Coating metal on poly(aryl ether ketone) surfaces
IL96313A (en) 1989-11-14 1995-03-30 Sangi Kk Antibacterial ceramic
JPH03199403A (ja) * 1989-12-27 1991-08-30 Chugoku Pearl Hanbai Kk 無菌性手袋
US5256390A (en) 1990-07-03 1993-10-26 Ethyl Corporation Biocidal zeolite particles
US5296238A (en) 1991-02-26 1994-03-22 Toagosei Chemical Industry Co., Inc. Microbicides
US5282847A (en) 1991-02-28 1994-02-01 Medtronic, Inc. Prosthetic vascular grafts with a pleated structure
EP0677989B1 (fr) 1991-08-09 1998-09-16 E.I. Du Pont De Nemours And Company Composition antimicrobienne, procede pour sa preparation et son utilisation
US5503840A (en) 1991-08-09 1996-04-02 E. I. Du Pont De Nemours And Company Antimicrobial compositions, process for preparing the same and use
US5180585A (en) 1991-08-09 1993-01-19 E. I. Du Pont De Nemours And Company Antimicrobial compositions, process for preparing the same and use
WO1993007924A1 (fr) 1991-10-18 1993-04-29 Spire Corporation Revetements bactericides s'appliquant a des implants
JPH05124919A (ja) 1991-11-05 1993-05-21 Sangi Co Ltd 抗菌性セラミツクス
JPH05230325A (ja) 1992-02-24 1993-09-07 Polyplastics Co 防菌、防カビ性ポリアセタール樹脂組成物
US5681575A (en) 1992-05-19 1997-10-28 Westaim Technologies Inc. Anti-microbial coating for medical devices
US5492763A (en) 1992-06-08 1996-02-20 Spire Corporation Infection resistant medical devices and process
EP0606762B1 (fr) 1992-12-25 1998-08-05 Japan Synthetic Rubber Co., Ltd. Composition résineuse antibacterielle
US5522904A (en) 1993-10-13 1996-06-04 Hercules Incorporated Composite femoral implant having increased neck strength
US6180606B1 (en) 1994-09-28 2001-01-30 Gensci Orthobiologics, Inc. Compositions with enhanced osteogenic potential, methods for making the same and uses thereof
JP3121503B2 (ja) 1994-10-18 2001-01-09 レンゴー株式会社 抗菌剤
JP2860951B2 (ja) 1995-01-12 1999-02-24 株式会社萩原技研 抗菌性ポリマー組成物
US5731087A (en) 1995-06-07 1998-03-24 Union Carbide Chemicals & Plastics Technology Corporation Lubricious coatings containing polymers with vinyl and carboxylic acid moieties
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
US5756145A (en) 1995-11-08 1998-05-26 Baylor College Of Medicine Durable, Resilient and effective antimicrobial coating for medical devices and method of coating therefor
DE69632996T2 (de) 1995-12-26 2005-07-21 Toyo Boseki K.K. In organischen Lösungsmitteln lösliche Mucopolysaccharide, antibakterielles antithrombogenes Mittel und medizinisches Material
US6015816A (en) 1996-02-29 2000-01-18 The Research Foundation Of State University Of New York Antimicrobial compositions
US5688561A (en) 1996-04-16 1997-11-18 Kabushiki Kaisha Nippankenkyusho Coating method
WO1999009149A1 (fr) 1997-08-01 1999-02-25 Massachusetts Institute Of Technology Matrices de polymeres tridimensionnelles
AU8846398A (en) 1997-08-11 1999-03-01 University Of Toronto Innovations Foundation, The Antimicrobial cement compositions
JP3143660B2 (ja) 1997-11-27 2001-03-07 工業技術院長 亜鉛含有リン酸三カルシウムからなるセラミックス及び亜鉛徐放性生体用セラミックス
US6248342B1 (en) 1998-09-29 2001-06-19 Agion Technologies, Llc Antibiotic high-pressure laminates
US6585767B1 (en) 1998-11-23 2003-07-01 Agion Technologies, Inc. Antimicrobial suturing ring for heart valve
US6296863B1 (en) 1998-11-23 2001-10-02 Agion Technologies, Llc Antimicrobial fabric and medical graft of the fabric
US6436422B1 (en) 1998-11-23 2002-08-20 Agion Technologies L.L.C. Antibiotic hydrophilic polymer coating
US6723428B1 (en) 1999-05-27 2004-04-20 Foss Manufacturing Co., Inc. Anti-microbial fiber and fibrous products
EP1066825A1 (fr) 1999-06-17 2001-01-10 The Procter & Gamble Company Produit antimicrobien pour les soins du corps
US8323341B2 (en) 2007-09-07 2012-12-04 Intrinsic Therapeutics, Inc. Impaction grafting for vertebral fusion
US6267590B1 (en) 1999-11-24 2001-07-31 Agion Technologies, Llc Antimicrobial dental products
DE10037850A1 (de) 2000-08-01 2002-02-21 Herbert P Jennissen Verfahren zur Herstellung bioaktiver Implantatoberflächen
AU2001288317A1 (en) 2000-08-30 2002-03-13 Agion Technologies, Llc Bi-laminar, hyaluronan coatings with silver-based anti-microbial properties
DE10043151A1 (de) 2000-08-31 2002-03-28 Peter Steinruecke Knochenzement mit antimikrobieller Wirksamkeit
DE10055465A1 (de) 2000-11-09 2002-05-23 Blz Gmbh Knochenersatzwerkstoff und Verfahren zur Herstellung eines Knochenersatz-Implantats
DE20020649U1 (de) * 2000-12-06 2002-04-11 stryker Trauma GmbH, 24232 Schönkirchen Vorrichtung für den chirurgischen oder therapeutischen Gebrauch, insbesondere Implantate und chirurgische Instrumente sowie deren Zubehör
EP1347684B1 (fr) 2001-01-04 2008-05-28 Byotrol PLC Composition antimicrobienne
EP1359948A1 (fr) 2001-01-30 2003-11-12 IsoTis S.A. Procede d'application d'un revetement bioactif sur un dispositif medical
DE60138521D1 (de) 2001-02-27 2009-06-10 Co Ligne Ag Medizinisches Implantat
CN1612804A (zh) 2001-12-03 2005-05-04 C·R·巴德公司 抗微生物医用器材、抗微生物聚合物涂层及其制备方法
US7357949B2 (en) 2001-12-21 2008-04-15 Agion Technologies Inc. Encapsulated inorganic antimicrobial additive for controlled release
CA2481488C (fr) 2002-04-09 2012-01-24 Astra Tech Ab Dispositif prothetique medical recouvert d'une couche d'hydroxyde de metal correspondant
DE10243132B4 (de) * 2002-09-17 2006-09-14 Biocer Entwicklungs Gmbh Antiinfektiöse, biokompatible Titanoxid-Beschichtungen für Implantate sowie Verfahren zu deren Herstellung
US7270813B2 (en) 2002-10-08 2007-09-18 Osteotech, Inc. Coupling agents for orthopedic biomaterials
FR2848856B1 (fr) 2002-12-24 2007-05-25 Cadorel Catherine Materiau a usage medical ou veterinaire, son procede d'obtention et ses applications
US20060259020A1 (en) * 2003-09-17 2006-11-16 Minnesota Scientific, Inc. Bacteria resistant coating for surgical instrument
WO2005027722A2 (fr) 2003-09-17 2005-03-31 Minnesota Scientific, Inc. Revetement resistant aux bacteries pour instrument chirurgical
US20050149196A1 (en) 2004-01-07 2005-07-07 St. Francis Medical Technologies, Inc. Artificial spinal disk replacement device with rotation limiter and lateral approach implantation method
NZ548447A (en) 2004-01-12 2010-04-30 Univ Pennsylvania Up-regulation of bone morphogenetic protein (BMP) gene expression in bone cells by electromagnetic signals
US20050203529A1 (en) 2004-03-03 2005-09-15 Boehm Frank H.Jr. Minimally-invasive method for performing spinal fusion and bone graft capsule for facilitating the same
WO2006024253A1 (fr) * 2004-09-03 2006-03-09 Weinmann Geräte für Medizin GmbH & Co. KG Matieres plastiques pour appareils medicaux
US20060069438A1 (en) 2004-09-29 2006-03-30 Zucherman James F Multi-piece artificial spinal disk replacement device with multi-segmented support plates
US7670384B2 (en) 2004-10-14 2010-03-02 Biomet Manufacturing Corp. Bone graft composition comprising a bone material and a carrier comprising denatured demineralized bone
EA011594B1 (ru) 2004-12-30 2009-04-28 Синвеншен Аг Композиция, включающая агент, обеспечивающий сигнал, имплантируемый материал и лекарство
AU2006235025A1 (en) 2005-04-04 2006-10-19 The Regents Of The University Of California Inorganic materials for hemostatic modulation and therapeutic wound healing
US7662186B2 (en) * 2005-05-06 2010-02-16 Titan Spine, Llc Anterior interbody spinal implant
WO2006127838A2 (fr) * 2005-05-26 2006-11-30 Zimmer Dental, Inc. Dispositif de prothese dentaire
EP1902087A1 (fr) 2005-07-01 2008-03-26 Cinvention Ag Procede de fabrication de materiaux composites poreux reticules
DE602006018023D1 (de) 2005-08-08 2010-12-16 Angstrom Medica Inc Zementprodukte sowie verfahren zu deren herstellung und verwendung
JP2007091501A (ja) 2005-09-27 2007-04-12 Sinanen Zeomic Co Ltd 抗菌性ゼオライト及び抗菌性樹脂組成物
WO2007056671A1 (fr) 2005-11-02 2007-05-18 Osteotech, Inc. Greffe osseuse hemostatique
GB0601687D0 (en) 2006-01-27 2006-03-08 Smith & Nephew Antimicrobial materials
US7879027B2 (en) 2006-04-24 2011-02-01 Warsaw Orthopedic, Inc. Controlled release devices for fusion of osteal structures
US7661430B2 (en) 2006-05-19 2010-02-16 Richard Mason Antimicrobial dental appliances including mouthguards and mouthpieces
US20080033572A1 (en) 2006-08-03 2008-02-07 Ebi L.P. Bone graft composites and methods of treating bone defects
WO2008039488A2 (fr) 2006-09-25 2008-04-03 Vita Special Purpose Corporation Composites bioactifs supportant des charges
FR2906147B1 (fr) * 2006-09-26 2012-11-02 Biomatlante Procede de sablage de polymeres biocompatibles
WO2008048266A1 (fr) 2006-10-20 2008-04-24 Ticona Llc Polyéther éther cétone/mélange de sulfure de polyphénylène
CN101234304A (zh) * 2007-02-02 2008-08-06 中国科学院化学研究所 一种聚醚醚酮多孔膜及其制备方法
US20080208340A1 (en) 2007-02-26 2008-08-28 Daniel Boyd Synthetic bone graft
WO2008122594A2 (fr) 2007-04-05 2008-10-16 Cinvention Ag Implant thérapeutique partiellement biodégradable pour la réparation de l'os et du cartilage
US20090012612A1 (en) 2007-04-10 2009-01-08 David White Devices and methods for push-delivery of implants
JP6017110B2 (ja) 2007-05-29 2016-11-09 ティーピーケイ ホールディング カンパニー リミテッド 粒子含有表面とその関連方法
EP2238992B1 (fr) 2008-01-28 2014-05-14 NGK Spark Plug Co., Ltd. Implant biologique ayant une surface sous forme de mousse et son procédé de production
KR101618887B1 (ko) * 2008-02-01 2016-05-09 신세스 게엠바하 다공성 생적합성 고분자 재료 및 방법
US8545222B2 (en) 2008-10-21 2013-10-01 Chan Qian Wang Method of dental implant restoration
WO2010099221A1 (fr) 2009-02-25 2010-09-02 Orthobond Corp. Surfaces anti-infectieuses fonctionnalisées et leurs procédés de fabrication
WO2010114827A1 (fr) 2009-04-01 2010-10-07 Difusion Technologies, Inc. Régulation de la croissance osseuse au moyen de zéolite en combinaison avec des substituts de greffe osseuse
DE102009023459B4 (de) 2009-06-02 2017-08-31 Aap Implantate Ag Osteosynthese mit Nanosilber
CN104941004B (zh) 2009-11-25 2018-09-14 扩散技术公司 用抗微生物金属离子对掺杂沸石的塑料的后加载方法
RU2526168C2 (ru) 2009-12-11 2014-08-20 Дифьюжн Текнолоджиз, Инк. Способ получения противомикробных имплантатов из полиэфирэфиркетона
EP2338532B1 (fr) 2009-12-23 2018-01-10 Fundacion Inasmet Article Peek poreux en tant qu'implant
CA2795836C (fr) 2010-05-07 2015-11-17 Difusion Technologies, Inc. Implant medical comprenant une resine thermoplastique pourvue de particules d'aluminosilicate
WO2014152649A1 (fr) 2013-03-15 2014-09-25 Difusion Technologies, Inc. Implants orthopédiques à auto-stérilisation à efficacité améliorée

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0116865A1 (fr) 1983-01-21 1984-08-29 Kanebo, Ltd. Article polymère possédant des propriétés antibactériennes contenant des particules de zéolites et procédé pour sa fabrication
US6582715B1 (en) 1999-04-27 2003-06-24 Agion Technologies, Inc. Antimicrobial orthopedic implants
EP1813292A1 (fr) 2006-01-25 2007-08-01 Inion Oy Implant chirurgical et procédé de fabrication

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2512538A4

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8778378B2 (en) 2009-12-21 2014-07-15 Orthovita, Inc. Bioactive antibacterial bone graft materials
EP2786854A4 (fr) * 2011-11-29 2015-10-07 Wuhan Constant Science And Technology Ltd Procédé utilisant de la matière peek pour fabriquer un os crânio-cérébral, équipement spécial et utilisation
WO2017025364A1 (fr) 2015-08-13 2017-02-16 Raumedic Ag Composant de fixation pour maintenir un moyen de travail médical
DE102015215509A1 (de) 2015-08-13 2017-02-16 Raumedic Ag Fixierkomponente zur Halterung eines medizinischen Arbeitsmittels
CN116021707A (zh) * 2023-03-27 2023-04-28 四川爱思达航天科技有限公司 一种peek材料的注塑加工成型方法

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US20140366362A1 (en) 2014-12-18
EP2512538A2 (fr) 2012-10-24
CN102834122A (zh) 2012-12-19
CN102834122B (zh) 2015-03-11
BR112012016027A2 (pt) 2018-05-29
US20130004585A1 (en) 2013-01-03
US20130037991A1 (en) 2013-02-14
BR112012016027B1 (pt) 2019-01-15
RU2012129171A (ru) 2014-01-20
WO2011072212A3 (fr) 2011-11-17
US8840914B2 (en) 2014-09-23
US8821912B2 (en) 2014-09-02
RU2526168C2 (ru) 2014-08-20
US9132576B2 (en) 2015-09-15
EP2512538A4 (fr) 2013-09-25
EP2512538B1 (fr) 2017-02-22

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