WO2011024146A3 - Adam12 inhibitors and their use against inflammation-induced fibrosis - Google Patents

Adam12 inhibitors and their use against inflammation-induced fibrosis Download PDF

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Publication number
WO2011024146A3
WO2011024146A3 PCT/IB2010/053865 IB2010053865W WO2011024146A3 WO 2011024146 A3 WO2011024146 A3 WO 2011024146A3 IB 2010053865 W IB2010053865 W IB 2010053865W WO 2011024146 A3 WO2011024146 A3 WO 2011024146A3
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WO
WIPO (PCT)
Prior art keywords
adam12
induced fibrosis
inflammation
use against
inhibitors
Prior art date
Application number
PCT/IB2010/053865
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French (fr)
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WO2011024146A2 (en
Inventor
Lucie Peduto
Gérard EBERL
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Institut Pasteur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Pasteur filed Critical Institut Pasteur
Priority to US13/393,113 priority Critical patent/US20120225082A1/en
Priority to EP17195306.0A priority patent/EP3358351B1/en
Priority to EP10754592.3A priority patent/EP2470909B1/en
Publication of WO2011024146A2 publication Critical patent/WO2011024146A2/en
Publication of WO2011024146A3 publication Critical patent/WO2011024146A3/en
Priority to US14/479,006 priority patent/US9777276B2/en
Priority to US15/690,076 priority patent/US10961536B2/en

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Abstract

The present invention relates to the field of fibrosis and inflammation and more particularly to the use of ADAM12 (A Disintegrin and Metalloproteinase 12) inhibitors to prevent or treat inflammation-induced fibrosis. The present invention also relates to the use of ADAM12 as a marker for inflammation-induced fibrosis and to the ablation of ADAM12 expressing cells as therapeutic approach to interfere with the development of pro-fibrotic cells.
PCT/IB2010/053865 2009-08-28 2010-08-27 Adam12 inhibitors and their use against inflammation-induced fibrosis WO2011024146A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US13/393,113 US20120225082A1 (en) 2009-08-28 2010-08-27 ADAM12 Inhibitors and Their Use Against Inflammation-Induced Fibrosis
EP17195306.0A EP3358351B1 (en) 2009-08-28 2010-08-27 Adam12 inhibitors and their use against inflammation-induced fibrosis
EP10754592.3A EP2470909B1 (en) 2009-08-28 2010-08-27 Adam12 inhibitors and their use against inflammation-induced fibrosis
US14/479,006 US9777276B2 (en) 2009-08-28 2014-09-05 ADAM12 inhibitors and their use against inflammation-induced fibrosis
US15/690,076 US10961536B2 (en) 2009-08-28 2017-08-29 ADAM12 inhibitors and their use against inflammation-induced fibrosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA2,676,946 2009-08-28
CA2676946A CA2676946A1 (en) 2009-08-28 2009-08-28 Adam12 inhibitors and their use against inflammation-induced fibrosis

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/393,113 A-371-Of-International US20120225082A1 (en) 2009-08-28 2010-08-27 ADAM12 Inhibitors and Their Use Against Inflammation-Induced Fibrosis
US14/479,006 Division US9777276B2 (en) 2009-08-28 2014-09-05 ADAM12 inhibitors and their use against inflammation-induced fibrosis

Publications (2)

Publication Number Publication Date
WO2011024146A2 WO2011024146A2 (en) 2011-03-03
WO2011024146A3 true WO2011024146A3 (en) 2011-06-16

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US (3) US20120225082A1 (en)
EP (2) EP3358351B1 (en)
CA (1) CA2676946A1 (en)
WO (1) WO2011024146A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2676946A1 (en) 2009-08-28 2011-02-28 Lucie Peduto Adam12 inhibitors and their use against inflammation-induced fibrosis
EP2990043B1 (en) * 2013-04-25 2018-09-05 Yamaguchi University Inhibitors of adam12 for use in treating neurological disorders
WO2017134265A1 (en) * 2016-02-05 2017-08-10 Institut Pasteur Use of inhibitors of adam12 as adjuvants in tumor therapies
CN113350368B (en) * 2021-07-21 2023-07-11 山东科金生物发展有限公司 Application of gene inhibitor in preparation of epidermal stem cell migration pharmaceutical preparation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0342682A2 (en) * 1988-05-19 1989-11-23 Warner-Lambert Company Hydroxamate derivatives of selected nonsteroidal anti-inflammatory acyl residues having cyclooxygenase and 5-lipoxygenase inhibition
WO1997040072A2 (en) * 1996-04-19 1997-10-30 The University Of Sheffield Adam proteins and uses thereof
WO2006014903A2 (en) * 2004-07-27 2006-02-09 Five Prime Therapeutics, Inc. Compositions and methods of use for adam12 antagonists in treating disease

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595700A (en) 1984-12-21 1986-06-17 G. D. Searle & Co. Thiol based collagenase inhibitors
US4681894A (en) 1986-09-26 1987-07-21 Ortho Pharmaceutical Corporation Hydroxamic acids and esters
US5892112A (en) 1990-11-21 1999-04-06 Glycomed Incorporated Process for preparing synthetic matrix metalloprotease inhibitors
EP0639982A1 (en) 1992-05-01 1995-03-01 British Biotech Pharmaceuticals Limited Use of mmp inhibitors
GB9405076D0 (en) 1994-03-16 1994-04-27 Inst Of Ophtalmology A medical use of matrix metalloproteinase inhibitors
WO1995029689A1 (en) 1994-04-28 1995-11-09 Merck & Co., Inc. N-carboxyalkyl derivatives as antidegenerative active agents
US5968795A (en) 1996-05-15 1999-10-19 Bayer Corporation Biaryl acetylenes as inhibitors of matrix metalloproteases
US5925637A (en) 1997-05-15 1999-07-20 Bayer Corporation Inhibition of matrix metalloproteases by substituted biaryl oxobutyric acids
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
AU4074799A (en) 1998-05-14 1999-11-29 Du Pont Pharmaceuticals Company Substituted aryl hydroxamic acids as metalloproteinase inhibitors
HUP0102714A3 (en) 1998-07-30 2003-01-28 Warner Lambert Co Tricyclic sulfonamid derivatives as inhibitors of matrix metalloproteinases and medicaments containing the same
PT1819359E (en) * 2004-12-09 2015-05-28 Janssen Biotech Inc Anti-integrin immunoconjugates, methods of their production and their use
AR070127A1 (en) * 2008-01-11 2010-03-17 Novartis Ag PIRROLO - PIRIMIDINAS AND PIRROLO -PIRIDINAS
AU2009322184B2 (en) * 2008-12-04 2016-03-31 Lankenau Institute For Medical Research Compositions and methods for the treatment and prevention of lens fibrotic diseases
CA2676946A1 (en) 2009-08-28 2011-02-28 Lucie Peduto Adam12 inhibitors and their use against inflammation-induced fibrosis
US8703128B2 (en) * 2011-01-24 2014-04-22 New York University Methods of modulating TGFβ signaling

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0342682A2 (en) * 1988-05-19 1989-11-23 Warner-Lambert Company Hydroxamate derivatives of selected nonsteroidal anti-inflammatory acyl residues having cyclooxygenase and 5-lipoxygenase inhibition
WO1997040072A2 (en) * 1996-04-19 1997-10-30 The University Of Sheffield Adam proteins and uses thereof
WO2006014903A2 (en) * 2004-07-27 2006-02-09 Five Prime Therapeutics, Inc. Compositions and methods of use for adam12 antagonists in treating disease

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JORGENSEN LOUISE HELSKOV ET AL: "Transgenic overexpression of ADAM12 suppresses muscle regeneration and aggravates dystrophy in aged mdx mice", AMERICAN JOURNAL OF PATHOLOGY, vol. 171, no. 5, November 2007 (2007-11-01), pages 1599 - 1607, XP002631501, ISSN: 0002-9440 *
PAULISSEN GENEVIEVE ET AL: "Expression of ADAMs and their inhibitors in sputum from patients with asthma", MOLECULAR MEDICINE (BALTIMORE), vol. 12, no. 7-8, July 2006 (2006-07-01), pages 171 - 179, XP002631502, ISSN: 1076-1551 *

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EP3358351A1 (en) 2018-08-08
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